Rational design and synthesis of novel N-benzylindole-based epalrestat analogs as selective aldose reductase inhibitors: An unexpected discovery of a new glucose-lowering agent (AK-4) acting as a mitochondrial uncoupler

Authors: Kousaxidis, Antonios, Paoli, Paolo, Kovacikova, Lucia, Genovese, Massimo, Santi, Alice, Stefek, Milan, Petrou, Anthi, Nicolaou, Ioannis

Source: In European Journal of Medicinal Chemistry 5 January 2025 281

Chronic lactate exposure promotes cardiomyocyte cytoskeleton remodelling

Authors: Luti, Simone ^a, Militello, Rosamaria ^a, Pinto, Gabriella ^b, Illiano, Anna ^b, Marzocchini, Riccardo ^a, Santi, Alice ^a, Becatti, Matteo ^a, Amoresano, Angela ^b, Gamberi, Tania ^a, Pellegrino, Alessio ^c, Modesti, Alessandra ^{a, ∗}, Modesti, Pietro Amedeo ^c

Source: In Heliyon 30 January 2024 10(2)

A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition

Authors: Laghezza, Antònio, Cerchia, Carmen, Genovese, Massimo, Leuci, Rosalba, Pranzini, Erica, Santi, Alice, Brunetti, Leonardo, Piemontese, Luca, Tortorella, Paolo, Biswas, Abanish

Source: Journal of medicinal chemistry. 66(5):3566-3587

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631865159&indx=1&recIds=ETOCRN631865159

Designed multiple ligands for the treatment of type 2 diabetes mellitus and its complications: Discovery of (5-arylidene-4-oxo-2-thioxothiazolidin-3-yl)alkanoic acids active as novel dual-targeted PTP1B/AKR1B1 inhibitors

Authors: Maccari, Rosanna, Wolber, Gerhard, Genovese, Massimo, Sardelli, Gemma, Talagayev, Valerij, Balestri, Francesco, Luti, Simone, Santi, Alice, Moschini, Roberta, Del Corso, Antonella, Paoli, Paolo, Ottanà, Rosaria

Source: In European Journal of Medicinal Chemistry 5 April 2023 252

SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis

Authors: Pranzini, Erica, Pardella, Elisa, Muccillo, Livio, Leo, Angela, Nesi, Ilaria, Santi, Alice, Parri, Matteo, Zhang, Tong, Uribe, Alejandro Huerta, Lottini, Tiziano, Sabatino, Lina, Caselli, Anna, Arcangeli, Annarosa, Raugei, Giovanni, Colantuoni, Vittorio, Cirri, Paolo, Chiarugi, Paola, Maddocks, Oliver D.K., Paoli, Paolo, Taddei, Maria Letizia

Source: In Cell Reports 16 August 2022 40(7)

Molecular, Physical, and Technical Performance Response After a Competitive Match in Male Professional Soccer Players.

Authors: Modesti, Alessandra, Militello, Rosamaria, Tanturli, Alice, Santi, Alice, Gulisano, Massimo, Petri, Cristian, Pengue, Luca, Pellegrino, Alessio, Modesti, Pietro Amedeo, Luti, Simone

Source: Antioxidants; Jan2025, Vol. 14 Issue 1, p73, 17p

Subject Terms: ATHLETES' health, OXIDATIVE stress, SOCCER players, HOMEOSTASIS, METABOLOMICS

A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity

Authors: Sblano, Sabina, Cerchia, Carmen, Laghezza, Antonio, Piemontese, Luca, Brunetti, Leonardo, Leuci, Rosalba, Gilardi, Federica, Thomas, Aurelien, Genovese, Massimo, Santi, Alice, Tortorella, Paolo, Paoli, Paolo, Lavecchia, Antonio, Loiodice, Fulvio

Source: In European Journal of Medicinal Chemistry 5 May 2022 235

Limiting serine availability during tumor progression promotes muscle wasting in cancer cachexia.

Authors: Pranzini, Erica, Muccillo, Livio, Nesi, Ilaria, Santi, Alice, Mancini, Caterina, Lori, Giulia, Genovese, Massimo, Lottini, Tiziano, Comito, Giuseppina, Caselli, Anna, Arcangeli, Annarosa, Sabatino, Lina, Colantuoni, Vittorio, Taddei, Maria Letizia, Cirri, Paolo, Paoli, Paolo

Source: Cell Death Discovery; 12/21/2024, Vol. 10 Issue 1, p1-14, 14p

Lactate supports cell-autonomous ECM production to sustain metastatic behavior in prostate cancer.

Authors: Ippolito, Luigi, Duatti, Assia, Iozzo, Marta, Comito, Giuseppina, Pardella, Elisa, Lorito, Nicla, Bacci, Marina, Pranzini, Erica, Santi, Alice, Sandrini, Giada, Catapano, Carlo V, Serni, Sergio, Spatafora, Pietro, Morandi, Andrea, Giannoni, Elisa, Chiarugi, Paola

Source: EMBO Reports; Aug2024, Vol. 25 Issue 8, p3506-3531, 26p

Redox cycler based therapeutic option against mitochondrial pathologies linked to respiratory chain dysfunction

Authors: Bonesso, Daniele, Donadon, Michael, Rossa, Andrea, Biasutto, Lucia, Favero, Marta, Mattarei, Andrea, Iozzo, Marta, Santi, Alice, Purhonen, Janne, Giannoni, Elisa, Chiarugi, Paola, Kalljarvi, Jukka, Calura, Enrica, Zeviani, Massimo, Viscomi, Carlo, Szabo, Ildiko

Source: In BBA - Bioenergetics 1 September 2024 1865 Supplement

Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme

Authors: Caselli, Anna, Paoli, Paolo, Santi, Alice, Mugnaioni, Camilla, Toti, Alessandra, Camici, Guido, Cirri, Paolo

Source: In BBA - Proteins and Proteomics October 2016 1864(10):1339-1355

Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function.

