Non-ceruloplasmin copper and urinary copper in clinically stable Wilson disease: Alignment with recommended targets

Authors: Ott, Peter, Sandahl, Thomas, Ala, Aftab, Cassiman, David, Couchonnal-Bedoya, Eduardo, Cury, Rubens Gisbert, Czlonkowska, Anna, Denk, Gerald, D’Inca, Renata, de Assis Aquino Gondim, Francisco, Moore, Joanna, Poujois, Aurelia, Twardowschy, Carlos Alexandre, Weiss, Karl Heinz, Zuin, Massimo, Kamlin, C.Omar F., Schilsky, Michael L.

Source: In JHEP Reports August 2024 6(8)

Effects of tetrathiomolybdate on copper metabolism in healthy volunteers and in patients with Wilson disease

Authors: Kirk, Frederik Teicher, Munk, Ditte Emilie, Swenson, Eugene Scott, Quicquaro, Adam Michael, Vendelbo, Mikkel Holm, Larsen, Agnete, Schilsky, Michael L., Ott, Peter, Sandahl, Thomas Damgaard

Source: In Journal of Hepatology April 2024 80(4):586-595

Major Depressive Disorder in an International Multisite Wilson Disease Registry

Authors: Camarata, Michelle A., Ala, Aftab, Coskun, Ayse K., Deng, Yanhong, Embel, Veysel K., Gonzalez-Peralta, Regino, Maciejewski, Kaitlin R., Patel, Amar, Rubman, Susan, To, Uyen, Tomlin, Ricarda, Schilsky, Michael L., Zimbrean, Paula C.

Source: In Journal of the Academy of Consultation-Liaison Psychiatry March-April 2023 64(2):106-117

Trientine tetrahydrochloride versus penicillamine for maintenance therapy in Wilson disease (CHELATE): a randomised, open-label, non-inferiority, phase 3 trial

Authors: To, Uyen, Patel, Amar, Hettiarachchi, Daksshi, Giorgini, Alessia, Monico, Sara, Litwin, Tomasz, Piechal, Agnieszka, Skowronska, Marta, Lachaux, Alain, Belmalih, Abdelouahed, Boogers, Alexandra, Mohr, Isabelle, Langel, Andrea, Freitas, Christian, Barbosa, Egberto Reis, Sandahl, Thomas D, Gerdes, Lisbet, Obadia, Alexandre, Rahli, Djamila, Cosgrove, Jeremy, Schilsky, Michael L ^*, Czlonkowska, Anna, Zuin, Massimo, Cassiman, David, Twardowschy, Carlos, Poujois, Aurelia, Gondim, Francisco de Assis A, Denk, Gerald, Cury, Rubens G, Ott, Peter, Moore, Joanna, Ala, Aftab, D'Inca, Renata, Couchonnal-Bedoya, Eduardo, D'Hollander, Koenraad, Dubois, Nicolas, Kamlin, C Omar F, Weiss, Karl Heinz

Source: In The Lancet Gastroenterology & Hepatology December 2022 7(12):1092-1102

The Effect of Mental Health, Neurological Disease, and Liver Disease on Quality of Life in Patients With Wilson Disease

Authors: Camarata, Michelle A., Ala, Aftab, Coskun, Ayse K., Deng, Yanhong, Gonzalez-Peralta, Regino P., Maciejewski, Kaitlin R., Patel, Amar, Rubman, Susan, To, Uyen, Tomlin, Ricarda, Schilsky, Michael L., Zimbrean, Paula C.

Source: In Journal of the Academy of Consultation-Liaison Psychiatry September-October 2021 62(5):528-537

Direct Measurement of ATP7B Peptides Is Highly Effective in the Diagnosis of Wilson Disease

Authors: Collins, Christopher J., Yi, Fan, Dayuha, Remwilyn, Duong, Phi, Horslen, Simon, Camarata, Michelle, Coskun, Ayse K., Houwen, Roderick H.J., Pop, Tudor L., Zoller, Heinz, Yoo, Han-wook, Jung, Sung Won, Weiss, Karl H., Schilsky, Michael L., Ferenci, Peter, Hahn, Si Houn

Source: In Gastroenterology June 2021 160(7):2367-2382

Accurate non-ceruloplasmin bound copper: a new biomarker for the assessment and monitoring of Wilson disease patients using HPLC coupled to ICP-MS/MS.

