The Asparagine Hydroxylase FIH: A Unique Oxygen Sensor

Authors: Volkova, Yulia L., Pickel, Christina, Jucht, Agnieszka E., Wenger, Roland H., Scholz, Carsten C.

Source: Antioxidants & redox signaling. 37(13/15):913-935

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Hypoxia in chronic kidney disease: towards a paradigm shift?

Authors: Faivre, Anna, Scholz, Carsten C., de Seigneux, Sophie

Source: Nephrology dialysis transplantation. 36(10):1782-1790

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131325657.0x000001&indx=1&recIds=ETOCvdc_100131325657.0x000001

Thermomechanical properties of bat and human red blood cells—Implications for hibernation.

Authors: Fregin, Bob, Hossain, Mohammed Faruq, Biedenweg, Doreen, Friedrichs, Virginia, Balkema-Buschmann, Anne, Bokelmann, Marcel, Lehnert, Kristin, Mokbel, Dominic, Aland, Sebastian, Scholz, Carsten C., Lehmann, Philipp, Otto, Oliver, Kerth, Gerald

Source: Proceedings of the National Academy of Sciences of the United States of America; 10/22/2024, Vol. 121 Issue 43, p1-10, 21p

Subject Terms: THERMOMECHANICAL properties of metals, HYPOTHERMIA, ERYTHROCYTE deformability, CELLULAR mechanics, ERYTHROCYTES

Inhibition of firefly luciferase activity by a HIF prolyl hydroxylase inhibitor

Authors: Günter, Julia, Wenger, Roland H., Scholz, Carsten C.

Source: In Journal of Photochemistry & Photobiology, B: Biology September 2020 210

Oxygen-dependent bond formation with FIH regulates the activity of the client protein OTUB1

Authors: Pickel, Christina, Günter, Julia, Ruiz-Serrano, Amalia, Spielmann, Patrick, Fabrizio, Jacqueline-Alba, Wolski, Witold, Peet, Daniel J., Wenger, Roland H., Scholz, Carsten C.

Source: In Redox Biology September 2019 26

HIF hydroxylase inhibitors decrease cellular oxygen consumption depending on their selectivity

Authors: Sulser, Pascale, Pickel, Christina, Günter, Julia, Leissing, Thomas M., Crean, Daniel, Schofield, Christopher J., Wenger, Roland H., Scholz, Carsten C.

Source: FASEB journal. 34(2):2344-2358

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PHD1-3 oxygen sensors in vivo—lessons learned from gene deletions.

Authors: Jucht, Agnieszka E.¹ (AUTHOR), Scholz, Carsten C.² (AUTHOR) carsten.scholz@med.uni-greifswald.de

Source: Pflügers Archiv: European Journal of Physiology. Sep2024, Vol. 476 Issue 9, p1307-1337. 31p.

Subject Terms: *TRANSCRIPTION factors, *OXYGEN detectors, *ANEMIA treatment, *DELETION mutation, *GENETIC translation, *DIOXYGENASES

Generation of renal Epo-producing cell lines by conditional gene tagging reveals rapid HIF-2 driven Epo kinetics, cell autonomous feedback regulation, and a telocyte phenotype

Authors: Imeri, Faik, Nolan, Karen A., Bapst, Andreas M., Santambrogio, Sara, Abreu-Rodríguez, Irene, Spielmann, Patrick, Pfundstein, Svende, Libertini, Silvana, Crowther, Lisa, Orlando, Ilaria M.C., Dahl, Sophie L., Keodara, Anna, Kuo, Willy, Kurtcuoglu, Vartan, Scholz, Carsten C., Qi, Weihong, Hummler, Edith, Hoogewijs, David, Wenger, Roland H.

Source: In Kidney International February 2019 95(2):375-387

Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes

Authors: Crifo, Bianca, Schaible, Bettina, Brown, Eric, Halligan, Doug N., Scholz, Carsten C., Fitzpatrick, Susan F., Kirwan, Anna, Roche, Helen M., Criscuoli, Mattia, Naldini, Antonella

Source: Journal of immunology. 202(5):1521-1530

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Fate‐mapping of erythropoietin‐producing cells in mouse models of hypoxaemia and renal tissue remodelling reveals repeated recruitment and persistent functionality

Authors: Dahl, Sophie L., Pfundstein, Svende, Hunkeler, Rico, Dong, Xingtong, Knöpfel, Thomas, Spielmann, Patrick, Scholz, Carsten C., Nolan, Karen A., Wenger, Roland H.

