Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium

Authors: Brouwer, Kim L.R., Evers, Raymond, Hayden, Elizabeth, Hu, Shuiying, Li, Cindy Yanfei, Meyer zu Schwabedissen, Henriette E., Neuhoff, Sibylle, Oswald, Stefan, Piquette‐Miller, Micheline, Saran, Chitra, Sjöstedt, Noora, Sprowl, Jason A., Stahl, Simone H., Yue, Wei

Source: Clinical pharmacology & therapeutics. 112(3):461-484

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100158381727.0x000001&indx=1&recIds=ETOCvdc_100158381727.0x000001

Novel Bile Acid-Dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors

Authors: Saran, Chitra, Sundqvist, Louise, Ho, Henry, Niskanen, Jonna, Honkakoski, Paavo, Brouwer, Kim L.R. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics February 2022 380(2):114-125

Endogenous Coproporphyrin I and III are Altered in Multidrug Resistance-Associated Protein 2-Deficient (TR−) Rats

Authors: Bezençon, Jacqueline, Saran, Chitra, Hussner, Janine, Beaudoin, James J., Zhang, Yueping, Shen, Hong, Fallon, John K., Smith, Philip C., Meyer zu Schwabedissen, Henriette E., Brouwer, Kim L.R.

Source: In Journal of Pharmaceutical Sciences January 2021 110(1):404-411

Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions

Authors: Kang, Hee Eun, Malinen, Melina M., Saran, Chitra, Honkakoski, Paavo, Brouwer, Kim L.R. ^*

Source: In Drug Metabolism and Disposition October 2019 47(10):1222-1230

CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma

Authors: Ross, Nathan T., Lohmann, Felix, Carbonneau, Seth, Fazal, Aleem, Weihofen, Wilhelm A., Gleim, Scott, Salcius, Michael, Sigoillot, Frederic, Henault, Martin, Carl, Sarah H., Rodríguez-Molina, Juan B., Miller, Howard R., Brittain, Scott M., Murphy, Jason, Zambrowski, Mark, Boynton, Geoffrey, Wang, Yuan, Chen, Aye, Molind, Gregory J., Wilbertz, Johannes H., Artus-Revel, Caroline G., Jia, Min, Akinjiyan, Favour A., Turner, Jonathan, Knehr, Judith, Carbone, Walter, Schuierer, Sven, Reece-Hoyes, John S., Xie, Kevin, Saran, Chitra, Williams, Eric T., Roma, Guglielmo, Spencer, Matt, Jenkins, Jeremy, George, Elizabeth L., Thomas, Jason R., Michaud, Gregory, Schirle, Markus, Tallarico, John, Passmore, Lori A., Chao, Jeffrey A., Beckwith, Rohan E. J.

Source: Nature chemical biology. 16(1):50-59

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193389809.0x000001&indx=1&recIds=ETOCvdc_100193389809.0x000001

A novel differentiated HuH-7 cell model to examine bile acid metabolism, transport and cholestatic hepatotoxicity.

Authors: Saran, Chitra^1,2 (AUTHOR), Fu, Dong² (AUTHOR), Ho, Henry² (AUTHOR), Klein, Abigail² (AUTHOR), Fallon, John K.³ (AUTHOR), Honkakoski, Paavo^2,4 (AUTHOR), Brouwer, Kim L. R.² (AUTHOR) kbrouwer@unc.edu

Source: Scientific Reports. 8/22/2022, Vol. 12 Issue 1, p1-14. 14p.

Subject Terms: *BILE acids, *BILE salts, *ENTEROHEPATIC circulation, *HEPATOTOXICOLOGY, *LIVER cells, *CYTOCHROME P-450, *BILE, *FARNESOID X receptor

Ocular Metabolism of Levobunolol: Historic and Emerging Metabolic Pathways

Authors: Argikar, Upendra A. ^*, Dumouchel, Jennifer L., Dunne, Christine E., Saran, Chitra, Cirello, Amanda L., Gunduz, Mithat

Source: In Drug Metabolism and Disposition August 2016 44(8):1304-1312

A Comparison of LC-MS/MS and a Fully Integrated Autosampler/Solid-Phase Extraction System for the Analysis of Protein Binding Samples

Authors: Amaral, Adam ^*, Saran, Chitra ^{*, **}, Amin, Jakal, Hatsis, Panos

Source: In SLAS Discovery July 2016 21(6):620-625

Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity.

