Randomized phase 2 study to assess the role of single-agent nivolumab to maintain remission in acute myeloid leukemia

Authors: Pyzer, Athalia R. ¹, Dillon, Laura W. ², Sharon, Elad ³, Karrison, Theodore G. ⁴, Zha, Yuanyuan ¹, Fulton, Noreen ¹, Gui, Gege ^{2, 5}, Andrew, Georgia ², Streicher, Howard ³, Sweet, Kendra ⁶, Yaghmour, George ⁷, Liu, Jane Jijun ⁸, Jonas, Brian A. ⁹, Schimmer, Aaron D. ¹⁰, Grant, Steven ¹¹, Zeidan, Amer M. ¹², Hildebrandt, Gerhard C. ¹³, Lowrey, Christopher H. ¹⁴, Mattison, Ryan J. ¹⁵, Palmisiano, Neil ¹⁶, Salhotra, Amandeep ¹⁷, Tzachanis, Dimitrios ¹⁸, Baer, Maria R. ¹⁹, Lin, Tara L. ²⁰, Patel, Prapti ²¹, Chen, Helen ³, Stadler, Walter M. ¹, Odenike, Olatoyosi ¹, Larson, Richard A. ¹, Gajewski, Thomas F. ²², Hourigan, Christopher S. ^{2, 5}, Stock, Wendy ¹, Liu, Hongtao ^{1, 23, ∗}

Source: In Blood Advances 13 May 2025 9(9):2144-2152

Outcome of adolescents and young adult acute myeloid leukemia patients compared with middle-aged patients: A single centre retrospective experience

Authors: Chen, RuiQi, AlHumaid, Mohaned, Daher-Reyes, Georgina, Atenafu, Eshetu G., Chan, Steven, Gupta, Vikas, Maze, Dawn, Schuh, Andre C., Minden, Mark D., Yee, Karen, Schimmer, Aaron D., Sibai, Hassan

Source: In Leukemia Research December 2024 147

The proteomic landscape of genotoxic stress-induced micronuclei

Authors: MacDonald, Kate M., Khan, Shahbaz, Lin, Brian, Hurren, Rose, Schimmer, Aaron D., Kislinger, Thomas, Harding, Shane M.

Source: In Molecular Cell 4 April 2024 84(7):1377-1391

Outcomes of intensive and nonintensive blast-reduction strategies in accelerated and blast-phase MPN

Authors: Davidson, Marta B., Kennedy, James A., Capo-Chichi, Jose-Mario, Shi, Yuliang, Xu, Wei, Cheung, Verna, Arruda, Andrea, Bankar, Aniket, Richard-Carpentier, Guillaume, Chan, Steven, Maze, Dawn, Minden, Mark D., Schimmer, Aaron D., Schuh, Andre C., Sibai, Hassan, Yee, Karen, Tierens, Anne, Viswabandya, Auro, Gupta, Vikas

Source: In Blood Advances 12 March 2024 8(5):1281-1294

Contribution of metabolic abnormalities to acute myeloid leukemia pathogenesis

Authors: Egan, Grace, Schimmer, Aaron D.

Source: In Trends in Cell Biology June 2023 33(6):455-462

Applying CRISPR-Cas9 screens to dissect hematological malignancies

Authors: Iyer, Deepak Narayanan, Schimmer, Aaron D., Chang, Hong

Source: In Blood Advances 23 May 2023 7(10):2252-2270

Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis.

Authors: Young, Kira A., Hosseini, Mohsen, Mistry, Jayna J., Morganti, Claudia, Mills, Taylor S., Cai, Xiurong, James, Brandon T., Nye, Griffin J., Fournier, Natalie R., Voisin, Veronique, Chegini, Ali, Schimmer, Aaron D., Bader, Gary D., Egan, Grace, Mansour, Marc R., Challen, Grant A., Pietras, Eric M., Fisher-Wellman, Kelsey H., Ito, Keisuke, Chan, Steven M.

