GLOMNET: A Hover Deep Learning Model for Glomerulus Instance Segmentation

Authors: Moreau, Noemie, Shabani, Michelle, Schell, Christoph, Bozek, Katarzyna

Source: 2024 IEEE International Symposium on Biomedical Imaging (ISBI) Biomedical Imaging (ISBI), 2024 IEEE International Symposium on. :1-5 May, 2024

Relation: 2024 IEEE International Symposium on Biomedical Imaging (ISBI)

Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity

Authors: Braun, Lukas M. ^{1, 2}, Giesler, Sophie ¹, Andrieux, Geoffroy ³, Riemer, Roxane ¹, Talvard-Balland, Nana ¹, Duquesne, Sandra ¹, Rückert, Tamina ^{1, 2}, Unger, Susanne ⁴, Kreutmair, Stefanie ⁴, Zwick, Melissa ^{1, 2}, Follo, Marie ¹, Hartmann, Alina ¹, Osswald, Natascha ¹, Melchinger, Wolfgang ¹, Chapman, Stefanie ¹, Hutchinson, James A. ⁵, Haferkamp, Sebastian ⁶, Torster, Leopold ⁷, Kött, Julian ⁷, Gebhardt, Christoffer ⁷, Hellwig, Dirk ⁸, Karantzelis, Nikolaos ¹, Wallrabenstein, Till ¹, Lowinus, Theresa ¹, Yücel, Mehtap ¹, Brehm, Niklas ¹, Rawluk, Justyna ¹, Pfeifer, Dietmar ¹, Bronsert, Peter ⁹, Rogg, Manuel ⁹, Mattern, Sven ¹⁰, Heikenwälder, Mathias ^{11, 12, 13}, Fusco, Stefano ¹⁴, Malek, Nisar P. ¹⁴, Singer, Stephan ^{10, 13}, Schmitt-Graeff, Annette ¹⁵, Ceteci, Fatih ¹⁶, Greten, Florian R. ¹⁶, Blazar, Bruce R. ¹⁷, Boerries, Melanie ^{3, 18}, Köhler, Natalie ^{1, 19}, Duyster, Justus ^{1, 18}, Ihorst, Gabriele ²⁰, Lassmann, Silke ⁹, Keye, Philip ²¹, Minguet, Susana ²², Schadendorf, Dirk ^{23, 24}, Ugurel, Selma ²³, Rafei-Shamsabadi, David ²⁵, Thimme, Robert ²⁶, Hasselblatt, Peter ²⁶, Bengsch, Bertram ^{18, 26, 27}, Schell, Christoph ⁹, Pearce, Erika L. ²⁸, Meiss, Frank ^{25, 31}, Becher, Burkhard ^{4, 31}, Funke-Lorenz, Carolin ^{23, 31}, Placke, Jan-Malte ^{23, 31}, Apostolova, Petya ^{1, 18, 28, 29, 30, 31, ∗}, Zeiser, Robert ^{1, 18, 27, 31, 32, ∗∗}

Source: In Cancer Cell 10 February 2025 43(2):269-291

Reactive oxygen species regulate early development of the intestinal macrophage-microbiome interface

Authors: Mansoori Moghadam, Zohreh ^{1, 2, 3}, Zhao, Bei ^{1, 4, 5}, Raynaud, Candice ⁶, Strohmeier, Valentina ¹, Neuber, Jana ^{1, 2, 3}, Lösslein, Anne Kathrin ^{1, 2}, Qureshi, Sabrina ¹, Gres, Vitka ^{1, 2}, Ziegelbauer, Tara ¹, Baasch, Sebastian ^{1, 2, 7}, Schell, Christoph ⁸, Warnatz, Klaus ^{1, 9, 10}, Inohara, Naohiro ¹¹, Nuñez, Gabriel ¹¹, Clavel, Thomas ⁶, Rosshart, Stephan P. ^{4, 5, 12}, Kolter, Julia ^{1, 2}, Henneke, Philipp ^{1, 2, ∗}

