Emerging and Evolving Concepts in Cancer Immunotherapy Imaging

Authors: Dercle, Laurent, Sun, Shawn, Seban, Romain-David, Mekki, Ahmed, Sun, Roger, Tselikas, Lambros, Hans, Sophie, Bernard-Tessier, Alice, Bouvier, Fadila Mihoubi, Aide, Nicolas

Source: Radiology. 306(1):32-46

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Fibroblast heterogeneity in solid tumors: From single cell analysis to whole-body imaging

Authors: Peltier, Agathe, Seban, Romain-David, Buvat, Irène, Bidard, François-Clément, Mechta-Grigoriou, Fatima

Source: Seminars in cancer biology. 86(P3):262-272

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FEATURED ARTICLE OF THE MONTH. Absolute Lymphocyte Count After COVID-19 Vaccination Is Associated with Vaccine-Induced Hypermetabolic Lymph Nodes on ^1^8F-FDG PET/CT: A Focus in Breast Cancer Care

Authors: Seban, Romain-David, Richard, Capucine, Nascimento-Leite, Camila, Ghidaglia, Jerome, Provost, Claire, Gonin, Julie, Tourneau, ChristopheLe, Romano, Emanuela, Deleval, Nicolas, Champion, Laurence

Source: Journal of nuclear medicine. 63(8):1231-1238

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Clinico-pathological factors predicting pathological response in early triple-negative breast cancer.

Authors: Helal, Clara, Djerroudi, Lounes, Ramtohul, Toulsie, Laas, Enora, Vincent-Salomon, Anne, Jin, Maxime, Seban, Romain-David, Bieche, Ivan, Bello-Roufai, Diana, Bidard, Francois-Clement, Cottu, Paul, Loirat, Delphine, Carton, Matthieu, Lerebours, Florence, Kiavue, Nicolas, Romano, Emanuela, Bonneau, Claire, Cabel, Luc

Source: NPJ Breast Cancer; 2/13/2025, Vol. 11 Issue 1, p1-9, 9p

Pre-treatment [18F]FDG PET/CT biomarkers for the prediction of antibody–drug conjugates efficacy in metastatic breast cancer.

Authors: Seban, Romain-David^1,2 (AUTHOR) romain.seban@gmail.com, Champion, Laurence^1,2 (AUTHOR), De Moura, Alexandre³ (AUTHOR), Lerebours, Florence³ (AUTHOR), Loirat, Delphine⁴ (AUTHOR), Pierga, Jean-Yves^5,6 (AUTHOR), Djerroudi, Lounes⁷ (AUTHOR), Genevee, Thomas⁸ (AUTHOR), Huchet, Virginie⁹ (AUTHOR), Jehanno, Nina⁹ (AUTHOR), Bidard, Francois-Clement^6,10 (AUTHOR), Buvat, Irene² (AUTHOR)

Source: European Journal of Nuclear Medicine & Molecular Imaging. Jan2025, Vol. 52 Issue 2, p708-718. 11p.

Subject Terms: *METASTATIC breast cancer, *CANCER invasiveness, *PROGRESSION-free survival, *SURVIVAL rate, *OVERALL survival

[18F]FDG PET/CT for predicting triple-negative breast cancer outcomes after neoadjuvant chemotherapy with or without pembrolizumab.

Authors: Seban, Romain-David^1,2 (AUTHOR) romaindavid.seban@curie.fr, Arnaud, Emilie³ (AUTHOR), Loirat, Delphine³ (AUTHOR), Cabel, Luc³ (AUTHOR), Cottu, Paul³ (AUTHOR), Djerroudi, Lounes⁴ (AUTHOR), Hescot, Segolene¹ (AUTHOR), Loap, Pierre⁵ (AUTHOR), Bonneau, Claire^6,7 (AUTHOR), Bidard, Francois-Clement^8,9 (AUTHOR), Huchet, Virginie¹⁰ (AUTHOR), Jehanno, Nina¹⁰ (AUTHOR), Berenbaum, Arnaud¹ (AUTHOR), Champion, Laurence^1,2 (AUTHOR), Buvat, Irene² (AUTHOR)

Source: European Journal of Nuclear Medicine & Molecular Imaging. Nov2023, Vol. 50 Issue 13, p4024-4035. 12p.

Subject Terms: *TRIPLE-negative breast cancer, *NEOADJUVANT chemotherapy, *CANCER prognosis, *TUMOR classification, *PEMBROLIZUMAB, *POSITRON emission tomography

A common [18F]-FDG PET radiomic signature to predict survival in patients with HPV-induced cancers.

