A NOTCH2 pathogenic variant and HES1 regulate osteoclastogenesis in induced pluripotent stem cells

Authors: Canalis, Ernesto, Schilling, Lauren, Denker, Emily, Stoddard, Christopher, Yu, Jungeun

Source: In Bone February 2025 191

TNFα has differential effects on the transcriptome profile of selected populations in murine cartilage

Authors: Canalis, Ernesto, Schilling, Lauren, Denker, Emily

Source: In Osteoarthritis and Cartilage Open December 2024 6(4)

NOTCH2 promotes osteoclast maturation and metabolism and modulates the transcriptome profile during osteoclastogenesis

Authors: Canalis, Ernesto, Schilling, Lauren, Yu, Jungeun, Denker, Emily

Source: In Journal of Biological Chemistry February 2024 300(2)

Antisense oligonucleotides targeting a NOTCH3 mutation in male mice ameliorate the cortical osteopenia of lateral meningocele syndrome

Authors: Canalis, Ernesto, Mocarska, Magda, Schilling, Lauren, Jafar-nejad, Paymaan, Carrer, Michele

Source: In Bone December 2023 177

NOTCH2 sensitizes the chondrocyte to the inflammatory response of tumor necrosis factor α

Authors: Canalis, Ernesto, Yu, Jungeun, Singh, Vijender, Mocarska, Magda, Schilling, Lauren

Source: In Journal of Biological Chemistry December 2023 299(12)

Hairy and enhancer of split 1 is a primary effector of NOTCH2 signaling and induces osteoclast differentiation and function

Authors: Yu, Jungeun, Schilling, Lauren, Eller, Tabitha, Canalis, Ernesto

Source: In Journal of Biological Chemistry December 2021 297(6)

Activation of Notch3 in osteoblasts/osteocytes causes compartment-specific changes in bone remodeling

Authors: Canalis, Ernesto, Zanotti, Stefano, Schilling, Lauren, Eller, Tabitha, Yu, Jungeun

Source: In Journal of Biological Chemistry January-June 2021 296

A NOTCH3 pathogenic variant influences osteogenesis and can be targeted by antisense oligonucleotides in induced pluripotent stem cells.

Authors: Canalis, Ernesto, Yu, Jungeun, Schilling, Lauren, Jafar-nejad, Paymaan, Carrer, Michele

Source: PLoS ONE; 1/3/2025, Vol. 20 Issue 1, p1-17, 17p

Subject Terms: INDUCED pluripotent stem cells, CHROMOSOME abnormalities, CRANIOFACIAL abnormalities, NEURAL crest, SKELETAL abnormalities, NOTCH genes

Antisense oligonucleotides targeting Notch2 ameliorate the osteopenic phenotype in a mouse model of Hajdu-Cheney syndrome

Authors: Canalis, Ernesto, Grossman, Tamar R., Carrer, Michele, Schilling, Lauren, Yu, Jungeun

Source: In Journal of Biological Chemistry 20 March 2020 295(12):3952-3964

An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice

Authors: Yu, Jungeun, Siebel, Christian W., Schilling, Lauren, Canalis, Ernesto

Source: Journal of cellular physiology. 235(1):210-220

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100122876156.0x000001&indx=1&recIds=ETOCvdc_100122876156.0x000001

Nuclear factor of activated T cells 1 and 2 are required for vertebral homeostasis

Authors: Canalis, Ernesto, Schilling, Lauren, Eller, Tabitha, Yu, Jungeun

Source: Journal of cellular physiology. 235(11):8520-8532

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107144993.0x000001&indx=1&recIds=ETOCvdc_100107144993.0x000001

The lateral meningocele syndrome mutation causes marked osteopenia in mice

Authors: Canalis, Ernesto, Yu, Jungeun, Schilling, Lauren, Yee, Siu-Pok ^**, Zanotti, Stefano

Source: In Journal of Biological Chemistry September 2018 293(36):14165-14177

Induction of the Hajdu-Cheney Syndrome Mutation in CD19 B Cells in Mice Alters B-Cell Allocation but Not Skeletal Homeostasis

Authors: Yu, Jungeun, Zanotti, Stefano, Schilling, Lauren, Schoenherr, Chris, Economides, Aris N., Sanjay, Archana, Canalis, Ernesto

Source: In The American Journal of Pathology June 2018 188(6):1430-1446

Sustained Notch2 signaling in osteoblasts, but not in osteoclasts, is linked to osteopenia in a mouse model of Hajdu-Cheney syndrome

Authors: Zanotti, Stefano, Yu, Jungeun, Sanjay, Archana, Schilling, Lauren, Schoenherr, Chris, Economides, Aris N., Canalis, Ernesto

Source: In Journal of Biological Chemistry 21 July 2017 292(29):12232-12244

Nuclear factor of activated T cells 2 is required for osteoclast differentiation and function in vitro but not in vivo

Authors: Yu, Jungeun, Zanotti, Stefano, Schilling, Lauren, Canalis, Ernesto

Source: Journal of cellular biochemistry. 119(11):9334-9345

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100122794716.0x000001&indx=1&recIds=ETOCvdc_100122794716.0x000001

Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis, and Bone Resorption

Authors: Canalis, Ernesto, Schilling, Lauren, Yee, Siu-Pok, Lee, Sun-Kyeong ^**, Zanotti, Stefano

Source: In Journal of Biological Chemistry 22 January 2016 291(4):1538-1551

Use of antisense oligonucleotides to target Notch3 in skeletal cells.

Authors: Canalis, Ernesto, Carrer, Michele, Eller, Tabitha, Schilling, Lauren, Yu, Jungeun

Source: PLoS ONE; 5/10/2022, Vol. 17 Issue 5, p1-16, 16p

Subject Terms: NOTCH genes, MESENCHYMAL stem cells, OLIGONUCLEOTIDES, CANCELLOUS bone, COMPACT bone, BONE growth

This result is not displayed to guests.
Login for full access.

Effects of Sex and Notch Signaling on the Osteocyte Cell Pool.

Authors: Canalis, Ernesto^1,2 canalis@uchc.edu, Schilling, Lauren¹, Zanotti, Stefano^1,2

Source: Journal of Cellular Physiology. Feb2017, Vol. 232 Issue 2, p363-370. 8p.

Subject Terms: *OSTEOCYTES, *NOTCH proteins, *CELLULAR signal transduction, *MECHANOTRANSDUCTION (Cytology), *RNA sequencing, *LABORATORY mice

This result is not displayed to guests.
Login for full access.