Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer

Authors: Mittmann, Gesa, Laiouar-Pedari, Sara, Mehrtens, Hendrik A., Haggenmüller, Sarah, Bucher, Tabea-Clara, Chanda, Tirtha, Gaisa, Nadine T., Wagner, Mathias, Klamminger, Gilbert Georg, Rau, Tilman T., Neppl, Christina, Compérat, Eva Maria, Gocht, Andreas, Hämmerle, Monika, Rupp, Niels J., Westhoff, Jula, Krücken, Irene, Seidl, Maximillian, Schürch, Christian M., Bauer, Marcus, Solass, Wiebke, Tam, Yu Chun, Weber, Florian, Grobholz, Rainer, Augustyniak, Jaroslaw, Kalinski, Thomas, Hörner, Christian, Mertz, Kirsten D., Döring, Constanze, Erbersdobler, Andreas, Deubler, Gabriele, Bremmer, Felix, Sommer, Ulrich, Brodhun, Michael, Griffin, Jon, Lenon, Maria Sarah L., Trpkov, Kiril, Cheng, Liang, Chen, Fei, Levi, Angelique, Cai, Guoping, Nguyen, Tri Q., Amin, Ali, Cimadamore, Alessia, Shabaik, Ahmed, Manucha, Varsha, Ahmad, Nazeel, Messias, Nidia, Sanguedolce, Francesca, Taheri, Diana, Baraban, Ezra, Jia, Liwei, Shah, Rajal B., Siadat, Farshid, Swarbrick, Nicole, Park, Kyung, Hassan, Oudai, Sakhaie, Siamak, Downes, Michelle R., Miyamoto, Hiroshi, Williamson, Sean R., Holland-Letz, Tim, Schneider, Carolin V., Kather, Jakob Nikolas, Tolkach, Yuri, Brinker, Titus J.

Subject Terms: Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Artificial Intelligence, Computer Science - Computer Vision and Pattern Recognition

Access URL: http://arxiv.org/abs/2410.15012

Dermatologist-like explainable AI enhances melanoma diagnosis accuracy: eye-tracking study

Authors: Chanda, Tirtha, Haggenmueller, Sarah, Bucher, Tabea-Clara, Holland-Letz, Tim, Kittler, Harald, Tschandl, Philipp, Heppt, Markus V., Berking, Carola, Utikal, Jochen S., Schilling, Bastian, Buerger, Claudia, Navarrete-Dechent, Cristian, Goebeler, Matthias, Kather, Jakob Nikolas, Schneider, Carolin V., Durani, Benjamin, Durani, Hendrike, Jansen, Martin, Wacker, Juliane, Wacker, Joerg, Consortium, Reader Study, Brinker, Titus J.

Subject Terms: Computer Science - Artificial Intelligence, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Human-Computer Interaction

Access URL: http://arxiv.org/abs/2409.13476

Prompt Injection Attacks on Large Language Models in Oncology

Authors: Clusmann, Jan, Ferber, Dyke, Wiest, Isabella C., Schneider, Carolin V., Brinker, Titus J., Foersch, Sebastian, Truhn, Daniel, Kather, Jakob N.

Subject Terms: Computer Science - Cryptography and Security, Computer Science - Artificial Intelligence, Computer Science - Machine Learning

Access URL: http://arxiv.org/abs/2407.18981

Adverse Liver and Renal Outcomes After Initiating SGLT‐2i and GLP‐1RA Therapy Among Patients With Diabetes and MASLD.

Authors: Krishnan, Arunkumar^1,2 (AUTHOR) dr.arunkumar.krishnan@gmail.com, Schneider, Carolin V.³ (AUTHOR), Mukherjee, Diptasree⁴ (AUTHOR), Woreta, Tinsay A.⁵ (AUTHOR), Alqahtani, Saleh A.^6,7 (AUTHOR)

Source: Journal of Diabetes. Apr2025, Vol. 17 Issue 4, p1-11. 11p.