Authors: Niyoteka, Stephane^1,2 (AUTHOR) stephane.niyoteka@gustaveroussy.fr, Seban, Romain-David^3,4 (AUTHOR), Rouhi, Rahimeh^1,2 (AUTHOR), Scarsbrook, Andrew^5,6 (AUTHOR), Genestie, Catherine⁷ (AUTHOR), Classe, Marion^1,7 (AUTHOR), Carré, Alexandre^1,2 (AUTHOR), Sun, Roger^1,2 (AUTHOR), La Greca Saint-Esteven, Agustina⁸ (AUTHOR), Chargari, Cyrus^1,2 (AUTHOR), McKenna, Jack⁵ (AUTHOR), McDermott, Garry⁵ (AUTHOR), Malinen, Eirik⁹ (AUTHOR), Tanadini-Lang, Stephanie⁸ (AUTHOR), Guckenberger, Matthias⁸ (AUTHOR), Guren, Marianne G.^10,11 (AUTHOR), Lemanski, Claire¹² (AUTHOR), Deutsch, Eric^1,2 (AUTHOR), Robert, Charlotte^1,2 (AUTHOR)

Source: European Journal of Nuclear Medicine & Molecular Imaging. Nov2023, Vol. 50 Issue 13, p4010-4023. 14p.

Subject Terms: *OVERALL survival, *POSITRON emission tomography, *CANCER patients, *MACHINE learning, *HUMAN papillomavirus, *FEATURE extraction

Prognostic value of inflammatory response biomarkers using peripheral blood and [18F]-FDG PET/CT in advanced NSCLC patients treated with first-line chemo- or immunotherapy

Authors: Seban, Romain-David, Assié, Jean-Baptiste, Giroux-Leprieur, Etienne, Massiani, Marie-Ange, Bonardel, Gérald, Chouaid, Christos, Deleval, Nicolas, Richard, Capucine, Mezquita, Laura, Girard, Nicolas, Champion, Laurence

Source: In Lung Cancer September 2021 159:45-55

Spleen Glucose Metabolism on [18F]-FDG PET/CT for Cancer Drug Discovery and Development cannot be Overlooked

Authors: Seban, Romain-David, Synn, Shwe, Muneer, Izza, Champion, Laurence, Schwartz, Lawrence H., Dercle, Laurent

Source: Current cancer drug targets. 21(11):944-952

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Total Metabolic Tumor Volume on 18F-FDG PET/CT Is a Useful Prognostic Biomarker for Patients with Extensive Small-Cell Lung Cancer Undergoing First-Line Chemo-Immunotherapy.

Authors: Grambow-Velilla, Julia^1,2 (AUTHOR), Seban, Romain-David^3,4 (AUTHOR) romain.seban@gmail.com, Chouahnia, Kader⁵ (AUTHOR), Assié, Jean-Baptiste⁶ (AUTHOR), Champion, Laurence^3,4 (AUTHOR), Girard, Nicolas^7,8 (AUTHOR), Bonardel, Gerald⁹ (AUTHOR), Matton, Lise⁵ (AUTHOR), Soussan, Michael¹ (AUTHOR), Chouaïd, Christos¹⁰ (AUTHOR), Duchemann, Boris^5,11 (AUTHOR)

Source: Cancers. Apr2023, Vol. 15 Issue 8, p2223. 14p.

Subject Terms: *LUNG cancer, *CONFIDENCE intervals, *CANCER chemotherapy, *ANTINEOPLASTIC agents, *RETROSPECTIVE studies, *ACQUISITION of data, *CANCER patients, *TREATMENT effectiveness, *RADIOPHARMACEUTICALS, *POSITRON emission tomography, *MEDICAL records, *DESCRIPTIVE statistics, *DEOXY sugars, *COMPUTED tomography, *TUMOR markers, *PROGRESSION-free survival, *PREDICTION models, *IMMUNOTHERAPY, *LONGITUDINAL method, *OVERALL survival, *PROPORTIONAL hazards models

FDG-PET biomarkers associated with long-term benefit from first-line immunotherapy in patients with advanced non-small cell lung cancer

Authors: Seban, Romain-David, Assie, Jean-Baptiste, Giroux-Leprieur, Etienne, Massiani, Marie-Ange, Soussan, Michael, Bonardel, Gérald, Chouaid, Christos, Playe, Margot, Goldfarb, Lucas, Duchemann, Boris, Girard, Nicolas, Champion, Laurence

Source: Annals of nuclear medicine. 34(12):968-974

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Baseline metabolic tumor burden on FDG PET/CT scans predicts outcome in advanced NSCLC patients treated with immune checkpoint inhibitors

