Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implications for drug design
Flavins and flavoproteins

Authors: Davioud-Charvet, E., McLeish, M. J., Veine, D., Giegel, D., Andricopulo, A. D., Becker, K., Muller, S., Schirmer, R. H., Williams, C. H., Kenyon, G. L.

Source: FLAVINS AND FLAVOPROTEINS. :845-852

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN047500254&indx=1&recIds=ETOCCN047500254

Disulfide reductases - current developments
Flavins and flavoproteins

Authors: Irmler, A., Bechthold, A., Davioud-Charvet, E., Hofmann, V., Reau, R., Gromer, S., Schirmer, R. H., Becker, K.

Source: FLAVINS AND FLAVOPROTEINS. :803-816

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN047500217&indx=1&recIds=ETOCCN047500217

Mechanism of high M~r thioredoxin reductase from Drosophila melanogaster
Flavins and flavoproteins

Authors: Bauer, H., Williams, C. H., Schirmer, R. H., Massey, V.

Source: FLAVINS AND FLAVOPROTEINS. :131-136

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN047499148&indx=1&recIds=ETOCCN047499148

Haemolysis risk in methylene blue treatment of G6PD-sufficient and G6PD-deficient West-African children with uncomplicated falciparum malaria: a synopsis of four RCTs

Authors: Mller, O., Mockenhaupt, F. P., Marks, B., Meissner, P., Coulibaly, B., Kuhnert, R., Buchner, H., Schirmer, R. H., Walter-Sack, I., Si, A.

Source: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 22(4):376-385

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN329656327&indx=1&recIds=ETOCRN329656327

Myristoylated adenylate kinase-2 of Plasmodium falciparum forms a heterodimer with myristoyltransferase

Authors: Rahlfs, S., Koncarevic, S., Iozef, R., Mwongela Mailu, B., Savvides, S. N., Schirmer, R. H., Becker, K.

Source: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 163(2):77-84

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN242856257&indx=1&recIds=ETOCRN242856257

Cytotoxic interactions of methylene blue with trypanosomatid-specific disulfide reductases and their dithiol products

Authors: Buchholz, K., Comini, M. A., Wissenbach, D., Schirmer, R. H., Krauth-Siegel, R. L., Gromer, S.

Source: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 160(1):65-69

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN230152431&indx=1&recIds=ETOCRN230152431

Molecular basis of glutathione reductase deficiency in human blood cells

Authors: Kamerbeek, N. M., van Zwieten, R., de Boer, M., Morren, G., Vuil, H., Bannink, N., Lincke, C., Dolman, K. M., Becker, K., Schirmer, R. H.

Source: BLOOD -NEW YORK-. 109(8):3560-3566

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN207145346&indx=1&recIds=ETOCRN207145346

Antioxidative Enzyme des Malariaerregers als Drug-Targets

Authors: Becker, K., Schirmer, R. H.

Source: BIOSPEKTRUM -HEIDELBERG-. (2):138-141

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN205711592&indx=1&recIds=ETOCRN205711592

Eosin B as a Novel Antimalarial Agent for Drug-Resistant Plasmodium falciparum

Authors: Massimine, K. M., McIntosh, M. T., Doan, L. T., Atreya, C. E., Gromer, S., Sirawaraporn, W., Elliott, D. A., Joiner, K. A., Schirmer, R. H., Anderson, K. S.

Source: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY -JOURNAL-. 50(9):3132-3141

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN193971694&indx=1&recIds=ETOCRN193971694

A Fluoro Analogue of the Menadione Derivative 6-[2'-(3'-Methyl)-1',4'-naphthoquinolyl]hexanoic Acid Is a Suicide Substrate of Glutathione Reductase. Crystal Structure of the Alkylated Human Enzyme

Authors: Bauer, H., Fritz-Wolf, K., Winzer, A., Kuhner, S., Little, S., Yardley, V., Vezin, H., Palfey, B., Schirmer, R. H., Davioud-Charvet, E.