Source: Acta physiologica. 234(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100148311614.0x000001&indx=1&recIds=ETOCvdc_100148311614.0x000001

The functional interplay between the HIF pathway and the ubiquitin system – more than a one-way road

Authors: Günter, Julia, Ruiz-Serrano, Amalia, Pickel, Christina, Wenger, Roland H., Scholz, Carsten C.

Source: In Experimental Cell Research 15 July 2017 356(2):152-159

Carbon dioxide-dependent regulation of NF-κB family members RelB and p100 gives molecular insight into CO2-dependent immune regulation

Authors: Keogh, Ciara E., Scholz, Carsten C., Rodriguez, Javier, Selfridge, Andrew C., von Kriegsheim, Alexander, Cummins, Eoin P.

Source: In Journal of Biological Chemistry 7 July 2017 292(27):11561-11571

Selective Hypoxia-Sensitive Oxomer Formation by FIH Prevents Binding of the NF-κB Inhibitor IκBβ to NF-κB Subunits.

Authors: Volkova, Yulia L., Jucht, Agnieszka E., Oechsler, Nina, Krishnankutty, Roopesh, von Kriegsheim, Alex, Wenger, Roland H., Scholz, Carsten C.

Source: Molecular & Cellular Biology; 2024, Vol. 44 Issue 4, p138-148, 11p

Subject Terms: OXYGEN detectors, AMINO acid sequence

Genetic Knockdown and Pharmacologic Inhibition of Hypoxia-Inducible Factor (HIF) Hydroxylases

Authors: Pickel, Christina, Taylor, Cormac T., Scholz, Carsten C.

Source: Methods in molecular biology. 1742:1-14

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN614630770&indx=1&recIds=ETOCRN614630770

Intermittent hypoxia confers pro-metastatic gene expression selectively through NF-κB in inflammatory breast cancer cells

Authors: Gutsche, Katrin, Randi, Elisa B., Blank, Volker, Fink, Daniel, Wenger, Roland H., Leo, Cornelia, Scholz, Carsten C.

Source: In Free Radical Biology and Medicine December 2016 101:129-142

Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia

Alternate Title: Hypercapnia Suppresses HIF (English)

Authors: Selfridge, Andrew C., Cavadas, Miguel A.S., Scholz, Carsten C., Campbell, Eric L. ^**, Welch, Lynn C., Lecuona, Emilia, Colgan, Sean P. ^**, Barrett, Kim E., Sporn, Peter H.S., Sznajder, Jacob I., Cummins, Eoin P., Taylor, Cormac T.

Source: In Journal of Biological Chemistry 27 May 2016 291(22):11800-11808

OTUB1 regulates lung development, adult lung tissue homeostasis, and respiratory control

Authors: Ruiz‐Serrano, Amalia, Monné Rodríguez, Josep M., Günter, Julia, Sherman, Samantha P. M., Jucht, Agnieszka E., Fluechter, Pascal, Volkova, Yulia L., Pfundstein, Svende, Pellegrini, Giovanni, Wagner, Carsten A., Schneider, Christoph, Wenger, Roland H., Scholz, Carsten C.

Source: FASEB journal. 35(12)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100137120045.0x000001&indx=1&recIds=ETOCvdc_100137120045.0x000001

Paricalcitol protects against TGF-β1-induced fibrotic responses in hypoxia and stabilises HIF-α in renal epithelia

Authors: Nolan, Karen A., Brennan, Eoin P., Scholz, Carsten C., Cullen, Cliodhna, Ryan, Aidan, Taylor, Cormac T., Godson, Catherine

Source: In Experimental Cell Research 15 January 2015 330(2):371-381

Evolution of hypoxia and hypoxia-inducible factor asparaginyl hydroxylase regulation in chronic kidney disease.

Authors: Faivre, Anna, Dissard, Romain, Kuo, Willy, Verissimo, Thomas, Legouis, David, Arnoux, Grégoire, Heckenmeyer, Carolyn, Fernandez, Marylise, Tihy, Matthieu, Rajaram, Renuga D, Delitsikou, Vasiliki, Le, Ngoc An, Spingler, Bernhard, Mueller, Bert, Shulz, Georg, Lindenmeyer, Maja, Cohen, Clemens, Rutkowski, Joseph M, Moll, Solange, Scholz, Carsten C

Source: Nephrology Dialysis Transplantation; Oct2023, Vol. 38 Issue 10, p2276-2288, 13p

Subject Terms: HYPOXIA-inducible factors, CHRONIC kidney failure, HYPOXEMIA, CLINICAL trials, GLOMERULAR filtration rate, ANIMAL development

Targeting the HIF pathway in inflammation and immunity

Authors: Scholz, Carsten C, Taylor, Cormac T

Source: In Current Opinion in Pharmacology August 2013 13(4):646-653