First‐in‐human, randomized, double‐blind, placebo‐controlled, dose escalation trial of the anti‐herpes simplex virus monoclonal antibody HDIT101 in healthy volunteers

Authors: Blank, Antje, Hohmann, Nicolas, Dettmer, Marlen, Manka‐Stuhlik, Anette, Mikus, Gerd, Stoll, Felicitas, Stützle‐Schnetz, Marlies, Thomas, Daniel, Exner, Evelyn, Schmitt‐Bormann, Beate, Schaller, Torsten, Laage, Rico, Schönborn‐Kellenberger, Oliver, Arndt, Michaela, Haefeli, Walter E., Krauss, Jürgen

Source: Clinical and translational science. 15(10):2366-2377

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Targeting SAMHD1 with hydroxyurea in first‐line cytarabine‐based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT‐AML trial

Authors: Jädersten, Martin, Lilienthal, Ingrid, Tsesmetzis, Nikolaos, Lourda, Magda, Bengtzén, Sofia, Bohlin, Anna, Arnroth, Cornelia, Erkers, Tom, Seashore‐Ludlow, Brinton, Giraud, Géraldine, Barkhordar, Giti S., Tao, Sijia, Fogelstrand, Linda, Saft, Leonie, Östling, Päivi, Schinazi, Raymond F., Kim, Baek, Schaller, Torsten, Juliusson, Gunnar, Deneberg, Stefan, Lehmann, Sören, Rassidakis, Georgios Z., Höglund, Martin, Henter, Jan‐Inge, Herold, Nikolas

Source: Journal of internal medicine. 292(6):925-940

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A CoA‐Transferase and Acyl‐CoA Dehydrogenase Convert 2‐(Carboxymethyl)cyclohexane‐1‐Carboxyl‐CoA During Anaerobic Naphthalene Degradation.

Authors: Kong, Yachao, Riebe, Jan, Feßner, Malte, Schaller, Torsten, Wölper, Christoph, Stappert, Florian, Meckelmann, Sven W., Krajnc, Matthias, Weyrauch, Philip, Schmitz, Oliver J., Merten, Christian, Niemeyer, Jochen, Hu, Xiaoke, Meckenstock, Rainer U.

Source: Environmental Microbiology; Dec2024, Vol. 26 Issue 12, p1-18, 18p

Subject Terms: CARBOXYL group, NAPHTHALENE, GENE clusters, DEHYDROGENASES, MOIETIES (Chemistry)

The ability of SAMHD1 to block HIV-1 but not SIV requires expression of MxB

Authors: Buffone, Cindy, Kutzner, Juliane, Opp, Silvana, Martinez-Lopez, Alicia, Selyutina, Anastasia, Coggings, Si Ana, Studdard, Lydia R., Ding, Lingmei, Kim, Baek, Spearman, Paul, Schaller, Torsten, Diaz-Griffero, Felipe

Source: In Virology May 2019 531:260-268

What is the role of acid–acid interactions in asymmetric phosphoric acid organocatalysis? A detailed mechanistic study using interlocked and non-interlocked catalystsIn memory of Prof. Carsten Schmuck.Electronic supplementary information (ESI) available. See DOI: 10.1039/d0sc01026j

Authors: Jansen, Dennis, Gramüller, Johannes, Niemeyer, Felix, Schaller, Torsten, Letzel, Matthias C., Grimme, Stefan, Zhu, Hui, Gschwind, Ruth M., Niemeyer, Jochen

Source: Chemical science. 11(17):4381-4390

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Conversion of Ultrasmall Glutathione-Coated Silver Nanoparticles during Dispersion in Water into Ultrasmall Silver Sulfide Nanoparticles.

Authors: Wolff, Natalie, Prymak, Oleg, Białas, Nataniel, Schaller, Torsten, Loza, Kateryna, Niemeyer, Felix, Heggen, Marc, Weidenthaler, Claudia, Oliveira, Cristiano L. P., Epple, Matthias

Source: Nanomaterials (2079-4991); Sep2024, Vol. 14 Issue 17, p1449, 20p

Subject Terms: SILVER nanoparticles, X-ray photoelectron spectroscopy, SILVER sulfide, SILVER clusters, OPTICAL spectroscopy

Increased Cytotoxicity of Bimetallic Ultrasmall Silver–Platinum Nanoparticles (2 nm) on Cells and Bacteria in Comparison to Silver Nanoparticles of the Same Size.

Authors: Wolff, Natalie, Białas, Nataniel, Loza, Kateryna, Heggen, Marc, Schaller, Torsten, Niemeyer, Felix, Weidenthaler, Claudia, Beuck, Christine, Bayer, Peter, Prymak, Oleg, Oliveira, Cristiano L. P., Epple, Matthias

Source: Materials (1996-1944); Aug2024, Vol. 17 Issue 15, p3702, 21p

Subject Terms: PLATINUM nanoparticles, GOLD nanoparticles, NANOPARTICLE size, SILVER nanoparticles, X-ray photoelectron spectroscopy

Possibilities and limitations of solution-state NMR spectroscopy to analyze the ligand shell of ultrasmall metal nanoparticles.