Source: In Blood January 2025

Implication of transcription factor FOXD2 dysfunction in syndromic congenital anomalies of the kidney and urinary tract (CAKUT)

Authors: Riedhammer, Korbinian M., Nguyen, Thanh-Minh T., Koşukcu, Can, Calzada-Wack, Julia, Li, Yong, Assia Batzir, Nurit, Saygılı, Seha, Wimmers, Vera, Kim, Gwang-Jin, Chrysanthou, Marialena, Bakey, Zeineb, Sofrin-Drucker, Efrat, Kraiger, Markus, Sanz-Moreno, Adrián, Amarie, Oana V., Rathkolb, Birgit, Klein-Rodewald, Tanja, Garrett, Lillian, Hölter, Sabine M., Seisenberger, Claudia, Haug, Stefan, Schlosser, Pascal, Marschall, Susan, Wurst, Wolfgang, Fuchs, Helmut, Gailus-Durner, Valerie, Wuttke, Matthias, Hrabe de Angelis, Martin, Ćomić, Jasmina, Akgün Doğan, Özlem, Özlük, Yasemin, Taşdemir, Mehmet, Ağbaş, Ayşe, Canpolat, Nur, Orenstein, Naama, Çalışkan, Salim, Weber, Ruthild G., Bergmann, Carsten, Jeanpierre, Cecile, Saunier, Sophie, Lim, Tze Y., Hildebrandt, Friedhelm, Alhaddad, Bader, Basel-Salmon, Lina, Borovitz, Yael, Wu, Kaman, Antony, Dinu, Matschkal, Julia, Schaaf, Christian W., Renders, Lutz, Schmaderer, Christoph, Rogg, Manuel, Schell, Christoph, Meitinger, Thomas, Heemann, Uwe, Köttgen, Anna, Arnold, Sebastian J., Ozaltin, Fatih, Schmidts, Miriam, Hoefele, Julia

Source: In Kidney International April 2024 105(4):844-864

Gene editing of hematopoietic stem cells restores T-cell response in familial hemophagocytic lymphohistiocytosis

Authors: Dettmer-Monaco, Viviane, Weißert, Kristoffer, Ammann, Sandra, Monaco, Gianni, Lei, Lei, Gräßel, Linda, Rhiel, Manuel, Rositzka, Julia, Kaufmann, Masako M., Geiger, Kerstin, Andrieux, Geoffroy, Lao, Jessica, Thoulass, Gudrun, Schell, Christoph, Boerries, Melanie, Illert, Anna L., Cornu, Tatjana I., Ehl, Stephan, Aichele, Peter, Cathomen, Toni

Source: In The Journal of Allergy and Clinical Immunology January 2024 153(1):243-255

Disruption of the Rab7-Dependent Final Common Pathway of Endosomal and Autophagic Processing Results in a Severe Podocytopathy

Authors: Vöing, Kristin, Michgehl, Ulf, Mertens, Nils David, Picciotto, Cara, Maywald, Mee-Ling, Goretzko, Jonas, Waimann, Sofie, Gilhaus, Kevin, Rogg, Manuel, Schell, Christoph

Source: Journal of the American Society of Nephrology. 34(7):1191-1206

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632886327&indx=1&recIds=ETOCRN632886327

Traction force microscopy with optimized regularization and automated Bayesian parameter selection for comparing cells

Authors: Huang, Yunfei, Schell, Christoph, Huber, Tobias B., Simsek, Ahmet N., Hersch, Nils, Merkel, Rudolf, Gompper, Gerhard, Sabass, Benedikt

Source: Scientific Reports 9, 539 (2019)

Subject Terms: Physics - Biological Physics, Quantitative Biology - Cell Behavior, Quantitative Biology - Quantitative Methods

