Toward curing neurological autoimmune disorders: Biomarkers, immunological mechanisms, and therapeutic targets

Authors: Segal, Yahel ^{1, 4, 9}, Soltys, John ^{2, 4, 9}, Clarkson, Benjamin D.S. ^{1, 3, 4, 9}, Howe, Charles L. ^{3, 4, 5, 10}, Irani, Sarosh R. ^{2, 4, 6, 7, 8, 10}, Pittock, Sean J. ^{1, 3, 4, 10, ∗}

Source: In Neuron 5 February 2025 113(3):345-379

CSF cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (GFAP) autoimmunity.

Authors: Segal, Yahel¹ (AUTHOR), Mangioris, Georgios¹ (AUTHOR), Lennon, Vanda^1,2 (AUTHOR), Yang, Binxia¹ (AUTHOR), Dubey, Divyanshu^1,2,3 (AUTHOR), Flanagan, Eoin P.^1,2,3 (AUTHOR), McKeon, Andrew^1,2,3 (AUTHOR), Mills, John R.¹ (AUTHOR), Toledano, Michel^2,3 (AUTHOR), Vodopivec, Ivana⁴ (AUTHOR), Pittock, Sean J.^1,2,3 (AUTHOR), Zekeridou, Anastasia^1,2,3 (AUTHOR) zekeridou.anastasia@mayo.edu

Source: Annals of Clinical & Translational Neurology. Apr2025, Vol. 12 Issue 4, p855-860. 6p.

Subject Terms: *GLIAL fibrillary acidic protein, *CHEMOKINES, *AUTOIMMUNITY, *INTERLEUKIN-6, *CYTOKINES

Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis

Authors: Novikova, Natalia S., Diatlova, Anastasia S., Derevtsova, Kristina Z., Korneva, Elena A., Viktorovna, Tamara V., Ostrinki, Yuri, Abraham, Lital, Quinn, Shir, Segal, Yahel, Churilov, Leonid P., Blank, Miri, Shoenfeld, Yehuda, Aharoni, Rina, Amital, Howard

Source: In Journal of Neuroimmunology 15 December 2019 337

Epidemiology of autoimmune encephalitis and comparison to infectious causes—Experience from a tertiary center.

Authors: Segal, Yahel¹ (AUTHOR), Rotschild, Ofer¹ (AUTHOR), Mina, Yair^1,2 (AUTHOR), Maayan Eshed, Gadi¹ (AUTHOR), Levinson, Tal³ (AUTHOR), Paran, Yael^2,3 (AUTHOR), Dekel, Michal^2,3 (AUTHOR), Cohen‐Poradosu, Ronit³ (AUTHOR), Ashkenazi, Adi⁴ (AUTHOR), Moreno, Itamar⁴ (AUTHOR), Aizenstein, Orna^2,4,5 (AUTHOR), Halutz, Ora^2,6 (AUTHOR), Alcalay, Yifat^2,7 (AUTHOR), Gadoth, Avi^1,2 (AUTHOR) avig@tlvmc.gov.il

Source: Annals of Clinical & Translational Neurology. Sep2024, Vol. 11 Issue 9, p2337-2349. 13p.

Subject Terms: *TEMPORAL lobe, *CEREBROSPINAL fluid, *PARASITIC diseases, *ENCEPHALITIS, *SEIZURES (Medicine), *VIRAL encephalitis

The value of Autoimmune Syndrome Induced by Adjuvant (ASIA) - Shedding light on orphan diseases in autoimmunity

Authors: Segal, Yahel, Dahan, Shani, Sharif, Kassem, Bragazzi, Nicola Luigi, Watad, Abdulla, Amital, Howard

Source: In Autoimmunity Reviews May 2018 17(5):440-448

Novelties in the field of autoimmunity – 1st Saint Petersburg congress of autoimmunity, the bridge between east and west

Authors: Dahan, Shani, Segal, Yahel, Watad, Abdulla, Azrielant, Shir, Shemer, Asaf, Maymon, Dror, Stroev, Yuri I., Sobolevskaya, Polina A., Korneva, Elena A., Blank, Miri, Gilburd, Boris, Shovman, Ora, Amital, Howard, Ehrenfeld, Michael, Tanay, Amir, Kivity, Shay, Pras, Elon, Chapman, Joav, Damoiseaux, Jan, Cervera, Ricard, Putterman, Chaim, Shapiro, Iziaslav, Mouthon, Luc, Perricone, Roberto, Bizzaro, Nicola, Koren, Omry, Riemekasten, Gabriela, Chereshnev, Valeriy A., Mazurov, Vadim I., Goloviznin, Mark, Gurevich, Victor, Churilov, Leonid P., Shoenfeld, Yehuda

Source: In Autoimmunity Reviews December 2017 16(12):1175-1184

Interest of rare autoantibodies in autoimmune encephalitis and paraneoplastic neurological syndromes: the utility (or futility) of rare antibody discovery.

