IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network

Authors: Schmacke, Niklas A., O’Duill, Fionan, Gaidt, Moritz M., Szymanska, Inga, Kamper, Julia M., Schmid-Burgk, Jonathan L., Mädler, Sophia C., Mackens-Kiani, Timur, Kozaki, Tatsuya, Chauhan, Dhruv, Nagl, Dennis, Stafford, Che A., Harz, Hartmann, Fröhlich, Adrian L., Pinci, Francesca, Ginhoux, Florent, Beckmann, Roland, Mann, Matthias, Leonhardt, Heinrich, Hornung, Veit

Source: In Immunity 13 December 2022 55(12):2271-2284

Highly Parallel Profiling of Cas9 Variant Specificity

Authors: Schmid-Burgk, Jonathan L., Gao, Linyi, Li, David, Gardner, Zachary, Strecker, Jonathan, Lash, Blake, Zhang, Feng

Source: In Molecular Cell 21 May 2020 78(4):794-800

RNA-guided DNA insertion with CRISPR-associated transposases

Authors: Strecker, Jonathan, Ladha, Alim, Gardner, Zachary, Schmid-Burgk, Jonathan L., Makarova, Kira S., Koonin, Eugene V., Zhang, Feng

Source: Science, 2019 Jul 01. 365(6448), 48-53.

Access URL: https://www.jstor.org/stable/26745321

Optical Pooled Screens in Human Cells

Authors: Feldman, David, Singh, Avtar, Schmid-Burgk, Jonathan L., Carlson, Rebecca J., Mezger, Anja, Garrity, Anthony J., Zhang, Feng, Blainey, Paul C.

Source: In Cell 17 October 2019 179(3):787-799

Synthetic RIG-I agonist-mediated cancer immunotherapy synergizes with MAP kinase inhibition against BRAF-mutated melanoma

Authors: Grützner, Christian, Tan, Yu Pan, Müller, Patrick, Schlee-Guimaraes, Thais M., Jentzsch, Marius, Schmid-Burgk, Jonathan L., Renn, Marcel, Behrendt, Rayk, Hartmann, Gunther

Source: In Molecular Therapy - Nucleic Acids 10 September 2024 35(3)

Disruptive non-disruptive applications of CRISPR/Cas9

Authors: Schmid-Burgk, Jonathan L

Source: In Current Opinion in Biotechnology December 2017 48:203-209

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3

Authors: Gaidt, Moritz M., Ebert, Thomas S., Chauhan, Dhruv, Ramshorn, Katharina, Pinci, Francesca, Zuber, Sarah, O’Duill, Fionan, Schmid-Burgk, Jonathan L., Hoss, Florian, Buhmann, Raymund, Wittmann, Georg, Latz, Eicke, Subklewe, Marion, Hornung, Veit

Source: In Cell 16 November 2017 171(5):1110-1124

Human Monocytes Engage an Alternative Inflammasome Pathway

Authors: Gaidt, Moritz M., Ebert, Thomas S., Chauhan, Dhruv, Schmidt, Tobias, Schmid-Burgk, Jonathan L., Rapino, Francesca, Robertson, Avril A.B., Cooper, Matthew A., Graf, Thomas, Hornung, Veit

Source: In Immunity 19 April 2016 44(4):833-846

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

Authors: Schmid-Burgk, Jonathan L., Chauhan, Dhruv, Schmidt, Tobias, Ebert, Thomas S., Reinhardt, Julia, Endl, Elmar, Hornung, Veit

Source: In Journal of Biological Chemistry 1 January 2016 291(1):103-109

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2′O-Methylated Self RNA

Authors: Schuberth-Wagner, Christine, Ludwig, Janos, Bruder, Ann Kristin, Herzner, Anna-Maria, Zillinger, Thomas, Goldeck, Marion, Schmidt, Tobias, Schmid-Burgk, Jonathan L., Kerber, Romy, Wolter, Steven, Stümpel, Jan-Philip, Roth, Andreas, Bartok, Eva, Drosten, Christian, Coch, Christoph, Hornung, Veit, Barchet, Winfried, Kümmerer, Beate M., Hartmann, Gunther, Schlee, Martin

Source: In Immunity 21 July 2015 43(1):41-51

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

Authors: Wassermann, Ruth, Gulen, Muhammet F., Sala, Claudia, Perin, Sonia Garcia, Lou, Ye, Rybniker, Jan, Schmid-Burgk, Jonathan L., Schmidt, Tobias, Hornung, Veit, Cole, Stewart T., Ablasser, Andrea

