Evaluation of Protein Kinase cAMP-Activated Catalytic Subunit Alpha as a Therapeutic Target for Fibrolamellar Carcinoma

Authors: Schalm, Stefanie S., O’Hearn, Erin, Wilson, Kevin, LaBranche, Timothy P., Silva, Grace, Zhang, Zhuo, DiPietro, Lucian, Bifulco, Neil, Woessner, Richard, Stransky, Nicolas, Sappal, Darshan, Campbell, Robert, Lobbardi, Riadh, Palmer, Michael, Kim, Joseph, Ye, Chaoyang, Dorsch, Marion, Lengauer, Christoph, Guzi, Timothy, Kadambi, Vivek, Garner, Andrew, Hoeflich, Klaus P.

Source: In Gastro Hep Advances 2023 2(3):307-321

BLU-945, a potent and selective next-generation EGFR TKI, has antitumor activity in models of osimertinib-resistant non-small-cell lung cancer.

Authors: Lim, Sun Min, Schalm, Stefanie S., Lee, Eun Ji, Park, Sewon, Conti, Chiara, Millet, Yves A., Woessner, Rich, Zhang, Zhuo, Tavera-Mendoza, Luz E., Stevison, Faith, Albayya, Faris, Dineen, Thomas A., Hsieh, John, Oh, Seung Yeon, Zalutskaya, Alena, Rotow, Julia, Goto, Koichi, Lee, Dae-Ho, Yun, Mi Ran, Cho, Byoung Chul

Source: Therapeutic Advances in Medical Oncology; 10/21/2024, p1-20, 20p

IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition

Authors: Kernytsky, Andrew, Wang, Fang, Hansen, Erica, Schalm, Stefanie, Straley, Kimberly, Gliser, Camelia, Yang, Hua, Travins, Jeremy, Murray, Stuart, Dorsch, Marion, Agresta, Sam, Schenkein, David P., Biller, Scott A., Su, Shinsan M., Liu, Wei ^*, Yen, Katharine E.

Source: In Blood 8 January 2015 125(2):296-303

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

Authors: Rohle, Dan, Popovici-Muller, Janeta, Palaskas, Nicolaos, Turcan, Sevin, Grommes, Christian, Campos, Carl, Tsoi, Jennifer, Clark, Owen, Oldrini, Barbara, Komisopoulou, Evangelia, Kunii, Kaiko, Pedraza, Alicia, Schalm, Stefanie, Silverman, Lee, Miller, Alexandra, Wang, Fang, Yang, Hua, Chen, Yue, Kernytsky, Andrew, Rosenblum, Marc K., Liu, Wei, Biller, Scott A., Su, Shinsan M., Brennan, Cameron W., Chan, Timothy A., Graeber, Thomas G., Yen, Katharine E., Mellinghoff, Ingo K.

Source: Science, 2013 May 01. 340(6132), 626-630.

Access URL: http://dx.doi.org/10.1126/science.1236062

Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

Authors: Wang, Fang, Travins, Jeremy, DeLaBarre, Byron, Penard-Lacronique, Virginie, Schalm, Stefanie, Hansen, Erica, Straley, Kimberly, Kernytsky, Andrew, Liu, Wei, Gliser, Camelia, Yang, Hua, Gross, Stefan, Artin, Erin, Saada, Veronique, Mylonas, Elena, Quivoron, Cyril, Popovici-Muller, Janeta, Saunders, Jeffrey O., Salituro, Francesco G., Yan, Shunqi, Murray, Stuart, Wei, Wentao, Gao, Yi, Dang, Lenny, Dorsch, Marion, Agresta, Sam, Schenkein, David P., Biller, Scott A., Su, Shinsan M., de Botton, Stephane, Yen, Katharine E.

Source: Science, 2013 May 01. 340(6132), 622-626.

Access URL: http://dx.doi.org/10.1126/science.1234769

Proteolytic processing of protocadherin proteins requires endocytosis

Authors: Buchanan, Sean M., Schalm, Stefanie S., Maniatis, Tom

Source: Proceedings of the National Academy of Sciences of the United States of America, 2010 Oct 01. 107(41), 17774-17779.