Authors: Segal, Yahel, Zekeridou, Anastasia

Source: Current Opinion in Neurology; Jun2024, Vol. 37 Issue 3, p295-304, 10p

Defining the CSF Cytokine and Chemokine Profile of Patients with Autoimmune GFAP Meningoencephalomyelitis.

Authors: Segal, Yahel, Mangioris, Georgios, Pittock, Sean, Yang, Binxia, Dubey, Divyanshu, Flanagan, Eoin, Mills, John, Toledano, Michel, Vodopivec, Ivana, McKeon, Andrew, Zekeridou, Anastasia

Source: Neurology; 2024Supplement7, Vol. 103, pS89-S90, 2p

Corrigendum to “Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis” [J Neuroimmunol. 2019 Dec 15;337:577070. doi: 10.1016/j.jneuroim.2019.577070. Epub 2019 Oct 24]

Authors: Novikova, Natalia S., Diatlova, Anastasia S., Derevtsova, Kristina Z., Korneva, Elena A., Abraham, Lital, Quinn, Shir, Segal, Yahel, Churilov, Leonid P., Fedotkina, Tamara V., Ostrinski, Yuri, Blank, Miri, Shoenfeld, Yehuda, Aharoni, Rina, Amital, Howard

Source: In Journal of Neuroimmunology 15 February 2020 339

Preventing post-stroke dementia. The MARCH Trial. Protocol and statistical analysis plan of a randomized clinical trial testing the safety and efficacy of Maraviroc in post-stroke cognitive impairment.

Authors: Assayag, Einor Ben, Molad, Jeremy, Seyman, Estelle, Rotschild, Ofer, Zeltzer, Ehud, Sadeh-Gonik, Udi, Bregman, Noa, Alpernas, Aviva, Segal, Yahel, Bashat, Dafna Ben, Nathan, Talya, Hawwari, Muhamad, Tene, Oren, Hallevi, Hen

Source: European Stroke Journal; Sep2022, Vol. 7 Issue 3, p314-322, 9p

The importance of tissue-based assay in the diagnosis of autoimmune encephalitis.

Authors: Gadoth, Avi^1,2 (AUTHOR) avig@tlvmc.gov.il, Segal, Yahel¹ (AUTHOR), Paran, Yael^2,3 (AUTHOR), Aizenstein, Orna^2,4 (AUTHOR), Alcalay, Yifat^2,5 (AUTHOR)

Source: Journal of Neurology. Jul2022, Vol. 269 Issue 7, p3588-3596. 9p.

Subject Terms: *ENCEPHALITIS, *ANTIBODY titer, *IMMUNOFLUORESCENCE, *DIAGNOSIS, *CANCER patients

Chapter 31 - Nutritional Aspects of the Mosaic of Rheumatic Autoimmune Diseases a Recipe for Therapy?

Authors: Dahan, Shani, Segal, Yahel, Shoenfeld, Yehuda

Source: In Mosaic of Autoimmunity 2019:307-314

PD-1-inhibitor-induced PCA-2 (MAP1B) Autoimmunity in a Patient with Renal Cell Carcinoma.

Authors: Segal, Yahel¹ (AUTHOR), Bukstein, Felix² (AUTHOR), Raz, Michal³ (AUTHOR), Aizenstein, Orna^4,5 (AUTHOR), Alcalay, Yifat^5,6 (AUTHOR), Gadoth, Avi^1,5 (AUTHOR) avig@tlvmc.gov.il

Source: Cerebellum. Apr2022, Vol. 21 Issue 2, p328-331. 4p.

Subject Terms: *PARANEOPLASTIC syndromes, *RENAL cell carcinoma, *IMMUNE checkpoint inhibitors, *CEREBELLUM degeneration, *AUTOIMMUNITY

