De novo lipogenesis protects dormant breast cancer cells from ferroptosis and promotes metastasis

Authors: Beatriz Puente-Cobacho, Cintia Esteo, Patricia Altea-Manzano, Jose Luis Garcia-Perez, José L. Quiles, Pedro Sanchez-Rovira, María D. Martín-Salvago, Lucía Molina-Jiménez, Rafael J. Luque, Sarah-Maria Fendt, Laura Vera-Ramirez

Source: Redox Biology, Vol 80, Iss , Pp 103480- (2025)

Subject Terms: Tumor cell dormancy, Breast cancer, Metastasis, Lipid peroxidation, Lipid metabolism, Ferroptosis, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231724004580; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/5fbe88cfe8124491a3760da88518d80f

Plasma Iron Levels at Early Breast Cancer Diagnosis Are Associated With Development of Secondary Metastases: A Single-Center Retrospective Cohort Study

Authors: Jasmine De Troy, Sarah-Maria Fendt, Sigrid Hatse, Patrick Neven, Ann Smeets, Annouschka Laenen, Hans Wildiers

Source: Breast Cancer: Basic and Clinical Research, Vol 19 (2025)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1178-2234

Access URL: https://doaj.org/article/ab434d4a6785471c9297d6cc4775c1ba

miR-449a/miR-340 reprogram cell identity and metabolism in fusion-negative rhabdomyosarcoma

Authors: Enrico Pozzo, Laura Yedigaryan, Nefele Giarratana, Chao-chi Wang, Gabriel Miró Garrido, Ewoud Degreef, Vittoria Marini, Gianmarco Rinaldi, Bernard K. van der Veer, Gabriele Sassi, Guy Eelen, Mélanie Planque, Alessandro Fanzani, Kian Peng Koh, Peter Carmeliet, Jason T. Yustein, Sarah-Maria Fendt, Anne Uyttebroeck, Maurilio Sampaolesi

Source: Cell Reports, Vol 44, Iss 1, Pp 115171- (2025)

Subject Terms: CP: Cancer, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124724015225; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/6c789bd664d445469e5a2489c7cb0b99

mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism

Authors: Tal Levy, Kai Voeltzke, Laura Hruby, Khawla Alasad, Zuelal Bas, Marteinn Snaebjörnsson, Ran Marciano, Katerina Scharov, Mélanie Planque, Kim Vriens, Stefan Christen, Cornelius M. Funk, Christina Hassiepen, Alisa Kahler, Beate Heider, Daniel Picard, Jonathan K. M. Lim, Anja Stefanski, Katja Bendrin, Andres Vargas-Toscano, Ulf D. Kahlert, Kai Stühler, Marc Remke, Moshe Elkabets, Thomas G. P. Grünewald, Andreas S. Reichert, Sarah-Maria Fendt, Almut Schulze, Guido Reifenberger, Barak Rotblat, Gabriel Leprivier

Source: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b77120ef8e324fda80f5122560600dc1

Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program

Authors: Tatjana Geukens, Maxim De Schepper, Wouter Van Den Bogaert, Karen Van Baelen, Marion Maetens, Anirudh Pabba, Amena Mahdami, Sophia Leduc, Edoardo Isnaldi, Ha-Linh Nguyen, Imane Bachir, Maysam Hajipirloo, Gitte Zels, Josephine Van Cauwenberge, Kristien Borremans, Vincent Vandecaveye, Birgit Weynand, Peter Vermeulen, Eleonora Leucci, Maria Francesca Baietti, George Sflomos, Laura Battista, Cathrin Brisken, Patrick W. B. Derksen, Thijs Koorman, Daan Visser, Colinda L. G. J. Scheele, Daniela S. Thommen, Sigrid Hatse, Sarah-Maria Fendt, Evy Vanderheyden, Thomas Van Brussel, Rogier Schepers, Bram Boeckx, Diether Lambrechts, Giuseppe Marano, Elia Biganzoli, Ann Smeets, Ines Nevelsteen, Kevin Punie, Patrick Neven, Hans Wildiers, François Richard, Giuseppe Floris, Christine Desmedt

Source: npj Breast Cancer, Vol 10, Iss 1, Pp 1-14 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2374-4677

Access URL: https://doaj.org/article/64acb1b4e34a40a5a3f7576042fa573b

The novel family of Warbicin® compounds inhibits glucose uptake both in yeast and human cells and restrains cancer cell proliferation

Authors: Ward Vanthienen, Juan Fernández-García, Maria Francesca Baietti, Elisa Claeys, Frederik Van Leemputte, Long Nguyen, Vera Goossens, Quinten Deparis, Dorien Broekaert, Sophie Vlayen, Dominique Audenaert, Michel Delforge, Alessandro D’Amuri, Griet Van Zeebroeck, Eleonora Leucci, Sarah-Maria Fendt, Johan M. Thevelein

