Ad26.COV2.S priming provided a solid immunological base for mRNA-based COVID-19 booster vaccination

Authors: Geers, Daryl, Sablerolles, Roos S.G., van Baarle, Debbie, Kootstra, Neeltje A., Rietdijk, Wim J.R., Schmitz, Katharina S., Gommers, Lennert, Bogers, Susanne, Nieuwkoop, Nella J., van Dijk, Laura L.A., van Haren, Eva, Lafeber, Melvin, Dalm, Virgil A.S.H., Goorhuis, Abraham, Postma, Douwe F., Visser, Leo G., Huckriede, Anke L.W., Sette, Alessandro, Grifoni, Alba, de Swart, Rik L., Koopmans, Marion P.G., van der Kuy, P. Hugo M., GeurtsvanKessel, Corine H., de Vries, Rory D.

Source: In iScience 20 January 2023 26(1)

Design and evaluation of neutralizing and fusion inhibitory peptides to Crimean-Congo hemorrhagic fever virus

Authors: Mears, Megan C., Rodriguez, Sergio E., Schmitz, Katharina S., Padilla, Angel, Biswas, Sudipta, Cajimat, Maria N.B., Mire, Chad E., Welch, Stephen R., Bergeron, Éric, Alabi, Christopher A., Porotto, Matteo, Bente, Dennis A.

Source: In Antiviral Research November 2022 207

Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters

Authors: Rissmann, Melanie, Noack, Danny, van Riel, Debby, Schmitz, Katharina S., de Vries, Rory D., van Run, Peter, Lamers, Mart M., Geurts van Kessel, Corine H., Koopmans, Marion P. G., Fouchier, Ron A. M., Kuiken, Thijs, Haagmans, Bart L., Rockx, Barry

Source: Emerging microbes & infections. 11(1):1778-1786

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194682179.0x000001&indx=1&recIds=ETOCvdc_100194682179.0x000001

Absence of COVID-19-associated changes in plasma coagulation proteins and pulmonary thrombosis in the ferret model

Authors: Kreft, Iris C., Winiarczyk, Roy R.A., Tanis, Fric J., van der Zwaan, Carmen, Schmitz, Katharina S., Hoogendijk, Arie J., de Swart, Rik L., Moscona, Anne, Porotto, Matteo, Salvatori, Daniela C.F., de Vries, Rory D., de Maat, Moniek P.M., van den Biggelaar, Maartje, van Vlijmen, Bart J.M.

Source: Thrombosis research. 210:6-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154778664.0x000001&indx=1&recIds=ETOCvdc_100154778664.0x000001

Orthopoxvirus-specific antibodies wane to undetectable levels 1 year after MVA-BN vaccination of at-risk individuals, the Netherlands, 2022 to 2023.

Authors: van Leeuwen, Leanne P. M., Shamier, Marc C., Verstrepen, Babs E., Götz, Hannelore M., Schmitz, Katharina S., Akhiyate, Najlae, Wijnans, Koen, Bogers, Susanne, van Royen, Martin E., van Gorp, Eric C. M., Koopmans, Marion P. G., de Vries, Rory D., GeurtsvanKessel, Corine H., Zaeck, Luca M.

Source: Eurosurveillance (15607917); 9/19/2024, Vol. 29 Issue 38, p8-12, 5p

Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds.

Authors: Schmitz, Katharina S.¹ (AUTHOR) k.schmitz@erasmusmc.nl, Lange, Mona V.¹ (AUTHOR) mona.lange@pei.de, Gommers, Lennert¹ (AUTHOR) l.gommers@erasmusmc.nl, Handrejk, Kim¹ (AUTHOR) k.handrejk@erasmusmc.nl, Porter, Danielle P.² (AUTHOR) danielle.porter@gilead.com, Alabi, Christopher A.³ (AUTHOR) caa238@cornell.edu, Moscona, Anne^4,5,6,7 (AUTHOR) am939@cumc.columbia.edu, Porotto, Matteo^4,5,8 (AUTHOR) mp3509@cumc.columbia.edu, de Vries, Rory D.¹ (AUTHOR) r.d.devries@erasmusmc.nl, de Swart, Rik L.¹ (AUTHOR) r.deswart@erasmusmc.nl

Source: Viruses (1999-4915). Jun2022, Vol. 14 Issue 6, pN.PAG-N.PAG. 20p.

