Sublethal necroptosis signaling promotes inflammation and liver cancer

Authors: Vucur, Mihael, Ghallab, Ahmed, Schneider, Anne T., Adili, Arlind, Cheng, Mingbo, Castoldi, Mirco, Singer, Michael T., Büttner, Veronika, Keysberg, Leonie S., Küsgens, Lena, Kohlhepp, Marlene, Görg, Boris, Gallage, Suchira, Barragan Avila, Jose Efren, Unger, Kristian, Kordes, Claus, Leblond, Anne-Laure, Albrecht, Wiebke, Loosen, Sven H., Lohr, Carolin, Jördens, Markus S., Babler, Anne, Hayat, Sikander, Schumacher, David, Koenen, Maria T., Govaere, Olivier, Boekschoten, Mark V., Jörs, Simone, Villacorta-Martin, Carlos, Mazzaferro, Vincenzo, Llovet, Josep M., Weiskirchen, Ralf, Kather, Jakob N., Starlinger, Patrick, Trauner, Michael, Luedde, Mark, Heij, Lara R., Neumann, Ulf P., Keitel, Verena, Bode, Johannes G., Schneider, Rebekka K., Tacke, Frank, Levkau, Bodo, Lammers, Twan, Fluegen, Georg, Alexandrov, Theodore, Collins, Amy L., Nelson, Glyn, Oakley, Fiona, Mann, Derek A., Roderburg, Christoph, Longerich, Thomas, Weber, Achim, Villanueva, Augusto, Samson, Andre L., Murphy, James M., Kramann, Rafael, Geisler, Fabian, Costa, Ivan G., Hengstler, Jan G., Heikenwalder, Mathias, Luedde, Tom

Source: In Immunity 11 July 2023 56(7):1578-1595

A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development.

Authors: Schneider, Anne T., Koppe, Christiane, Crouchet, Emilie, Papargyriou, Aristeidis, Singer, Michael T., Büttner, Veronika, Keysberg, Leonie, Szydlowska, Marta, Jühling, Frank, Moehlin, Julien, Chen, Min-Chun, Leone, Valentina, Mueller, Sebastian, Neuß, Thorsten, Castoldi, Mirco, Lesina, Marina, Bergmann, Frank, Hackert, Thilo, Steiger, Katja, Knoefel, Wolfram T.

Source: Nature Communications; 2/19/2025, Vol. 16 Issue 1, p1-18, 18p

Subject Terms: APOPTOSIS, PRIMARY cell culture, TRANSFORMING growth factors, RECEPTOR-interacting proteins, CYTOLOGY

Spontaneous Cholemia in C57BL/6 Mice Predisposes to Liver Cancer in NASH

Authors: Gallage, Suchira, Ali, Adnan, Barragan Avila, Jose Efren, Herebian, Diran, Karimi, Mohammad M., Irvine, Elaine E., McHugh, Domhnall, Schneider, Anne T., Vucur, Mihael, Keitel, Verena, Gil, Jesús, Withers, Dominic J., Luedde, Tom, Heikenwalder, Mathias

Source: In Cellular and Molecular Gastroenterology and Hepatology 2022 13(3):875-878

JNK signaling prevents biliary cyst formation through a CASPASE-8–dependent function of RIPK1 during aging

Authors: Müller, Katrin, Honcharova-Biletska, Hanna, Koppe, Christiane, Egger, Michèle, Chan, Lap Kwan, Schneider, Anne T., Küsgens, Lena, Böhm, Friederike, Boege, Yannick, Healy, Marc E., Schmitt, Johannes, Comtesse, Sarah, Castoldi, Mirco, Preisinger, Christian, Szydlowska, Marta, Focaccia, Enrico, Gaisa, Nadine T., Loosen, Sven H., Jörs, Simone, Tacke, Frank, Roderburg, Christoph, Keitel, Verena, Bode, Johannes G., Boor, Peter, Davis, Roger J., Longerich, Thomas, Geisler, Fabian, Heikenwalder, Mathias, Weber, Achim, Vucur, Mihael, Luedde, Tom

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Mar . 118(12), 1-11.

Access URL: https://www.jstor.org/stable/27039620

microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis

Authors: Roy, Sanchari, Hooiveld, Guido J., Seehawer, Marco, Caruso, Stefano, Heinzmann, Florian, Schneider, Anne T., Frank, Anna K., Cardenas, David Vargas, Sonntag, Roland, Luedde, Mark, Trautwein, Christian, Stein, Ilan, Pikarsky, Eli, Loosen, Sven, Tacke, Frank, Ringelhan, Marc, Avsaroglu, Seda Kilinc, Goga, Andrei, Buendia, Marie-Annick, Vucur, Mihael, Heikenwalder, Mathias, Zucman-Rossi, Jessica, Zender, Lars, Roderburg, Christoph, Luedde, Tom

Source: In Gastroenterology December 2018 155(6):1951-1966

RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer

Authors: Schneider, Anne T., Gautheron, Jérémie, Feoktistova, Maria, Roderburg, Christoph, Loosen, Sven H., Roy, Sanchari, Benz, Fabian, Schemmer, Peter, Büchler, Markus W., Nachbur, Ueli, Neumann, Ulf P., Tolba, Rene, Luedde, Mark, Zucman-Rossi, Jessica, Panayotova-Dimitrova, Diana, Leverkus, Martin, Preisinger, Christian, Tacke, Frank, Trautwein, Christian, Longerich, Thomas, Vucur, Mihael, Luedde, Tom

Source: In Cancer Cell 9 January 2017 31(1):94-109

Elevated Serum Levels of CCL23 Are Associated with Poor Outcome after Resection of Biliary Tract Cancer.