Access URL: http://dx.doi.org/10.1073/pnas.1013105107

Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret

Authors: Schalm, Stefanie S., Ballif, Bryan A., Buchanan, Sean M., Phillips, Greg R., Maniatis, Tom

Source: Proceedings of the National Academy of Sciences of the United States of America, 2010 Aug 01. 107(31), 13894-13899.

Access URL: https://www.jstor.org/stable/25708821

BLU-701 tumour suppression and intracranial activity as a single agent and in combination with BLU-945 in models of non-small cell lung cancer (NSCLC) driven by EGFR mutations

Authors: Tavera, Luz, Zhang, Zhuo, Wardwell, Scott, Job, Ebby, McGinn, Katie, Chen, Maxine, Iliou, Maria, Albayya, Faris, Campbell, John, Eno, Meredith, Fernando, Dilinie, Dineen, Tom, Ahmad, Omar, Wilson, Douglas, Barvian, Kevin, Hsieh, John, Medendorp, Clare, Timsit, Yoav, Guo, Jian, Perez, Nisha, Schalm, Stefanie, Woessner, Richard, Conti, Chiara

Source: Lung cancer. 165(S1):S37-S37

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155623054.0x000001&indx=1&recIds=ETOCvdc_100155623054.0x000001

Characterization of a Conserved C-terminal Motif (RSPRR) in Ribosomal Protein S6 Kinase 1 Required for Its Mammalian Target of Rapamycin-dependent Regulation

Authors: Schalm, Stefanie S. ^{‡, §}, Tee, Andrew R. ^{‡, ¶}, Blenis, John ^∥

Source: In Journal of Biological Chemistry 25 March 2005 280(12):11101-11106

PI3-kinase and TOR: PIKTORing cell growth

Authors: Richardson, Celeste J, Schalm, Stefanie S, Blenis, John

Source: In Seminars in Cell and Developmental Biology 2004 15(2):147-159

Development of KT-253, a Highly Potent and Selective Heterobifunctional MDM2 Degrader for the Treatment of Acute Myeloid Leukemia

Authors: Mayo, Michele ^*, Chutake, Yogesh ^*, Karnik, Rahul ^*, McDonald, Alice ^*, Cho, Patricia S. ^*, Filiatrault, Jessica ^*, Chen, Dapeng ^*, Dixit, Vaishali ^*, Proctor, William ^*, Breitkopf, Susanne ^*, Qi, Frank ^*, Hu, Kan-Nian ^*, Sharma, Kirti ^*, Ewesuedo, Reggie ^*, Weiss, Matt ^*, Growney, Joseph D. ^*, Williams, Juliet ^*, Schalm, Stefanie S ^*

Source: In Blood 15 November 2022 140 Supplement 1:6239-6240

Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer

Authors: Eno, Meredith S., Brubaker, Jason D., Campbell, John E., De Savi, Chris, Guzi, Timothy J., Williams, Brett D., Wilson, Douglas, Wilson, Kevin, Brooijmans, Natasja, Kim, Joseph, Özen, Ayşegül, Perola, Emanuele, Hsieh, John, Brown, Victoria, Fetalvero, Kristina, Garner, Andrew, Zhang, Zhuo, Stevison, Faith, Woessner, Rich, Singh, Jatinder, Timsit, Yoav, Kinkema, Caitlin, Medendorp, Clare, Lee, Christopher, Albayya, Faris, Zalutskaya, Alena, Schalm, Stefanie, Dineen, Thomas A.

Source: Journal of Medicinal Chemistry; July 2022, Vol. 65 Issue: 14 p9662-9677, 16p

TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function

Authors: Schalm, Stefanie S., Fingar, Diane C., Sabatini, David M., Blenis, John ^*

Source: In Current Biology 13 May 2003 13(10):797-806

Protein Kinase A Downregulation Delays the Development and Progression of Polycystic Kidney Disease

Authors: Wang, Xiaofang, Jiang, Li, Thao, Ka, Sussman, Caroline R., LaBranche, Timothy, Palmer, Michael, Harris, Peter C., McKnight, G. Stanley, Hoeflich, Klaus P., Schalm, Stefanie, Torres, Vicente E.

