The FGFR inhibitor PD173074 binds to the C‐terminus of oncofetal HMGA2 and modulates its DNA‐binding and transcriptional activation functions

Authors: Ahmed, Syed Moiz, Ragunathan, Priya, Shin, Joon, Peter, Sabrina, Kleissle, Sabrina, Neuenschwander, Martin, Schäfer, Reinhold, Kries, Jens Peter V., Grüber, Gerhard, Dröge, Peter

Source: FEBS letters. 597(15):1977-1988

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189956767.0x000001&indx=1&recIds=ETOCvdc_100189956767.0x000001

Tumour mutational burden and survival with molecularly matched therapy

Authors: de Bortoli, Till, Benary, Manuela, Horak, Peter, Lamping, Mario, Stintzing, Sebastian, Tinhofer, Ingeborg, Leyvraz, Serge, Schäfer, Reinhold, Klauschen, Frederick, Keller, Ulrich, Stenzinger, Albrecht, Fröhling, Stefan, Kurzrock, Razelle, Keilholz, Ulrich, Rieke, Damian T., Jelas, Ivan

Source: In European Journal of Cancer September 2023 190

Silencing effects of mutant RAS signalling on transcriptomes

Authors: Sers, Christine, Schäfer, Reinhold

Source: In Advances in Biological Regulation January 2023 87

Biomarker-driven therapies for metastatic uveal melanoma: A prospective precision oncology feasibility study

Authors: Leyvraz, Serge, Konietschke, Frank, Peuker, Caroline, Schütte, Moritz, Kessler, Thomas, Ochsenreither, Sebastian, Ditzhaus, Marc, Sprünken, Erin D., Dörpholz, Gina, Lamping, Mario, Rieke, Damian T., Klinghammer, Konrad, Burock, Susen, Ulrich, Claas, Poch, Gabriela, Schäfer, Reinhold, Klauschen, Frederick, Joussen, Antonia, Yaspo, Marie-Laure, Keilholz, Ulrich

Source: European journal of cancer. 169:146-155

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164911685.0x000001&indx=1&recIds=ETOCvdc_100164911685.0x000001

Rapid testing of candidate oncogenes and tumour suppressor genes in signal transduction and neoplastic transformation

Authors: Liu, Sha, Medina-Perez, Paula, Ha-Thi, Minh-Cam, Wieland, Anja, Stecklum, Maria, Hoffmann, Jens, Tchernitsa, Oleg, Sers, Christine, Schäfer, Reinhold

Source: In Advances in Biological Regulation January 2022 83

RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence

Authors: Regan, Joseph L., Schumacher, Dirk, Staudte, Stephanie, Steffen, Andreas, Lesche, Ralf, Toedling, Joern, Jourdan, Thibaud, Haybaeck, Johannes, Mumberg, Dominik, Henderson, David, Győrffy, Balázs, Regenbrecht, Christian R.A., Keilholz, Ulrich, Schäfer, Reinhold, Lange, Martin

Source: In iScience 25 June 2021 24(6)

Mutation-specific effects of NRAS oncogenes in colorectal cancer cells

Authors: Kuhn, Natalia, Klinger, Bertram, Uhlitz, Florian, Sieber, Anja, Rivera, Maria, Klotz-Noack, Kathleen, Fichtner, Iduna, Hoffmann, Jens, Blüthgen, Nils, Falk, Christine, Sers, Christine, Schäfer, Reinhold

Source: In Advances in Biological Regulation January 2021 79

Generation of Patient-Derived Colorectal Cancer Organoids for RAS Studies

Authors: Schumacher, Dirk, Regan, Joseph L., Przybilla, Dorothea, Schäfer, Reinhold

Source: Methods in molecular biology. 2262:349-360

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626641800&indx=1&recIds=ETOCRN626641800

SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells

Authors: Klotz-Noack, Kathleen, Klinger, Bertram, Rivera, Maria, Bublitz, Natalie, Uhlitz, Florian, Riemer, Pamela, Lüthen, Mareen, Sell, Thomas, Kasack, Katharina, Gastl, Bastian, Ispasanie, Sylvia S.S., Simon, Tincy, Janssen, Nicole, Schwab, Matthias, Zuber, Johannes, Horst, David, Blüthgen, Nils, Schäfer, Reinhold, Morkel, Markus, Sers, Christine

Source: In Cell Reports 22 September 2020 32(12)

Pretreatment with methanolic extract of Pistacia lentiscus L. increases sensitivity to DNA damaging drugs in primary high-grade serous ovarian cancer cells

Authors: Charid, Imane ^*, Kessler, Mirjana, Darb-Esfahani, Silvia, Zemojtel, Tomasz, Abobaker, Salem, Tyuarets, Sandra, Schrauwen, Stefanine, Atmani-Kilani, Dina, Benaida-Debbache, Nadjet, Schäfer, Reinhold, Castillo-Tong, Dan Cacsire, Atmani, Djebbar, Cherbal, Farid, Amant, Frederic, Sehouli, Jalid, Kulbe, Hagen, Braicu, Elena I.

Source: In European Journal of Integrative Medicine August 2020 37

Support of a molecular tumour board by an evidence-based decision management system for precision oncology

Authors: Lamping, Mario, Benary, Manuela, Leyvraz, Serge, Messerschmidt, Clemens, Blanc, Eric, Kessler, Thomas, Schütte, Moritz, Lenze, Dido, Jöhrens, Korinna, Burock, Susen, Klinghammer, Konrad, Ochsenreither, Sebastian, Sers, Christine, Schäfer, Reinhold, Tinhofer, Ingeborg, Beule, Dieter, Klauschen, Frederick, Yaspo, Marie-Laure, Keilholz, Ulrich, Rieke, Damian T.