Source: Nature Communications; 4/16/2025, Vol. 16 Issue 1, p1-15, 15p

Subject Terms: HEMATOPOIETIC stem cells, CYTOLOGY, LIFE sciences, MEMBRANE potential, WILDLIFE conservation, RESPIRATION

Cardiovascular Disease Among Patients With AML and CHIP-Related Mutations

Authors: Calvillo-Argüelles, Oscar, Schoffel, Alice, Capo-Chichi, José-Mario, Abdel-Qadir, Husam, Schuh, Andre, Carrillo-Estrada, Montserrat, Liu, Shiying, Gupta, Vikas, Schimmer, Aaron D., Yee, Karen, Shlush, Liran I., Natarajan, Pradeep, Thavendiranathan, Paaladinesh

Source: In JACC: CardioOncology March 2022 4(1):38-49

Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production

Authors: Lee, Jong Bok, Khan, Dilshad H., Hurren, Rose, Xu, Mingjing, Na, Yoosu, Kang, Hyeonjeong, Mirali, Sara, Wang, Xiaoming, Gronda, Marcela, Jitkova, Yulia, MacLean, Neil, Arruda, Andrea, Alaniz, Zoe, Konopleva, Marina Y., Andreeff, Michael, Minden, Mark D., Zhang, Li ^**, Schimmer, Aaron D. ^*

Source: In Blood 22 July 2021 138(3):234-245

Very long chain fatty acid metabolism is required in acute myeloid leukemia

Authors: Tcheng, Matthew, Roma, Alessia, Ahmed, Nawaz, Smith, Richard W., Jayanth, Preethi, Minden, Mark D., Schimmer, Aaron D., Hess, David A., Hope, Kristin, Rea, Kevin A., Akhtar, Tariq A., Bohrnsen, Eric, D'Alessandro, Angelo, Mohsen, Al-Walid, Vockley, Jerry, Spagnuolo, Paul A. ^*

Source: In Blood 24 June 2021 137(25):3518-3532

E1 Enzymes as Therapeutic Targets in Cancer

Authors: Barghout, Samir H., Schimmer, Aaron D. ^*

Source: In Pharmacological Reviews January 2021 73(1):1-58

Outcomes and adverse events in older acute lymphoblastic Leukemia patients treated with a pediatric-inspired protocol with Pegylated or native Asparaginase.

Authors: Perusini, Maria Agustina, Andrews, Claire, Atenafu, Eshetu G., Gupta, Vikas, Maze, Dawn, Schuh, Andre C., Yee, Karen WL., Bankar, Aniket, Davidson, Marta B., Richard-Carpentier, Guillaume, Chan, Steven M., Sibai, Jad, Schimmer, Aaron D., Minden, Mark D., Sibai, Hassan

Source: Hematology; Dec2024, Vol. 29 Issue 1, p1-11, 11p

Subject Terms: LYMPHOBLASTIC leukemia, OLDER patients, ACUTE leukemia, OVERALL survival, FEBRILE neutropenia

Mitochondrial carrier homolog 2 is necessary for AML survival

Authors: Khan, Dilshad H. ¹, Mullokandov, Michael ², Wu, Yan ¹, Voisin, Veronique ³, Gronda, Marcela ¹, Hurren, Rose ¹, Wang, Xiaoming ¹, MacLean, Neil ¹, Jeyaraju, Danny V. ¹, Jitkova, Yulia ¹, Xu, G. Wei ¹, Laister, Rob ¹, Seneviratne, Ayesh ¹, Blatman, Zachary M. ¹, Ketela, Troy ¹, Bader, Gary D. ^{3, 4}, Marhon, Sajid A. ¹, De Carvalho, Daniel D. ¹, Minden, Mark D. ¹, Gross, Atan ², Schimmer, Aaron D. ^{1, 1}

Source: In Blood 2 July 2020 136(1):81-92

Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal

Authors: Singh, Rashim Pal, Jeyaraju, Danny V., Voisin, Veronique, Hurren, Rose, Xu, Changjiang, Hawley, James R., Barghout, Samir H., Khan, Dilshad H., Gronda, Marcela, Wang, Xiaoming, Jitkova, Yulia, Sharon, David, Liyanagae, Sanduni, MacLean, Neil, Seneviratene, Ayesh K., Mirali, Sara, Borenstein, Adina, Thomas, Geethu E., Soriano, Joelle, Orouji, Elias, Minden, Mark D., Arruda, Andrea, Chan, Steven M., Bader, Gary D., Lupien, Mathieu, Schimmer, Aaron D.