Source: Frontiers in Oncology, Vol 14 (2024)

Subject Terms: glucose uptake, yeast, cancer cells, Warburg effect, transport-associated phosphorylation, synthetic inhibitors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1411983/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/a8c6508b076646c7a024f4d85755eb93

HIF1α-dependent uncoupling of glycolysis suppresses tumor cell proliferation

Authors: Andrés A. Urrutia, Claudia Mesa-Ciller, Andrea Guajardo-Grence, H. Furkan Alkan, Inés Soro-Arnáiz, Anke Vandekeere, Ana Margarida Ferreira Campos, Sebastian Igelmann, Lucía Fernández-Arroyo, Gianmarco Rinaldi, Doriane Lorendeau, Katrien De Bock, Sarah-Maria Fendt, Julián Aragonés

Source: Cell Reports, Vol 43, Iss 4, Pp 114103- (2024)

Subject Terms: CP: Cancer, CP: Metabolism, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124724004315; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/df60877c819f4259a9847dd08cbb7f8b

Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy

Authors: Ali Talebi, Vincent de Laat, Xander Spotbeen, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, Frank Vanderhoydonc, Lara Rizotto, Mélanie Planque, Ginevra Doglioni, Sahar Motamedi, David Nittner, Tania Roskams, Patrizia Agostinis, Oliver Bechter, Veerle Boecxstaens, Marjan Garmyn, Marie O’Farrell, Alan Wagman, George Kemble, Eleonora Leucci, Sarah-Maria Fendt, Jean-Christophe Marine, Johannes V. Swinnen

Source: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-16 (2023)

Subject Terms: Lipid metabolism, Therapy resistance, Melanoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/8829970c22234a53b950a2b7f4311f51

Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution

Authors: Johannes Robert Fleischer, Alexandra Maria Schmitt, Gwendolyn Haas, Xingbo Xu, Elisabeth Maria Zeisberg, Hanibal Bohnenberger, Stefan Küffer, Laure-Anne Teuwen, Philipp Johannes Karras, Tim Beißbarth, Annalen Bleckmann, Mélanie Planque, Sarah-Maria Fendt, Peter Vermeulen, Michael Ghadimi, Joanna Kalucka, Tiago De Oliveira, Lena-Christin Conradi

Source: Molecular Cancer, Vol 22, Iss 1, Pp 1-22 (2023)

Subject Terms: Colorectal cancer liver metastases, Histopathological growth patterns, Vessel co-option, Sprouting angiogenesis, Glycolysis, WNT signalling, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/380114cc6bdc4ae19d7ea19ff089eb9c

PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma

Authors: Emma Phillips, Jörg Balss, Frederic Bethke, Stefan Pusch, Stefan Christen, Thomas Hielscher, Martina Schnölzer, Michael N. C. Fletcher, Antje Habel, Claudia Tessmer, Lisa-Marie Brenner, Mona Göttmann, David Capper, Christel Herold-Mende, Andreas von Deimling, Sarah-Maria Fendt, Violaine Goidts

Source: Oncogenesis, Vol 11, Iss 1, Pp 1-12 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2157-9024

Access URL: https://doaj.org/article/a08fd162f6184b9cb768a5cefba94123

Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers

Authors: Tom Van Nyen, Mélanie Planque, Lilian van Wagensveld, Joao A. G. Duarte, Esther A. Zaal, Ali Talebi, Matteo Rossi, Pierre-René Körner, Lara Rizzotto, Stijn Moens, Wout De Wispelaere, Regina E. M. Baiden-Amissah, Gabe S. Sonke, Hugo M. Horlings, Guy Eelen, Emanuele Berardi, Johannes V. Swinnen, Celia R. Berkers, Peter Carmeliet, Diether Lambrechts, Ben Davidson, Reuven Agami, Sarah-Maria Fendt, Daniela Annibali, Frédéric Amant

Source: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ea6155ed60d848d191feda4d57429fb3

Combining the antianginal drug perhexiline with chemotherapy induces complete pancreatic cancer regression in vivo

Authors: Gabriela Reyes-Castellanos, Nadine Abdel Hadi, Scarlett Gallardo-Arriaga, Rawand Masoud, Julie Garcia, Sophie Lac, Abdessamad El Kaoutari, Tristan Gicquel, Mélanie Planque, Sarah-Maria Fendt, Laetitia Karine Linares, Odile Gayet, Fabienne Guillaumond, Nelson Dusetti, Juan Iovanna, Alice Carrier

Source: iScience, Vol 26, Iss 6, Pp 106899- (2023)

Subject Terms: Biological sciences, Cancer systems biology, Cancer, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004223009768; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/a215de16132949808608621f7b7c9ed6

