Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1

Authors: Rubén Rodríguez-Agudo, Irene González-Recio, Marina Serrano-Maciá, Miren Bravo, Petar Petrov, Delia Blaya, Jose María Herranz, María Mercado-Gómez, Claudia María Rejano-Gordillo, Sofía Lachiondo-Ortega, Clàudia Gil-Pitarch, Mikel Azkargorta, Sebastiaan Martijn Van Liempd, Luis Alfonso Martinez-Cruz, A.L. Simão, Félix Elortza, César Martín, Yulia A. Nevzorova, Francisco Javier Cubero, Teresa C. Delgado, Josepmaria Argemi, Ramón Bataller, Kristina Schoonjans, Jesús M. Banales, Rui E. Castro, Pau Sancho-Bru, Matías A. Avila, Josep Julve, Ramiro Jover, Jon Mabe, Jorge Simon, Naroa Goikoetxea-Usandizaga, María L. Martínez-Chantar

Source: JHEP Reports, Vol 6, Iss 1, Pp 100918- (2024)

Subject Terms: Alcohol-related liver disease, NIAAA model, microRNA, SIRT1, Nicotinamide adenine dinucleotide salvage pathway, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555923002495; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/2c731ca37cd542a581f44cda78d386a6

Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen

Authors: Rubén Rodríguez-Agudo, Naroa Goikoetxea-Usandizaga, Marina Serrano-Maciá, Pablo Fernández-Tussy, David Fernández-Ramos, Sofía Lachiondo-Ortega, Irene González-Recio, Clàudia Gil-Pitarch, María Mercado-Gómez, Laura Morán, Maider Bizkarguenaga, Fernando Lopitz-Otsoa, Petar Petrov, Miren Bravo, Sebastiaan Martijn Van Liempd, Juan Manuel Falcon-Perez, Amaia Zabala-Letona, Arkaitz Carracedo, Jose Vicente Castell, Ramiro Jover, Luis Alfonso Martínez-Cruz, Teresa Cardoso Delgado, Francisco Javier Cubero, María Isabel Lucena, Raúl Jesús Andrade, Jon Mabe, Jorge Simón, María Luz Martínez-Chantar

Source: Antioxidants, Vol 11, Iss 5, p 897 (2022)

Subject Terms: drug-induced liver injury (DILI), acetaminophen (APAP), ammonia, methionine cycle, miR-873-5p, therapy, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/11/5/897; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/2ad42c57fdeb4f66bad2d0eabf53b813