The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk

Authors: M. Pilar Valdecantos, Laura Ruiz, Cintia Folgueira, Patricia Rada, Beatriz Gomez-Santos, Maite Solas, Ana B. Hitos, Joss Field, Vera Francisco, Carmen Escalona-Garrido, Sebastián Zagmutt, María Calderon-Dominguez, Paula Mera, Irma Garcia-Martinez, Elsa Maymó-Masip, Diana Grajales, Rosa Alen, Alfonso Mora, Neira Sáinz, Irene Vides-Urrestarazu, Nuria Vilarrasa, José M. Arbones-Mainar, Carlos Zaragoza, María J. Moreno-Aliaga, Patricia Aspichueta, Sonia Fernández-Veledo, Joan Vendrell, Dolors Serra, Laura Herrero, Renate Schreiber, Rudolf Zechner, Guadalupe Sabio, David Hornigold, Cristina M. Rondinone, Lutz Jermutus, Joseph Grimsby, Ángela M. Valverde

Source: Nature Communications, Vol 15, Iss 1, Pp 1-29 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6e46df4151b04affa21678e1243d004d

CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst

Authors: Sebastián Zagmutt, Paula Mera, Ismael González-García, Kevin Ibeas, María del Mar Romero, Arnaud Obri, Beatriz Martin, Anna Esteve-Codina, M. Carmen Soler-Vázquez, Marianela Bastias-Pérez, Laia Cañes, Elisabeth Augé, Carme Pelegri, Jordi Vilaplana, Xavier Ariza, Jordi García, José Martinez-González, Núria Casals, Miguel López, Richard Palmiter, Elisenda Sanz, Albert Quintana, Laura Herrero, Dolors Serra

Source: Biology of Sex Differences, Vol 14, Iss 1, Pp 1-26 (2023)

Subject Terms: CPT1A, Fatty acid metabolism, AgRP neurons, Energy balance, Food intake, Thirst, Medicine, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2042-6410

Access URL: https://doaj.org/article/9eef829aeb3f49da853bf659361e7019

Moderate SIRT1 overexpression protects against brown adipose tissue inflammation

Authors: Carmen Escalona-Garrido, Patricia Vázquez, Paula Mera, Sebastián Zagmutt, Ester García-Casarrubios, Ana Montero-Pedrazuela, Fernanda Rey-Stolle, Ana Guadaño-Ferraz, Francisco J. Rupérez, Dolors Serra, Laura Herrero, Maria Jesus Obregon, Ángela M. Valverde

Source: Molecular Metabolism, Vol 42, Iss , Pp 101097- (2020)

Subject Terms: Brown adipose tissue, Inflammation, Sirtuin 1, Triiodothyronine, Insulin resistance, Uncoupling protein-1, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221287782030171X; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/7d496ba10e464044b06e42ab8217b5d1

Impact of Adaptive Thermogenesis in Mice on the Treatment of Obesity

Authors: Marianela Bastías-Pérez, Sebastián Zagmutt, M Carmen Soler-Vázquez, Dolors Serra, Paula Mera, Laura Herrero

Source: Cells, Vol 9, Iss 2, p 316 (2020)

Subject Terms: obesity, adaptive thermogenesis, brown adipose tissue, basal metabolic rate, thermoneutrality, chronic cold, ambient temperature and body temperature, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/2/316; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/f5ab628bba3b4264814a59675041f459

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To be or not to be a fat burner, that is the question for cpt1c in cancer cells

Authors: Rut Fadó, Sebastian Zagmutt, Laura Herrero, Helena Muley, Rosalía Rodríguez-Rodríguez, Huichang Bi, Dolors Serra, Núria Casals

Source: Cell Death and Disease, Vol 14, Iss 1, Pp 1-9 (2023)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/253d82ab8418418b819f50de3f1bcef8

Integrated Metabolomics, Lipidomics, and Genomics Reveal the Presence of a New Biomarker, Butanediol Glucuronide, Associated with the Activation of Liver Ketogenesis and Lipid Oxidation by Tomato-Based Sofrito in Obese Rats

Authors: José Fernando Rinaldi de Alvarenga, Mar Garcia-Aloy, Marynka Ulaszewska, Sebastian Zagmutt, Marta Perez-Montero, Urska Vrhovsek, Rosa M. Lamuela-Raventós, Rosalia Rodriguez-Rodriguez

Source: Antioxidants, Vol 11, Iss 11, p 2165 (2022)

Subject Terms: Mediterranean diet, obesity, ketogenesis, metabolomics, lipidomics, butanediol glucuronide, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/11/11/2165; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/6e81cc16fab04d4b9a64d0886fe98b26