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List of Contributors

Authors: Afek, Arnon, Afeltra, Antonella, Afflitto, Gabriele Gallo, Alessandri, Cristiano, Alivernini, Stefano, Alunno, Alessia, Amital, Howard, Andreoli, Laura, Antonelli, Alessandro, Arisi, Mariachiara, Artusi, Carolina, Atzeni, Fabiola, Ballanti, Eleonora, Barbati, Cristiana, Barilaro, Giuseppe, Bartoloni, Elena, Ben-Ami, Dana, Bettencourt, Andreia, Bizzaro, Nicola, Blank, Miri, Bogdanos, Dimitrios P., Boleixa, Daniela, Borba, Vânia Vieira, Borgiani, Paola, Bragazzi, Nicola Luigi, Brzosko, Iwona, Brzosko, Marek, Calzavara-Pinton, Piergiacomo, Campi, Irene, Cantarini, Luca, Carranza-Muleiro, Rosa A., Carvalho, Cláudia, Caso, Francesco, Ceccarelli, Fulvia, Cervera, Ricard, Chapman, Joab, Chen, Xian, Chimenti, Maria Sole, Ciccacci, Cinzia, Cipriano, Enrica, Cohen Tervaert, Jan Willem, Colasanti, Tania, Conigliaro, Paola, Conti, Fabrizio, Coplan, Louis, Costa, Luisa, Croci, Stefania, Cruz-Domínguez, María del Pilar, Cutolo, Maurizio, Dahan, Shani, Damoiseaux, Jan, De Carolis, Caterina, Del Puente, Antonio, Domingues, Vinicius, Dreyfus, David H., Drori, Tali, Ehrenfeld, Michael, Espinosa, Gerard, Farina, Antonella, Farina, Giuseppina Alessandra, Ferraccioli, Gianfranco, Finucci, Annacarla, Fioravanti, Antonella, Fischer, Katarzyna, Fonti, Giulia Lavinia, Francesca, Barone, Franceschini, Franco, Freire de Carvalho, Jozélio, Fujio, Keishi, García-Collinot, Grettel, Generali, Elena, Gerardi, Maria Chiara, Gerli, Roberto, Gertel, Smadar, Giat, Eitan, Greco, Elisabetta, Gremese, Elisa, Grunebaum, Eyal, Gualtierotti, Roberta, Guarino, Maria Domenica, Guzner-Gur, Hanan, He, Shu-Gui, Iannuccelli, Cristina, Jara, Luis J., Jeandel, Pierre-Yves, Kivity, Dr Shaye, Kotyla, Przemyslaw J., Krosser, Alec, Latini, Andrea, Leon-Ponte, Matilde, Lerner, Aaron, Levy, Roger Abramino, Lichtbroun, Benjamin, Lucchetti, Ramona, Lu, Qianjin, Margiotta, Domenico P.E., Marinho, António, Martínez-Bencomo, Michel A., Matthias, Torsten, Medina, Gabriela, Meroni, Pier Luigi, Lichtbroun, Michael, Moreira Balbi, Gustavo Guimarães, Muratore, Francesco, Navarini, Luca, Novelli, Giuseppe, Pacucci, Viviana Antonella, Peluso, Rosario, Pendolino, Monica, Pérez, Dolores, Perricone, Carlo, Perricone, Roberto, Persani, Luca, Petricca, Luca, Pipitone, Nicolò, Ramires de Jesús, Guilherme, Resende, Gustavo, Rizenbah, Chen, Rodríguez-Pintó, Ignasi, Rose, Noel R., Rosenthal, Eric, Rossi, Mariateresa, Sakkas, Lazaros I., Salvarani, Carlo, Sarzi-Puttini, Piercarlo, Scarpa, Raffaele, Segal, Yahel, Segel, Michael J., Selmi, Carlo, Seluk, Dr Lior, Serena, Colafrancesco, Sharabi, Amir, Sharif, Kassem, Shoenfeld, Netta, Shoenfeld, Yehuda, Signorelli, Flavio, Silva, Ana Martins, Silva, Berta Martins, Slomovich, Sharon, Somech, Raz, Soriano, Alessandra, Szekanecz, Zoltán, Tanaka, Yoshiya, Tenti, Sara, Tincani, Angela, Tolusso, Barbara, Torres-Ruiz, Jiram, Toubi, Elias, Tozzoli, Renato, Triggianese, Paola, Trombetta, Amelia Chiara, Tsokos, George C., Tsuchida, Yumi, Vadasz, Zahava, Valesini, Guido, van Beers, Joyce, van Paassen, Pieter, Vannucchi, Guia Maria, Vasconcelos, Carlos, Venturini, Marina, Vera-Lastra, Olga, Versini, Mathilde, Vomero, Marta, Watad, Abdulla, Wu, Haijing, Zeng, Yong

Source: In Mosaic of Autoimmunity 2019:xix-xxiv

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Characteristics of Pericardial Biopsy: 100 Cases in a Single Center.

Authors: Boldes, Ortal Fallek, Dahan, Shani, Segal, Yahel, Ben-AmiShor, Dana, Huber, Robert K., Barshack, Iris, Horowitz, Yuval, Segal, Gad, Dagan, Amir

Source: Israel Medical Association Journal; Mar2019, Vol. 21 Issue 3, p183-187, 5p