Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline: caution is warranted

Authors: Acar, Delphine Diana, Witkowski, Wojciech, Wejda, Magdalena, Wei, Ruifang, Desmet, Tim, Schepens, Bert, De Cae, Sieglinde, Sedeyn, Koen, Eeckhaut, Hannah, Fijalkowska, Daria, Roose, Kenny, Vanmarcke, Sandrine, Poupon, Anne, Jochmans, Dirk, Zhang, Xin, Abdelnabi, Rana, Foo, Caroline S., Weynand, Birgit, Reiter, Dirk, Callewaert, Nico, Remaut, Han, Neyts, Johan, Saelens, Xavier, Gerlo, Sarah, Vandekerckhove, Linos

Source: In eBioMedicine February 2024 100

Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa.

Authors: Declercq, Jozefien, Gerlo, Sarah, Van Nevel, Sharon, De Ruyck, Natalie, Holtappels, Gabriele, Delesie, Liesbeth, Tobback, Els, Lammens, Inés, Gerebtsov, Nikita, Sedeyn, Koen, Saelens, Xavier, Lambrecht, Bart N., Gevaert, Philippe, Vandekerckhove, Linos, Vanhee, Stijn

Source: Science Translational Medicine; 10/23/2024, Vol. 16 Issue 770, p1-13, 13p

Subject Terms: SARS-CoV-2, BOOSTER vaccines, RESPIRATORY mucosa, ANTIBODY formation, BONE marrow

New antibody-based prevention and treatment options for influenza

Authors: Sedeyn, Koen, Saelens, Xavier

Source: In Antiviral Research October 2019 170

CD8+ T cell immunity against human respiratory syncytial virus

Authors: Rossey, Iebe, Sedeyn, Koen, De Baets, Sarah, Schepens, Bert, Saelens, Xavier

Source: In Vaccine 21 October 2014 32(46):6130-6137

Respiratory syncytial virus nonstructural proteins 1 and 2: Exceptional disrupters of innate immune responses.

Authors: Sedeyn, Koen^1,2,3 (AUTHOR), Schepens, Bert^1,2 (AUTHOR), Saelens, Xavier^1,2,3 (AUTHOR) Xavier.saelens@vib-ugent.be

Source: PLoS Pathogens. 10/17/2019, Vol. 15 Issue 10, p1-18. 18p.

Subject Terms: *INTERFERON receptors, *VIRAL nonstructural proteins, *VIRAL proteins, *RESPIRATORY syncytial virus, *RESPIRATORY diseases, *PROTEOMICS, *IMMUNE response

Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins.

Authors: Tušar, Livija, Loboda, Jure, Impens, Francis, Sosnowski, Piotr, Van Quickelberghe, Emmy, Vidmar, Robert, Demol, Hans, Sedeyn, Koen, Saelens, Xavier, Vizovišek, Matej, Mihelič, Marko, Fonović, Marko, Horvat, Jaka, Kosec, Gregor, Turk, Boris, Gevaert, Kris, Turk, Dušan

Source: Communications Biology; 4/24/2023, Vol. 6 Issue 1, p1-15, 15p

Subject Terms: CATHEPSINS, PROTEOMICS, DRUG discovery, CYSTEINE, SUPPORT vector machines

Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity.

Authors: Thery, Fabien, Martina, Lia, Asselman, Caroline, Zhang, Yifeng, Vessely, Madeleine, Repo, Heidi, Sedeyn, Koen, Moschonas, George D., Bredow, Clara, Teo, Qi Wen, Zhang, Jingshu, Leandro, Kevin, Eggermont, Denzel, De Sutter, Delphine, Boucher, Katie, Hochepied, Tino, Festjens, Nele, Callewaert, Nico, Saelens, Xavier, Dermaut, Bart

Source: Nature Communications; 10/1/2021, Vol. 12 Issue 1, p1-21, 21p

Subject Terms: HERPES simplex virus, MOYAMOYA disease, RESPIRATORY syncytial virus, LISTERIOSIS, CEREBROVASCULAR disease

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

How RSV Proteins Join Forces to Overcome the Host Innate Immune Response.

