Frequent CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression

Authors: Miklos Diossy, Viktoria Tisza, Hua Li, Pranshu Sahgal, Jia Zhou, Zsofia Sztupinszki, Denise Young, Darryl Nousome, Claire Kuo, Jiji Jiang, Yongmei Chen, Reinhard Ebner, Isabell A. Sesterhenn, Joel T. Moncur, Gregory T. Chesnut, Gyorgy Petrovics, Gregory T. Klus, Gabor Valcz, Pier Vitale Nuzzo, Dezso Ribli, Judit Börcsök, Aurel Prosz, Marcin Krzystanek, Thomas Ried, David Szuts, Kinza Rizwan, Salma Kaochar, Shailja Pathania, Alan D. D’Andrea, Istvan Csabai, Shiv Srivastava, Matthew L. Freedman, Albert Dobi, Sandor Spisak, Zoltan Szallasi

Source: npj Precision Oncology, Vol 8, Iss 1, Pp 1-13 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2397-768X

Access URL: https://doaj.org/article/3508a45a6daf4e298c016ff52086528b

Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting

Authors: Aurel Prosz, Pranshu Sahgal, Brandon M. Huffman, Zsofia Sztupinszki, Clare X. Morris, David Chen, Judit Börcsök, Miklos Diossy, Viktoria Tisza, Sandor Spisak, Pornlada Likasitwatanakul, Orsolya Rusz, Istvan Csabai, Michael Cecchini, Yasmine Baca, Andrew Elliott, Peter Enzinger, Harshabad Singh, Jessalyn Ubellaker, Jean-Bernard Lazaro, James M. Cleary, Zoltan Szallasi, Nilay S. Sethi

Source: npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2397-768X

Access URL: https://doaj.org/article/b6b069037e684be89e6db272774fcef6

Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter system

Authors: Sandor Spisak, David Chen, Pornlada Likasitwatanakul, Paul Doan, Zhixin Li, Pratyusha Bala, Laura Vizkeleti, Viktoria Tisza, Pushpamali De Silva, Marios Giannakis, Brian Wolpin, Jun Qi, Nilay S. Sethi

Source: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/64f740c5a2e84b8d8be33accd3e0a80f

Biologically informed deep learning for explainable epigenetic clocks

Authors: Aurel Prosz, Orsolya Pipek, Judit Börcsök, Gergely Palla, Zoltan Szallasi, Sandor Spisak, István Csabai

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/d55cd8a828df4fc898caef58429cfbca

Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma

Authors: Aurel Prosz, Haohui Duan, Viktoria Tisza, Pranshu Sahgal, Sabine Topka, Gregory T. Klus, Judit Börcsök, Zsofia Sztupinszki, Timothy Hanlon, Miklos Diossy, Laura Vizkeleti, Dag Rune Stormoen, Istvan Csabai, Helle Pappot, Joseph Vijai, Kenneth Offit, Thomas Ried, Nilay Sethi, Kent W. Mouw, Sandor Spisak, Shailja Pathania, Zoltan Szallasi

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/939969bbc4324201be410156a45cd9e5

A biallelic multiple nucleotide length polymorphism explains functional causality at 5p15.33 prostate cancer risk locus

Authors: Sandor Spisak, Viktoria Tisza, Pier Vitale Nuzzo, Ji-Heui Seo, Balint Pataki, Dezso Ribli, Zsofia Sztupinszki, Connor Bell, Mersedeh Rohanizadegan, David R. Stillman, Sarah Abou Alaiwi, Alan H. Bartels, Marton Papp, Anamay Shetty, Forough Abbasi, Xianzhi Lin, Kate Lawrenson, Simon A. Gayther, Mark Pomerantz, Sylvan Baca, Norbert Solymosi, Istvan Csabai, Zoltan Szallasi, Alexander Gusev, Matthew L. Freedman

Source: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/56f577f878744951b0fa9132df89b32d

Epigenomic charting and functional annotation of risk loci in renal cell carcinoma

Authors: Amin H. Nassar, Sarah Abou Alaiwi, Sylvan C. Baca, Elio Adib, Rosario I. Corona, Ji-Heui Seo, Marcos A. S. Fonseca, Sandor Spisak, Talal El Zarif, Viktoria Tisza, David A. Braun, Heng Du, Monica He, Abdallah Flaifel, Michel Alchoueiry, Thomas Denize, Sayed G. Matar, Andres Acosta, Sachet Shukla, Yue Hou, John Steinharter, Gabrielle Bouchard, Jacob E. Berchuck, Edward O’Connor, Connor Bell, Pier Vitale Nuzzo, Gwo-Shu Mary Lee, Sabina Signoretti, Michelle S. Hirsch, Mark Pomerantz, Elizabeth Henske, Alexander Gusev, Kate Lawrenson, Toni K. Choueiri, David J. Kwiatkowski, Matthew L. Freedman

Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5c45bbe4ef1e4b0b9d9d760011ce2040

Author Correction: Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting

Authors: Aurel Prosz, Pranshu Sahgal, Brandon M. Huffman, Zsofia Sztupinszki, Clare X. Morris, David Chen, Judit Börcsök, Miklos Diossy, Viktoria Tisza, Sandor Spisak, Pornlada Likasitwatanakul, Orsolya Rusz, Istvan Csabai, Michael Cecchini, Yasmine Baca, Andrew Elliott, Peter Enzinger, Harshabad Singh, Jessalyn Ubellaker, Jean-Bernard Lazaro, James M. Cleary, Zoltan Szallasi, Nilay S. Sethi

