LARP1 haploinsufficiency is associated with an autosomal dominant neurodevelopmental disorder

Authors: James Chettle, Raymond J. Louie, Olivia Larner, Robert Best, Kevin Chen, Josephine Morris, Zinaida Dedeic, Anna Childers, R. Curtis Rogers, Barbara R. DuPont, Cindy Skinner, Sébastien Küry, Kevin Uguen, Marc Planes, Danielle Monteil, Megan Li, Aviva Eliyahu, Lior Greenbaum, Nofar Mor, Thomas Besnard, Bertrand Isidor, Benjamin Cogné, Alyssa Blesson, Anne Comi, Ingrid M. Wentzensen, Blake Vuocolo, Seema R. Lalani, Roberta Sierra, Lori Berry, Kent Carter, Stephan J. Sanders, Sarah P. Blagden

Source: HGG Advances, Vol 5, Iss 4, Pp 100345- (2024)

Subject Terms: LARP1, autism, ASD, NDD, neurodevelopmental, metabolism, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S266624772400085X; https://doaj.org/toc/2666-2477

Access URL: https://doaj.org/article/e0e49cd5da4340678f3756e671807267

A phase I open-label, dose-escalation study of NUC-3373, a targeted thymidylate synthase inhibitor, in patients with advanced cancer (NuTide:301)

Authors: Pavlina Spiliopoulou, Farasat Kazmi, Francesca Aroldi, Thomas Holmes, David Thompson, Lucinda Griffiths, Cathy Qi, Matthew Parkes, Simon Lord, Gareth J. Veal, David J. Harrison, Vicky M. Coyle, Jill Graham, Thomas R. Jeffry Evans, Sarah P. Blagden

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-16 (2024)

Subject Terms: NUC-3373, 5-FU, 5-fluorouracil, Fluoropyrimidines, Thymidylate synthase, Resistant cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/8de199adb6da4ff4b44e74190f835493

Cancer Precision-Prevention trial of Metformin in adults with Li Fraumeni syndrome (MILI) undergoing yearly MRI surveillance: a randomised controlled trial protocol

Authors: Miriam Dixon-Zegeye, Rachel Shaw, Linda Collins, Kendra Perez-Smith, Alexander Ooms, Maggie Qiao, Pan Pantziarka, Louise Izatt, Marc Tischkowitz, Rachel E. Harrison, Angela George, Emma R. Woodward, Simon Lord, Lara Hawkes, D. Gareth Evans, James Franklin, Helen Hanson, Sarah P. Blagden

Source: Trials, Vol 25, Iss 1, Pp 1-14 (2024)

Subject Terms: Metformin, Li-Fraumeni syndrome, LFS, Cancer, p53, TP53, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/cf49679192c94035afcc32e77d21fae6

Adipocyte-like signature in ovarian cancer minimal residual disease identifies metabolic vulnerabilities of tumor-initiating cells

Authors: Mara Artibani, Kenta Masuda, Zhiyuan Hu, Pascal C. Rauher, Garry Mallett, Nina Wietek, Matteo Morotti, Kay Chong, Mohammad KaramiNejadRanjbar, Christos E. Zois, Sunanda Dhar, Salma El-Sahhar, Leticia Campo, Sarah P. Blagden, Stephen Damato, Pubudu N. Pathiraja, Shibani Nicum, Fergus Gleeson, Alexandros Laios, Abdulkhaliq Alsaadi, Laura Santana Gonzalez, Takeshi Motohara, Ashwag Albukhari, Zhen Lu, Robert C. Bast Jr., Adrian L. Harris, Christer S. Ejsing, Robin W. Klemm, Christopher Yau, Tatjana Sauka-Spengler, Ahmed Ashour Ahmed

Source: JCI Insight, Vol 6, Iss 11 (2021)

Subject Terms: Oncology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/aed4f3377d6c477db1f5a1a0d72b84ea

An inflammation based score can optimize the selection of patients with advanced cancer considered for early phase clinical trials.

Authors: David J Pinato, Chara Stavraka, Michael J Flynn, Martin D Forster, Séan M O'Cathail, Michael J Seckl, Rebecca S Kristeleit, David Olmos, Samantha J Turnbull, Sarah P Blagden

Source: PLoS ONE, Vol 9, Iss 1, p e83279 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3883636?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/2edb1a12d61e4577bf54b5381ef4a2ae

First-in-human phase I/II, open-label study of the anti-OX40 agonist INCAGN01949 in patients with advanced solid tumors

Authors: Rebecca Kristeleit, Juan Martin-Liberal, Kristen Spencer, Janice M Mehnert, Maria Vieito, Elizabeth J Davis, Angela Orcurto, Thomas Condamine, Daniel C Cho, Jennifer Pulini, Rowan E Miller, Sarah P Blagden, Dominik Berthold, Dana B Cardin, Prashanth Hari Dass, John E Janik, Jason Clark, Xuejun Chen

Source: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 10 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/10/10/e004235.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/ac1ed19fc2ac410aa1aabfc845b35fef

La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

Authors: Roni M Lahr, Bruno D Fonseca, Gabrielle E Ciotti, Hiba A Al-Ashtal, Jian-Jun Jia, Marius R Niklaus, Sarah P Blagden, Tommy Alain, Andrea J Berman

Source: eLife, Vol 6 (2017)

Subject Terms: TOP mRNAs, 5' cap, La-related protein 1, eIF4E, RNA binding protein, X-ray crystallography, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/24146; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/52cd9152533a46c6bc990f5a688837bf