CpsA mediates infection of recruited lung myeloid cells by Mycobacterium tuberculosis

Authors: Grigsby, Steven J., Prasad, G.V.R. Krishna, Wallach, Joshua B., Mittal, Ekansh, Hsu, Fong-Fu, Schnappinger, Dirk, Philips, Jennifer A.

Source: In Cell Reports 23 January 2024 43(1)

Chemical–genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy

Authors: Koh, Eun-Ik, Oluoch, Peter O., Ruecker, Nadine, Proulx, Megan K., Soni, Vijay, Murphy, Kenan C., Papavinasasundaram, Kadamba, Reames, Charlotte J., Trujillo, Carolina, Zaveri, Anisha, Zimmerman, Matthew D., Aslebagh, Roshanak, Baker, Richard E., Shaffer, Scott A., Guinn, Kristine M., Fitzgerald, Michael, Dartois, Véronique, Ehrt, Sabine, Hung, Deborah T., Ioerger, Thomas R., Rubin, Eric J., Rhee, Kyu Y., Schnappinger, Dirk, Sassetti, Christopher M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Apr 01. 119(15), 1-12.

Access URL: https://www.jstor.org/stable/27151819

Polyfluorinated salicylic acid analogs do not interfere with siderophore biosynthesis

Authors: Hegde, Pooja, Orimoloye, Moyosore O., Sharma, Sachin, Engelhart, Curtis A., Schnappinger, Dirk, Aldrich, Courtney C.

Source: In Tuberculosis May 2023 140

Identification of a Series Containing a Pentafluorophenyl Moiety That Targets Pks13 to Inhibit Growth of Mycobacterium tuberculosis.

Authors: Green, Simon R., Harrison, Justin R., Thompson, Stephen, Murugesan, Dinakaran, Libardo, M. Daben J., Engelhart, Curtis A., Meshanni, Jaclynn, Fletcher, Daniel, Scullion, Paul, Edwards, Darren, Epemolu, Ola, Mutter, Nicole, Shishikura, Yoko, Riley, Jennifer, Ioerger, Thomas R., Roca Guillén, Jose Juan, López, Laura Guijarro, Read, Kevin D., Barry III, Clifton E., Schnappinger, Dirk

Source: ACS Infectious Diseases; 3/14/2025, Vol. 11 Issue 3, p715-726, 12p

Metabolically Stable Adenylation Inhibitors of Biotin Protein Ligase as Antibacterial Agents.

Authors: Liu, Qiang, Engelhart, Curtis A., Wallach, Joshua B., Tiwari, Divya, Ge, Peng, Manna, Adhar, Panda, Subhankar, McCue, William M., Wong, Tsung-Yun, Sharma, Sachin, Jayasinghe, Yahani P., Fuller, Jessica, Ronning, Donald R., Bockman, Matthew R., Cheung, Ambrose, Dartois, Véronique, Zimmerman, Matthew D., Schnappinger, Dirk, Aldrich, Courtney C.

Source: Journal of Medicinal Chemistry; 2/13/2025, Vol. 68 Issue 3, p3065-3087, 23p

Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis

Authors: Bosch, Barbara, DeJesus, Michael A., Poulton, Nicholas C., Zhang, Wenzhu, Engelhart, Curtis A., Zaveri, Anisha, Lavalette, Sophie, Ruecker, Nadine, Trujillo, Carolina, Wallach, Joshua B., Li, Shuqi, Ehrt, Sabine, Chait, Brian T., Schnappinger, Dirk, Rock, Jeremy M.

Source: In Cell 19 August 2021 184(17):4579-4592

Rediscovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis

Authors: Wang, Heng, Xu, Min, Engelhart, Curtis A., Zhang, Xi, Yan, Baohua, Pan, Miaomiao, Xu, Yuanyuan, Fan, Shilong, Liu, Renhe, Xu, Lan, Hua, Lan, Schnappinger, Dirk, Chen, Shawn

Source: In Journal of Biological Chemistry January-June 2021 296

Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA‐damage response and leads to cell death

Authors: Zaveri, Anisha, Wang, Ruojun, Botella, Laure, Sharma, Ritu, Zhu, Linnan, Wallach, Joshua B., Song, Naomi, Jansen, Robert S., Rhee, Kyu Y., Ehrt, Sabine, Schnappinger, Dirk

Source: Molecular microbiology. 114(4):641-652

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150134400.0x000001&indx=1&recIds=ETOCvdc_100150134400.0x000001

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition

Authors: Ballinger, Elaine, Mosior, John, Hartman, Travis, Burns-Huang, Kristin, Gold, Ben, Morris, Roxanne, Goullieux, Laurent, Blanc, Isabelle, Vaubourgeix, Julien, Lagrange, Sophie, Fraisse, Laurent, Sans, Stéphanie, Couturier, Cedric, Bacqué, Eric, Rhee, Kyu, Scarry, Sarah M., Aubé, Jeffrey, Yang, Guangbin, Ouerfelli, Ouathek, Schnappinger, Dirk, Ioerger, Thomas R., Engelhart, Curtis A., McConnell, Jennifer A., McAulay, Kathrine, Fay, Allison, Roubert, Christine, Sacchettini, James, Nathan, Carl

Source: Science, 2019 Feb 01. 363(6426), 498-498.

