T-cell exhaustion induced by continuous bispecific molecule exposure is ameliorated by treatment-free intervals

Authors: Philipp, Nora, Kazerani, Maryam, Nicholls, Alyssa, Vick, Binje, Wulf, Jan, Straub, Tobias, Scheurer, Michaela, Muth, Amelie, Hänel, Gerulf, Nixdorf, Daniel, Sponheimer, Monika, Ohlmeyer, Malte, Lacher, Sonja M., Brauchle, Bettina, Marcinek, Anetta, Rohrbacher, Lisa, Leutbecher, Alexandra, Rejeski, Kai, Weigert, Oliver, von Bergwelt-Baildon, Michael, Theurich, Sebastian, Kischel, Roman, Jeremias, Irmela, Bücklein, Veit, Subklewe, Marion

Source: Blood. 140(10):1104-1118

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183236861.0x000001&indx=1&recIds=ETOCvdc_100183236861.0x000001

Treatment-Free Intervals during CD19xCD3 BiTE ® Construct-Mediated T-Cell Stimulation Induce Functional Reinvigoration and Transcriptional Reprogramming of Exhausted T Cells

Authors: Zieger, Nora, Kazerani Pasikhani, Maryam, Straub, Tobias, Nicholls, Alyssa, Hänel, Gerulf, Wulf, Jan, Scheurer, Michaela, Nixdorf, Daniel, Sponheimer, Monika, Lacher, Sonja M, Brauchle, Bettina, Marcinek, Anetta, Rohrbacher, Lisa, Leutbecher, Alexandra, von Bergwelt, Michael, Spiekermann, Karsten, Weigert, Oliver, Theurich, Sebastian, Buecklein, Veit L, Kischel, Roman, Subklewe, Marion

Source: In Blood 23 November 2021 138 Supplement 1:513-513

Treatment-Free Intervals Mitigate T-Cell Exhaustion Induced By Continuous CD19xCD3-BiTE® Construct Stimulation in Vitro

Authors: Zieger, Nora ^*, Nicholls, Alyssa ^*, Wulf, Jan ^*, Hänel, Gerulf ^*, Kazerani Pasikhani, Maryam ^*, Buecklein, Veit ^*, Brauchle, Bettina ^*, Marcinek, Anetta ^*, Nixdorf, Daniel ^*, Rohrbacher, Lisa ^*, Scheurer, Michaela ^*, Kischel, Roman ^*, Spiekermann, Karsten, Weigert, Oliver, Theurich, Sebastian ^*, von Bergwelt, Michael ^*, Subklewe, Marion

Source: In Blood 5 November 2020 136 Supplement 1:44-45

Predictors of Efficacy for Blinatumomab in BCP-ALL Patients: Non-Responders Show Impaired CD19-BiTE®-Mediated Cytotoxicity in Vitro

Authors: Bücklein, Veit ^*, Scheurer, Michaela ^*, Brauchle, Bettina ^*, Kischel, Roman ^*, von Bergwelt, Michael ^*, Spiekermann, Karsten, Subklewe, Marion ^*

Source: In Blood 13 November 2019 134 Supplement 1:2632-2632