Access URL: http://arxiv.org/abs/1810.05848

Exhaustion of CD39-Expressing CD8+ T Cells in Crohn’s Disease Is Linked to Clinical Outcome

Authors: Globig, Anna-Maria, Mayer, Lena Sophie, Heeg, Maximilian, Andrieux, Geoffroy, Ku, Manching, Otto-Mora, Patricia, Hipp, Anna Veronika, Zoldan, Katharina, Pattekar, Ajinkya, Rana, Nisha, Schell, Christoph, Boerries, Melanie, Hofmann, Maike, Neumann-Haefelin, Christoph, Kuellmer, Armin, Schmidt, Arthur, Boettler, Tobias, Tomov, Vesselin, Thimme, Robert, Hasselblatt, Peter, Bengsch, Bertram

Source: In Gastroenterology October 2022 163(4):965-981

Progressive liver, kidney, and heart degeneration in children and adults affected by TULP3 mutations

Authors: Devane, John, Ott, Elisabeth, Olinger, Eric G., Epting, Daniel, Decker, Eva, Friedrich, Anja, Bachmann, Nadine, Renschler, Gina, Eisenberger, Tobias, Briem-Richter, Andrea, Grabhorn, Enke Freya, Powell, Laura, Wilson, Ian J., Rice, Sarah J., Miles, Colin G., Wood, Katrina, Trivedi, Palak, Hirschfield, Gideon, Pietrobattista, Andrea, Wohler, Elizabeth, Mezina, Anya, Sobreira, Nara, Agolini, Emanuele, Maggiore, Giuseppe, Dahmer-Heath, Mareike, Yilmaz, Ali, Boerries, Melanie, Metzger, Patrick, Schell, Christoph, Grünewald, Inga, Konrad, Martin, König, Jens, Schlevogt, Bernhard, Sayer, John A., Bergmann, Carsten

Source: American journal of human genetics. 109(5):928-943

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163384405.0x000001&indx=1&recIds=ETOCvdc_100163384405.0x000001

EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission

Authors: Maier, Jasmin I., Rogg, Manuel, Helmstädter, Martin, Sammarco, Alena, Schilling, Oliver, Sabass, Benedikt, Miner, Jeffrey H., Dengjel, Jörn, Walz, Gerd, Werner, Martin, Huber, Tobias B., Schell, Christoph

Source: In Cell Reports 23 March 2021 34(12)

Development of Nivolumab/Ipilimumab-Associated Autoimmune Nephritis during Steroid Therapy

Authors: Gebauer, Ellen, Bechtel-Walz, Wibke, Schell, Christoph, Erbel, Michelle, Walz, Gerd, Hermle, Tobias

Source: Case reports in nephrology and dialysis. 11(3):270-274

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100143348408.0x000001&indx=1&recIds=ETOCvdc_100143348408.0x000001

Renal phenotyping in a hypomorphic murine model of propionic aciduria reveals common pathomechanisms in organic acidurias.

Authors: Schumann, Anke, Martinez-Pizarro, Ainhoa, Richard, Eva, Schell, Christoph, Kössinger, Anna Laura, Zeyer, Karina A., Tholen, Stefan, Schilling, Oliver, Barry, Michael, Neubauer, Björn, Köttgen, Michael, Hannibal, Luciana, Desviat, Lourdes R., Spiekerkötter, Ute

Source: Scientific Reports; 12/16/2024, Vol. 14 Issue 1, p1-12, 12p

Subject Terms: MITOCHONDRIAL dynamics, CHRONIC kidney failure, MEDICAL sciences, ENERGY metabolism, EPITHELIAL cells

The role of the co‐chaperone DNAJB11 in polycystic kidney disease: Molecular mechanisms and cellular origin of cyst formation.

