Immune correlates analysis of the Imbokodo (HVTN 705/HPX2008) efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned female sex at birth: a two-phase case-control study

Authors: Allagappen, Jon, Andriesen, Jessica, Ayres, Alison, Baral, Saman, Bekker, Linda-Gail, Besethi, Asiphe, Borremans, Caroline, Braams, Esmee, Brackett, Caroline, Brumskine, William, Chilengi, Roma, Choi, Rachel, Dubula, Thozama, Dumas, Jaiden Seongmi, Dunn, Brooke, Etikala, Radhika, Euler, Zelda, Everett, Sarah, Garrett, Nigel, Gelderblom, Huub, Gill, Katherine, Gillespie, Kevin, Goedhart, Dimitri, Goosmann, Erik, Grant, Shannon, Hands, Ellie, Haynes, Barton, Herringer, Bronwill, Hoosain, Zaheer, Hosseinipour, Mina, Hunidzarira, Portia, Hutter, Julia, Inambao, Mubiana, Innes, Craig, Keyes, Taylor, Kilembe, William, Kotze, Philippus, Kotze, Sheena, Laher, Fatima, Laszlo, Imre, Lazarus, Erica, Liao, Hua-Xin, Lin, Yong, Lu, Helen, Lucas, Judith, Malahleha, Mookho, McNair, Tara, Meerts, Peter, Mgaga, Zinhle, Montlha, Mahlodi, Mosito, Boitumelo, Moultrie, Andrew, Mudrak, Sarah, Oriol-Mathieu, Valérie, Sarzotti-Kelsoe, Marcella, Mathebula, Matson Tso, Matoga, Mitch, McClennen, Rachael, Mda, Pamela, Naicker, Vimla, Naidoo, Logashvari, Okkers, Cindy-Ann, Omarjee, Saleha, Pasmans, Hella, Philip, Tricia, Pinter, Abraham, Pitsi, Annah, Ramos, Ornelia, Randhawa, April, Roels, Sanne, Rohith, Shamiska, Rutten, Lucy, Sadoff, Jerald, Salinas, Gabriela, Salzgeber, Yvonne, Scheppler, Lorenz, Schwedhelm, Katharine, Schuller, Nicolette, Sharak, Angelina, Stanfield-Oakley, Sherry, Sopher, Carrie, Tafatatha, Terence, Takuva, Simbarashe G., Tang, Chan, Vandebosch, An, Viegas, Edna, Voillet, Valentin, Wegmann, Frank, Weijtens, Mo, Wilcox, Stephany, Williams, Anthony, Yu, Chenchen, Yu, Pei-Chun, Yuan, Olive, Zhang, Xuehan, Kenny, Avi, van Duijn, Janine, Dintwe, One, Heptinstall, Jack, Burnham, Randy, Sawant, Sheetal, Zhang, Lu, Mielke, Dieter, Khuzwayo, Sharon, Omar, Faatima Laher, Goodman, Derrick, Fong, Youyi, Benkeser, David, Zou, Rodger, Hural, John, Hyrien, Ollivier, Juraska, Michal, Luedtke, Alex, van der Laan, Lars, Giorgi, Elena E., Magaret, Craig, Carpp, Lindsay N., Pattacini, Laura, van de Kerkhof, Tom, Korber, Bette, Willems, Wouter, Fisher, Leigh H., Schuitemaker, Hanneke, Swann, Edith, Kublin, James G., Pau, Maria G., Buchbinder, Susan, Tomaka, Frank, Nijs, Steven, Lavreys, Ludo, Gelderblom, Huub C., Corey, Lawrence, Mngadi, Kathryn, Gray, Glenda E., Borducchi, Erica, Hendriks, Jenny, Seaton, Kelly E., Zolla-Pazner, Susan, Barouch, Dan H., Ferrari, Guido, De Rosa, Stephen C., McElrath, M Juliana, Andersen-Nissen, Erica, Stieh, Daniel J., Tomaras, Georgia D., Gilbert, Peter B.