Subject Terms: *SODIUM-glucose cotransporter 2 inhibitors, *GLUCAGON-like peptide-1 agonists, *FATTY liver, *LIVER failure, *CHRONIC kidney failure, *KIDNEY physiology, *HEMODIALYSIS, *TYPE 2 diabetes

Longitudinal Evaluation of Individuals With Severe Alpha-1 Antitrypsin Deficiency (Pi∗ZZ Genotype)

Authors: Fromme, Malin ¹, Payancé, Audrey ², Mandorfer, Mattias ³, Thorhauge, Katrine H. ^{4, 5}, Pons, Monica ^{6, 7}, Miravitlles, Marc ⁸, Stolk, Jan ⁹, van Hoek, Bart ¹⁰, Stirnimann, Guido ¹¹, Frankova, Sona ¹², Sperl, Jan ¹², Kremer, Andreas E. ¹³, Burbaum, Barbara ¹, Schrader, Christina ¹, Kadioglu, Amine ¹, Walkenhaus, Michelle ¹, Schneider, Carolin V. ¹, Klebingat, Fabienne ¹, Balcar, Lorenz ³, Kappe, Naomi N. ^{9, 10}, Schaefer, Benedikt ¹⁴, Chorostowska-Wynimko, Joanna ¹⁵, Aigner, Elmar ¹⁶, Gensluckner, Sophie ¹⁶, Striedl, Philipp ¹⁶, Roger, Pauline ¹⁷, Ryan, John ¹⁸, Roche, Suzanne ¹⁸, Vögelin, Marius ¹³, Ala, Aftab ¹⁹, Bantel, Heike ²⁰, Verbeek, Jef ²¹, Mariño, Zoe ²², Praktiknjo, Michael ²³, Gevers, Tom J.G. ²⁴, Reuken, Philipp A. ²⁵, Berg, Thomas ²⁶, George, Jacob ²⁷, Demir, Münevver ²⁸, Bruns, Tony ¹, Trautwein, Christian ^{1, 29}, Zoller, Heinz ¹⁴, Trauner, Michael ³, Genesca, Joan ^{6, 7}, Griffiths, William J. ³⁰, Clark, Virginia ³¹, Krag, Aleksander ^{4, 5}, Turner, Alice M. ³², McElvaney, Noel G. ¹⁸, Strnad, Pavel ^{1, ∗}

Source: In Gastroenterology February 2025 168(2):367-381

Association between incretin-based drugs and risk of cholangiocarcinoma among patients with type 2 diabetes: A large population-based matched cohort study

Authors: Krishnan, Arunkumar, Schneider, Carolin V., Arkenau, Hendrik-Tobias, Mauro, Ezequiel Matias, Forner, Alejandro, Scott Butsch, W., Walsh, Declan, Alqahtani, Saleh A.

Source: In Journal of Clinical & Translational Endocrinology December 2024 38

Alpha-1 Antitrypsin Augmentation and the Liver Phenotype of Adults With Alpha-1 Antitrypsin Deficiency (Genotype Pi∗ZZ)

Authors: Fromme, Malin, Hamesch, Karim, Schneider, Carolin V., Mandorfer, Mattias, Pons, Monica, Thorhauge, Katrine H., Pereira, Vitor, Sperl, Jan, Frankova, Sona, Reichert, Matthias C., Benini, Federica, Burbaum, Barbara, Kleinjans, Moritz, Amzou, Samira, Rademacher, Laura, Bewersdorf, Lisa, Verbeek, Jef, Nevens, Frederik, Genesca, Joan, Miravitlles, Marc, Nuñez, Alexa, Schaefer, Benedikt, Zoller, Heinz, Janciauskiene, Sabina, Waern, Johan, Oliveira, António, Maia, Luís, Simões, Carolina, Mahadeva, Ravi, Fraughen, Daniel D., Trauner, Michael, Krag, Aleksander, Lammert, Frank, Bals, Robert, Gaisa, Nadine T., Aigner, Elmar, Griffiths, William J., Denk, Helmut, Teumer, Alexander, McElvaney, Noel G., Turner, Alice M., Trautwein, Christian, Strnad, Pavel

Source: In Clinical Gastroenterology and Hepatology February 2024 22(2):283-294

A missense variant in human perilipin 2 (PLIN2 Ser251Pro) reduces hepatic steatosis in mice

Authors: Scorletti, Eleonora, Saiman, Yedidya, Jeon, Sookyoung, Schneider, Carolin V., Buyco, Delfin G., Lin, Chelsea, Himes, Blanca E., Mesaros, Clementina A., Vujkovic, Marijana, Creasy, Kate Townsend, Furth, Emma E., Billheimer, Jeffrey T., Hand, Nicholas J., Kaplan, David E., Chang, Kyong-Mi, Tsao, Philip S., Lynch, Julie A., Dempsey, Joseph L., Harkin, Julia, Bayen, Susovon, Conlon, Donna, Guerraty, Marie, Phillips, Michael C., Rader, Daniel J., Carr, Rotonya M.

