New Multitarget Rivastigmine–Indole Hybrids as Potential Drug Candidates for Alzheimer’s Disease

Authors: Leo Bon, Angelika Banaś, Inês Dias, Inês Melo-Marques, Sandra M. Cardoso, Sílvia Chaves, M. Amélia Santos

Source: Pharmaceutics, Vol 16, Iss 2, p 281 (2024)

Subject Terms: Alzheimer´s disease, multitarget drugs, rivastigmine–indole, antioxidants, cholinesterases, amyloid-β aggregation, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/16/2/281; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/6f923be9007c40599210a36b8a0e3721

LPS-induced mitochondrial dysfunction regulates innate immunity activation and α-synuclein oligomerization in Parkinson's disease

Authors: A. Raquel Esteves, Diana F. Silva, Diogo Banha, Emanuel Candeias, Beatriz Guedes, Sandra M. Cardoso

Source: Redox Biology, Vol 63, Iss , Pp 102714- (2023)

Subject Terms: Parkinson's disease, Lipopolysaccharides, Mitochondrial dysfunction, Innate immunity activation, α-synuclein oligomerization, Medicine (General), R5-920, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2213231723001155; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/afa23a29705d44608f9f7c94050897eb

Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons

Authors: Diana F. Silva, Emanuel Candeias, A. Raquel Esteves, João D. Magalhães, I. Luísa Ferreira, Daniela Nunes-Costa, A. Cristina Rego, Nuno Empadinhas, Sandra M. Cardoso

Source: Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-18 (2020)

Subject Terms: Alzheimer’s disease, β-N-Methylamino-l-alanine, Mitochondrial dysfunction, Neuronal innate immunity, Neurodegeneration, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-020-02004-y; https://doaj.org/toc/1742-2094

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Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease

Authors: Gaia Fancellu, Karam Chand, Daniel Tomás, Elisabetta Orlandini, Luca Piemontese, Diana F. Silva, Sandra M. Cardoso, Sílvia Chaves, M. Amélia Santos

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 211-226 (2020)

Subject Terms: alzheimer’s disease, multi-target drugs, tacrine-benzofuran hybrids, ache inhibitors, metal chelators, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/8f0d99935d294f969cab5237efdc3b2d

Novel Rivastigmine Derivatives as Promising Multi-Target Compounds for Potential Treatment of Alzheimer’s Disease

Authors: David Vicente-Zurdo, Noelia Rosales-Conrado, M. Eugenia León-González, Leonardo Brunetti, Luca Piemontese, A. Raquel Pereira-Santos, Sandra M. Cardoso, Yolanda Madrid, Sílvia Chaves, M. Amélia Santos

Source: Biomedicines, Vol 10, Iss 7, p 1510 (2022)

Subject Terms: Alzheimer’s disease, multi-target drugs, rivastigmine, neurodegenerative, amyloid aggregation, acetylcholinesterase, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/7/1510; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/bb8b37ac68d846fe80f3c1a79f47530c

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates

Authors: Luca Piemontese, Daniel Tomás, Asha Hiremathad, Vito Capriati, Emanuel Candeias, Sandra M. Cardoso, Sílvia Chaves, M. Amélia Santos

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1212-1224 (2018)

Subject Terms: Alzheimer’s disease, multipotent drugs, donepezil mimetics, AChE inhibitors, anti-Aβ aggregation, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/576dcbc606174caaba74b8e132d38b00

Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease

Authors: Tânia Fernandes, Rosa Resende, Diana F. Silva, Ana P. Marques, Armanda E. Santos, Sandra M. Cardoso, M. Rosário Domingues, Paula I. Moreira, Cláudia F. Pereira

Source: Biomedicines, Vol 9, Iss 8, p 881 (2021)

Subject Terms: Alzheimer’s disease, subcellular fractions, ER-mitochondria contacts, Ca2+ signaling, mitochondrial dysfunction, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/9/8/881; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/3c2f824e50674e3c8260bf601158a508

Novel Donepezil–Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer’s Disease

Authors: Fausto Queda, Sonia Calò, Karolina Gwizdala, João D. Magalhães, Sandra M. Cardoso, Sílvia Chaves, Luca Piemontese, M. Amélia Santos

Source: Molecules, Vol 26, Iss 6, p 1658 (2021)