Source: In eBioMedicine October 2024 108

Pharmacokinetic serum concentrations of VRC01 correlate with prevention of HIV-1 acquisition

Authors: Seaton, Kelly E., Huang, Yunda, Karuna, Shelly, Heptinstall, Jack R., Brackett, Caroline, Chiong, Kelvin, Zhang, Lily, Yates, Nicole L., Sampson, Mark, Rudnicki, Erika, Juraska, Michal, deCamp, Allan C., Edlefsen, Paul T., Mullins, James I., Williamson, Carolyn, Rossenkhan, Raabya, Giorgi, Elena E., Kenny, Avi, Angier, Heather, Randhawa, April, Weiner, Joshua A., Rojas, Michelle, Sarzotti-Kelsoe, Marcella, Zhang, Lu, Sawant, Sheetal, Ackerman, Margaret E., McDermott, Adrian B., Mascola, John R., Hural, John, McElrath, M. Julianna, Andrew, Philip, Hidalgo, Jose A., Clark, Jesse, Laher, Fatima, Orrell, Catherine, Frank, Ian, Gonzales, Pedro, Edupuganti, Srilatha, Mgodi, Nyaradzo, Corey, Lawrence, Morris, Lynn, Montefiori, David, Cohen, Myron S., Gilbert, Peter B., Tomaras, Georgia D.

Source: In eBioMedicine July 2023 93

A Pentavalent HIV-1 Subtype C Vaccine Containing Computationally Selected gp120 Strains Improves the Breadth of V1V2 Region Responses.

Authors: Shen, Xiaoying, Korber, Bette, Spreng, Rachel L., Sawant, Sheetal S., deCamp, Allan, McMillan, Arthur S., Mathura, Ryan, Zolla-Pazner, Susan, Pinter, Abraham, Parks, Robert, Bowman, Cindy, Sutherland, Laura, Scearce, Richard, Yates, Nicole L., Montefiori, David C., Haynes, Barton F., Tomaras, Georgia D.

Source: Vaccines; Feb2025, Vol. 13 Issue 2, p133, 25p

Subject Terms: COMBINED vaccines, SCAFFOLD proteins, VACCINE effectiveness, ANTIBODY formation, VACCINE trials

GeM-LR: Discovering predictive biomarkers for small datasets in vaccine studies.

Authors: Lin, Lin, Spreng, Rachel L., Seaton, Kelly E., Dennison, S. Moses, Dahora, Lindsay C., Schuster, Daniel J., Sawant, Sheetal, Gilbert, Peter B., Fong, Youyi, Kisalu, Neville, Pollard, Andrew J., Tomaras, Georgia D., Li, Jia

Source: PLoS Computational Biology; 11/14/2024, Vol. 20 Issue 11, p1-23, 23p

Subject Terms: VACCINE trials, VACCINE effectiveness, VACCINE development, COMMUNICABLE diseases, REGRESSION analysis

Prevalence of multidrug-resistant Gram-negative bacteria cases at admission in a multispeciality hospital

Authors: Nagvekar, Vasant, Sawant, Sheetal, Amey, Supriya

Source: In Journal of Global Antimicrobial Resistance September 2020 22:457-461

Persistence of vaccine-elicited immune response up to 14 years post-HIV gp120-NefTat/AS01B vaccination

Authors: Van Der Meeren, Olivier, Jongert, Erik, Seaton, Kelly E., Koutsoukos, Marguerite, Aerssens, Annelies, Brackett, Caroline, Debois, Muriel, Janssens, Michel, Leroux-Roels, Geert, Mesia Vela, Doris, Sawant, Sheetal, Yates, Nicole L., Tomaras, Georgia D., Leroux-Roels, Isabel, Roman, François

Source: Vaccine. 38(7):1678-1689

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097884560.0x000001&indx=1&recIds=ETOCvdc_100097884560.0x000001

HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers

Authors: Nyanhete, Tinashe, Frisbee, Alyse, Bradley, Todd, Faison, William, Robins, Elizabeth, Payne, Tamika, Freel, Stephanie, Sawant, Sheetal, Weinhold, Kent, Wiehe, Kevin, Haynes, Barton, Ferrari, Guido, Li, Qi-Jing, Moody, M., Tomaras, Georgia

Source: Scientific reports. 9(1):1-17

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185362778.0x000001&indx=1&recIds=ETOCvdc_100185362778.0x000001

Randomized, Double-Blind Evaluation of Late Boost Strategies for HIV-Uninfected Vaccine Recipients in the RV 144 HIV Vaccine Efficacy Trial

Authors: RV305 Study Team, Rerks-Ngarm, Supachai, Pitisuttithum, Punnee, Excler, Jean-Louis, Nitayaphan, Sorachai, Kaewkungwal, Jaranit, Premsri, Nakorn, Kunasol, Prayura, Karasavvas, Nicos, Schuetz, Alexandra, Ngauy, Viseth, Sinangil, Faruk, Dawson, Peter, deCamp, Allan C., Phogat, Sanjay, Garunathan, Sanjay, Tartaglia, James, DiazGranados, Carlos, Ratto-Kim, Silvia, Pegu, Poonam, Eller, Michael, Karnasuta, Chitraporn, Montefiori, David C., Sawant, Sheetal, Vandergrift, Nathan, Wills, Saintedym, Tomaras, Georgia D., Robb, Merlin L., Michael, Nelson L., Kim, Jerome H., Vasan, Sandhya, O'Connell, Robert J.

Source: The Journal of Infectious Diseases, 2017 Apr . 215(8), 1255-1263.

Access URL: http://www.jstor.org/stable/26166999

The immunogenicity of an HIV-1 Gag conserved element DNA vaccine in people with HIV and receiving antiretroviral therapy.

Authors: Jacobson, Jeffrey M., Felber, Barbara K., Huichao Chen, Pavlakis, George N., Mullins, James I., De Rosa, Stephen C., Kuritzkes, Daniel R., Tomaras, Georgia D., Kinslow, Jennifer, Yajing Bao, Olefsky, Maxine, Rosati, Margherita, Bear, Jenifer, Heptinstall, Jack R., Lu Zhang, Sawant, Sheetal, Hannaman, Drew, Laird, Gregory M., Cyktor, Joshua C., Heath, Sonya L.

Source: AIDS (02699370); Jun2024, Vol. 38 Issue 7, p963-973, 11p

Viral vector delivered immunogen focuses HIV-1 antibody specificity and increases durability of the circulating antibody recall response.

Authors: Williams, LaTonya D.^1,2,3, latonya.williams@duke.edu, Shen, Xiaoying^2,3, latonya.williams@duke.edu, Sawant, Sheetal S.^1,2,3, Akapirat, Siriwat⁴, Dahora, Lindsay C.^1,2,3,5, Tay, Matthew Zirui^1,2,3,6, Stanfield-Oakley, Sherry^1,2,3, Wills, Saintedym^1,2,3,5, Goodman, Derrick^1,2,3, Tenney, DeAnna^1,2,3, Spreng, Rachel L.^1,2,3, Zhang, Lu^1,2,3, Yates, Nicole L.^1,2,3, Montefiori, David C.^2,3, Eller, Michael A.^7,8, Easterhoff, David^3,9, Hope, Thomas J.¹⁰, Rerks-Ngarm, Supachai¹¹, Pittisuttithum, Punnee¹², Nitayaphan, Sorachai¹²

Source: PLoS Pathogens; 5/31/2023, Vol. 18 Issue 5, p1-46, 46p

Effect of HIV-1 envelope cytoplasmic tail on adenovirus primed virus encoded virus-like particle immunizations

Authors: Andersson, Anne-Marie C., Ragonnaud, Emeline, Seaton, Kelly E., Sawant, Sheetal, Folgori, Antonella, Colloca, Stefano, Labranche, Celia, Montefiori, David C., Tomaras, Georgia D., Holst, Peter J.