Subject Terms: *MEASLES virus, *ANTIVIRAL agents, *INTRAVENOUS immunoglobulins, *VACCINE effectiveness, *VACCINATION coverage, *MEASLES, *YOUNG adults

Virus neutralization assays for human respiratory syncytial virus using airway organoids.

Authors: van Dijk, Laura L.A., Rijsbergen, Laurine C., Rubio, Bruno Tello, Schmitz, Katharina S., Gommers, Lennert, Comvalius, Anouskha D., Havelaar, Alexander, van Amerongen, Geert, Schepp, Rutger, Lamers, Mart M., GeurtsvanKessel, Corine H., Haagmans, Bart L., van Binnendijk, Rob, de Swart, Rik L., de Vries, Rory D.

Source: Cellular & Molecular Life Sciences; 6/17/2024, Vol. 81 Issue 1, p1-13, 13p

Subject Terms: VIRAL antibodies, RESPIRATORY syncytial virus, PRIMARY cell culture, ORGANOIDS, EPITHELIAL cells, AIRWAY (Anatomy)

Functional properties of measles virus proteins derived from a subacute sclerosing panencephalitis patient who received repeated remdesivir treatments.

Authors: Schmitz, Katharina S.¹, Handrejk, Kim¹, Liepina, Lelde², Bauer, Lisa¹, Haas, Griffin D.³, van Puijfelik, Fabiënne¹, Kroeze, Edwin J. B. Veldhuis¹, Riekstina, Marta⁴, Strautmanis, Jurgis², Huyen Cao⁵, Verdijk, Robert M.⁶, GeurtsvanKessel, Corine H.¹, van Boheemen, Sander¹, van Riel, Debby¹, Lee, Benhur³, Porotto, Matteo^7,8,9, de Swart, Rik L.¹, de Vries, Rory D.¹ r.d.devries@erasmusmc.nl

Source: Journal of Virology. Mar2024, Vol. 98 Issue 3, p1-19. 19p.

Subject Terms: *MEASLES virus, *VIRAL proteins, *REMDESIVIR, *NUCLEOTIDE sequencing, CENTRAL nervous system infections

Rational attenuation of canine distemper virus (CDV) to develop a morbillivirus animal model that mimics measles in humans.

Authors: Schmitz, Katharina S.¹, Rennick, Linda J.², Tilston-Lunel, Natasha L.², Comvalius, Anouskha D.¹, Laksono, Brigitta M.¹, Geers, Daryl¹, van Run, Peter¹, de Vries, Rory D.¹, de Swart, Rik L.¹ r.deswart@erasmusmc.nl, Duprex, W. Paul²

Source: Journal of Virology. Mar2024, Vol. 98 Issue 3, p1-13. 13p.

Subject Terms: *CANINE distemper virus, *MORBILLIVIRUSES, *MEASLES, *LEUKOCYTES, *MEASLES virus, *VIRUS diseases

A measles virus-based vaccine induces robust chikungunya virus-specific CD4+ T-cell responses in a phase II clinical trial.

Authors: Schmitz, Katharina S.¹ (AUTHOR), Comvalius, Anouskha D.¹ (AUTHOR), Nieuwkoop, Nella J.¹ (AUTHOR), Geers, Daryl¹ (AUTHOR), Weiskopf, Daniela² (AUTHOR), Ramsauer, Katrin³ (AUTHOR), Sette, Alessandro^2,4 (AUTHOR), Tschismarov, Roland³ (AUTHOR), de Vries, Rory D.¹ (AUTHOR), de Swart, Rik L.¹ (AUTHOR) r.deswart@erasmusmc.nl

Source: Vaccine. Oct2023, Vol. 41 Issue 43, p6495-6504. 10p.

