GABARAPL1 is essential in extracellular vesicle cargo loading and metastasis development

Authors: Beaumont, Joel E.J., Ju, Jinzhe, Barbeau, Lydie M.O., Demers, Imke, Savelkouls, Kim G., Derks, Kasper, Bouwman, Freek G., Wauben, Marca H.M., Zonneveld, Marijke I., Keulers, Tom G.H., Rouschop, Kasper M.A.

Source: In Radiotherapy and Oncology January 2024 190

MAP1LC3C repression reduces CIITA- and HLA class II expression in non-small cell lung cancer.

Authors: Barbeau, Lydie M. O., Beelen, Nicky A., Savelkouls, Kim G., Keulers, Tom G. H., Wieten, Lotte, Rouschop, Kasper M. A.

Source: PLoS ONE; 2/10/2025, Vol. 20 Issue 2, p1-19, 19p

Subject Terms: NON-small-cell lung carcinoma, IMMUNE checkpoint inhibitors, SQUAMOUS cell carcinoma, PROGRESSION-free survival, LUNG cancer

Sertraline/chloroquine combination therapy to target hypoxic and immunosuppressive serine/glycine synthesis-dependent glioblastomas.

Authors: Sánchez-Castillo, Anaís, Savelkouls, Kim G., Baldini, Alessandra, Hounjet, Judith, Sonveaux, Pierre, Verstraete, Paulien, De Keersmaecker, Kim, Dewaele, Barbara, Björkblom, Benny, Melin, Beatrice, Wu, Wendy Y., Sjöberg, Rickard L., Rouschop, Kasper M. A., Broen, Martijn P. G., Vooijs, Marc, Kampen, Kim R.

Source: Oncogenesis; 11/13/2024, Vol. 13 Issue 1, p1-18, 18p

Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKα activation.

Authors: Beaumont, Joël E. J., Barbeau, Lydie M. O., Ju, Jinzhe, Savelkouls, Kim G., Bouwman, Freek G., Zonneveld, Marijke I., Bronckaers, Annelies, Kampen, Kim R., Keulers, Tom G. H., Rouschop, Kasper M. A.

Source: Journal of Extracellular Vesicles; Jul2024, Vol. 13 Issue 7, p1-19, 19p

Subject Terms: PROTEIN synthesis, AMINO acid synthesis, TUMOR microenvironment, PROTEIN metabolism, EXTRACELLULAR vesicles, NEOVASCULARIZATION, GLYCOLYSIS

1866: Targeting serine/glycine metabolism improves radiotherapy response in Non-Small Cell Lung Cancer

Authors: Castillo, Anaís Sánchez, Heylen, Elien, Hounjet, Judith, Savelkouls, Kim G., Lieuwes, Natasja G., Biemans, Rianne, Dubois, Ludwig J., Reynders, Kobe, Rouschop, Kasper M., Vaes, Rianne D.W., De Keersmaecker, Kim, Lambrecht, Maarten, Hendricks, Lizza E.L., De Ruysscher, Dirk K.M., Vooijs, Marc, Kampen, Kim R.

Source: In Radiotherapy and Oncology May 2024 194 Supplement 1:S5217-S5220

EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition

Authors: Jutten, Barry, Keulers, Tom G., Peeters, Hanneke J. M., Schaaf, Marco B. E., Savelkouls, Kim G. M., Compter, Inge, Clarijs, Ruud, Schijns, Olaf E. M. G., Ackermans, Linda, Teernstra, Onno P. M., Zonneveld, Marijke I., Colaris, Resi M. E., Dubois, Ludwig, Vooijs, Marc A., Bussink, Johan, Sotelo, Julio, Theys, Jan, Lammering, Guido, Rouschop, Kasper M. A.

Source: Autophagy. 14(2):283-295

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100062590621.0x000001&indx=1&recIds=ETOCvdc_100062590621.0x000001

Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer.

Authors: Sánchez-Castillo, Anaís, Heylen, Elien, Hounjet, Judith, Savelkouls, Kim G., Lieuwes, Natasja G., Biemans, Rianne, Dubois, Ludwig J., Reynders, Kobe, Rouschop, Kasper M., Vaes, Rianne D. W., De Keersmaecker, Kim, Lambrecht, Maarten, Hendriks, Lizza E. L., De Ruysscher, Dirk K. M., Vooijs, Marc, Kampen, Kim R.

Source: British Journal of Cancer; Mar2024, Vol. 130 Issue 4, p568-584, 17p

Secretion of pro‐angiogenic extracellular vesicles during hypoxia is dependent on the autophagy‐related protein GABARAPL1

Authors: Keulers, Tom G., Libregts, Sten F., Beaumont, Joel E.J., Savelkouls, Kim G., Bussink, Johan, Duimel, Hans, Dubois, Ludwig, Zonneveld, Marijke I., López‐Iglesias, Carmen, Bezstarosti, Karel, Demmers, Jeroen A., Vooijs, Marc, Wauben, Marca, Rouschop, Kasper M.A.

Source: Journal of extracellular vesicles. 10(14)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139377463.0x000001&indx=1&recIds=ETOCvdc_100139377463.0x000001

Immunoregulatory gene polymorphisms are associated with ANCA-related vasculitis

Authors: Slot, Marjan C., Sokolowska, Milena G., Savelkouls, Kim G., Janssen, Rob G.J.H., Damoiseaux, Jan G.M.C., Cohen Tervaert, Jan Willem

Source: In Clinical Immunology 2008 128(1):39-45

Correction: Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer.

Authors: Sánchez-Castillo, Anaís, Heylen, Elien, Hounjet, Judith, Savelkouls, Kim G., Lieuwes, Natasja G., Biemans, Rianne, Dubois, Ludwig J., Reynders, Kobe, Rouschop, Kasper M., Vaes, Rianne D. W., De Keersmaecker, Kim, Lambrecht, Maarten, Hendriks, Lizza E. L., De Ruysscher, Dirk K. M., Vooijs, Marc, Kampen, Kim R.

Source: British Journal of Cancer; Mar2024, Vol. 130 Issue 4, p701-701, 1p

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