It is time for a moonshot to find “Cures” for diabetic retinal disease

Authors: Levine, S. Robert, Sapieha, Przemyslaw, Dutta, Sanjoy, Sun, Jennifer K., Gardner, Thomas W.

Source: In Progress in Retinal and Eye Research September 2022 90

Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition

Authors: Crespo-Garcia, Sergio, Tsuruda, Pamela R., Dejda, Agnieszka, Ryan, Rathi D., Fournier, Frederik, Chaney, Shawnta Y., Pilon, Frederique, Dogan, Taner, Cagnone, Gael, Patel, Priyanka, Buscarlet, Manuel, Dasgupta, Sonali, Girouard, Gabrielle, Rao, Surabhi R., Wilson, Ariel M., O’Brien, Robert, Juneau, Rachel, Guber, Vera, Dubrac, Alexandre, Beausejour, Christian, Armstrong, Scott, Mallette, Frederick A., Yohn, Christopher B., Joyal, Jean-Sebastien, Marquess, Dan, Beltran, Pedro J., Sapieha, Przemyslaw

Source: In Cell Metabolism 6 April 2021 33(4):818-832

Corticosteroids reduce pathological angiogenesis yet compromise reparative vascular remodeling in a model of retinopathy.

Authors: Hata, Masayuki, Hata, Maki, Dejda, Agnieszka, Pilon, Frédérique, Diaz-Marin, Roberto, Fournier, Frédérik, Joyal, Jean-Sebastien, Cagnone, Gael, Yotaro Ochi, Crespo-Garcia, Sergio, Wilson, Ariel M., Sapieha, Przemyslaw

Source: Proceedings of the National Academy of Sciences of the United States of America; 12/24/2024, Vol. 121 Issue 52, p1-6, 14p

Subject Terms: MACULAR degeneration, MYELOID cells, VASCULAR remodeling, DIABETIC retinopathy, RETROLENTAL fibroplasia

The 10q26 Risk Haplotype of Age-Related Macular Degeneration Aggravates Subretinal Inflammation by Impairing Monocyte Elimination

Authors: Beguier, Fanny, Housset, Michael, Roubeix, Christophe, Augustin, Sebastien, Zagar, Yvrick, Nous, Caroline, Mathis, Thibaud, Eandi, Chiara, Benchaboune, Mustapha, Drame-Maigné, Adèle, Carpentier, Wassila, Chardonnet, Solenne, Touhami, Sara, Blot, Guillaume, Conart, Jean Baptiste, Charles-Messance, Hugo, Potey, Anaïs, Girmens, Jean-François, Paques, Michel, Blond, Fréderic, Leveillard, Thierry, Koertvely, Elod, Roger, Jerome E., Sahel, José-Alain, Sapieha, Przemyslaw, Delarasse, Cécile, Guillonneau, Xavier, Sennlaub, Florian

Source: In Immunity 18 August 2020 53(2):429-441

The effects of anti‐VEGF and kinin B1 receptor blockade on retinal inflammation in laser‐induced choroidal neovascularization

Authors: Hachana, Soumaya, Fontaine, Olivier, Sapieha, Przemyslaw, Lesk, Mark, Couture, Réjean, Vaucher, Elvire

Source: British journal of pharmacology. 177(9):1949-1966

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107063655.0x000001&indx=1&recIds=ETOCvdc_100107063655.0x000001

The protein tyrosine phosphatase PTPRJ/DEP-1 contributes to the regulation of the Notch-signaling pathway and sprouting angiogenesis

Authors: Fournier, Patrick, Viallard, Claire, Dejda, Agnieszka, Sapieha, Przemyslaw, Larrivée, Bruno, Royal, Isabelle

Source: Angiogenesis. 23(2):145-157

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168238416.0x000001&indx=1&recIds=ETOCvdc_100168238416.0x000001

NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy

Authors: Miloudi, Khalil, Oubaha, Malika, Ménard, Catherine, Dejda, Agnieszka, Guber, Vera, Cagnone, Gael, Wilson, Ariel M., Tétreault, Nicolas, Mawambo, Gaëlle, Binet, Francois, Chidiac, Rony, Delisle, Chantal, Buscarlet, Manuel, Cerani, Agustin, Crespo-Garcia, Sergio, Bentley, Katie, Rezende, Flavio, Joyal, Jean-Sebastien, Mallette, Frédérick A., Gratton, Jean-Philippe, Larrivée, Bruno, Sapieha, Przemyslaw

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Mar 01. 116(10), 4538-4547.

Access URL: https://www.jstor.org/stable/26683126

Multifocal Electroretinography Changes after UBX1325 (Foselutoclax) Treatment in Neovascular Age-Related Macular Degeneration.

Authors: Macha, Nathan, Yu, Minzhong, Sapieha, Przemyslaw, Klier, Sharon, Ghosh, Anirvan, White, Lorraine, Maturi, Raj K.

Source: Journal of Clinical Medicine; Sep2024, Vol. 13 Issue 18, p5540, 12p

Subject Terms: MACULAR degeneration, ENDOTHELIAL growth factors, INTRAVITREAL injections, ELECTRORETINOGRAPHY, TREATMENT effectiveness

Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest

Authors: Sapieha, Przemyslaw, Mallette, Frédérick A.