Authors: Van Royen, Tessa, Rossey, Iebe, Sedeyn, Koen, Schepens, Bert, Saelens, Xavier

Source: Viruses (1999-4915); Feb2022, Vol. 14 Issue 2, p419, 1p

Subject Terms: IMMUNE response, MITOCHONDRIAL proteins, PATTERN perception receptors, RESPIRATORY syncytial virus, PROTEINS, RESPIRATORY infections

Protective Efficacy of Recombinant Influenza Hemagglutinin Ectodomain Fusions.

Authors: Mittal, Nidhi, Sengupta, Nayanika, Malladi, Sameer Kumar, Reddy, Poorvi, Bhat, Madhuraj, Rajmani, Raju S., Sedeyn, Koen, Saelens, Xavier, Dutta, Somnath, Varadarajan, Raghavan

Source: Viruses (1999-4915); Sep2021, Vol. 13 Issue 9, p1710, 1p

Subject Terms: FLU vaccine efficacy, HEMAGGLUTININ, VACCINE effectiveness, SEASONAL influenza, INFLUENZA A virus, H1N1 subtype, H1N1 influenza, INFLUENZA

An affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models

Authors: Schepens, Bert, van Schie, Loes, Nerinckx, Wim, Roose, Kenny, Van Breedam, Wander, Fijalkowska, Daria, Devos, Simon, Weyts, Wannes, De Cae, Sieglinde, Vanmarcke, Sandrine, Lonigro, Chiara, Eeckhaut, Hannah, Van Herpe, Dries, Borloo, Jimmy, Oliveira, Ana Filipa, Catani, João Paulo Portela, Creytens, Sarah, De Vlieger, Dorien, Michielsen, Gitte, Marchan, Jackeline Cecilia Zavala, Moschonas, George D., Rossey, Iebe, Sedeyn, Koen, Van Hecke, Annelies, Zhang, Xin, Langendries, Lana, Jacobs, Sofie, ter Horst, Sebastiaan, Seldeslachts, Laura, Liesenborghs, Laurens, Boudewijns, Robbert, Thibaut, Hendrik Jan, Dallmeier, Kai, Velde, Greetje Vande, Weynand, Birgit, Beer, Julius, Schnepf, Daniel, Ohnemus, Annette, Remory, Isabel, Foo, Caroline S., Abdelnabi, Rana, Maes, Piet, Kaptein, Suzanne J. F., Rocha-Pereira, Joana, Jochmans, Dirk, Delang, Leen, Peelman, Frank, Staeheli, Peter, Schwemmle, Martin, Devoogdt, Nick, Tersago, Dominique, Germani, Massimiliano, Heads, James, Henry, Alistair, Popplewell, Andrew, Ellis, Mark, Brady, Kevin, Turner, Alison, Dombrecht, Bruno, Stortelers, Catelijne, Neyts, Johan, Callewaert, Nico, Saelens, Xavier

Source: Science Translational Medicine; November 2021, Vol. 13 Issue: 621

A Vulnerable, Membrane-Proximal Site in Human Respiratory Syncytial Virus F Revealed by a Prefusion-Specific Single-Domain Antibody.

Authors: Rossey, Iebe^1,2,3, Ching-Lin Hsieh⁴, Sedeyn, Koen^1,2,3, Ballegeer, Marlies^1,2,3, Schepens, Bert^1,2,3, McLellan, Jason S.⁴, Saelens, Xavier^1,2,3 xavier.saelens@vib-ugent.be

Source: Journal of Virology. Jun2021, Vol. 95 Issue 11, p1-13. 13p.

Subject Terms: *RESPIRATORY syncytial virus, *CHIMERIC proteins, *RESPIRATORY diseases, *IMMUNOGLOBULINS, *BINDING sites

Corrigendum: Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.

Authors: Rossey, Iebe, Gilman, Morgan S. A., Kabeche, Stephanie C., Sedeyn, Koen, Wrapp, Daniel, Kanekiyo, Masaru, Chen, Man, Mas, Vicente, Spitaels, Jan, Melero, José A., Graham, Barney S., Schepens, Bert, McLellan, Jason S., Saelens, Xavier

Source: Nature Communications; Nov2017, Vol. 8 Issue 11, p16165, 1p