Diet-induced loss of adipose hexokinase 2 correlates with hyperglycemia

Authors: Mitsugu Shimobayashi, Amandine Thomas, Sunil Shetty, Irina C Frei, Bettina K Wölnerhanssen, Diana Weissenberger, Anke Vandekeere, Mélanie Planque, Nikolaus Dietz, Danilo Ritz, Anne Christin Meyer-Gerspach, Timm Maier, Nissim Hay, Ralph Peterli, Sarah-Maria Fendt, Nicolas Rohner, Michael N Hall

Source: eLife, Vol 12 (2023)

Subject Terms: obesity, glucose, lipid metabolism, adipose tissue, diabetes, selective insulin resistance, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/85103; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/c1e2768af6504e0cbd38f53c60cca042

Metabolite-derived protein modifications modulating oncogenic signaling

Authors: Yawen Liu, Anke Vandekeere, Min Xu, Sarah-Maria Fendt, Patricia Altea-Manzano

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: tumor suppressor gene, post-translational modification, metabolites, tumor microenvironment, oncogenic signaling, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.988626/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/34bcaf3d66e34ed29b4a2b7591601221

GBM tumors are heterogeneous in their fatty acid metabolism and modulating fatty acid metabolism sensitizes cancer cells derived from recurring GBM tumors to temozolomide

Authors: Sweta Parik, Juan Fernández-García, Francesca Lodi, Karen De Vlaminck, Marleen Derweduwe, Steven De Vleeschouwer, Raf Sciot, Wietse Geens, Linqian Weng, Francesca Maria Bosisio, Gabriele Bergers, Johnny Duerinck, Frederick De Smet, Diether Lambrechts, Jo A. Van Ginderachter, Sarah-Maria Fendt

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: glioblastoma, fatty acid metabolism, lipotoxicity, SCD1, FADS2, tumor heterogeneity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.988872/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/9b367757c6e54473af57787cad0920a8

Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle

Authors: Guillaume Tournaire, Shauni Loopmans, Steve Stegen, Gianmarco Rinaldi, Guy Eelen, Sophie Torrekens, Karen Moermans, Peter Carmeliet, Bart Ghesquière, Bernard Thienpont, Sarah-Maria Fendt, Nick van Gastel, Geert Carmeliet

Source: Cell Reports, Vol 40, Iss 4, Pp 111105- (2022)

Subject Terms: CP: Metabolism, CP: Stem cell research, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221112472200907X; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/1c265b47dd804462b08881f936fd1519

2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer

Authors: Arnaud Blomme, Catriona A. Ford, Ernest Mui, Rachana Patel, Chara Ntala, Lauren E. Jamieson, Mélanie Planque, Grace H. McGregor, Paul Peixoto, Eric Hervouet, Colin Nixon, Mark Salji, Luke Gaughan, Elke Markert, Peter Repiscak, David Sumpton, Giovanny Rodriguez Blanco, Sergio Lilla, Jurre J. Kamphorst, Duncan Graham, Karen Faulds, Gillian M. MacKay, Sarah-Maria Fendt, Sara Zanivan, Hing Y. Leung

Source: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/2a468699bc1a4fa682a39a1ff7c055bc

Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines

Authors: Ruben Boon, Manoj Kumar, Tine Tricot, Ilaria Elia, Laura Ordovas, Frank Jacobs, Jennifer One, Jonathan De Smedt, Guy Eelen, Matthew Bird, Philip Roelandt, Ginevra Doglioni, Kim Vriens, Matteo Rossi, Marta Aguirre Vazquez, Thomas Vanwelden, François Chesnais, Adil El Taghdouini, Mustapha Najimi, Etienne Sokal, David Cassiman, Jan Snoeys, Mario Monshouwer, Wei-Shou Hu, Christian Lange, Peter Carmeliet, Sarah-Maria Fendt, Catherine M. Verfaillie

Source: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0a789642bd074590a245141b427513bf

Differentiation but not ALS mutations in FUS rewires motor neuron metabolism

Authors: Tijs Vandoorne, Koen Veys, Wenting Guo, Adria Sicart, Katlijn Vints, Ann Swijsen, Matthieu Moisse, Guy Eelen, Natalia V. Gounko, Laura Fumagalli, Raheem Fazal, Christine Germeys, Annelies Quaegebeur, Sarah-Maria Fendt, Peter Carmeliet, Catherine Verfaillie, Philip Van Damme, Bart Ghesquière, Katrien De Bock, Ludo Van Den Bosch

Source: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/fa80c26ad33443938150866628a1b0dd

Metabolic vulnerabilities of metastasizing cancer cells

Authors: Sarah-Maria Fendt

Source: BMC Biology, Vol 17, Iss 1, Pp 1-4 (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12915-019-0672-2; https://doaj.org/toc/1741-7007

Access URL: https://doaj.org/article/cadaffc94d6d4ede8fb647da99e626fc