Authors: Harrington, Chris F., Carpenter, Geoff, Coverdale, James P.C., Douglas, Leisa, Mills, Craig, Willis, Karl, Schilsky, Michael L.

Source: Clinical Chemistry & Laboratory Medicine; Jan2025, Vol. 63 Issue 2, p320-328, 9p

Subject Terms: COPPER, BLOOD proteins, GRADIENT elution (Chromatography), MEDICAL registries, CHEMICAL speciation

Building Clinical and Research Delivery Networks: A Blue Print for Multidisciplinary Management and Consensus in Wilson Disease.

Authors: Ala, Aftab, Liu Yin, James, Schilsky, Michael L.

Source: GE Portuguese Journal of Gastroenterology; 2025, Vol. 32 Issue 2, p75-77, 3p

Chapter 30 - Wilson disease

Authors: To, Uyen ^{a, b}, Schilsky, Michael L. ^{a, b}

Source: In Hepatology 2025:841-859

Transjugular intrahepatic portosystemic shunt as a bridge to liver transplant: Current state and future directions

Authors: Sellers, Cortlandt M., Nezami, Nariman, Schilsky, Michael L., Kim, Hyun S.

Source: In Transplantation Reviews April 2019 33(2):64-71

Bis-choline tetrathiomolybdate in patients with Wilson's disease: an open-label, multicentre, phase 2 study

Authors: Weiss, Karl Heinz, Askari, Frederick K, Czlonkowska, Anna, Ferenci, Peter, Bronstein, Jeff M, Bega, Danny, Ala, Aftab, Nicholl, David, Flint, Susan, Olsson, Lars, Plitz, Thomas, Bjartmar, Carl, Schilsky, Michael L

Source: In The Lancet Gastroenterology & Hepatology December 2017 2(12):869-876

Wilson Disease: Diagnosis, Treatment, and Follow-up

Authors: Schilsky, Michael L.

Source: In Clinics in Liver Disease November 2017 21(4):755-767

Wilson Disease and the COVID-19 pandemic: exploring patients' mental health and vaccination attitudes in a longitudinal study.

Authors: Coskun, Ayse K., Aydin, Adem, Tosun, Sumeyra, To, Uyen, Rubman, Susan, Schilsky, Michael L., Zimbrean, Paula C.

Source: Frontiers in Psychology; 2024, p1-14, 14p

Subject Terms: COVID-19 pandemic, COVID-19, HEALTH attitudes, MENTAL health, HEPATOLENTICULAR degeneration

Effects of trientine and penicillamine on intestinal copper uptake: A mechanistic ⁶⁴Cu PET/CT study in healthy humans.

Authors: Kirk, Frederik Teicher, Munk, Ditte Emilie, Swenson, Eugene Scott, Quicquaro, Adam Michael, Vendelbo, Mikkel Holm, Schilsky, Michael L., Ott, Peter, Sandahl, Thomas Damgaard

Source: Hepatology (02709139); May2024, Vol. 79 Issue 5, p1065-1074, 10p

A century for progress in the diagnosis of Wilson disease

Authors: Schilsky, Michael L.

Source: In Journal of Trace Elements in Medicine and Biology October 2014 28(4):492-494

Psychiatric aspects of Wilson disease: a review

Authors: Zimbrean, Paula C., Schilsky, Michael L.

Source: In General Hospital Psychiatry January-February 2014 36(1):53-62

An abbreviated history of liver transplantation.

Authors: Schilsky, Michael L., Emre, Sukru H.