Authors: Seban, Romain-David, Mezquita, Laura, Berenbaum, Arnaud, Dercle, Laurent, Botticella, Angela, Le Pechoux, Cécile, Caramella, Caroline, Deutsch, Eric, Grimaldi, Serena, Adam, Julien, Ammari, Samy, Planchard, David, Leboulleux, Sophie, Besse, Benjamin

Source: European journal of nuclear medicine and molecular imaging. 47(5):1147-1157

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167897690.0x000001&indx=1&recIds=ETOCvdc_100167897690.0x000001

Prognostic 18F-FDG PET biomarkers in metastatic mucosal and cutaneous melanoma treated with immune checkpoint inhibitors targeting PD-1 and CTLA-4

Authors: Seban, Romain-David, Moya-Plana, Antoine, Antonios, Lara, Yeh, Randy, Marabelle, Aurélien, Deutsch, Eric, Schwartz, Lawrence H., Gómez, Ruth Gabriela Herrera, Saenger, Yvonne, Robert, Caroline, Ammari, Samy, Dercle, Laurent

Source: European journal of nuclear medicine and molecular imaging. 47(10):2301-2312

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167898615.0x000001&indx=1&recIds=ETOCvdc_100167898615.0x000001

Metabolic Response by 18F-FDG PET/CT in Metastatic Malignant Struma Ovarii Treated With Targeted Therapies

Authors: Seban, Romain-David, Bozec, Laurence, Nascimento-Leite, Camila, Champion, Laurence

Source: Clinical nuclear medicine. 46(1):52-54

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189216219.0x000001&indx=1&recIds=ETOCvdc_100189216219.0x000001

Kinetics and nadir of responses to immune checkpoint blockade by anti-PD1 in patients with classical Hodgkin lymphoma

Authors: Dercle, Laurent, Ammari, Samy, Seban, Romain-David, Schwartz, Lawrence H., Houot, Roch, Labaied, Nizar, Mokrane, Fatima-Zohra, Lazarovici, Julien, Danu, Alina, Marabelle, Aurélien, Ribrag, Vincent, Michot, Jean-Marie

Source: In European Journal of Cancer March 2018 91:136-144

68Ga-DOTATOC PET/CT Imaging of a Muscular Solitary Fibrous Tumor

Authors: Richard, Capucine, Cros, Jérôme, Seban, Romain-David, Champion, Laurence, Hescot, Ségolène

Source: Clinical nuclear medicine. 48(5):e228-e229

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Clinical Potential of HER2 PET as a Predictive Biomarker to Guide the Use of Trastuzumab Deruxtecan in Breast Cancer Patients

Authors: Seban, Romain-David, Champion, Laurence, Bellesoeur, Audrey, Vincent-Salomon, Anne, Bidard, Francois-Clement

Source: Journal of nuclear medicine. 64(7):1164-1165

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632771690&indx=1&recIds=ETOCRN632771690

Prognostic and theranostic 18F-FDG PET biomarkers for anti-PD1 immunotherapy in metastatic melanoma: association with outcome and transcriptomics

Authors: Seban, Romain-David, Nemer, John S., Marabelle, Aurélien, Yeh, Randy, Deutsch, Eric, Ammari, Samy, Moya-Plana, Antoine, Mokrane, Fatima-Zohra, Gartrell, Robyn D., Finkel, Grace, Barker, Luke, Bigorgne, Amélie E., Schwartz, Lawrence H., Saenger, Yvonne, Robert, Caroline, Dercle, Laurent

Source: European journal of nuclear medicine and molecular imaging. 46(11):2298-2310

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The role of multimodal imaging in guiding resectability and cytoreduction in pancreatic neuroendocrine tumors: focus on PET and MRI

Authors: Rozenblum, Laura, Mokrane, Fatima-Zohra, Yeh, Randy, Sinigaglia, Mathieu, Besson, Florent, Seban, Romain-David, Chougnet, Cecile N, Revel-Mouroz, Paul, Zhao, Binsheng, Otal, Philippe, Schwartz, Lawrence H., Dercle, Laurent

Source: Abdominal radiology. 44(7):2474-2493

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125518624.0x000001&indx=1&recIds=ETOCvdc_100125518624.0x000001

Rapid and objective CT scan prognostic scoring identifies metastatic patients with long-term clinical benefit on anti-PD-1/-L1 therapy

Authors: Dercle, Laurent, Ammari, Samy, Champiat, Stéphane, Massard, Christophe, Ferté, Charles, Taihi, Lokmane, Seban, Romain-David, Aspeslagh, Sandrine, Mahjoubi, Linda, Kamsu-Kom, Nyam, Robert, Caroline, Marabelle, Aurélien, Schlumberger, Martin, Soria, Jean-Charles, Postel-Vinay, Sophie

Source: In European Journal of Cancer September 2016 65:33-42