Source: In Cell Host & Microbe 10 June 2015 17(6):799-810

Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I

Authors: Weber, Michaela, Sediri, Hanna, Felgenhauer, Ulrike, Binzen, Ina, Bänfer, Sebastian, Jacob, Ralf, Brunotte, Linda, García-Sastre, Adolfo, Schmid-Burgk, Jonathan L., Schmidt, Tobias, Hornung, Veit, Kochs, Georg, Schwemmle, Martin, Klenk, Hans-Dieter, Weber, Friedemann

Source: In Cell Host & Microbe 11 March 2015 17(3):309-319

Designer Nuclease-Mediated Generation of Knockout THP1 Cells

Authors: Schmidt, Tobias, Schmid-Burgk, Jonathan L., Ebert, Thomas S., Gaidt, Moritz M., Hornung, Veit

Source: Methods in molecular biology. 1338:261-272

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN603369500&indx=1&recIds=ETOCRN603369500

OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines

Authors: Schmid-Burgk, Jonathan L., Schmidt, Tobias, Gaidt, Moritz M., Pelka, Karin, Latz, Eicke, Ebert, Thomas S., Hornung, Veit

Source: Genome research. 24(10):1719-1723

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN603391287&indx=1&recIds=ETOCRN603391287

Antiviral signalling by a cyclic nucleotide activated CRISPR protease

Authors: Rouillon, Christophe, Schneberger, Niels, Chi, Haotian, Blumenstock, Katja, Da Vela, Stefano, Ackermann, Katrin, Moecking, Jonas, Peter, Martin F., Boenigk, Wolfgang, Seifert, Reinhard, Bode, Bela E., Schmid-Burgk, Jonathan L., Svergun, Dmitri, Geyer, Matthias, White, Malcolm F., Hagelueken, Gregor

Source: Nature; February 2023, Vol. 614 Issue: 7946 p168-174, 7p

Correction: Myoglobin regulates fatty acid trafficking and lipid metabolism in mammary epithelial cells.

Authors: Armbruster, Julia, Aboouf, Mostafa A., Gassmann, Max, Egert, Angela, Schorle, Hubert, Hornung, Veit, Schmidt, Tobias, Schmid-Burgk, Jonathan L., Kristiansen, Glen, Bicker, Anne, Hankeln, Thomas, Zhu, Hao, Gorr, Thomas A.

Source: PLoS ONE; 12/27/2024, Vol. 19 Issue 12, p1-1, 1p

Subject Terms: CLINICAL chemistry, CLINICAL pharmacology, LIPID metabolism, EPITHELIAL cells, UNIVERSITY hospitals

Design principles for cyclin K molecular glue degraders

Authors: Kozicka, Zuzanna, Suchyta, Dakota J., Focht, Vivian, Kempf, Georg, Petzold, Georg, Jentzsch, Marius, Zou, Charles, Di Genua, Cristina, Donovan, Katherine A., Coomar, Seemon, Cigler, Marko, Mayor-Ruiz, Cristina, Schmid-Burgk, Jonathan L., Häussinger, Daniel, Winter, Georg E., Fischer, Eric S., Słabicki, Mikołaj, Gillingham, Dennis, Ebert, Benjamin L., Thomä, Nicolas H.

Source: Nature Chemical Biology; 20230101, Issue: Preprints p1-10, 10p

Synthesis of an arrayed sgRNA library targeting the human genome.

Authors: Schmidt, Tobias¹, Schmid-Burgk, Jonathan L.¹, Veit Hornung¹ veit.hornung@uni-bonn.de

Source: Scientific Reports. 10/9/2015, p1-10. 10p.

Subject Terms: *HUMAN genome, *CHEMICAL synthesis, *RNA analysis, *CELL analysis, *PROTEIN analysis

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

Authors: Ablasser, Andrea¹, Schmid-Burgk, Jonathan L.¹, Hemmerling, Inga¹, Horvath, Gabor L.², Schmidt, Tobias¹, Latz, Eicke³, Hornung, Veit¹

Source: Nature. 11/28/2013, Vol. 503 Issue 7477, p530-534. 5p.

Subject Terms: *NATURAL immunity, *MULTICELLULAR organisms, *CONNEXINS, *GAP junctions (Cell biology), *INTERFERONS, *CHEMOKINES

Diverse enzymatic activities mediate antiviral immunity in prokaryotes.

Authors: Gao, Linyi, Altae-Tran, Han, Böhning, Francisca, Makarova, Kira S., Segel, Michael, Schmid-Burgk, Jonathan L., Koob, Jeremy, Wolf, Yuri I., Koonin, Eugene V., Zhang, Feng, zhang@broadinstitute.org

Source: Science; 8/28/2020, Vol. 369 Issue 6507, p1077-1084, 8p, 5 Diagrams