Source: Clinical Liver Disease; Jan-Jun2024, Vol. 23 Issue 1, pE244-E253, 10p

Colaboradores

Authors: Abrams, Charles S., Adler, Ronald S., Agarwal, Anupam, Akin, Cem, Aksamit, Allen J., Jr., Al-Awqati, Qais, Allen, Upton D., Allos, Ban Mishu, Angus, Derek C., Appelbaum, Frederick R., Armitage, James O., Armstrong, April W., Armstrong, Deborah K., Arnaout, M. Amin, Arnold, Robert M., Aronson, Louise, Atkinson, John P., Attia, Evelyn, Auerbach, Andrew D., Ayanian, John Z., Baddour, Larry M., Baden, Lindsey R., Bailey, Thomas C., Bain, Barbara J., Bajorin, Dean F., Baloh, Robert W., Bangham, Charles R.M., Barasch, Jonathan, Barrett, Bruce, Bartholomew, John R., Bartleson, J.D., Barton, Mary B., Basner, Robert C., Bass, Adam J., Bass, Anne R., Bauman, Julie E., Bausch, Daniel G., Bayer, Arnold S., Bazarian, Jeffrey J., Bearman, Gonzalo M., Becker, Richard C., Beckham, J. David, Beckman, Joshua A., Beigel, John H., Bel, Elisabeth H., Belda, Walter, Jr., Benarroch, Eduardo E., Berger, Joseph R., Berliner, Nancy, Bernat, James L., Bessesen, Daniel H., Bibbins-Domingo, Kirsten, Biesecker, Leslie G., Biundo, Joseph J., Blankson, Joel N., Bloch, Karen C., Blom, Henk J., Boden, William E., Boivin, Guy, Bolognia, Jean, Bonomo, Robert A., Booth, Sarah L., Bosaeus, Ingvar G., Brenner, David J., Bridges, S. Louis, Jr., Brochard, Laurent, Brodsky, Robert A., Brook, Itzhak, Brown, Jennifer R., Brunetti, Enrico, Bryant, Amy E., Budge, Philip J., Buffet, Pierre A., Bushinsky, David A., Bykerk, Vivian P., Calabresi, Peter A., Calello, Diane P., Calfee, David P., Callahan, S. Todd, Camilleri, Michael, Canoso, Juan J., Cappellini, Maria Domenica, Carabello, Blase A., Carucci, Laura R., Castells, Mariana, Catherino, William H., Cederholm, Tommy E., Chalasani, Naga P., Chambers, Henry F., Chang, Larry W., Chang, Lin, Chao, Nelson J., Chatterjee, Mitali, Chaturvedi, Seemant, Chen, Lin H., Chen, Sharon C-A, Chon, Susan Y., Christiani, David C., Chu, Edward, Cieslak, Theodore J., Cioffi, George A., Clancy, Carolyn M., Clauss, Heather, Clauw, Daniel J., Clemmons, David R., Coffman, Thomas M., Cohen, David, Cohen, Jeffrey, Cohen, Myron S., Cohen, Steven P., Connors, Joseph M., Cook, Deborah J., Cook, Lucy B.M., Cooney, Kathleen A., Craigen, William J., Crandall, Jill P., Croft, Simon L., Crow, Mary K., Crump, John A., Cudkowicz, Merit E., Cunningham-Rundles, Charlotte, Dahir, Kathryn M., Damon, Inger K., Daras, Michael, Dart, Richard C., Davidson, Nancy E., Deane, Kevin D., DeAngelis, Lisa M., DeCamp, Malcolm M., DeLoughery, Thomas G., del Rio, Carlos, De Luca, Gabriele C., Denning, David W., Deuster, Patricia A., DeZern, Amy E., Dhatariya, Ketan K., Diasio, Robert B., Diemert, David J., Digre, Kathleen B., Dilsizian, Vasken, Dionne, Jodie A., Di Paola, Jorge, Dispenzieri, Angela, Dogra, Sunil, Doroshow, James H., Douglas, John M., Jr., Drazen, Jeffrey M., Drekonja, Dimitri, Dubberke, Erik R., DuBeau, Catherine E., Dumler, J. Stephen, Duvic, Madeleine, Ebi, Kristie, Edwards, Kathryn M., Edwards, N. Lawrence, Eikelboom, John W., Einhorn, Lawrence H., Elliott, Perry M., Emanuel, Ezekiel J., Falagas, Matthew E., Falk, Gary W., Fang, James C., Farley, Monica M., Feder, Gene, Feller-Kopman, David J., File, Thomas McDonald, Jr., Fishman, Glenn I., Flack, John M., Fleckenstein, James M., Fleisher, Lee A., Flint, Paul W., Fogel, Evan L., Fontana, Robert J., Forsmark, Chris E., Fournier, Pierre-Edouard, Fowler, Vance G., Jr., Franco, Manuel A., Fraser, Victoria J., Freeman, Roy, Freund, Karen M., Froberg, Blake A., Gallagher, Patrick G., Gandhi, Monica, Gandhi, Rajesh