The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas

Authors: Skowron, Margaretha A., Becker, Teresa K., Kurz, Lukas, Jostes, Sina, Bremmer, Felix, Fronhoffs, Florian, Funke, Kai, Wakileh, Gamal A., Müller, Melanie R., Burmeister, Aaron, Lenz, Thomas, Stefanski, Anja, Stühler, Kai, Petzsch, Patrick, Köhrer, Karl, Altevogt, Peter, Albers, Peter, Kristiansen, Glen, Schorle, Hubert, Nettersheim, Daniel

Source: Molecular oncology. 16(4):982-1008

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141234106.0x000001&indx=1&recIds=ETOCvdc_100141234106.0x000001

On the origin of germ cell neoplasia in situ: Dedifferentiation of human adult Sertoli cells in cross talk with seminoma cells in vitro

Authors: Fink, Cornelia, Baal, Nelli, Wilhelm, Jochen, Sarode, Poonam, Weigel, Roswitha, Schumacher, Valérie, Nettersheim, Daniel, Schorle, Hubert, Schröck, Carmen, Bergmann, Martin, Kliesch, Sabine, Kressin, Monika, Savai, Rajkumar

Source: In Neoplasia July 2021 23(7):731-742

Cultivation of Testicular Germ Cell Cancer Cell Lines and Establishment of Gene-Edited Subclones Using CRISPR/Cas9

Authors: Jostes, Sina, Nettersheim, Daniel, Schneider, Simon, Schorle, Hubert

Source: Methods in molecular biology. 2195:85-98

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624736422&indx=1&recIds=ETOCRN624736422

The New Tumour Biomarker miRNA‐371‐3p Influences Cisplatin Sensitivity of Testicular Germ Cell Tumour Cell Lines.

Authors: Weiten, Richard, Engler, Theadora, Schorle, Hubert, Ellinger, Jörg, Saponaro, Miriam, Alajati, Abdullah, Nettersheim, Daniel, Syring‐Schmandke, Isabella

Source: Journal of Cellular & Molecular Medicine; Dec2024, Vol. 28 Issue 24, p1-7, 7p

Subject Terms: TREATMENT effectiveness, GERM cells, CELL lines, BIOMARKERS, PROGNOSIS, CISPLATIN

Protamine 2 deficiency results in Septin 12 abnormalities.

Authors: Sanovec, Ondrej, Frolikova, Michaela, Kraus, Veronika, Vondrakova, Jana, Qasemi, Maryam, Spevakova, Daniela, Simonik, Ondrej, Moritz, Lindsay, Caswell, Drew Lewis, Liska, Frantisek, Ded, Lukas, Cerny, Jiri, Avidor-Reiss, Tomer, Hammoud, Saher Sue, Schorle, Hubert, Postlerova, Pavla, Steger, Klaus, Komrskova, Katerina

Source: Frontiers in Cell & Developmental Biology; 2024, p1-23, 23p

Subject Terms: CYTOSKELETAL proteins, MITOCHONDRIAL proteins, NUCLEAR DNA, SPERM motility, SPERMATOZOA

Mammalian germ cells are determined after PGC colonization of the nascent gonad

Authors: Nicholls, Peter K., Schorle, Hubert, Naqvi, Sahin, Hu, Yueh-Chiang, Fan, Yuting, Carmell, Michelle A., Dobrinski, Ina, Watson, Adrienne L., Carlson, Daniel F., Fahrenkrug, Scott C., Page, David C.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Dec . 116(51), 25677-25687.

Access URL: https://www.jstor.org/stable/26863912

Choice of factors and medium impinge on success of ESC to TSC conversion

Authors: Kaiser, Franziska, Kubaczka, Caroline, Graf, Monika, Langer, Nina, Langkabel, Jan, Arévalo, Lena, Schorle, Hubert

Source: In Placenta 15 January 2020 90:128-137

Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumor fate

Authors: Jostes, Sina V., Fellermeyer, Martin, Arévalo, Lena, Merges, Gina E., Kristiansen, Glen, Nettersheim, Daniel, Schorle, Hubert

Source: International journal of cancer. 146(6):1592-1605

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150043153.0x000001&indx=1&recIds=ETOCvdc_100150043153.0x000001

High success rate of first proficiency testing for RET fusions and RET mutations in lung and thyroid cancer samples by various methods.

