Brain transplantation of genetically corrected Sanfilippo type B neural stem cells induces partial cross-correction of the disease

Authors: Pearse, Yewande, Clarke, Don, Kan, Shih-hsin, Le, Steven Q., Sanghez, Valentina, Luzzi, Anna, Pham, Ivy, Nih, Lina R., Cooper, Jonathan D., Dickson, Patricia I., Iacovino, Michelina

Source: In Molecular Therapy - Methods & Clinical Development 8 December 2022 27:452-463

Genetically Corrected iPSC-Derived Neural Stem Cell Grafts Deliver Enzyme Replacement to Affect CNS Disease in Sanfilippo B Mice

Authors: Clarke, Don, Pearse, Yewande, Kan, Shih-hsin, Le, Steven Q., Sanghez, Valentina, Cooper, Jonathan D., Dickson, Patricia I., Iacovino, Michelina

Source: In Molecular Therapy - Methods & Clinical Development 21 September 2018 10:113-127

A Humoral Immune Response Alters the Distribution of Enzyme Replacement Therapy in Murine Mucopolysaccharidosis Type I

Authors: Le, Steven Q., Kan, Shih-hsin, Clarke, Don, Sanghez, Valentina, Egeland, Martin, Vondrak, Kristen N., Doherty, Terence M., Vera, Moin U., Iacovino, Michelina, Cooper, Jonathan D., Sands, Mark S., Dickson, Patricia I.

Source: In Molecular Therapy - Methods & Clinical Development 16 March 2018 8:42-51

Altered cofactor regulation with disease-associated p97/VCP mutations

Authors: Zhang, Xiaoyi, Gui, Lin, Zhang, Xiaoyan, Bulfer, Stacie L., Sanghez, Valentina, Wong, Daniel E., Lee, YouJin, Lehmann, Lynn, Lee, James Siho, Shih, Pei-Yin, Lin, Henry J., Iacovino, Michelina, Weihl, Conrad C., Arkin, Michelle R., Wang, Yanzhuang, Chou, Tsui-Fen

Source: Proceedings of the National Academy of Sciences of the United States of America, 2015 Apr 01. 112(14), E1705-E1714.

Access URL: https://www.jstor.org/stable/26462523

Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice

Authors: Sanghez, Valentina, Cubuk, Cankut, Sebastián-Leon, Patricia, Carobbio, Stefania, Dopazo, Joaquin, Vidal-Puig, Antonio, Bartolomucci, Alessandro

Source: Stress. 19(2):214-224

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100104044737.0x000001&indx=1&recIds=ETOCvdc_100104044737.0x000001

Psychosocial stress induces hyperphagia and exacerbates diet-induced insulin resistance and the manifestations of the Metabolic Syndrome

Authors: Sanghez, Valentina, Razzoli, Maria, Carobbio, Stefania, Campbell, Mark, McCallum, Jacob, Cero, Cheryl, Ceresini, Graziano, Cabassi, Aderville, Govoni, Paolo, Franceschini, Paolo, de Santis, Valentina, Gurney, Allison, Ninkovic, Ivana, Parmigiani, Stefano, Palanza, Paola, Vidal-Puig, Antonio, Bartolomucci, Alessandro

Source: In Psychoneuroendocrinology December 2013 38(12):2933-2942

Vulnerability to chronic subordination stress-induced depression-like disorders in adult 129SvEv male mice

Authors: Dadomo, Harold, Sanghez, Valentina, Di Cristo, Luisana, Lori, Andrea, Ceresini, Graziano, Malinge, Isabelle, Parmigiani, Stefano, Palanza, Paola, Sheardown, Malcolm, Bartolomucci, Alessandro

Source: In Progress in Neuropsychopharmacology & Biological Psychiatry 2011 35(6):1461-1471

Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation

Authors: Kuang, Yu-Lin, Munoz, Antonio, Nalula, Gilbert, Santostefano, Katherine E., Sanghez, Valentina, Sanchez, Gabriela, Terada, Naohiro, Mattis, Aras N., Iacovino, Michelina, Iribarren, Carlos, Krauss, Ronald M., Medina, Marisa W.