Authors: Roderburg, Christoph, Labuhn, Simon, Bednarsch, Jan, Lang, Sven A., Schneider, Anne T., Hammerich, Linda, Vucur, Mihael, Ulmer, Tom F., Neumann, Ulf P., Luedde, Tom, Loosen, Sven H.

Source: Mediators of Inflammation; 12/1/2022, p1-9, 9p

Subject Terms: BILIARY tract cancer, GALLBLADDER cancer, TUMOR markers, CHOLANGIOGRAPHY, TUMOR surgery, PROGNOSIS, SURGICAL excision

Serum Levels of CXCL13 Are an Independent Predictor of Survival Following Resection of Biliary Tract Cancer.

Authors: Loosen, Sven H., Ulmer, Tom F., Labuhn, Simon, Bednarsch, Jan, Lang, Sven A., Alizai, Patrick H., Schneider, Anne T., Vucur, Mihael, Neumann, Ulf P., Luedde, Tom, Roderburg, Christoph

Source: Cancers; Sep2022, Vol. 14 Issue 17, p4073, 12p

Subject Terms: BILE duct tumors, TUMOR markers, CHEMOKINES

The enigma of RIPK1 in the liver: More than just a kinase

Authors: Vucur, Mihael, Schneider, Anne T., Gautheron, Jérémie, Luedde, Tom

Source: Molecular & cellular oncology. 4(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100053923505.0x000001&indx=1&recIds=ETOCvdc_100053923505.0x000001

Serum Levels of Soluble Urokinase Plasminogen Activator Receptor Predict Tumor Response and Outcome to Immune Checkpoint Inhibitor Therapy.

Authors: Loosen, Sven H., Gorgulho, Joao, Jördens, Markus S., Schulze-Hagen, Maximilian, Beier, Fabian, Vucur, Mihael, Schneider, Anne T., Koppe, Christiane, Mertens, Alexander, Kather, Jakob N., Tacke, Frank, Keitel, Verena, Brümmendorf, Tim H., Roderburg, Christoph, Luedde, Tom

Source: Frontiers in Oncology; 4/1/2021, Vol. 11, pN.PAG-N.PAG, 12p

Subject Terms: IMMUNE checkpoint inhibitors, PLASMINOGEN activators, UROKINASE, IPILIMUMAB, LOGISTIC regression analysis, IMMUNE response

JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging.

Authors: MÃ?ller, Katrin, Honcharova-Biletska, Hanna, Koppe, Christiane, Egger, MichÃ?le, Lap Kwan Chan, Schneider, Anne T., KÃ?sgens, Lena, BÃ?hm, Friederike, Boege, Yannick, Healy, Marc E., Schmitt, Johannes, Comtesse, Sarah, Castoldi, Mirco, Preisinger, Christian, Szydlowska, Marta, Focaccia, Enrico, Gaisa, Nadine T., Loosen, Sven H., JÃ?rs, Simone, Tacke, Frank

Source: Proceedings of the National Academy of Sciences of the United States of America; 3/23/2021, Vol. 118 Issue 12, p1-11, 11p

Subject Terms: AGING, APOPTOSIS, LIVER cells, CURCUMIN, PROTEIN kinases, CELL death

Circulating levels of microRNA193a-5p predict outcome in early stage hepatocellular carcinoma.

Authors: Loosen, Sven H., Wirtz, Theresa H., Roy, Sanchari, Vucur, Mihael, Castoldi, Mirco, Schneider, Anne T., Koppe, Christiane, Ulmer, Tom F., Roeth, Anjali A., Bednarsch, Jan, Alizai, Patrick H., Paffenholz, Pia, Demir, Münevver, Trautwein, Christian, Tacke, Frank, Neumann, Ulf P., Roderburg, Christoph, Luedde, Tom

Source: PLoS ONE; 9/22/2020, Vol. 15 Issue 9, p1-12, 12p

Subject Terms: HEPATOCELLULAR carcinoma, ETIOLOGY of diseases, LIVER transplantation, LIVER cancer, BIOMARKERS, CIRCULATING tumor DNA

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A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes.

Authors: Feoktistova, Maria, Makarov, Roman, Brenji, Sihem, Schneider, Anne T., Hooiveld, Guido J., Luedde, Tom, Leverkus, Martin, Yazdi, Amir S., Panayotova-Dimitrova, Diana

Source: Cells (2073-4409); Feb2020, Vol. 9 Issue 2, p351, 1p

Subject Terms: KERATINOCYTES, CELL death, IMMUNOREGULATION, APOPTOSIS, SKIN diseases

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