Authors: Siebolts, Udo, Pappesch, Roberto, Bauer, Marcus, Dietmaier, Wolfgang, Ernst, Mareike, Haak, Anja, Hartmann, Nils, Ilm, Katharina, Kalbourtzis, Stavros, Krause, Thomas, Kazdal, Daniel, Schorle, Hubert, Utpatel, Kirsten, Merkelbach-Bruse, Sabine

Source: Virchows Archiv: European Journal of Pathology; Sep2024, Vol. 485 Issue 3, p519-526, 8p

Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming

Authors: Schwarz, Benjamin A., Cetinbas, Murat, Clement, Kendell, Walsh, Ryan M., Cheloufi, Sihem, Gu, Hongcang, Langkabel, Jan, Kamiya, Akihide, Schorle, Hubert, Meissner, Alexander, Sadreyev, Ruslan I., Hochedlinger, Konrad

Source: In Cell Stem Cell 2 August 2018 23(2):289-305

Cell-Specific Deletion of Glucosylceramide Synthase in Brain Leads to Severe Neural Defects after Birth

Authors: Jennemann, Richard, Sandhoff, Roger, Wang, Shijun, Kiss, Eva, Gretz, Norbert, Zuliani, Cecilia, Martin-Villalba, Ana, Jäger, Richard, Schorle, Hubert, Kenzelmann, Marc, Bonrouhi, Mahnaz, Wiegandt, Herbert, Gröne, Hermann-Josef, Hakomori, Sen-itiroh

Source: Proceedings of the National Academy of Sciences of the United States of America, 2005 Aug . 102(35), 12459-12464.

Access URL: https://www.jstor.org/stable/3376600

Epigenetic drugs and their molecular targets in testicular germ cell tumours

Authors: Jostes, Sina, Nettersheim, Daniel, Schorle, Hubert

Source: Nature reviews.Urology. 16(4):245-259

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129205276.0x000001&indx=1&recIds=ETOCvdc_100129205276.0x000001

Breaking the first lineage barrier – many roads to trophoblast stem cell fate

Authors: Kubaczka, Caroline, Kaiser, Franziska, Schorle, Hubert

Source: In Placenta December 2017 60 Supplement 1:S52-S56

Overexpression of histone demethylase Fbxl10 leads to enhanced migration in mouse embryonic fibroblasts

Authors: Rohde, Magdalena, Sievers, Elisabeth, Janzer, Andreas, Willmann, Dominica, Egert, Angela, Schorle, Hubert, Schüle, Roland, Kirfel, Jutta

Source: In Experimental Cell Research 1 November 2016 348(2):123-131

Overexpression of Human sFLT1 in the Spongiotrophoblast Is Sufficient to Induce Placental Dysfunction and Fetal Growth Restriction in Transgenic Mice.

Authors: Vogtmann, Rebekka, Riedel, Alina, Sassmannshausen, Ivanka, Langer, Sarah, Kühnel-Terjung, Elisabeth, Kimmig, Rainer, Schorle, Hubert, Winterhager, Elke, Gellhaus, Alexandra

Source: International Journal of Molecular Sciences; Feb2024, Vol. 25 Issue 4, p2040, 20p

Subject Terms: TRANSGENIC mice, FETAL development, PLACENTA, FETAL growth retardation, GENETIC overexpression, GENE expression

Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts

Authors: Kubaczka, Caroline, Senner, Claire E., Cierlitza, Monika, Araúzo-Bravo, Marcos J., Kuckenberg, Peter, Peitz, Michael, Hemberger, Myriam, Schorle, Hubert

Source: In Cell Stem Cell 5 November 2015 17(5):557-568

Injury-Induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics

Authors: Belin, Stephane, Nawabi, Homaira, Wang, Chen, Tang, Shaojun, Latremoliere, Alban, Warren, Peter, Schorle, Hubert, Uncu, Ceren, Woolf, Clifford J., He, Zhigang, Steen, Judith A.

Source: In Neuron 20 May 2015 86(4):1000-1014

Xenografting of Cancer Cell Lines for In Vivo Screening of the Therapeutic Potential of HDAC Inhibitors

Authors: Nettersheim, Daniel, Jostes, Sina, Schorle, Hubert

Source: Methods in molecular biology. 1510:211-216

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN608653258&indx=1&recIds=ETOCRN608653258

Derivation and Maintenance of Murine Trophoblast Stem Cells under Defined Conditions

Authors: Kubaczka, Caroline, Senner, Claire, Araúzo-Bravo, Marcos J., Sharma, Neha, Kuckenberg, Peter, Becker, Astrid, Zimmer, Andreas, Brüstle, Oliver, Peitz, Michael, Hemberger, Myriam, Schorle, Hubert

Source: In Stem Cell Reports 11 February 2014 2(2):232-242

Loss of the cleaved-protamine 2 domain leads to incomplete histone-to-protamine exchange and infertility in mice.

Authors: Arévalo, Lena¹, lena.arevalo@ukbonn.de, Merges, Gina Esther¹, Schneider, Simon¹, Oben, Franka Enow¹, Neumann, Isabelle Sophie¹, Schorle, Hubert¹, lena.arevalo@ukbonn.de

Source: PLoS Genetics; 6/28/2022, Vol. 18 Issue 6, p1-26, 26p