Source: In European Journal of Cancer March 2020 127:41-51

A diagnostic challenge of KIT p.V559D and BRAF p.G469A mutations in a paragastric mass.

Authors: Habringer, Stefan, Ihlow, Jana, Kleo, Karsten, Klostermann, Anna, Schmidt, Max, Chai, Lidan, Knödler, Maren, Leyvraz, Serge, Sigler, Christian, Sinn, Bruno, Maschmeyer, Georg, Jegodka, Yvette, Benary, Manuela, Ott, Claus-Eric, Tinhofer, Ingeborg, Schäfer, Reinhold, Möbs, Markus, Keller, Ulrich, Keilholz, Ulrich, Rieke, Damian T

Source: Oncologist; Oct2024, Vol. 29 Issue 10, p908-912, 5p

Subject Terms: THERAPEUTIC use of antineoplastic agents, GASTROINTESTINAL tumors, CANCER invasiveness, DIFFERENTIAL diagnosis, COMPUTED tomography, TREATMENT effectiveness, TRANSFERASES, GENETIC mutation, GENETIC testing, GENOTYPES

VIST - a Variant-Information Search Tool for precision oncology

Authors: Ševa, Jurica, Wiegandt, David Luis, Götze, Julian, Lamping, Mario, Rieke, Damian, Schäfer, Reinhold, Jähnichen, Patrick, Kittner, Madeleine, Pallarz, Steffen, Starlinger, Johannes, Keilholz, Ulrich, Leser, Ulf

Source: BMC bioinformatics. 20(1):1-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189850245.0x000001&indx=1&recIds=ETOCvdc_100189850245.0x000001

Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells

Authors: Regan, Joseph L., Schumacher, Dirk, Staudte, Stephanie, Steffen, Andreas, Haybaeck, Johannes, Keilholz, Ulrich, Schweiger, Caroline, Golob-Schwarzl, Nicole, Mumberg, Dominik, Henderson, David, Lehrach, Hans, Regenbrecht, Christian R.A., Schäfer, Reinhold, Lange, Martin

Source: In Cell Reports 5 December 2017 21(10):2813-2828

Growth-Inhibitory Activity and Downregulation of the Class II Tumor-Suppressor Gene H-rev107 in Tumor Cell Lines and Experimental Tumors

Authors: Sers, Christine, Emmenegger, Urban, Husmann, Knut, Bucher, Katharina, Andres, Ann-Catherine, Schäfer, Reinhold

Source: The Journal of Cell Biology, 1997 Feb . 136(4), 935-944.

Access URL: https://www.jstor.org/stable/1617922

A primary undifferentiated pleomorphic sarcoma of the lumbosacral region harboring a LMNA-NTRK1 gene fusion with durable clinical response to crizotinib: a case report

Authors: Zhou, Ning, Schäfer, Reinhold, Li, Tao, Fang, Meiyu, Liu, Luying

Source: BMC cancer. 18(1):1-8

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175708243.0x000001&indx=1&recIds=ETOCvdc_100175708243.0x000001

Guidelines for the selection of functional assays to evaluate the hallmarks of cancer

Authors: Menyhárt, Otília, Harami-Papp, Hajnalka, Sukumar, Saraswati, Schäfer, Reinhold, Magnani, Luca, de Barrios, Oriol, Győrffy, Balázs

Source: In BBA - Reviews on Cancer December 2016 1866(2):300-319

Assay Establishment and Validation of a High-Throughput Screening Platform for Three-Dimensional Patient-Derived Colon Cancer Organoid Cultures

Authors: Boehnke, Karsten, Iversen, Philip W., Schumacher, Dirk, Lallena, María José, Haro, Rubén, Amat, Joaquín, Haybaeck, Johannes, Liebs, Sandra, Lange, Martin, Schäfer, Reinhold, Regenbrecht, Christian R.A., Reinhard, Christoph ^*, Velasco, Juan A. ^{*, **}

Source: In SLAS Discovery October 2016 21(9):931-941

Y-box protein-1/p18 as novel serum marker for ovarian cancer diagnosis: A study by the Tumor Bank Ovarian Cancer (TOC)

Authors: Rohr, Irena, Braicu, Elena I., En-Nia, Abdelaziz, Heinrich, Michaela, Richter, Rolf, Chekerov, Radoslav, Dechend, Ralf, Heidecke, Harald, Dragun, Duska, Schäfer, Reinhold, Gorny, Xenia, Lindquist, Jonathan A., Brandt, Sabine, Sehouli, Jalid, Mertens, Peter R.

Source: In Cytokine September 2016 85:157-164

Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe

Authors: Gastl, Bastian, Klotz-Noack, Kathleen, Klinger, Bertram, Ispasanie, Sylvia, Salib, Krenoula Hani Fouad, Zuber, Johannes, Mamlouk, Soulafa, Bublitz, Natalie, Blüthgen, Nils, Horst, David, Morkel, Markus, Schäfer, Reinhold, Sers, Christine

Source: Cell death and disease. 11(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174649911.0x000001&indx=1&recIds=ETOCvdc_100174649911.0x000001