Source: In JHEP Reports January 2024 6(1)

Large-scale identification of undiagnosed hepatic steatosis using natural language processing

Authors: Schneider, Carolin V., Li, Tang, Zhang, David, Mezina, Anya I., Rattan, Puru, Huang, Helen, Creasy, Kate Townsend, Scorletti, Eleonora, Zandvakili, Inuk, Vujkovic, Marijana, Hehl, Leonida, Fiksel, Jacob, Park, Joseph, Wangensteen, Kirk, Risman, Marjorie, Chang, Kyong-Mi, Serper, Marina, Carr, Rotonya M., Schneider, Kai Markus, Chen, Jinbo, Rader, Daniel J.

Source: In eClinicalMedicine August 2023 62

The enteric nervous system relays psychological stress to intestinal inflammation

Authors: Schneider, Kai Markus, Blank, Niklas, Alvarez, Yelina, Thum, Katharina, Lundgren, Patrick, Litichevskiy, Lev, Sleeman, Madeleine, Bahnsen, Klaas, Kim, Jihee, Kardo, Simon, Patel, Shaan, Dohnalová, Lenka, Uhr, Giulia T., Descamps, Hélène C., Kircher, Susanna, McSween, Alana M., Ardabili, Ashkan Rezazadeh, Nemec, Kelsey M., Jimenez, Monica T., Glotfelty, Lila G., Eisenberg, Joshua D., Furth, Emma E., Henao-Mejia, Jorge, Bennett, F. Chris, Pierik, Marie J., Romberg-Camps, Mariëlle, Mujagic, Zlatan, Prinz, Marco, Schneider, Carolin V., Wherry, E. John, Bewtra, Meenakshi, Heuckeroth, Robert O., Levy, Maayan, Thaiss, Christoph A.

Source: In Cell 22 June 2023 186(13):2823-2838

Prevalence of at‐risk MASH, MetALD and alcohol‐associated steatotic liver disease in the general population.

Authors: Schneider, Carolin V.¹ (AUTHOR) cschneider@ukaachen.de, Schneider, Kai Markus¹ (AUTHOR), Raptis, Anastasia¹ (AUTHOR), Huang, Helen¹ (AUTHOR), Trautwein, Christian¹ (AUTHOR), Loomba, Rohit² (AUTHOR) roloomba@health.ucsd.edu

Source: Alimentary Pharmacology & Therapeutics. May2024, Vol. 59 Issue 10, p1271-1281. 11p.

Subject Terms: *LIVER diseases, *FATTY liver, *OBESITY in women, *OVERWEIGHT men

Geographic Terms: UNITED Kingdom

Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD) Impacts Long‐Term Outcomes After Curative‐Intent Surgery for Hepatocellular Carcinoma.

Authors: Uluk, Deniz, Pein, Justus, Herda, Sophia, Schliephake, Frederik, Schneider, Carolin V., Bitar, Jude, Dreher, Katharina, Eurich, Dennis, Zhang, Ingrid W., Schaffrath, Lukas, Auer, Timo A., Collettini, Federico, Engelmann, Cornelius, Tacke, Frank, Pratschke, Johann, Lurje, Isabella, Lurje, Georg

Source: Alimentary Pharmacology & Therapeutics; Apr2025, Vol. 61 Issue 8, p1318-1332, 15p

Subject Terms: ETIOLOGY of diseases, PORTAL vein, BODY composition, OVERALL survival, HEPATOCELLULAR carcinoma

Alpha-1 antitrypsin deficiency: A re-surfacing adult liver disorder

Authors: Fromme, Malin, Schneider, Carolin V., Trautwein, Christian, Brunetti-Pierri, Nicola, Strnad, Pavel

Source: In Journal of Hepatology April 2022 76(4):946-958

SARS-CoV-2 infection in alpha1-antitrypsin deficiency

Authors: Schneider, Carolin V., Strnad, Pavel

Source: In Respiratory Medicine August 2021 184

A genome-first approach to mortality and metabolic phenotypes in MTARC1 p.Ala165Thr (rs2642438) heterozygotes and homozygotes

Authors: Schneider, Carolin V., Schneider, Kai Markus, Conlon, Donna M., Park, Joseph, Vujkovic, Marijana, Zandvakili, Inuk, Ko, Yi-An, Trautwein, Christian, Carr, Rotonya M., Strnad, Pavel, Thaiss, Christoph A., Rader, Daniel J.

