Antibiotic-induced loss of gut microbiome metabolic output correlates with clinical responses to CAR T-cell therapy

Authors: Prasad, Rishika ¹, Rehman, Abdur ², Rehman, Lubna ², Darbaniyan, Faezeh ², Blumenberg, Viktoria ^{3, 4, 5}, Schubert, Maria-Luisa ⁶, Mor, Uria ⁷, Zamir, Eli ⁸, Schmidt, Sabine ⁸, Hayase, Tomo ¹, Chang, Chia-Chi ¹, McDaniel, Lauren ¹, Flores, Ivonne ¹, Strati, Paolo ², Nair, Ranjit ², Chihara, Dai ², Fayad, Luis E. ², Ahmed, Sairah ², Iyer, Swaminathan P. ², Wang, Michael ², Jain, Preetesh ², Nastoupil, Loretta J. ², Westin, Jason ², Arora, Reetakshi ², Turner, Joel ⁹, Khawaja, Fareed ¹⁰, Wu, Ranran ¹¹, Dennison, Jennifer B. ¹¹, Menges, Meghan ⁹, Hidalgo-Vargas, Melanie ⁹, Reid, Kayla ⁹, Davila, Marco L. ¹², Dreger, Peter ⁶, Korell, Felix ⁶, Schmitt, Anita ⁶, Tanner, Mark R. ¹³, Champlin, Richard E. ¹³, Flowers, Christopher R. ², Shpall, Elizabeth J. ¹³, Hanash, Samir ¹¹, Neelapu, Sattva S. ², Schmitt, Michael ⁶, Subklewe, Marion ^{3, 4, 5}, Francois-Fahrmann, Johannes ¹¹, Stein-Thoeringer, C. K. ^{14, 15}, Elinav, Eran ^{7, 8}, Jain, Michael D. ⁹, Hayase, Eiko ¹, Jenq, Robert R. ^{1, 13}, Saini, Neeraj Y. ^{2, 13, ∗}

Source: In Blood 20 February 2025 145(8):823-839

Gene therapy in transfusion-dependent non-β0/β0 genotype β-thalassemia: first real-world experience of beti-cel

Authors: Mirza, Adil ¹, Ritsert, Mona-Lisa ¹, Tao, Gloria ², Thakar, Himal ², Lobitz, Stephan ³, Heine, Sabine ⁴, Koscher, Leila ⁵, Dürken, Matthias ⁶, Schmitt, Anita ⁷, Schmitt, Michael ⁷, Pavel, Petra ⁸, Laier, Sascha ⁸, Jakoby, Donate ¹, Greil, Johann ¹, Kunz, Joachim ^{1, ∗∗}, Kulozik, Andreas ^{1, 9, ∗}

Source: In Blood Advances 14 January 2025 9(1):29-38

Extracorporeal photopheresis as a promising strategy for the treatment of graft-versus-host disease after CAR T-cell therapy

Authors: Han, Huixiu, Wang, Lei, Ding, Yuntian, Neuber, Brigitte, Hückelhoven-Krauss, Angela, Lin, Min, Yao, Hao, Chen, Qian, Sauer, Tim, Schubert, Maria-Luisa, Guo, Zhiqiang, Müller-Tidow, Carsten, Schmitt, Michael, Schmitt, Anita

Source: In Blood Advances 11 June 2024 8(11):2675-2690

Evaluation of all-cause mortality and cardiovascular safety in patients receiving chimeric antigen receptor T cell therapy: a prospective cohort study

Authors: Korell, Felix, Entenmann, Lukas, Romann, Sebastian, Giannitsis, Evangelos, Schmitt, Anita, Müller-Tidow, Carsten, Frey, Norbert, Dreger, Peter, Schmitt, Michael, Lehmann, Lorenz H

Source: In eClinicalMedicine March 2024 69

Autologous Stem Cell Collection after Daratumumab, Bortezomib, Thalidomide, and Dexamethasone versus Bortezomib, Cyclophosphamide, and Dexamethasone in Newly Diagnosed Multiple Myeloma

Authors: Sauer, Sandra, Kriegsmann, Katharina, Nientiedt, Cathleen, Schmitt, Anita, Müller-Tidow, Carsten, Raab, Marc-Steffen, Kauer, Joseph

Source: Transfusion medicine and hemotherapy. 50(5):371-381

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195567178.0x000001&indx=1&recIds=ETOCvdc_100195567178.0x000001

Impact of Clinical Parameters and Induction Regimens on Peripheral Blood Stem-Cell Mobilization and Collection in Multiple Myeloma Patients

Authors: Sauer, Sandra, Hieke, Lennart, Brandt, Julia, Müller-Tidow, Carsten, Schmitt, Anita, Kauer, Joseph, Kriegsmann, Katharina

Source: Transfusion medicine and hemotherapy. 50(5):382-395

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195567187.0x000001&indx=1&recIds=ETOCvdc_100195567187.0x000001