Subject Terms: arylsulfonamide, donepezil, anti-neurodegeneratives, Alzheimer´s disease, AChE inhibitors, Aβ aggregation, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/6/1658; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/6a74cf4adc6d4731819370f1c96aaaca

Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents

Authors: Viviana Poliseno, Sílvia Chaves, Leonardo Brunetti, Fulvio Loiodice, Antonio Carrieri, Antonio Laghezza, Paolo Tortorella, João D. Magalhães, Sandra M. Cardoso, M. Amélia Santos, Luca Piemontese

Source: Biomolecules, Vol 11, Iss 1, p 111 (2021)

Subject Terms: Alzheimer’s disease, tenuazonic acid, donepezil, neurodegenerative, metal chelation, multifunctional drugs, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/11/1/111; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/a3c4a1415d71427290b1e8bfee5412bc

The Microbiome-Mitochondria Dance in Prodromal Parkinson’s Disease

Authors: Sandra M. Cardoso, Nuno Empadinhas

Source: Frontiers in Physiology, Vol 9 (2018)

Subject Terms: mitochondria, bacteria, microbiome, neuronal innate immunity, Parkinson’s disease, Physiology, QP1-981

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fphys.2018.00471/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/caf2a4b5487941a589a37405e233c770

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease

Authors: Sílvia Chaves, Simonetta Resta, Federica Rinaldo, Marina Costa, Romane Josselin, Karolina Gwizdala, Luca Piemontese, Vito Capriati, A. Raquel Pereira-Santos, Sandra M. Cardoso, M. Amélia Santos

Source: Molecules, Vol 25, Iss 4, p 985 (2020)

Subject Terms: hydroxyphenyl-benzimidazole, donepezil, anti-neurodegeneratives, alzheimer´s disease, multifunctional drugs, metal chelation, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/4/985; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/59ba6ba596204f28bef514a8a69921be

Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and HIF-1α

Authors: Sónia C. Correia, Renato X. Santos, Sandra M. Cardoso, Maria S. Santos, Catarina R. Oliveira, Paula I. Moreira

Source: Neurobiology of Disease, Vol 45, Iss 1, Pp 206-218 (2012)

Subject Terms: Cyanide, Glucotoxicity, Hypoxia inducible factor-1α, Mitochondria, Mitochondrial network, Preconditioning, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

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Relation: http://www.sciencedirect.com/science/article/pii/S0969996111002592; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/00b99f26829341e28f077a6a61988e5d

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer’s Disease

Authors: Rajeshwari Rajeshwari, Karam Chand, Emanuel Candeias, Sandra M. Cardoso, Sílvia Chaves, M. Amélia Santos

Source: Molecules, Vol 24, Iss 3, p 587 (2019)

Subject Terms: Alzheimer’s disease, multitarget, tacrine hybrids, benzothiazole, acetylcholinesterase inhibitors, Aβ aggregation, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/24/3/587; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/ab10c78bc0154f96b152fc4f369db662

Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology

Authors: A. Raquel Esteves, Daniela M. Arduíno, Russell H. Swerdlow, Catarina R. Oliveira, Sandra M. Cardoso

Source: Neurobiology of Disease, Vol 37, Iss 3, Pp 723-730 (2010)

Subject Terms: Calpain activation, Alpha-synuclein oligomers, Mitochondrial dysfunction, Cybrids, Parkinson's disease, Alpha-synuclein aggregation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996109003660; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/7f872d9297f84676bf2dfd211756cd51

Mitochondrial Fusion/Fission, Transport and Autophagy in Parkinson's Disease: When Mitochondria Get Nasty

Authors: Daniela M. Arduíno, A. Raquel Esteves, Sandra M. Cardoso

Source: Parkinson's Disease, Vol 2011 (2011)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2042-0080

Access URL: https://doaj.org/article/feb070f21aae4663b1bc3719b50a4c4f

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Oxidative Stress Involvement in α-Synuclein Oligomerization in Parkinson's Disease Cybrids.

Authors: A. Raquel Esteves, Daniela M. Arduíno, Russell H. Swerdlow, Catarina R. Oliveira, Sandra M. Cardoso

Source: Antioxidants & Redox Signaling; Mar2009, Vol. 11 Issue 3, p439-448, 10p

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