Authors: Busch, Tilman, Neubauer, Björn, Schmitt, Lars, Cascante, Isabel, Knoblich, Luise, Wegehaupt, Oliver, Schöler, Felix, Tholen, Stefan, Hofherr, Alexis, Schell, Christoph, Schilling, Oliver, Westermann, Lukas, Köttgen, Michael

Source: FASEB Journal; 11/15/2024, Vol. 38 Issue 21, p1-18, 18p

TermineR: Extracting information on endogenous proteolytic processing from shotgun proteomics data.

Authors: Cosenza‐Contreras, Miguel, Seredynska, Adrianna, Vogele, Daniel, Pinter, Niko, Brombacher, Eva, Cueto, Ruth Fiestas, Dinh, Thien‐Ly Julia, Bernhard, Patrick, Rogg, Manuel, Liu, Junwei, Willems, Patrick, Stael, Simon, Huesgen, Pitter F., Kuehn, E. Wolfgang, Kreutz, Clemens, Schell, Christoph, Schilling, Oliver

Source: Proteomics; Oct2024, Vol. 24 Issue 19, p1-11, 11p

A reciprocal regulation of spermidine and autophagy in podocytes maintains the filtration barrier

Authors: Liang, Wei, Yamahara, Kosuke, Hernando-Erhard, Camila, Lagies, Simon, Wanner, Nicola, Liang, Huan, Schell, Christoph, Kammerer, Bernd, Huber, Tobias B., Bork, Tillmann

Source: In Kidney International December 2020 98(6):1434-1448

Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics

Authors: Brinkkoetter, Paul T., Bork, Tillmann, Salou, Sarah, Liang, Wei, Mizi, Athanasia, Özel, Cem, Koehler, Sybille, Hagmann, H. Henning, Ising, Christina, Kuczkowski, Alexander, Schnyder, Svenia, Abed, Ahmed, Schermer, Bernhard, Benzing, Thomas, Kretz, Oliver, Puelles, Victor G., Lagies, Simon, Schlimpert, Manuel, Kammerer, Bernd, Handschin, Christoph, Schell, Christoph, Huber, Tobias B.

Source: In Cell Reports 30 April 2019 27(5):1551-1566

Podocytes maintain high basal levels of autophagy independent of mtor signaling

Authors: Bork, Tillmann, Liang, Wei, Yamahara, Kosuke, Lee, Philipp, Tian, Zhejia, Liu, Shuya, Schell, Christoph, Thedieck, Kathrin, Hartleben, Bjoern, Patel, Ketan, Tharaux, Pierre-Louis, Lenoir, Olivia, Huber, Tobias B.

Source: Autophagy. 16(11):1932-1948

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111091776.0x000001&indx=1&recIds=ETOCvdc_100111091776.0x000001

ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier

Authors: Schell, Christoph, Sabass, Benedikt, Helmstaedter, Martin, Geist, Felix, Abed, Ahmed, Yasuda-Yamahara, Mako, Sigle, August, Maier, Jasmin I., Grahammer, Florian, Siegerist, Florian, Artelt, Nadine, Endlich, Nicole, Kerjaschki, Dontscho, Arnold, Hans-Henning, Dengjel, Jörn, Rogg, Manuel, Huber, Tobias B.

Source: In Developmental Cell 17 December 2018 47(6):741-757

Traction force microscopy with optimized regularization and automated Bayesian parameter selection for comparing cells

Authors: Huang, Yunfei, Schell, Christoph, Huber, Tobias, Şimşek, Ahmet, Hersch, Nils, Merkel, Rudolf, Gompper, Gerhard, Sabass, Benedikt

Source: Scientific reports. 9(1):1-16

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111633886.0x000001&indx=1&recIds=ETOCvdc_100111633886.0x000001

Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH)

Authors: Weißert, Kristoffer, Ammann, Sandra, Kögl, Tamara, Dettmer‐Monaco, Viviane, Schell, Christoph, Cathomen, Toni, Ehl, Stephan, Aichele, Peter

Source: EMBO molecular medicine. 14(12)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181993308.0x000001&indx=1&recIds=ETOCvdc_100181993308.0x000001