Source: In Cell Stem Cell 4 June 2020 26(6):926-937

Impact of preleukemic mutations and their persistence on hematologic recovery after induction chemotherapy for AML

Authors: Murphy, Tracy, Zou, Jinfeng, Daher-Reyes, Georgina S., Arruda, Andrea, Gupta, Vikas, McNamara, Caroline J., Minden, Mark D., Schimmer, Aaron D., Sibai, Hassan, Yee, Karen W.L., Korulla, Mariam, Stockley, Tracy, Kamel-Reid, Suzanne, Maze, Dawn, Tierens, Anne, Bratman, Scott V., Schuh, Andre C., Chan, Steven M.

Source: In Blood Advances 13 August 2019 3(15):2307-2311

Metformin reduces the competitive advantage of Dnmt3aR878HHSPCs

Authors: Hosseini, Mohsen, Voisin, Veronique, Chegini, Ali, Varesi, Angelica, Cathelin, Severine, Ayyathan, Dhanoop Manikoth, Liu, Alex C. H., Yang, Yitong, Wang, Vivian, Maher, Abdula, Grignano, Eric, Reisz, Julie A., D’Alessandro, Angelo, Young, Kira, Wu, Yiyan, Fiumara, Martina, Ferrari, Samuele, Naldini, Luigi, Gaiti, Federico, Pai, Shraddha, Egan, Grace, Schimmer, Aaron D., Bader, Gary D., Dick, John E., Xie, Stephanie Z., Trowbridge, Jennifer J., Chan, Steven M.

Source: Nature; 20250101, Issue: Preprints p1-10, 10p

The Mitochondrial Transacylase, Tafazzin, Regulates AML Stemness by Modulating Intracellular Levels of Phospholipids

Authors: Seneviratne, Ayesh K., Xu, Mingjing, Henao, Juan J. Aristizabal, Fajardo, Val A., Hao, Zhenyue, Voisin, Veronique, Xu, G. Wei, Hurren, Rose, Kim, S., MacLean, Neil, Wang, Xiaoming, Gronda, Marcela, Jeyaraju, Danny, Jitkova, Yulia, Ketela, Troy, Mullokandov, Michael, Sharon, David, Thomas, Geethu, Chouinard-Watkins, Raphaël, Hawley, James R., Schafer, Caitlin, Yau, Helen Loo, Khuchua, Zaza, Aman, Ahmed, Al-awar, Rima, Gross, Atan, Claypool, Steven M., Bazinet, Richard P., Lupien, Mathieu, Chan, Steven, De Carvalho, Daniel D., Minden, Mark D., Bader, Gary D., Stark, Ken D., LeBlanc, Paul, Schimmer, Aaron D.

Source: In Cell Stem Cell 4 April 2019 24(4):621-636

Genomic profiles and outcomes in de novo versus therapy-related core binding factor AML.

Authors: Chiu, May, Schimmer, Aaron D., Schuh, Andre C., Bankar, Aniket, Richard-Carpentier, Guillaume, Sibai, Hassan, Yee, Karen, Davidson, Marta, Chan, Steven M., Gupta, Vikas, Maze, Dawn

Source: Blood Cancer Journal; 10/31/2024, Vol. 14 Issue 1, p1-5, 5p

Subject Terms: ACUTE promyelocytic leukemia, INFORMED consent (Medical law), LEUKOCYTE count, TUMOR suppressor genes, CHROMOSOME abnormalities

Prevalence of oral lesions in and dental needs of patients with newly diagnosed acute leukemia

Authors: Watson, Erin, Wood, Robert E., Maxymiw, Walter G., Schimmer, Aaron D.

Source: In The Journal of the American Dental Association June 2018 149(6):470-480

AML refractory to primary induction with Ida-FLAG has a poor clinical outcome

Authors: Kavanagh, Simon, Heath, Emily, Hurren, Rose, Gronda, Marcela, Barghout, Samir H., Liyanage, Sanduni U., Siriwardena, Thirushi P., Claudio, Jaime, Zhang, Tong, Sukhai, Mahadeo, Stockley, Tracy L., Kamel-Reid, Suzanne, Rostom, Amr, Lutynski, Andrzej, Khalaf, Dina, Rydlewski, Anna, Chan, Steven M., Gupta, Vikas, Maze, Dawn, Sibai, Hassan, Schuh, Andre C., Yee, Karen, Minden, Mark D., Schimmer, Aaron D.

Source: In Leukemia Research May 2018 68:22-28