Subject Terms: *CHIKUNGUNYA virus, *MEASLES vaccines, *CHIKUNGUNYA, *T cells, *CLINICAL trials, *CD4 antigen, *MOSQUITO control, *PLANT protection

Inoculation of raccoons with a wild-type-based recombinant canine distemper virus results in viremia, lymphopenia, fever, and widespread histological lesions.

Authors: Roelofs, Dagmar, Schmitz, Katharina S., van Amerongen, Geert, Rijsbergen, Laurine C., Laksono, Brigitta M., Comvalius, Anouskha D., Nambulli, Sham, Rennick, Linda J., van Run, Peter, Duprex, W. Paul, van den Brand, Judith M. A., de Swart, Rik L., de Vries, Rory D.

Source: MSphere; Aug2023, Vol. 8 Issue 4, p1-18, 18p

Infection of ferrets with wild type-based recombinant canine distemper virus overwhelms the immune system and causes fatal systemic disease.

Authors: Laksono, Brigitta M., Roelofs, Dagmar, Comvalius, Anouskha D., Schmitz, Katharina S., Rijsbergen, Laurine C., Geers, Daryl, Nambulli, Sham, van Run, Peter, Duprex, W. Paul, van den Brand, Judith M. A., de Vries, Rory D., de Swart, Rik L.

Source: MSphere; Aug2023, Vol. 8 Issue 4, p1-20, 20p

Antibody and T-Cell Responses 6 Months After Coronavirus Disease 2019 Messenger RNA-1273 Vaccination in Patients With Chronic Kidney Disease, on Dialysis, or Living With a Kidney Transplant.

Authors: Sanders, Jan-Stephan F, Messchendorp, A Lianne, Vries, Rory D de, Baan, Carla C, Baarle, Debbie van, Binnendijk, Rob van, Diavatopoulos, Dimitri A, Geers, Daryl, Schmitz, Katharina S, GeurtsvanKessel, Corine H, Hartog, Gerco den, Kho, Marcia M L, Koopmans, Marion P G, Molen, Renate G van der, Remmerswaal, Ester B M, Rots, Nynke, Gansevoort, Ron T, Bemelman, Frederike J, Hilbrands, Luuk B, Reinders, Marlies E J

Source: Clinical Infectious Diseases; 2/1/2023, Vol. 76 Issue 3, pe188-e199, 12p

Subject Terms: TREATMENT of chronic kidney failure, IMMUNOGLOBULINS, COVID-19, COVID-19 vaccines, KIDNEY transplantation, PATIENTS, COMPARATIVE studies, INTERFERONS, MESSENGER RNA, IMMUNITY, RESEARCH funding, T cells, HEMODIALYSIS, TRANSPLANTATION of organs, tissues, etc.

Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers.

Authors: Sablerolles, Roos S G, Rietdijk, Wim J R, Goorhuis, Abraham, Postma, Douwe F, Visser, Leo G, Schmitz, Katharina S, Geers, Daryl, Bogers, Susanne, Haren, Eva van, Koopmans, Marion P G, Dalm, Virgil A S H, Kootstra, Neeltje A, Huckriede, Anke L W, Akkerman, Renate, Beukema, Martin, Lafeber, Melvin, Baarle, Debbie van, Vries, Rory D de, Kuy, P Hugo M van der, GeurtsvanKessel, Corine H

Source: Clinical Infectious Diseases; 2/1/2023, Vol. 76 Issue 3, pe533-e536, 4p

Subject Terms: COVID-19, IMMUNOGLOBULINS, COVID-19 vaccines, TIME, IMMUNE system, RESEARCH funding, DRUG allergy

Immunogenicity and Reactogenicity of Vaccine Boosters after Ad26.COV2.S Priming.

Authors: Sablerolles, Roos S. G.¹, Rietdijk, Wim J. R.¹, Goorhuis, Abraham¹, Postma, Douwe F.¹, Visser, Leo G.¹, Geers, Daryl¹, Schrnitz, Katharina S.¹, Garcia Garrido, Hannah M.¹, Koopmans, Marion P. G.¹, Dalm, Virgil A. S. H.¹, Kootstra, Neeltje A.¹, Huckriede, Anke L. W.¹, Lafeber, Melvin¹, Baarle, Debbie van¹, Geurtsvanl¹, de Vries, Rory D.¹, van der Kuy, P. Hugo M.¹, ath.vanderkuy@erasmusmc.nl, Schmitz, Katharina S², van Baarle, Debbie², GeurtsvanKessel, Corine H²

Source: New England Journal of Medicine; 3/10/2022, Vol. 386 Issue 10, p951-963, 13p

Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients.