Source: In Vaccine 17 October 2016 34(44):5344-5351

Safety and Immunogenicity of Ad26-vectored HIV Vaccine with Mosaic Immunogens and a Novel Mosaic Envelope Protein in HIV-uninfected Adults: A Phase 1/2a Study.

Authors: Stieh, Daniel J, Barouch, Dan H, Comeaux, Christy, Sarnecki, Michal, Stephenson, Kathryn E, Walsh, Stephen R, Sawant, Sheetal, Heptinstall, Jack, Tomaras, Georgia D, Kublin, James G, McElrath, M Juliana, Cohen, Kristen W, Rosa, Stephen C De, Alter, Galit, Ferrari, Guido, Montefiori, David, Mann, Philipp, Nijs, Steven, Callewaert, Katleen, Goepfert, Paul A

Source: Journal of Infectious Diseases; 4/15/2023, Vol. 227 Issue 8, p939-950, 12p

Subject Terms: AIDS vaccines, IMMUNE response, C++, CLINICAL trial registries, HIV infections

Multi-trial analysis of HIV-1 envelope gp41-reactive antibodies among global recipients of candidate HIV-1 vaccines.

Authors: Mayer-Blackwell, Koshlan, Johnson, Andrew M., Potchen, Nicole, Minot, Simon S., Heptinstall, Jack, Seaton, Kelly, Sawant, Sheetal, Xiaoying Shen, Tomaras, Georgia D., Fiore-Gartland, Andrew, Kublin, James G.

Source: Frontiers in Immunology; 10/12/2022, Vol. 13, p1-14, 14p

Subject Terms: IMMUNOGLOBULINS, HIV, EXPOSURE therapy, VACCINE trials, VACCINE effectiveness, AIDS vaccines

Geographic Terms: SOUTH Africa

Impact of adjuvants on the biophysical and functional characteristics of HIV vaccine-elicited antibodies in humans.

Authors: Xu, Shiwei, Carpenter, Margaret C., Spreng, Rachel L., Neidich, Scott D., Sarkar, Sharanya, Tenney, DeAnna, Goodman, Derrick, Sawant, Sheetal, Jha, Shalini, Dunn, Brooke, Juliana McElrath, M., Bekker, Valerie, Mudrak, Sarah V., Flinko, Robin, Lewis, George K., Ferrari, Guido, Tomaras, Georgia D., Shen, Xiaoying, Ackerman, Margaret E.

Source: NPJ Vaccines; 8/4/2022, Vol. 7 Issue 1, p1-14, 14p

Subject Terms: HIV antibodies, ANTIBODY-dependent cell cytotoxicity, IMMUNE response, HUMORAL immunity, AIDS vaccines

Early and Long-Term HIV-1 Immunogenicity Induced in Macaques by the Combined Administration of DNA, NYVAC and Env Protein-Based Vaccine Candidates: The AUP512 Study.

Authors: Perdiguero, Beatriz, Asbach, Benedikt, Gómez, Carmen E., Köstler, Josef, Barnett, Susan W., Koutsoukos, Marguerite, Weiss, Deborah E., Cristillo, Anthony D., Foulds, Kathryn E., Roederer, Mario, Montefiori, David C., Yates, Nicole L., Ferrari, Guido, Shen, Xiaoying, Sawant, Sheetal, Tomaras, Georgia D., Sato, Alicia, Fulp, William J., Gottardo, Raphael, Ding, Song

Source: Frontiers in Immunology; 7/22/2022, Vol. 13, p1-20, 20p

Subject Terms: IMMUNE response, HIV, MACAQUES, DNA, HIV-1 glycoprotein 120

Analysis of the HIV Vaccine Trials Network 702 Phase 2b-3 HIV-1 Vaccine Trial in South Africa Assessing RV144 Antibody and T-Cell Correlates of HIV-1 Acquisition Risk.