Authors: Santi, Alice, Kay, Emily J., Neilson, Lisa J., McGarry, Lynn, Lilla, Sergio, Mullin, Margaret, Paul, Nikki R., Fercoq, Frédéric, Koulouras, Grigorios, Rodriguez Blanco, Giovanny, Athineos, Dimitris, Mason, Susan, Hughes, Mark, Thomson, Gemma, Kieffer, Yann, Nixon, Colin, Blyth, Karen, Mechta-Grigoriou, Fatima, Carlin, Leo M., Zanivan, Sara

Source: Science Signaling; 3/12/2024, Vol. 17 Issue 827, p1-22, 22p

Subject Terms: CELL physiology, ENDOTHELIAL cells, FIBROBLASTS, BLOOD proteins, EXTRACELLULAR vesicles, CELL communication

Cancer associated fibroblasts transfer lipids and proteins to cancer cells through cargo vesicles supporting tumor growth

Authors: Santi, Alice, Caselli, Anna, Ranaldi, Francesco, Paoli, Paolo, Mugnaioni, Camilla, Michelucci, Elena, Cirri, Paolo

Source: In BBA - Molecular Cell Research December 2015 1853(12):3211-3223

RuvBL1 is required for mitochondrial integrity and supports the metabolic reprogramming of HCC cells

Authors: Simeone, Irene, Guida, Alice, Polvani, Simone, Ceni, Elisabetta, Bani, Daniele, Nardini, Patrizia, Guasti, Daniele, Bonora, Massimo, Santi, Alice, Galli, Andrea, Mello, Tommaso

Source: Journal of hepatology. 78(S1):S550-S550

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195504898.0x000001&indx=1&recIds=ETOCvdc_100195504898.0x000001

Targeting of tumor cells by custom antigen transfer: a novel approach for immunotherapy of cancer.

Authors: Nesi, Ilaria, Bella, Chiara Della, Taddei, Maria Letizia, Santi, Alice, Pranzini, Erica, Paoli, Paolo, D'Elios, Mario Milco, Ramazzotti, Matteo, Genovese, Massimo, Caselli, Anna, Cirri, Paolo

Source: Frontiers in Oncology; 2023, p1-12, 12p

Subject Terms: CYTOTOXIC T cells, MAJOR histocompatibility complex, GENETIC drift, IMMUNE system, IMMUNOTHERAPY, HUMAN carcinogenesis

The aggressiveness of succinate dehydrogenase subunit B-deficient chromaffin cells is reduced when their bioelectrical properties are restored by glibenclamide.

Authors: Amore, Francesca, Garella, Rachele, Santi, Alice, Guasti, Daniele, Martinelli, Serena, Canu, Letizia, Bani, Daniele, Neuzil, Jiri, Maggi, Mario, Squecco, Roberta, Rapizzi, Elena

Source: Endocrine-Related Cancer; Oct2023, Vol. 30 Issue 10, p126-141, 16p

Subject Terms: SUCCINATE dehydrogenase, CHROMAFFIN cells, GLIBENCLAMIDE, PARAGANGLIOMA, NEUROENDOCRINE tumors, POTASSIUM channels, POTASSIUM, POTASSIUM antagonists

The insulin-mimetic effect of Morin: A promising molecule in diabetes treatment

Authors: Paoli, Paolo, Cirri, Paolo, Caselli, Anna, Ranaldi, Francesco, Bruschi, Giulia, Santi, Alice, Camici, Guido

Source: In BBA - General Subjects April 2013 1830(4):3102-3111

Evidence of Insulin-Sensitizing and Mimetic Activity of the Sesquiterpene Quinone Avarone, a Protein Tyrosine Phosphatase 1B and Aldose Reductase Dual Targeting Agent from the Marine Sponge Dysidea avara.

Authors: Casertano, Marcello, Genovese, Massimo, Santi, Alice, Pranzini, Erica, Balestri, Francesco, Piazza, Lucia, Del Corso, Antonella, Avunduk, Sibel, Imperatore, Concetta, Menna, Marialuisa, Paoli, Paolo

Source: Pharmaceutics; Feb2023, Vol. 15 Issue 2, p528, 24p

Subject Terms: ALDOSE reductase, PROTEIN-tyrosine phosphatase, PHOSPHOPROTEIN phosphatases, INSULIN receptors, PEMETREXED, SPONGES (Invertebrates), TYPE 2 diabetes, INSULIN, MITOGEN-activated protein kinase phosphatases

Cancer Associated Fibroblasts: The Architects of Stroma Remodeling

Authors: Santi, Alice, Kugeratski, Fernanda G., Zanivan, Sara

Source: Proteomics. 18(5-6)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139524639.0x000001&indx=1&recIds=ETOCvdc_100139524639.0x000001

Transcriptomic Analysis of Colorectal Cancer Cells Treated with Oil Production Waste Products (OPWPs) Reveals Enrichment of Pathways of Mitochondrial Functionality.

Authors: Leo, Manuela, Muccillo, Livio, Pranzini, Erica, Barisciano, Giovannina, Parri, Matteo, Lopatriello, Giulia, Carlomagno, Marco, Santi, Alice, Taddei, Maria Letizia, Sabatino, Lina

Source: Cells (2073-4409); Dec2022, Vol. 11 Issue 24, p3992, 15p

Subject Terms: PETROLEUM waste, CANCER cell analysis, WASTE products, IRINOTECAN, MITOCHONDRIA, TRANSCRIPTOMES