Authors: GeurtsvanKessel, Corine H., Geers, Daryl, Schmitz, Katharina S., Mykytyn, Anna Z., Lamers, Mart M., Bogers, Susanne, Scherbeijn, Sandra, Gommers, Lennert, Sablerolle, Roos S. G., Nieuwkoop, Nella N., Rijsbergen, Laurine C., van Dijk, Laura L. A., de Wilde, Janet, Alblas, Kimberley, Breugem, Tim I., Rijnders, Bart J. A., de Jager, Herbert, Weiskopf, Daniela, van der Kuy, P. Hugo M., Sette, Alessandro

Source: Science Immunology; 2022, Vol. 7 Issue 69, p1-12, 12p

Low levels of monkeypox virus-neutralizing antibodies after MVA-BN vaccination in healthy individuals

Authors: Zaeck, Luca M., Lamers, Mart M., Verstrepen, Babs E., Bestebroer, Theo M., van Royen, Martin E., Götz, Hannelore, Shamier, Marc C., van Leeuwen, Leanne P. M., Schmitz, Katharina S., Alblas, Kimberley, van Efferen, Suzanne, Bogers, Susanne, Scherbeijn, Sandra, Rimmelzwaan, Guus F., van Gorp, Eric C. M., Koopmans, Marion P. G., Haagmans, Bart L., GeurtsvanKessel, Corine H., de Vries, Rory D.

Source: Nature Medicine; 20220101, Issue: Preprints p1-9, 9p

SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients.

Authors: Geers, Daryl, Shamier, Marc C., Bogers, Susanne, den Hartog, Gerco, Gommers, Lennert, Nieuwkoop, Nella N., Schmitz, Katharina S., Rijsbergen, Laurine C., van Osch, Jolieke A. T., Dijkhuizen, Emma, Smits, Gaby, Comvalius, Anouskha, van Mourik, Djenolan, Caniels, Tom G., van Gils, Marit J., Sanders, Rogier W., Oude Munnink, Bas B., Molenkamp, Richard, de Jager, Herbert J., Haagmans, Bart L.

Source: Science Immunology; 2021, Vol. 6 Issue 59, p1-14, 14p

Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets.

Authors: Vries, Rory D. de, Schmitz, Katharina S., Bovier, Francesca T., Predella, Camilla, Khao, Jonathan, Noack, Danny, Haagmans, Bart L., Herfst, Sander, Stearns, Kyle N., Drew-Bear, Jennifer, Biswas, Sudipta, Rockx, Barry, McGill, Gaël, Dorrello, N. Valerio, Gellman, Samuel H., Alabi, Christopher A. caa238@cornell.edu, Swart, Rik L. de r.deswart@erasmusmc.nl, Moscona, Anne am939@cumc.columbia.edu, Porotto, Matteo mp3509@cumc.columbia.edu

Source: Science. 3/26/2021, Vol. 371 Issue 6536, p1379-1382. 4p. 4 Diagrams.

Subject Terms: *COVID-19 pandemic, *VIRAL transmission, *SARS disease, *MEMBRANE fusion, *LIPOPEPTIDE antibiotics

Phenotype and kinetics of SARS-CoV-2–specific T cells in COVID-19 patients with acute respiratory distress syndrome.

Authors: Weiskopf, Daniela, Schmitz, Katharina S., Raadsen, Matthijs P., Grifoni, Alba, Okba, Nisreen M. A., Endeman, Henrik, van den Akker, Johannes P. C., Molenkamp, Richard, Koopmans, Marion P. G., van Gorp, Eric C. M., Haagmans, Bart L., de Swart, Rik L., Sette, Alessandro, de Vries, Rory D.

Source: Science Immunology; 2020, Vol. 5 Issue 48, p1-10, 10p