Authors: Wolff, Natalie, Beuck, Christine, Schaller, Torsten, Epple, Matthias

Source: Nanoscale Advances; 7/7/2024, Vol. 6 Issue 13, p3285-3298, 14p

Phosphorescence Induction by Host‐Guest Complexation with Cyclodextrins – The Role of Regioisomerism and Affinity

Authors: Hayduk, Matthias, Schaller, Torsten, Niemeyer, Felix C., Rudolph, Kevin, Clever, Guido H., Rizzo, Fabio, Voskuhl, Jens

Source: Chemistry. 28(51)

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With me or against me: Tumor suppressor and drug resistance activities of SAMHD1

Authors: Herold, Nikolas, Rudd, Sean G., Sanjiv, Kumar, Kutzner, Juliane, Myrberg, Ida Hed, Paulin, Cynthia B.J., Olsen, Thale Kristin, Helleday, Thomas, Henter, Jan-Inge, Schaller, Torsten

Source: In Experimental Hematology August 2017 52:32-39

The Molecular Footprint of Peptides on the Surface of Ultrasmall Gold Nanoparticles (2 nm) Is Governed by Steric Demand.

Authors: Wagner, Lisa-Sofie, Prymak, Oleg, Schaller, Torsten, Beuck, Christine, Loza, Kateryna, Niemeyer, Felix, Gumbiowski, Nina, Kostka, Kathrin, Bayer, Peter, Heggen, Marc, Oliveira, Cristiano L. P., Epple, Matthias

Source: Journal of Physical Chemistry B; 5/2/2024, Vol. 128 Issue 17, p4266-4281, 16p

Molecular Tweezers Inhibit PARP‐1 by a New Mechanism

Authors: Wilch, Constanze, Talbiersky, Peter, Berchner‐Pfannschmidt, Utta, Schaller, Torsten, Kirsch, Michael, Klärner, Frank‐Gerrit, Schrader, Thomas

Source: European journal of organic chemistry. 2017(16):2223-2229

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112223186.0x000001&indx=1&recIds=ETOCvdc_100112223186.0x000001

High-Affinity Copolymers Inhibit Digestive Enzymes by Surface Recognition

Authors: Gilles, Patrick, Wenck, Kirstin, Stratmann, Inga, Kirsch, Michael, Smolin, Daniel A., Schaller, Torsten, de Groot, Herbert, Kraft, Arno, Schrader, Thomas

Source: Biomacromolecules. 18(6):1772-1784

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632275285&indx=1&recIds=ETOCRN632275285

SAMHD1 protects cancer cells from various nucleoside-based antimetabolites

Authors: Herold, Nikolas, Rudd, Sean G., Sanjiv, Kumar, Kutzner, Juliane, Bladh, Julia, Paulin, Cynthia B. J., Helleday, Thomas, Henter, Jan-Inge, Schaller, Torsten

Source: Cell cycle. 16(11):1029-1038

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100048233662.0x000001&indx=1&recIds=ETOCvdc_100048233662.0x000001

The Early Bird Catches the Worm – Can Evolution Teach us Lessons in Fighting HIV?

Authors: Schaller, Torsten

Source: Current HIV research. 14(3):183-210

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100077821637.0x000001&indx=1&recIds=ETOCvdc_100077821637.0x000001

Ultrastructure and Surface Composition of Glutathione-Terminated Ultrasmall Silver, Gold, Platinum, and Alloyed Silver–Platinum Nanoparticles (2 nm).

Authors: Wolff, Natalie, Loza, Kateryna, Heggen, Marc, Schaller, Torsten, Niemeyer, Felix, Bayer, Peter, Beuck, Christine, Oliveira, Cristiano L. P., Prymak, Oleg, Weidenthaler, Claudia, Epple, Matthias

Source: Inorganic Chemistry; 10/23/2023, Vol. 62 Issue 42, p17470-17485, 16p

Ribonucleotide reductase inhibitors suppress SAMHD1 ara‐CTPase activity enhancing cytarabine efficacy

Authors: Rudd, Sean G, Tsesmetzis, Nikolaos, Sanjiv, Kumar, Paulin, Cynthia BJ, Sandhow, Lakshmi, Kutzner, Juliane, Hed Myrberg, Ida, Bunten, Sarah S, Axelsson, Hanna, Zhang, Si Min, Rasti, Azita, Mäkelä, Petri, Coggins, Si'Ana A, Tao, Sijia, Suman, Sharda, Branca, Rui M, Mermelekas, Georgios, Wiita, Elisée, Lee, Sun, Walfridsson, Julian, Schinazi, Raymond F, Kim, Baek, Lehtiö, Janne, Rassidakis, Georgios Z, Pokrovskaja Tamm, Katja, Warpman‐Berglund, Ulrika, Heyman, Mats, Grandér, Dan, Lehmann, Sören, Lundbäck, Thomas, Qian, Hong, Henter, Jan‐Inge, Schaller, Torsten, Helleday, Thomas, Herold, Nikolas

Source: EMBO molecular medicine. 12(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103212656.0x000001&indx=1&recIds=ETOCvdc_100103212656.0x000001

HIV Interplay with SAMHD1

Authors: Schaller, Torsten, Goujon, Caroline, Malim, Michael H.

Source: Science, 2012 Mar . 335(6074), 1313-1314.

Access URL: http://dx.doi.org/10.1126/science.1221057

Evidence for SAMHD1 Tumor Suppressor Functions in Acute Myeloid Leukemia

Authors: Schaller, Torsten, Herold, Nikolas

Source: Acta haematologica. 143(1):7-8

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097146951.0x000001&indx=1&recIds=ETOCvdc_100097146951.0x000001

Signal Peptide Peptidase Cleavage of GB Virus B Core Protein Is Required for Productive Infection in Vivo

Authors: Targett-Adams, Paul, Schaller, Torsten, Hope, Graham, Lanford, Robert E., Lemon, Stanley M., Martin, Annette, McLauchlan, John

Source: In Journal of Biological Chemistry 29 September 2006 281(39):29221-29227