Source: In Med 9 July 2021 2(7):851-863

Physical activity is associated with reduced risk of liver disease in the prospective UK Biobank cohort

Authors: Schneider, Carolin V., Zandvakili, Inuk, Thaiss, Christoph A., Schneider, Kai Markus

Source: In JHEP Reports June 2021 3(3)

Prompt injection attacks on vision language models in oncology.

Authors: Clusmann, Jan, Ferber, Dyke, Wiest, Isabella C., Schneider, Carolin V., Brinker, Titus J., Foersch, Sebastian, Truhn, Daniel, Kather, Jakob Nikolas

Source: Nature Communications; 2/1/2025, Vol. 16 Issue 1, p1-9, 9p

Subject Terms: LANGUAGE models, DECISION support systems, ARTIFICIAL intelligence, INFORMATION storage & retrieval systems, GENERATIVE pre-trained transformers

The Aachen ACLF ICU score predicts ICU mortality in critically ill patients with acute-on-chronic liver failure.

Authors: Pollmanns, Maike R., Kister, Bastian, Abu Jhaisha, Samira, Adams, Jule K., Kabak, Elena, Brozat, Jonathan F., Schneider, Carolin V., Hohlstein, Philipp, Bruns, Tony, Küpfer, Lars, Trautwein, Christian, Koch, Alexander, Wirtz, Theresa H.

Source: Scientific Reports; 12/16/2024, Vol. 14 Issue 1, p1-11, 11p

Subject Terms: INTENSIVE care patients, LIVER failure, PROGNOSTIC tests, MACHINE learning, CRITICALLY ill

Liver Phenotypes of European Adults Heterozygous or Homozygous for Pi∗Z Variant of AAT (Pi∗MZ vs Pi∗ZZ genotype) and Noncarriers

Authors: Schneider, Carolin V., Hamesch, Karim, Gross, Annika, Mandorfer, Mattias, Moeller, Linda S., Pereira, Vitor, Pons, Monica, Kuca, Pawel, Reichert, Matthias C., Benini, Federica, Burbaum, Barbara, Voss, Jessica, Gutberlet, Marla, Woditsch, Vivien, Lindhauer, Cecilia, Fromme, Malin, Kümpers, Julia, Bewersdorf, Lisa, Schaefer, Benedikt, Eslam, Mohammed, Bals, Robert, Janciauskiene, Sabina, Carvão, Joana, Neureiter, Daniel, Zhou, Biaohuan, Wöran, Katharina, Bantel, Heike, Geier, Andreas, Dirrichs, Timm, Stickel, Felix, Teumer, Alexander, Verbeek, Jef, Nevens, Frederik, Govaere, Olivier, Krawczyk, Marcin, Roskams, Tania, Haybaeck, Johannes, Lurje, Georg, Chorostowska-Wynimko, Joanna, Genesca, Joan, Reiberger, Thomas, Lammert, Frank, Krag, Aleksander, George, Jacob, Anstee, Quentin M., Trauner, Michael, Datz, Christian, Gaisa, Nadine T., Denk, Helmut, Trautwein, Christian, Aigner, Elmar, Strnad, Pavel

Source: In Gastroenterology August 2020 159(2):534-548

A coding variant in the microsomal triglyceride transfer protein reduces both hepatic steatosis and plasma lipids.

Authors: Schneider, Carolin V.^1,2,3 (AUTHOR) cschneider@ukaachen.de, Hehl, Leonida¹ (AUTHOR), Creasy, Kate T.⁴ (AUTHOR), Vitali, Cecilia⁵ (AUTHOR), Vell, Mara S.¹ (AUTHOR), Vujkovic, Marijana² (AUTHOR), Park, Joseph² (AUTHOR), Scorletti, Eleonora^2,3 (AUTHOR), Seeling, Katharina S.¹ (AUTHOR), Rendel, Miriam D.¹ (AUTHOR), Conlon, Donna M.⁵ (AUTHOR), Huang, Helen² (AUTHOR), Zandvakili, Inuk^2,6 (AUTHOR), Valmiki, Swati⁷ (AUTHOR), Schneider, Kai Markus^1,8 (AUTHOR), Hussain, M. Mahmood⁷ (AUTHOR), Rader, Daniel J.⁵ (AUTHOR)

Source: Alimentary Pharmacology & Therapeutics. Jul2023, Vol. 58 Issue 2, p238-249. 12p. 1 Diagram, 5 Charts, 1 Graph.

Subject Terms: *FATTY liver, *BLOOD lipids, *MISSENSE mutation, *PROTEINS, *TRIGLYCERIDES