Source: Stem cell research. 37

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100096890309.0x000001&indx=1&recIds=ETOCvdc_100096890309.0x000001

Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation.

Authors: Sanghez, Valentina^1,2, Luzzi, Anna^1,2, Clarke, Don^1,2, Kee, Dustin^1,2, Beuder, Steven^1,2, Rux, Danielle³, Osawa, Mitsujiro⁴, Madrenas, Joaquín^2,5, Chou, Tsui-Fen^1,2, Kyba, Michael³, Iacovino, Michelina^1,2 iacovino@UCLA.edu

Source: PLoS ONE. 10/26/2017, Vol. 12 Issue 10, p1-18. 18p.

Subject Terms: *HEMATOPOIESIS, *ENDOTHELIAL cells, *PHENOTYPES, *TRANSCRIPTION factors, *NOTCH signaling pathway

A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation.

Authors: Perez, Harvey, Abdallah, May F., Chavira, Jose I., Norris, Angelina S., Egeland, Martin T., Vo, Karen L., Buechsenschuetz, Callan L., Sanghez, Valentina, Kim, Jeannie L., Pind, Molly, Nakamura, Kotoka, Hicks, Geoffrey G., Gatti, Richard A., Madrenas, Joaquin, Iacovino, Michelina, McKinnon, Peter J., Mathews, Paul J.

Source: eLife; 11/18/2021, p1-36, 36p

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Neural stem cells provide continuous enzyme replacement therapy and reduce neuropathology in Sanfilippo syndrome type B mice

Authors: Pearse, Yewande E.O., Clarke, Don, Shih-hsin, Kan, Le, Steven Q., Sanghez, Valentina, Cooper, Jonathan D., Dickson, Patricia I., Iacovino, Michelina

Source: Molecular genetics and metabolism. 123(2):S115-S115

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100063739669.0x000001&indx=1&recIds=ETOCvdc_100063739669.0x000001

Characterization on the cellular distribution of enzyme replacement therapy (ERT) under the influence of humoral immune response in MPS I mouse model

Authors: Sanghez, Valentina, Kan, Shih-hsin, Le, Steven Q, Clarke, Don, Vondrak, Kristen N, Vera, Moin, Iacovino, Michelina, Sands, Mark, Dickson, Patti

Source: Molecular genetics and metabolism. 120(1/2):S118-S118

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100052510546.0x000001&indx=1&recIds=ETOCvdc_100052510546.0x000001

430. Antibodies to Recombinant Human α-L-Iduronidase Enhance Uptake into Macrophages in Murine Mucopolysaccharidosis Type I

Authors: Sanghez, Valentina, Kan, Shih-Hsin, Le, Steven Q, Clarke, Don, Vondrak, Kristen, Vera, Moin U, Iacovino, Michelina, Sands, Mark S, Dickson, Patricia I

Source: In Molecular Therapy May 2016 24 Supplement 1:S170-S171

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Altered cofactor regulation with disease-associated p97/VCP mutations.

Authors: Xiaoyi Zhang, Lin Gui, Xiaoyan Zhang, Bulfer, Stacie L., Sanghez, Valentina, Wong, Daniel E., YouJin Lee, Lehmann, Lynn, Siho Lee, James, Pei-Yin Shih, Lin, Henry J., Iacovino, Michelina, Weihl, Conrad C., Arkin, Michelle R., Yanzhuang Wang, Tsui-Fen Chou

Source: Proceedings of the National Academy of Sciences of the United States of America; 4/7/2015, Vol. 112 Issue 14, pE1705-E1714, 10p

Subject Terms: MUSCLE diseases, DEMENTIA, AMYOTROPHIC lateral sclerosis, MOTOR neuron diseases, NEUROMUSCULAR diseases

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