Access URL: https://www.jstor.org/stable/26588396

Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development

Authors: Beites, Tiago, O'Brien, Kathryn, Tiwari, Divya, Engelhart, Curtis, Walters, Shaun, Andrews, Jenna, Yang, Hee-Jeong, Sutphen, Michelle, Weiner, Danielle, Dayao, Emmanuel, Zimmerman, Matthew, Prideaux, Brendan, Desai, Prashant, Masquelin, Thierry, Via, Laura, Dartois, Véronique, Boshoff, Helena, Barry, Clifton, Ehrt, Sabine, Schnappinger, Dirk

Source: Nature communications. 10(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190885009.0x000001&indx=1&recIds=ETOCvdc_100190885009.0x000001

Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression

Authors: Subramaniyam, Siddharth, DeJesus, Michael, Zaveri, Anisha, Smith, Clare, Baker, Richard, Ehrt, Sabine, Schnappinger, Dirk, Sassetti, Christopher, Ioerger, Thomas

Source: BMC bioinformatics. 20(1):1-15

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190710585.0x000001&indx=1&recIds=ETOCvdc_100190710585.0x000001

Large-scale chemical–genetics yields new M. tuberculosis inhibitor classes

Authors: Johnson, Eachan, LaVerriere, Emily, Office, Emma, Stanley, Mary, Meyer, Elisabeth, Kawate, Tomohiko, Gomez, James, Audette, Rebecca, Bandyopadhyay, Nirmalya, Betancourt, Natalia, Delano, Kayla, Silva, Israel, Davis, Joshua, Gallo, Christina, Gardner, Michelle, Golas, Aaron, Guinn, Kristine, Kennedy, Sofia, Korn, Rebecca, McConnell, Jennifer, Moss, Caitlin, Murphy, Kenan, Nietupski, Raymond, Papavinasasundaram, Kadamba, Pinkham, Jessica, Pino, Paula, Proulx, Megan, Ruecker, Nadine, Song, Naomi, Thompson, Matthew, Trujillo, Carolina, Wakabayashi, Shoko, Wallach, Joshua, Watson, Christopher, Ioerger, Thomas, Lander, Eric, Hubbard, Brian, Serrano-Wu, Michael, Ehrt, Sabine, Fitzgerald, Michael, Rubin, Eric, Sassetti, Christopher, Schnappinger, Dirk, Hung, Deborah

Source: Nature. 571(7763):72-78

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184158730.0x000001&indx=1&recIds=ETOCvdc_100184158730.0x000001

Two‐way regulation of protein expression for identification and validation of on‐target inhibitors of Mycobacterium tuberculosis

Authors: Grover, Shipra, Engelhart, Curtis A., Perez‐Herran, Esther, Tiwari, Divya, Li, Wei, Abrahams, Katherine A., Papavinasasundaram, Kadamba, Bean, James M., Sassetti, Christopher M., Mendoza‐Losana, Alfonso, Besra, Gurdyal S., Jackson, Mary, Aldrich, Courtney, Schnappinger, Dirk

Source: FASEB journal. 36

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196447424.0x000001&indx=1&recIds=ETOCvdc_100196447424.0x000001

Regulation of the Mycobacterium tuberculosis Hypoxic Response Gene Encoding α-Crystallin

Authors: Sherman, David R., Voskuil, Martin, Schnappinger, Dirk, Liao, Reiling, Harrell, Maria I., Schoolnik, Gary K.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2001 Jun . 98(13), 7534-7539.

Access URL: https://www.jstor.org/stable/3056023

A dose-response model for statistical analysis of chemical genetic interactions in CRISPRi screens.

Authors: Choudhery, Sanjeevani, DeJesus, Michael A., Srinivasan, Aarthi, Rock, Jeremy, Schnappinger, Dirk, Ioerger, Thomas R.

Source: PLoS Computational Biology; 5/20/2024, Vol. 20 Issue 5, p1-32, 32p

Subject Terms: ANALYTICAL chemistry, CRISPRS, NUCLEOTIDE sequencing, STATISTICAL models, ESCHERICHIA coli, PRECISION farming, AGRICULTURAL extension work

Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin.

Authors: Qu, Di, Ge, Peng, Botella, Laure, Park, Sae Woong, Lee, Ha-Na, Thornton, Natalie, Bean, James M., Krieger, Inna V., Sacchettini, James C., Ehrt, Sabine, Aldrich, Courtney C., Schnappinger, Dirk

Source: Nature Communications; 5/16/2024, Vol. 15 Issue 1, p1-11, 11p

Subject Terms: BIOTIN, SYNTHASES, POST-translational modification, MYCOBACTERIUM tuberculosis, PROTEINS, GLYCOLIPIDS

Weak links: Advancing target‐based drug discovery by identifying the most vulnerable targets.

Authors: Bosch, Barbara¹, DeJesus, Michael A.¹, Schnappinger, Dirk², Rock, Jeremy M.¹, rock@rockefeller.edu

Source: Annals of the New York Academy of Sciences; May2024, Vol. 1535 Issue 1, p10-19, 10p

Generation of Conditional Mutants in Higher Eukaryotes by Switching between the Expression of Two Genes

Authors: Baron, Udo, Schnappinger, Dirk, Helbl, Vera, Gossen, Manfred, Hillen, Wolfgang, Bujard, Hermann

Source: Proceedings of the National Academy of Sciences of the United States of America, 1999 Feb 01. 96(3), 1013-1018.

Access URL: https://www.jstor.org/stable/46936

Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis

Authors: Ehrt, Sabine, Schnappinger, Dirk, Rhee, Kyu

Source: Nature reviews.Microbiology. 16(8):496-507

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100133344352.0x000001&indx=1&recIds=ETOCvdc_100133344352.0x000001

Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis

Authors: Puckett, Susan, Trujillo, Carolina, Wang, Zhe, Eoh, Hyungjin, Ioerger, Thomas R., Krieger, Inna, Sacchettini, James, Schnappinger, Dirk, Rhee, Kyu Y., Ehrt, Sabine

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Mar . 114(11), E2225-E2232.

Access URL: https://www.jstor.org/stable/26480299