Source: JOURNAL- AMERICAN CHEMICAL SOCIETY. 128(33):10784-10794

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN193132640&indx=1&recIds=ETOCRN193132640

In Vitro Assessment of Methylene Blue on Chloroquine-Sensitive and -Resistant Plasmodium falciparum Strains Reveals Synergistic Action with Artemisinins

Authors: Akoachere, M., Buchholz, K., Fischer, E., Burhenne, J., Haefeli, W. E., Schirmer, R. H., Becker, K.

Source: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY -JOURNAL-. 49(11):4592-4597

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN177788606&indx=1&recIds=ETOCRN177788606

Dithiol Proteins as Guardians of the Intracellular Redox Milieu in Parasites: Old and New Drug Targets in Trypanosomes and Malaria-Causing Plasmodia

Authors: Krauth-Siegel, R. L., Bauer, H., Schirmer, R. H.

Source: ANGEWANDTE CHEMIE -INTERNATIONAL EDITION IN ENGLISH-. 44(5):690-715

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN163603029&indx=1&recIds=ETOCRN163603029

The conserved histidine 106 of large thioredoxin reductases is likely to have a structural role but not a base catalyst function

Authors: Jacob, J., Schirmer, R. H., Gromer, S.

Source: FEBS LETTERS. 579(3):745-748

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN162277168&indx=1&recIds=ETOCRN162277168

Comparative Structural Analysis of Oxidized and Reduced Thioredoxin from Drosophila melanogaster

Authors: Wahl, M. C., Irmler, A., Hecker, B., Schirmer, R. H., Becker, K.

Source: JOURNAL OF MOLECULAR BIOLOGY. 345(5):1119-1130

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN161288145&indx=1&recIds=ETOCRN161288145

5-Substituted Tetrazoles as Bioisosteres of Carboxylic Acids. Bioisosterism and Mechanistic Studies on Glutathione Reductase Inhibitors as Antimalarials

Authors: Biot, C., Bauer, H., Schirmer, R. H., Davioud-Charvet, E.

Source: JOURNAL OF MEDICINAL CHEMISTRY. 47(24):5972-5983

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN159417406&indx=1&recIds=ETOCRN159417406

Adenylate kinase and GTP:AMP phosphotransferase of the malarial parasite Plasmodium falciparum

Authors: Ulschmid, J. K., Rahlfs, S., Schirmer, R. H., Becker, K.

Source: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 136(2):211-220

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN150992813&indx=1&recIds=ETOCRN150992813

Methylene blue as an antimalarial agent

Authors: Schirmer, R. H., Coulibaly, B., Stich, A., Scheiwein, M., Merkle, H., Eubel, J., Becker, K., Becher, H., Muller, O., Zich, T.

Source: REDOX REPORT. 8(5):272-275

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN142210639&indx=1&recIds=ETOCRN142210639

Plasmodium falciparum thioredoxins and glutaredoxins as central players in redox metabolism

Authors: Rahlfs, S., Nickel, C., Deponte, M., Schirmer, R. H., Becker, K.

Source: REDOX REPORT. 8(5):246-250

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN142210585&indx=1&recIds=ETOCRN142210585

X-ray structure of glutathione S-transferase from the malarial parasite Plasmodium falciparum

Authors: Fritz-Wolf, K., Becker, A., Rahlfs, S., Harwaldt, P., Schirmer, R. H., Kabsch, W., Becker, K.

Source: PROCEEDINGS- NATIONAL ACADEMY OF SCIENCES USA. 100(24):13821-13826

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN141545357&indx=1&recIds=ETOCRN141545357

Mechanism-Based Inactivation of Thioredoxin Reductase from Plasmodium falciparum by Mannich Bases. Implication for Cytotoxicity

Authors: Davioud-Charvet, E., McLeish, M. J., Veine, D. M., Giegel, D., Arscott, L. D., Andricopulo, A. D., Becker, K., Muller, S., Schirmer, R. H., Williams, C. H.

Source: BIOCHEMISTRY -PENNSYLVANIA THEN WASHINGTON-. 42(45):13319-13330

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN140846167&indx=1&recIds=ETOCRN140846167