Source: Journal of the American Society of Nephrology; June 2022, Vol. 33 Issue: 6 p1087-1104, 18p

78 - BLU-701 tumour suppression and intracranial activity as a single agent and in combination with BLU-945 in models of non-small cell lung cancer (NSCLC) driven by EGFR mutations

Authors: Tavera, Luz, Zhang, Zhuo, Wardwell, Scott, Job, Ebby, McGinn, Katie, Chen, Maxine, Iliou, Maria, Albayya, Faris, Campbell, John, Eno, Meredith, Fernando, Dilinie, Dineen, Tom, Ahmad, Omar, Wilson, Douglas, Barvian, Kevin, Hsieh, John, Medendorp, Clare, Timsit, Yoav, Guo, Jian, Perez, Nisha, Schalm, Stefanie, Woessner, Richard, Conti, Chiara

Source: In Lung Cancer March 2022 165 Supplement 1:S37-S37

Identification of a Conserved Motif Required for mTOR Signaling

Authors: Schalm, Stefanie S., Blenis, John

Source: In Current Biology 16 April 2002 12(8):632-639

Ribosomal S6 Kinase 2 Inhibition by a Potent C-terminal Repressor Domain Is Relieved by Mitogen-activated Protein-Extracellular Signal-regulated Kinase Kinase-regulated Phosphorylation

Authors: Martin, Kathleen A. ^{‡, §}, Schalm, Stefanie S. ^{‡, ¶}, Romanelli, Angela ^{‡, ‖}, Keon, Kristen L. ^‡, Blenis, John ^{‡, **}

Source: In Journal of Biological Chemistry March 2001 276(11):7892-7898

Regulation of Ribosomal S6 Kinase 2 by Effectors of the Phosphoinositide 3-Kinase Pathway

Authors: Martin, Kathleen A. ^{‡, §}, Schalm, Stefanie S. ^{‡, ¶}, Richardson, Celeste ^{‡, ‖}, Romanelli, Angela ^{‡, **}, Keon, Kristen L. ^‡, Blenis, John ^{‡, ‡}

Source: In Journal of Biological Chemistry March 2001 276(11):7884-7891

P464: PULSE DOSING OF POTENT AND SELECTIVE HETEROBIFUNCTIONAL MDM2 DEGRADER KT‐253 DRIVES TUMOR REGRESSION AND DEMONSTRATES DIFFERENTIATED PHARMACOLOGY COMPARED TO P53/MDM2 SMALL MOLECULE INHIBITORS.

Authors: Schalm, Stefanie, Chutake, Yogesh, Breitkopf, Susanne, Mayo, Michele, Dumont, Nancy, Chen, Dapeng, Dixit, Vaishali, Karnik, Rahul, Mcdonald, Alice, Filiatrault, Jessica, Proctor, William, Qi, Frank, Hu, Kan‐Nian, Weiss, Matt, Gollerkeri, Ashwin, Sharma, Kirti, D Growney, Joseph, Williams, Juliet

Source: HemaSphere; 2023 Supplement 3, Vol. 7, p1-2, 2p

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics.

Authors: Sasaki, Masato, Knobbe, Christiane B., Munger, Joshua C., Lind, Evan F., Brenner, Dirk, Brüstle, Anne, Harris, Isaac S., Holmes, Roxanne, Wakeham, Andrew, Haight, Jillian, You-Ten, Annick, Li, Wanda Y., Schalm, Stefanie, Su, Shinsan M., Virtanen, Carl, Reifenberger, Guido, Ohashi, Pamela S., Barber, Dwayne L., Figueroa, Maria E., Melnick, Ari

Source: Nature. 8/30/2012, Vol. 488 Issue 7413, p656-659. 4p. 3 Graphs.

Subjects: GENETIC code, GENETIC mutation, HEMATOPOIETIC stem cells, PROGENITOR cells, EPIGENETICS, LABORATORY mice