T., Ganz, Leonard, Garan, Hasan, Garcia-Tsao, Guadalupe, Geisler, William M., Gelfand, Joel M., George, Tony P., Gepstein, Lior, Gertz, Morie A., Ghanem, Khalil G., Gharavi, Ali G., Ghossein, Cybele, Gill, Christopher J., Ginsburg, Geoffrey S., Glesby, Marshall J., Gnann, John W., Jr., Goldman, David L., Goldman, Lee, Goldstein, Larry B., Gordon, Anthony C., Gotlib, Jason, Gotuzzo, Eduardo, Grasemann, Hartmut, Green-McKenzie, Judith, Greenberg, Harry B., Greenberg, Steven A., Greer, David M., Greysen, S. Ryan, Griffin, Marie R., Griggs, Robert C., Grossman, Daniel, Guay-Woodford, Lisa M., Gulick, Roy M., Haake, David A., Hagman, Melissa M., Hagspiel, Klaus D., Harris, Raymond C., Havers, Fiona P., Heath, Elisabeth I., Hecht, Frederick M., Hensrud, Donald D., Hess, Jeremy, Hewlett, Erik L., Hift, Richard J., Hill, David R., Hill, Nicholas S., Hillyer, Christopher D., Hirsch, Hans H., Hoeper, Marius M., Hoit, Brian D., Holers, V. Michael, Holland, Steven M., Hollenberg, Anthony N., Hollenberg, Steven M., Howard, Jo, Hunter, David J., Hussain, Khalid, Iannuzzi, Michael C., Inman, Robert D., Inouye, Sharon K., Ison, Michael G., Jen, Joanna C., Jensen, Dennis M., Jensen, Michael D., Jensen, Robert T., Johnston, S. Claiborne, Jones, Robin L., Jordan, Richard C., Kahi, Charles J., Kaiser, Laurent, Kaminski, Henry J., Kamya, Moses R., Kao, Louise W., Kaplan, Steven A., Kastner, Daniel L., Katzka, David A., Katzman, Debra K., Kaushansky, Kenneth, Kaye, Keith S., Keating, Armand, Kelley, Robin K., Kennedy, Richard B., Khuri, Fadlo R., Kim, Rose, Kirchhoff, Louis V., Kirking, Hannah, Kirtane, Ajay J., Kishnani, Priya S., Klausner, Jeffrey D., Klion, Amy D., Klompas, Michael, Knopman, David S., Ko, Christine J., Kodali, Susheel, Kontoyiannis, Dimitrios P., Koppel, Barbara S., Korenblat, Kevin M., Korf, Bruce R., Kortepeter, Mark G., Koshy, Anita A., Kottilil, Shyamasundaran, Kovacs, Joseph A., Kovacs, Thomas O., Kowdley, Kris V., Kraft, Monica, Kramer, Christopher M., Krasnewich, Donna M., Kraus, William E., Krause, Peter J., Kroger, Andrew T., Kroshinsky, Daniela, Kuemmerle, John F., Kuipers, Ernst J., Kutner, Jean S., Laheru, Daniel, Lampert, Rachel, Landefeld, C. Seth, Landovitz, Raphael J., Landry, Donald W., Lange, Richard A., Lee, Hochang B., Lee, Nelson, Levey, Andrew S., Levine, Stephanie M., Lichtenstein, Gary R., Liebmann, Jeffrey M., Liebschutz, Jane M., Lim, Henry W., Lima, Aldo A.M., Limaye, Ajit P., Limdi, Nita A., Link, Mark S., Liu, Catherine, Lloyd-Jones, Donald M., Lopez, Fred A., Louie, Arnold, Lyness, Jeffrey M., MacKenzie, C. Ronald, MacLennan, Calman A., MacMillan, Harriet L., Madoff, Robert D., Maher, Jacquelyn, Maier, Lisa A., Maldarelli, Frank, Malhotra, Atul, Manary, Mark J., Marcos, Luis A., Marelli, Ariane J., Marks, Andrew R., Marschall, Jonas, Martin, Paul, Martinez, Fernando J., Mason, Joel B., Masur, Henry, Mathers, Amy J., Matthay, Michael A., McCool, F. Dennis, McInnes, Iain B., McLaughlin, Vallerie, McMichael, Amy, McMurray, John J.V., McQuaid, Kenneth R., Mead, Paul S., Means, Robert T., Jr., Melia, Michael T., Mellinghoff, Ingo K., Melton, Genevieve B., Merrick, Samuel T., Miceli, Marisa H., Michel, Marc, Mokdad, Ali H., Moy, Ernest, Mukherjee, Debabrata, Murr, Andrew H., Myerburg, Robert J., Nadeau, Kari C., Nath, Avindra, Neal-Perry, Genevieve, Neilson, Eric G., Nelson, Christina A., Nelson, David B., Nelson, Lewis S., Nestler, Eric J., Neuzil, Kathleen M., Nieman, Lynnette K., Niven, Alexander S., O’Connor, Christopher M., O’Connor, Francis G., O’Connor, Patrick G., O’Donnell, Anne E., O’Donnell, James S., Oh, Jae K., Okun, Michael S., O’Leary, Sean T., Olgin, Jeffrey