Neurofilament light chain serum levels correlate with the severity of neurotoxicity after CAR T-cell treatment

Authors: Schoeberl, Florian, Tiedt, Steffen, Schmitt, Anita, Blumenberg, Viktoria, Karschnia, Philipp, Burbano, Vanessa Granja, Bücklein, Veit L., Rejeski, Kai, Schmidt, Christian, Busch, Galina, von Bergwelt-Baildon, Michael, Tonn, Jörg-Christian, Schmitt, Michael ^†, Subklewe, Marion ^†, von Baumgarten, Louisa ^{†, *}

Source: In Blood Advances 24 May 2022 6(10):3022-3026

Response to extracorporeal photopheresis therapy of patients with steroid-refractory/-resistant GvHD is associated with up-regulation of Th22 cells and Tfh cells

Authors: Ni, Ming, Wang, Lei, Ding, Yuntian, Gong, Wenjie, Wang, Sanmei, Neuber, Brigitte, Schubert, Maria-Luisa, Sauer, Tim, Hückelhoven-Krauss, Angela, Luft, Thomas, Hegenbart, Ute, Schönland, Stefan, Eckstein, Volker, Wang, Jishi, Krüger, William, Müller-Tidow, Carsten, Dreger, Peter, Schmitt, Michael, Schmitt, Anita

Source: In Cytotherapy March 2022 24(3):311-319

Gene therapy in transfusion-dependent non-β0/β0genotype β-thalassemia: first real-world experience of beti-cel

Authors: Mirza, Adil, Ritsert, Mona-Lisa, Tao, Gloria, Thakar, Himal, Lobitz, Stephan, Heine, Sabine, Koscher, Leila, Dürken, Matthias, Schmitt, Anita, Schmitt, Michael, Pavel, Petra, Laier, Sascha, Jakoby, Donate, Greil, Johann, Kunz, Joachim, Kulozik, Andreas

Source: Blood Advances; January 2025, Vol. 9 Issue: 1 p29-38, 10p

Treatment of adult ALL patients with third-generation CD19-directed CAR T cells: results of a pivotal trial.

Authors: Schubert, Maria-Luisa¹ (AUTHOR), Schmitt, Anita¹ (AUTHOR), Hückelhoven-Krauss, Angela¹ (AUTHOR), Neuber, Brigitte¹ (AUTHOR), Kunz, Alexander¹ (AUTHOR), Waldhoff, Philip¹ (AUTHOR), Vonficht, Dominik^2,3,4 (AUTHOR), Yousefian, Schayan^5,6,7 (AUTHOR), Jopp-Saile, Lea^2,3,4 (AUTHOR), Wang, Lei¹ (AUTHOR), Korell, Felix¹ (AUTHOR), Keib, Anna¹ (AUTHOR), Michels, Birgit¹ (AUTHOR), Haas, Dominik¹ (AUTHOR), Sauer, Tim¹ (AUTHOR), Derigs, Patrick¹ (AUTHOR), Kulozik, Andreas⁸ (AUTHOR), Kunz, Joachim⁸ (AUTHOR), Pavel, Petra⁹ (AUTHOR), Laier, Sascha⁹ (AUTHOR)

Source: Journal of Hematology & Oncology. 7/22/2023, Vol. 16 Issue 1, p1-17. 17p.

Subject Terms: *T cells, *B cell lymphoma, *CHIMERIC antigen receptors, *PATIENTS' attitudes, *LYMPHOBLASTIC leukemia

Ibrutinib for improved chimeric antigen receptor T‐cell production for chronic lymphocytic leukemia patients

Authors: Fan, Fuli, Yoo, Hyeon Joo, Stock, Sophia, Wang, Lei, Liu, Yibin, Schubert, Maria‐Luisa, Wang, Sanmei, Neuber, Brigitte, Hückelhoven‐Krauss, Angela, Gern, Ulrike, Schmitt, Anita, Müller‐Tidow, Carsten, Dreger, Peter, Schmitt, Michael, Sellner, Leopold

Source: International journal of cancer. 148(2):419-428

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110343694.0x000001&indx=1&recIds=ETOCvdc_100110343694.0x000001

GVHD after CAR T-cell therapy post allogeneic hematopoietic cell transplantation — successfully treated by extracorporeal photopheresis.