Authors: Saran, Chitra¹ (AUTHOR), Brouwer, Kim L. R.² (AUTHOR) kbrouwer@unc.edu

Source: Toxicologic Pathology. Oct2023, Vol. 51 Issue 7/8, p405-413. 9p.

Subject Terms: *BILE acids, *FARNESOID X receptor, *DRUG side effects, *PROTEIN-tyrosine kinase inhibitors, *HEPATOTOXICOLOGY, *GENETIC mutation

Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro.

Authors: Saran, Chitra, Ho, Henry, hHonkakoski, Paavo, Brouwer, Kim L. R.

Source: Frontiers in Pharmacology; 3/22/2023, Vol. 14, p01-10, 10p

Subject Terms: MTOR inhibitors, HEPATITIS D virus, FARNESOID X receptor, HEPATITIS B virus, IMMUNOSUPPRESSIVE agents, SODIUM, MACROCYCLIC compounds

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Biotransformation and bioactivation reactions – 2016 literature highlights.

Authors: Khojasteh, S. Cyrus, Rietjens, Ivonne M. C. M., Dalvie, Deepak, Miller, Grover, Argikar, Upendra A., Dumouchel, Jennifer L., Dunne, Christine E., Saran, Chitra, Cirello, Amanda L., Gunduz, Mithat, Dekker, Stefan J., Zhang, Yongjie, Chris Vos, J., Vermeulen, Nico P. E., Commandeur, Jan N. M., Scian, Michele, Guttman, Miklos, Bouldin, Samantha D., Outten, Caryn E., Atkins, William M.

Source: Drug Metabolism Reviews; Aug2017, Vol. 49 Issue 3, p285-317, 33p

Subject Terms: BIOTRANSFORMATION (Metabolism), CYTOCHROME P-450, DRUG metabolism, CHEMICAL research, TOXICOLOGY

Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer.

Authors: Burks, Heather E., Abrams, Tinya, Kirby, Christina A., Baird, Jason, Fekete, Alexander, Hamann, Lawrence G., Kim, Sunkyu, Lombardo, Franco, Loo, Alice, Lubicka, Danuta, Macchi, Kaitlin, McDonnell, Donald P., Mishina, Yuji, Norris, John D., Nunez, Jill, Saran, Chitra, Sun, Yingchuan, Thomsen, Noel M., Chunrong Wang, Jianling Wang

Source: Journal of Medicinal Chemistry; 4/13/2017, Vol. 60 Issue 7, p2790-2818, 29p

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Author Correction: CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma

Authors: Ross, Nathan T., Lohmann, Felix, Carbonneau, Seth, Fazal, Aleem, Weihofen, Wilhelm A., Gleim, Scott, Salcius, Michael, Sigoillot, Frederic, Henault, Martin, Carl, Sarah H., Rodríguez-Molina, Juan B., Miller, Howard R., Brittain, Scott M., Murphy, Jason, Zambrowski, Mark, Boynton, Geoffrey, Wang, Yuan, Chen, Aye, Molind, Gregory J., Wilbertz, Johannes H., Artus-Revel, Caroline G., Jia, Min, Akinjiyan, Favour A., Turner, Jonathan, Knehr, Judith, Carbone, Walter, Schuierer, Sven, Reece-Hoyes, John S., Xie, Kevin, Saran, Chitra, Williams, Eric T., Roma, Guglielmo, Spencer, Matt, Jenkins, Jeremy, George, Elizabeth L., Thomas, Jason R., Michaud, Gregory, Schirle, Markus, Tallarico, John, Passmore, Lori A., Chao, Jeffrey A., Beckwith, Rohan E. J.

Source: Nature Chemical Biology; April 2020, Vol. 16 Issue: 4 p479-479, 1p