E., Olivier, Kenneth N., Olivotto, Iacopo, Olsen, Nancy J., Orenstein, Walter A., Ortel, Thomas L., O’Shea, John J., Osmon, Douglas R., Ostrem, Jill L., Ostrosky-Zeichner, Luis, Otto, Catherine M., Ottolini, Martin G., Ovsyannikova, Inna G., Pappas, Peter G., Park, Ben Ho, Patel, Robin, Patterson, Thomas F., Pawlotsky, Jean-Michel, Payne, Thomas H., Pearce, Elizabeth N., Pearson, Richard D., Perl, Trish M., Petersen, Brett W., Petri, William A., Jr., Pfeffer, Marc A., Philips, Jennifer A., Pisetsky, David S., Pletcher, Steven D., Plumb, Ian D., Poland, Gregory A., Powell, Frank, Pyeritz, Reed E., Quinn, Thomas C., Racaniello, Vincent, Radhakrishnan, Jai, Radich, Jerald, Rafailidis, Petros I., Raghu, Ganesh, Ragni, Margaret V., Rahman, Proton, Rajkumar, S. Vincent, Ralston, Stuart H., Raoult, Didier, Reboli, Annette C., Reddy, K. Rajender, Redelmeier, Donald A., Redlich, Carrie A., Reilly, John, Reller, Megan E., Reno, Hilary E.L., Resnick, Neil M., Rice, Louis B., Roach, E. Steve, Robinson, Jennifer G., Rogatsky, Inez, Rogers, Joseph G., Rolain, Jean-Marc, Rollins, Barrett J., Romero, José R., Rosen, Jennifer B., Rosenthal, Philip J., Russell, James A., Rustgi, Anil K., Safer, Joshua D., Saini, Sarbjit S., Salmon, Jane E., Salvana, Edsel Maurice T., Santoro, Nanette, Santucci, Peter A., Sarnak, Mark J., Savage, Kerry J., Savard, Patrice, Sawka, Michael N., Scanlon, Paul D., Schafer, Andrew I., Schiff, Manuel, Schilsky, Michael L., Schneider, Thomas Rudolf, Schooley, Robert T., Schriger, David L., Schuchter, Lynn M., Schwartz, Lawrence B., Seas, Carlos, Seifert, Steven A., Seifter, Julian Lawrence, Selcen, Duygu, Selim, Magdy, Semrad, Carol E., Sepulveda, Jorge, Shaw, Pamela J., Shaz, Beth H., Sheridan, Robert L., Sherman, Stuart, Shojania, Kaveh G., Shopsin, Bo, Shy, Michael E., Sidransky, Ellen, Sifri, Costi D., Siliciano, Robert F., Simel, David L., Skorecki, Karl, Slawski, Barbara A., Slutsky, Arthur S., Smetana, Gerald W., Smith, A. Gordon, Smith, Stephen R., Southwick, Frederick S., Spiegel, Allen M., Spiera, Robert, Spinola, Stanley M., Spong, Catherine Y., Stabler, Sally P., Stark, Paul, Clair, E. William St., Steiner, Theodore S., Stephens, David S., Stevens, David A., Stevens, Dennis L., Stokes, M. Barry, Stoller, James K., Stone, John H., Stone, Richard M., Su, Edwin P., Swerdloff, Ronald S., Swygard, Heidi, Sykes, Megan, Talbot, H. Keipp, Tamimi, Rulla M., Tanofsky-Kraff, Marian, Tarlo, Susan M., Taylor, Stephanie N., Teirstein, Paul S., Telford, Sam R., III, Thakker, Rajesh V., Therrien, Judith, Thompson, George R., III, Tormoehlen, Laura, Tosti, Antonella, Trehan, Indi, Umpierrez, Guillermo E., Valeri, Anthony Michael, Varga, John, Vaughn, Bradley V., Venook, Alan P., Verbalis, Joseph G., Vose, Julie M., Wachter, Robert M., Walsh, B. Timothy, Walsh, Edward E., Walsh, Thomas J., Walston, Jeremy D., Walter, Roland B., Wang, Christina, Wang, Kenneth K., Ware, Lorraine B., Warren, Cirle A., Watkins, Paul B., Weber, Thomas J., Weimer, Louis H., Weinberg, Geoffrey A., Weinstein, Robert S., Weiss, Roger D., Weiss, Roy E., Weitz, Jeffrey I., Welt, Frederick G.P., Wenzel, Richard P., Werth, Victoria P., West, Sterling G., White, A. Clinton, Jr., White, Christopher J., White, Julian, White, Perrin C., Whitley, Richard J., Whyte, Michael P., Wiebe, Samuel, Wiener-Kronish, Jeanine P., Wilber, David J., Wilcox, Mark H., Winikoff, Beverly, Winter, Jane N., Wittink, Marsha N., Wolff, Tracy A., Wolin, Edward M., Wormser, Gary P., Yancy, Clyde W., Young, Neal S., Young, Vincent B., Young, William F., Jr., Yu, Alan S.L., Zimetbaum, Peter, Zucker, Jane R.