Authors: Farid, Kiavasch Mohammad Nejad, Bug, Gesine, Schmitt, Anita, Lang, Fabian, Schubert, Maria-Luisa, Haberkorn, Uwe, Müller-Tidow, Carsten, Dreger, Peter, Schmitt, Michael

Source: Frontiers in Immunology; 2024, p1-9, 9p

Subject Terms: HEMATOPOIETIC stem cell transplantation, GRAFT versus host disease, T cells, LYMPHOBLASTIC leukemia, TREATMENT effectiveness

CAR T cells or allogeneic transplantation as standard of care for advanced large B-cell lymphoma: an intent-to-treat comparison

Authors: Dreger, Peter, Dietrich, Sascha, Schubert, Maria-Luisa, Selberg, Lorenz, Bondong, Andrea, Wegner, Mandy, Stadtherr, Peter, Kimmich, Christoph, Kosely, Florentina, Schmitt, Anita, Pavel, Petra, Liebers, Nora, Luft, Thomas, Hegenbart, Ute, Radujkovic, Aleksandar, Ho, Anthony Dick, Müller-Tidow, Carsten, Schmitt, Michael

Source: In Blood Advances 22 December 2020 4(24):6157-6168

Storage, Utilization, and Disposal of Hematopoietic Stem Cell Products in Patients with Multiple Myeloma

Authors: Krummradt, Felix, Sauer, Sandra, Pavel, Petra, Klein, Eva-Maria, Schmitt, Anita, Kriegsmann, Mark, Jordan, Karin, Müller-Tidow, Carsten, Goldschmidt, Hartmut, Wuchter, Patrick, Kriegsmann, Katharina

Source: In Biology of Blood and Marrow Transplantation September 2020 26(9):1589-1596

Feasibility and Safety of CD19 Chimeric Antigen Receptor T Cell Treatment for B Cell Lymphoma Relapse after Allogeneic Hematopoietic Stem Cell Transplantation

Authors: Schubert, Maria-Luisa, Dietrich, Sascha, Stilgenbauer, Stephan, Schmitt, Anita, Pavel, Petra, Kunz, Alexander, Bondong, Andrea, Wegner, Mandy, Stadtherr, Peter, Jung, Susanne, Ho, Anthony D., Müller-Tidow, Carsten, Schmitt, Michael, Dreger, Peter

Source: In Biology of Blood and Marrow Transplantation September 2020 26(9):1575-1580

Optimized Assessment of qPCR-Based Vector Copy Numbers as a Safety Parameter for GMP-Grade CAR T Cells and Monitoring of Frequency in Patients

Authors: Kunz, Alexander, Gern, Ulrike, Schmitt, Anita, Neuber, Brigitte, Wang, Lei, Hückelhoven-Krauss, Angela, Michels, Birgit, Hofmann, Susanne, Müller-Tidow, Carsten, Dreger, Peter, Schmitt, Michael, Schubert, Maria-Luisa

Source: In Molecular Therapy - Methods & Clinical Development 12 June 2020 17:448-454

Improvement of in vitro potency assays by a resting step for clinical-grade chimeric antigen receptor engineered T cells

Authors: WANG, LEI ^*, GONG, WENJIE ^*, WANG, SANMEI, NEUBER, BRIGITTE, SELLNER, LEOPOLD, SCHUBERT, MARIA-LUISA, HÜCKELHOVEN-KRAUSS, ANGELA, KUNZ, ALEXANDER, GERN, ULRIKE, MICHELS, BIRGIT, HINKELBEIN, MANDY, MECHLER, STEFANIE, RICHTER, PETRA, MÜLLER-TIDOW, CARSTEN, SCHMITT, MICHAEL, SCHMITT, ANITA

Source: In Cytotherapy May 2019 21(5):566-578

Third-generation anti-CD19 CAR T cells for relapsed/refractory chronic lymphocytic leukemia: a phase 1/2 study

Authors: Derigs, Patrick, Schubert, Maria-Luisa, Dreger, Peter, Schmitt, Anita, Yousefian, Schayan, Haas, Simon, Röthemeier, Caroline, Neuber, Brigitte, Hückelhoven-Krauss, Angela, Brüggemann, Monika, Bernhard, Helga, Kobbe, Guido, Lindemann, Albrecht, Rummel, Mathias, Michels, Birgit, Korell, Felix, Ho, Anthony D., Müller-Tidow, Carsten, Schmitt, Michael

Source: Leukemia; November 2024, Vol. 38 Issue: 11 p2419-2428, 10p

Proteasome inhibition enhances the anti-leukemic efficacy of chimeric antigen receptor (CAR) expressing NK cells against acute myeloid leukemia.

Authors: Sedloev, David, Chen, Qian, Unglaub, Julia M., Schanda, Nicola, Hao, Yao, Besiridou, Eleni, Neuber, Brigitte, Schmitt, Anita, Raffel, Simon, Liu, Yi, Janssen, Maike, Müller-Tidow, Carsten, Schmitt, Michael, Sauer, Tim

Source: Journal of Hematology & Oncology; 9/16/2024, Vol. 17 Issue 1, p1-22, 22p

Subject Terms: KILLER cells, ACUTE myeloid leukemia, CHIMERIC antigen receptors, CANCER cells, PROTEASOME inhibitors

Collection, Cryostorage, Transplantation, and Disposal of Hematopoietic Stem Cell Products

Authors: Kriegsmann, Katharina, Wack, Maurizio, Pavel, Petra, Schmitt, Anita, Kriegsmann, Mark, Bruckner, Thomas, Müller-Tidow, Carsten, Wuchter, Patrick

Source: In Biology of Blood and Marrow Transplantation February 2019 25(2):382-390