Authors: Moodie, Zoe, Dintwe, One, Sawant, Sheetal, Grove, Doug, Huang, Yunda, Janes, Holly, Heptinstall, Jack, Omar, Faatima Laher, Cohen, Kristen, Rosa, Stephen C De, Zhang, Lu, Yates, Nicole L, Sarzotti-Kelsoe, Marcella, Seaton, Kelly E, Laher, Fatima, Bekker, Linda Gail, Malahleha, Mookho, Innes, Craig, Kassim, Sheetal, Naicker, Nivashnee

Source: Journal of Infectious Diseases; 7/15/2022, Vol. 226 Issue 2, p246-257, 12p

Subject Terms: HIV prevention, VIRAL antigens, IMMUNOGLOBULINS, CLINICAL trials, AIDS vaccines, HIV seroconversion, RESEARCH funding, VIRAL antibodies, HIV

Geographic Terms: SOUTH Africa

Cooperation Between Systemic and Mucosal Antibodies Induced by Virosomal Vaccines Targeting HIV-1 Env: Protection of Indian Rhesus Macaques Against Low-Dose Intravaginal SHIV Challenges.

Authors: Lakhashe, Samir K., Amacker, Mario, Hariraju, Dinesh, Vyas, Hemant K., Morrison, Kyle S., Weiner, Joshua A., Ackerman, Margaret E., Roy, Vicky, Alter, Galit, Ferrari, Guido, Montefiori, David C., Tomaras, Georgia D., Sawant, Sheetal, Yates, Nicole L., Gast, Chris, Fleury, Sylvain, Ruprecht, Ruth M.

Source: Frontiers in Immunology; 2/22/2022, Vol. 13, p1-21, 21p

Subject Terms: RHESUS monkeys, IMMUNOGLOBULINS, VACCINE effectiveness, IMMUNE response, HIV

Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1.

Authors: Shida Shangguan, Ehrenberg, Philip K., Geretz, Aviva, Yum, Lauren, Kundu, Gautam, May, Kelly, Fourati, Slim, Nganou-Makamdop, Krystelle, Williams, LaTonya D., Sawant, Sheetal, Lewitus, Eric, Pitisuttithum, Punnee, Sorachai Nitayaphan, Suwat Chariyalertsak, Supachai Rerks-Ngarm, Rolland, Morgane, Douek, Daniel C., Gilbert, Peter, Tomaras, Georgia D., Michael, Nelson L.

Source: eLife; 10/13/2021, p1-24, 24p

Salmonella Typhi Vi capsule prime-boost vaccination induces convergent and functional antibody responses.

Authors: Dahora, Lindsay C., Verheul, Marije K., Williams, Katherine L., Jin, Celina, Stockdale, Lisa, Cavet, Guy, Giladi, Eldar, Hill, Jennifer, Kim, Dongkyoon, Leung, Yvonne, Bobay, Benjamin G., Spicer, Leonard D., Sawant, Sheetal, Rijpkema, Sjoerd, Dennison, S. Moses, Alam, S. Munir, Pollard, Andrew J., Tomaras, Georgia D.

Source: Science Immunology; 2021, Vol. 6 Issue 64, p1-13, 13p

Validation of a Triplex Pharmacokinetic Assay for Simultaneous Quantitation of HIV-1 Broadly Neutralizing Antibodies PGT121, PGDM1400, and VRC07-523-LS.

Authors: Wesley, Martina S., Chiong, Kelvin T., Seaton, Kelly E., Arocena, Christine A., Sawant, Sheetal, Hare, Jonathan, Hernandez, Kasey, Rojas, Michelle, Heptinstall, Jack, Beaumont, David, Crisafi, Katherine, Nkolola, Joseph, Barouch, Dan H., Sarzotti-Kelsoe, Marcella, Tomaras, Georgia D., Yates, Nicole L.

Source: Frontiers in Immunology; 8/24/2021, Vol. 12, p1-12, 12p

Subject Terms: HIV, HIV-1 glycoprotein 120, IMMUNOGLOBULINS, PHARMACOKINETICS, TREATMENT effectiveness