Source: In Goldman-Cecil. Tratado de medicina interna Edition: 27th Edition. 2025:xix-xxxix

195 - Enfermedad de Wilson

Authors: Schilsky, Michael L.

Source: In Goldman-Cecil. Tratado de medicina interna Edition: 27th Edition. 2025:1436-1437

Contributors for Volume 2

Authors: Agarwal, Anil Kumar, Al lami, Zahraa, Ala, Aftab, Anand, Anil C., Anirvan, Prajna, Arab, Juan P., Bagwan, Izhar, Bahure, Upasna, Baloji, Abhiman, Bataller, Ramon, Batsis, Irini, Behera, Manas Kumar, Berlinrut, Ilan, Bhamidimarri, Kalyan Ram, Bhongade, Megha, Bhujade, Harish, Bucuvalas, John C., Chayanupatkul, Maneerat, Clemente-Sanchez, Ana, Cussen, Christopher, De, Arka, Dieterich, Douglas T., DiNorcia, Joseph, Dunn, Winston, Duseja, Ajay, El Sabagh, Ahmed, El Talkhan, Mohamed, Em, Makkalon, Gupta, Sunita, Huisman, Tsipora M., Ilyas, Fariha, Jain, Shilpa, Jalal, Prasun K., Kalra, Naveen, Kamani, Lubna, Khandelwal, R., Khuroo, Mohammad Sultan, Khuroo, Naira Sultan, Kim, Edward, Liu Yin, James, Maiwall, R., Mallakmir, Snehal, Mehta, Heer, Mohamed, Islam B., Molmenti, Alexia, Molmenti, Ernesto P., Nagral, Aabha, Nair, Vinay, Odin, Joseph A, Panigrahi, Manas, Pena Polanco, Nathalie A., Prachanronarong, Kristina, Praharaj, Dibya L., Raja, Kishor, Satapathy, Sanjaya K., Schiano, Thomas D., Schilsky, Michael L., Singal, Ashwani K., Singh, Shivaram Prasad, Smith, Rachel W., To, Uyen, Vanatta, Jason M., Wallach, Frances, ZainAloor, Fuad

Source: In Hepatology 2025:xxv-xxix