Source: In Trends in Cell Biology August 2018 28(8):595-607

NETosis drives removal of senescent cells and favors revascularisation in retinopathy

Authors: Binet, François, Wilson, Ariel M., Sapieha, Przemyslaw

Source: M/S. 37(5):541-543

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626482100&indx=1&recIds=ETOCRN626482100

On phagocytes and macular degeneration

Authors: Guillonneau, Xavier, Eandi, Chiara M., Paques, Michel, Sahel, José-Alain, Sapieha, Przemyslaw, Sennlaub, Florian

Source: In Progress in Retinal and Eye Research November 2017 61:98-128

Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation

Authors: Calippe, Bertrand, Augustin, Sebastien, Beguier, Fanny, Charles-Messance, Hugo, Poupel, Lucie, Conart, Jean-Baptiste, Hu, Shulong J., Lavalette, Sophie, Fauvet, Alexandre, Rayes, Julie, Levy, Olivier, Raoul, William, Fitting, Catherine, Denèfle, Thomas, Pickering, Matthew C., Harris, Claire, Jorieux, Sylvie, Sullivan, Patrick M., Sahel, José-Alain, Karoyan, Philippe, Sapieha, Przemyslaw, Guillonneau, Xavier, Gautier, Emmanuel L., Sennlaub, Florian

Source: In Immunity 21 February 2017 46(2):261-272

Effect of human very low-density lipoproteins on cardiotrophin-like cytokine factor 1 (CLCF1) activity

Authors: Pasquin, Sarah, Chehboun, Salma, Dejda, Agnieszka, Meliani, Yasmine, Savin, Virginia, Warner, Gregory, Bosse, Roger, Tormo, Aurélie, Mayer, Gaétan, Sharma, Mukut, Sapieha, Przemyslaw, Martel, Catherine, Gauchat, Jean-François

Source: Scientific reports. 8(1):1-14

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125945498.0x000001&indx=1&recIds=ETOCvdc_100125945498.0x000001

A machine learning approach for automated assessment of retinal vasculature in the oxygen induced retinopathy model

Authors: Mazzaferri, Javier, Larrivée, Bruno, Cakir, Bertan, Sapieha, Przemyslaw, Costantino, Santiago

Source: Scientific reports. 8(1):1-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125145533.0x000001&indx=1&recIds=ETOCvdc_100125145533.0x000001

BMP9 (Bone Morphogenetic Protein-9)/Alk1 (Activin-Like Kinase Receptor Type I) Signaling Prevents Hyperglycemia-Induced Vascular Permeability

Authors: Akla, Naoufal, Viallard, Claire, Popovic, Natalija, Lora Gil, Cindy, Sapieha, Przemyslaw, Larrivée, Bruno

Source: Arteriosclerosis, thrombosis, and vascular biology. 38(8):1821-1836

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100064302489.0x000001&indx=1&recIds=ETOCvdc_100064302489.0x000001

ER Stress and Angiogenesis

Authors: Binet, François, Sapieha, Przemyslaw

Source: In Cell Metabolism 6 October 2015 22(4):560-575

Myeloid‐resident neuropilin‐1 promotes choroidal neovascularization while mitigating inflammation

Authors: Andriessen, Elisabeth M M A, Binet, François, Fournier, Frédérik, Hata, Masayuki, Dejda, Agnieszka, Mawambo, Gaëlle, Crespo‐Garcia, Sergio, Pilon, Frédérique, Buscarlet, Manuel, Beauchemin, Karine, Bougie, Véronique, Cumberlidge, Garth, Wilson, Ariel M, Bourgault, Steve, Rezende, Flavio A, Beaulieu, Normand, Delisle, Jean‐Sébastien, Sapieha, Przemyslaw

Source: EMBO molecular medicine. 13(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138908780.0x000001&indx=1&recIds=ETOCvdc_100138908780.0x000001

Retinal Neurons Curb Inflammation and Enhance Revascularization in Ischemic Retinopathies via Proteinase-Activated Receptor-2

Authors: Sitaras, Nicholas, Rivera, José Carlos, Noueihed, Baraa, Bien-Aimé, Milsa, Zaniolo, Karine, Omri, Samy, Hamel, David, Zhu, Tang, Hardy, Pierre, Sapieha, Przemyslaw, Joyal, Jean-Sébastien, Chemtob, Sylvain

Source: In The American Journal of Pathology February 2015 185(2):581-595

Omega-3 Supplementation Combined With Anti–Vascular Endothelial Growth Factor Lowers Vitreal Levels of Vascular Endothelial Growth Factor in Wet Age-Related Macular Degeneration

Authors: Rezende, Flavio A., Lapalme, Eric, Qian, Cynthia X., Smith, Lois E., SanGiovanni, John Paul, Sapieha, Przemyslaw

Source: In American Journal of Ophthalmology November 2014 158(5):1071-1078

Gut microbiota influences pathological angiogenesis in obesity‐driven choroidal neovascularization

Authors: Andriessen, Elisabeth MMA, Wilson, Ariel M, Mawambo, Gaelle, Dejda, Agnieszka, Miloudi, Khalil, Sennlaub, Florian, Sapieha, Przemyslaw

Source: EMBO molecular medicine. 8(12):1366-1379

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186098799.0x000001&indx=1&recIds=ETOCvdc_100186098799.0x000001