Single-molecule systems for the detection and monitoring of plasma-circulating nucleosomes and oncoproteins in diffuse midline glioma

Authors: Erez, Nir ^{1, 8}, Furth, Noa ^{1, 8}, Fedyuk, Vadim ¹, Wadden, Jack ², Aittaleb, Rayan ², Adam, Tiffany ², Schwark, Kallen ², Niculcea, Michael ², Miclea, Madeline ², Mody, Rajen ², Franson, Andrea ², Parmar, Hemant A. ³, Ibrahim, Mohannad ³, Lau, Benison ³, Eze, Augustine ⁴, Nourmohammadi, Niku ⁴, Fried, Iris ⁵, Nazarian, Javad ⁴, Ron, Guy ⁶, Venneti, Sriram ⁷, Koschmann, Carl ^{2, ∗}, Shema, Efrat ^{1, 9, ∗∗}

Source: In Cell Reports Medicine 21 January 2025 6(1)

Effective targeting of PDGFRA-altered high-grade glioma with avapritinib

Authors: Mayr, Lisa ^{1, 2, 41}, Neyazi, Sina ^{1, 41}, Schwark, Kallen ^{3, 41}, Trissal, Maria ^{1, 41}, Beck, Alexander ⁴, Labelle, Jenna ¹, Eder, Sebastian K. ^{1, 5}, Weiler-Wichtl, Liesa ², Marques, Joana G. ¹, de Biagi-Junior, Carlos A.O. ¹, Lo Cascio, Costanza ¹, Chapman, Owen ⁶, Sridhar, Sunita ⁶, Kenkre, Rishaan ⁶, Dutta, Aditi ⁶, Wang, Shanqing ⁶, Wang, Jessica ⁶, Hack, Olivia ¹, Nascimento, Andrezza ¹, Nguyen, Cuong M. ¹, Castellani, Sophia ¹, Rozowsky, Jacob S. ¹, Groves, Andrew ¹, Panditharatna, Eshini ¹, Cruzeiro, Gustavo Alencastro Veiga ¹, Haase, Rebecca D. ¹, Tabatabai, Kuscha ¹, Madlener, Sibylle ², Wadden, Jack ³, Adam, Tiffany ³, Kong, Seongbae ³, Miclea, Madeline ³, Patel, Tirth ³, Bruckner, Katharina ^{2, 7}, Senfter, Daniel ², Lämmerer, Anna ^{2, 8, 9}, Supko, Jeffrey ¹⁰, Guntner, Armin S. ¹¹, Palova, Hana ¹², Neradil, Jakub ^{13, 14}, Stepien, Natalia ², Lötsch-Gojo, Daniela ⁷, Berger, Walter ^{8, 9}, Leiss, Ulrike ², Rosenmayr, Verena ², Dorfer, Christian ⁷, Dieckmann, Karin ¹⁵, Peyrl, Andreas ², Azizi, Amedeo A. ², Baumgartner, Alicia ^{1, 2}, Slaby, Ondrej ^{12, 16}, Pokorna, Petra ¹², Clark, Louise M. ¹⁷, Cameron, Amy ¹⁷, Nguyen, Quang-De ¹⁷, Wakimoto, Hiroaki ¹⁸, Dubois, Frank ¹, Greenwald, Noah F. ^{19, 20}, Bandopadhayay, Pratiti ¹, Beroukhim, Rameen ^{19, 21}, Ligon, Keith ¹, Kramm, Christof ²², Bronsema, Annika ²³, Bailey, Simon ^{24, 25}, Stucklin, Ana Guerreiro ²⁶, Mueller, Sabine ²⁷, Skrypek, Mary ²⁸, Martinez, Nina ²⁹, Bowers, Daniel C. ³⁰, Jones, David T.W. ^{31, 32}, Jones, Chris ³³, Jäger, Natalie ³⁴, Sterba, Jaroslav ³⁵, Müllauer, Leonhard ³⁶, Haberler, Christine ³⁷, Kumar-Sinha, Chandan ³⁸, Chinnaiyan, Arul ³⁸, Mody, Rajen ³, Chavez, Lukas ⁶, Furtner, Julia ^{39, 40}, Koschmann, Carl ^{3, 41, ∗}, Gojo, Johannes ^{2, 41, ∗∗}, Filbin, Mariella G. ^{1, 19, 41, 42, ∗∗∗}

Source: In Cancer Cell February 2025

Dynamic microRNA activity identifies therapeutic targets in trastuzumab‐resistant HER2+ breast cancer

Authors: Decker, Joseph T., Hall, Matthew S., Blaisdell, Rachel B., Schwark, Kallen, Jeruss, Jacqueline S., Shea, Lonnie D.

Source: Biotechnology and bioengineering. 115(10):2613-2623

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100092717912.0x000001&indx=1&recIds=ETOCvdc_100092717912.0x000001

Receptor tyrosine kinase (RTK) targeting in pediatric high-grade glioma and diffuse midline glioma: Pre-clinical models and precision medicine.

Authors: Schwark, Kallen, Messinger, Dana, Cummings, Jessica R., Bradin, Joshua, Kawakibi, Abed, Babila, Clarissa M., Lyons, Samantha, Sunjong Ji, Cartaxo, Rodrigo T., Seongbae Kong, Cantor, Evan, Koschmann, Carl, Yadav, Viveka Nand

Source: Frontiers in Oncology; 8/1/2022, Vol. 12, p1-14, 14p

Subject Terms: PROTEIN-tyrosine kinases, ANIMAL models in research, GLIOMAS, INDIVIDUALIZED medicine, BRAIN tumors, SMALL molecules, KINASES

Dynamic microRNA activity identifies therapeutic targets in trastuzumab‐resistant HER2⁺ breast cancer.

Authors: Decker, Joseph T., Hall, Matthew S., Blaisdell, Rachel B., Schwark, Kallen, Jeruss, Jacqueline S., Shea, Lonnie D.

Source: Biotechnology & Bioengineering; Oct2018, Vol. 115 Issue 10, p2613-2623, 11p

HGG-04. USE OF AN ADVANCED RNA-SEQ FUSION PIPELINE RESULTS IN THE TARGETED TREATMENT AND SUSTAINED CLINICAL RESPONSE OF CHILDREN WITH RECURRENT PEDIATRIC HIGH-GRADE GLIOMA.

Authors: Schwark, Kallen, Bruzek, Amy, Kumar-Sinha, Chandan, Escolero, Sylvia, Marini, Bernard, Pasternak, Amy, Leonard, Marcia, Robertson, Patricia, Mody, Rajen, Chinnaiyan, Arul, Koschmann, Carl

Source: Neuro-Oncology; 2019 Supplement, Vol. 21, pii87-ii87, 1p