Guselkumab binding to CD64⁺ IL-23–producing myeloid cells enhances potency for neutralizing IL-23 signaling.

Authors: Sachen, Kacey L., Hammaker, Deepa, Sarabia, Indra, Stoveken, Brian, Hartman, John, Leppard, Kristin L., Manieri, Nicholas A., Bao, Phuc, Greving, Carrie, Lacy, Eilyn R., DuPrie, Matthew, Wertheimer, Joshua, Deming, Janise D., Brown, Joseph, Hart, Amy, Li, He, Freeman, Tom C., Keyes, Brice, Kohler, Kristen, White, Ian

Source: Frontiers in Immunology; 2025, p1-18, 18p

Subject Terms: MYELOID cells, FC receptors, RNA sequencing, CELL communication, FLOW cytometry

Su1743 GUSELKUMAB BINDING TO CD64+ IL-23–PRODUCING MYELOID CELLS ENHANCES POTENCY FOR NEUTRALIZING IL-23 SIGNALING

Authors: Abreu, Maria T., Atreya, Raja, Krueger, James G., Eyerich, Kilian, Greving, Carrie, Hammaker, Deepa, Stoveken, Brian, Hartman, John, Leppard, Kristin L., Sarabia, Indra, Wertheimer, Joshua, Deming, Janise, Kohler, Kristen, Li, He (., Freeman, Tom C., Hart, Amy, Keyes, Brice, Ritchlin, Christopher, McInnes, Iain B., Allez, Matthieu, Fourie, Anne M., Sachen, Kacey

Source: In Gastroenterology 18-21 May 2024 166(5) Supplement:S

Human splice factors contribute to latent HIV infection in primary cell models and blood CD4⁺ T cells from ART-treated individuals.

Authors: Moron-Lopez, Sara^1,2, Telwatte, Sushama^1,2, Sarabia, Indra³, Battivelli, Emilie⁴, Montano, Mauricio⁵, Macedo, Amanda B.³, Aran, Dvir¹, Butte, Atul J.¹, Jones, R. Brad⁶, Bosque, Alberto³, Verdin, Eric⁴, Greene, Warner C.^1,5, Wong, Joseph K.^1,2, Yukl, Steven A.^1,2, steven.yukl@ucsf.edu

Source: PLoS Pathogens; 11/30/2020, Vol. 16 Issue 11, p1-27, 27p

769 GUSELKUMAB, AN IL-23P19 SUBUNIT-SPECIFIC MONOCLONAL ANTIBODY, BINDS CD64+ MYELOID CELLS AND POTENTLY NEUTRALIZES IL-23 PRODUCED FROM THE SAME CELLS

Authors: Abreu, Maria T., Atreya, Raja, Krueger, James G., Eyerich, Kilian, Sachen, Kacey, Greving, Carrie, Hammaker, Deepa, Bao, Phuc, Lacy, Eilyn, Sarabia, Indra, Deming, Janise, Elloso, M. Merle, Ritchlin, Christopher, McInnes, Iain B., Allez, Matthieu, Fourie, Anne

Source: In Gastroenterology May 2023 164(6) Supplement:S

Activation of the Anti-Oxidative Stress Response Reactivates Latent HIV-1 Through the Mitochondrial Antiviral Signaling Protein Isoform MiniMAVS.

Authors: Sarabia, Indra, Novis, Camille L., Macedo, Amanda B., Takata, Hiroshi, Nell, Racheal, Kakazu, Juyeon C., Furler, Robert L., Shakya, Binita, Schubert, Heidi L., Hill, Christopher P., DePaula-Silva, Ana Beatriz, Spivak, Adam M., Trautmann, Lydie, Planelles, Vicente, Bosque, Alberto

Source: Frontiers in Immunology; 6/14/2021, Vol. 12, p1-18, 18p

Subject Terms: HIV, VIRUS diseases, MITOCHONDRIA, CELL death, T cells, NATURAL immunity, CELL communication

The Intact Noninducible Latent HIV-1 Reservoir Is Established in an In Vitro Primary TCM Cell Model of Latency.

Authors: Sarabia, Indra¹, Szu-Han Huang², Ward, Adam R.^1,2, Jones, R. Brad^1,2, Bosque, Alberto¹ abosque@gwu.edu

Source: Journal of Virology. Apr2021, Vol. 95 Issue 7, p1-16. 16p.

Subject Terms: *HIV, *PROTEIN kinase C, *T cell receptors, *PRIMARY cell culture, *HISTONE deacetylase

PLGA nanodepots co-encapsulating prostratin and anti-CD25 enhance primary natural killer cell antiviral and antitumor function.

Authors: Sweeney, Elizabeth E., Balakrishnan, Preethi B., Powell, Allison B., Bowen, Allan, Sarabia, Indra, Burga, Rachel A., Jones, R. Brad, Bosque, Alberto, Cruz, C. Russell Y., Fernandes, Rohan

Source: Nano Research; Mar2020, Vol. 13 Issue 3, p736-744, 9p

HIV-1 Latency and Latency Reversal: Does Subtype Matter?

Authors: Sarabia, Indra¹ (AUTHOR) sarabia@email.gwu.edu, Bosque, Alberto¹ (AUTHOR) abosque@gwu.edu

Source: Viruses (1999-4915). Dec2019, Vol. 11 Issue 12, p1104-1104. 1p.

Subject Terms: *VIRAL replication, *PATHOLOGY, *ANTIRETROVIRAL agents, *MATTER, *VARICELLA-zoster virus

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