Source: npj Precision Oncology, Vol 8, Iss 1, Pp 1-1 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2397-768X

Access URL: https://doaj.org/article/7b071e78f9934ab7a55cfa9bc5e11b2f

Author Correction: A biallelic multiple nucleotide length polymorphism explains functional causality at 5p15.33 prostate cancer risk locus

Authors: Sandor Spisak, Viktoria Tisza, Pier Vitale Nuzzo, Ji-Heui Seo, Balint Pataki, Dezso Ribli, Zsofia Sztupinszki, Connor Bell, Mersedeh Rohanizadegan, David R. Stillman, Sarah Abou Alaiwi, Alan H. Bartels, Marton Papp, Anamay Shetty, Forough Abbasi, Xianzhi Lin, Kate Lawrenson, Simon A. Gayther, Mark Pomerantz, Sylvan Baca, Norbert Solymosi, Istvan Csabai, Zoltan Szallasi, Alexander Gusev, Matthew L. Freedman

Source: Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0532d1b073b9480fac7a98562e9233a2

Androgen receptor and MYC equilibration centralizes on developmental super-enhancer

Authors: Haiyang Guo, Yiming Wu, Mannan Nouri, Sandor Spisak, Joshua W. Russo, Adam G. Sowalsky, Mark M. Pomerantz, Zhao Wei, Keegan Korthauer, Ji-Heui Seo, Liyang Wang, Seiji Arai, Matthew L. Freedman, Housheng Hansen He, Shaoyong Chen, Steven P. Balk

Source: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/347b7d0db16a4ab1a53e337245e1df79

A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures

Authors: Miklos Diossy, Zsofia Sztupinszki, Judit Borcsok, Marcin Krzystanek, Viktoria Tisza, Sandor Spisak, Orsolya Rusz, Jozsef Timar, István Csabai, Janos Fillinger, Judit Moldvay, Anders Gorm Pedersen, David Szuts, Zoltan Szallasi

Source: npj Precision Oncology, Vol 5, Iss 1, Pp 1-8 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2397-768X

Access URL: https://doaj.org/article/406462c44b26424ba7040c4796c0ef2d

Emergence and Genomic Features of a mcr-1 Escherichia coli from Duck in Hungary

Authors: Ama Szmolka, Ákos Gellért, Dóra Szemerits, Fanni Rapcsák, Sándor Spisák, András Adorján

Source: Antibiotics, Vol 12, Iss 10, p 1519 (2023)

Subject Terms: mcr-1 Escherichia coli, colistin resistance, waterfowl, plasmid genome, core genome MLST, multiresistance, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2079-6382/12/10/1519; https://doaj.org/toc/2079-6382

Access URL: https://doaj.org/article/aba65cc2a0944dba81d3c9830e9c4a06

Small extracellular vesicle DNA-mediated horizontal gene transfer as a driving force for tumor evolution: Facts and riddles

Authors: Gábor Valcz, Beáta Újvári, Edit I. Buzás, Tibor Krenács, Sándor Spisák, Ágnes Kittel, Zsolt Tulassay, Péter Igaz, István Takács, Béla Molnár

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: extracellular vesicles, exosomes, horizontal gene transfer, tumor evolution, cell-cell communication, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.945376/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/0bea5014dc7448178432a9d959456e4e

Rewired Metabolism Caused by the Oncogenic Deregulation of MYC as an Attractive Therapeutic Target in Cancers

Authors: Laura Vízkeleti, Sándor Spisák

Source: Cells, Vol 12, Iss 13, p 1745 (2023)

Subject Terms: protooncogene, MYC deregulation, altered cellular metabolism, therapeutic targets, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/13/1745; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/6c84e34c913d452db8e962c464500f41

Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents

Authors: Ádám Póti, Hella Gyergyák, Eszter Németh, Orsolya Rusz, Szilárd Tóth, Csenger Kovácsházi, Dan Chen, Bernadett Szikriszt, Sándor Spisák, Shunichi Takeda, Gergely Szakács, Zoltan Szallasi, Andrea L. Richardson, Dávid Szüts

Source: Genome Biology, Vol 20, Iss 1, Pp 1-13 (2019)

Subject Terms: Mutation signature, BRCA1, BRCA2, RAD51C, PALB2, RAD52, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13059-019-1867-0; https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/8760977339c040bda5b2a0d40c280508

Mobile Antimicrobial Resistance Genes in Probiotics

Authors: Adrienn Gréta Tóth, István Csabai, Maura Fiona Judge, Gergely Maróti, Ágnes Becsei, Sándor Spisák, Norbert Solymosi

Source: Antibiotics, Vol 10, Iss 11, p 1287 (2021)

Subject Terms: antimicrobial resistance, bacteriome, resistome, mobilome, probiotics, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2079-6382/10/11/1287; https://doaj.org/toc/2079-6382

Access URL: https://doaj.org/article/5942afe9b4f94793b54ded8dc0fc965e

Colorectal adenoma and cancer detection based on altered methylation pattern of SFRP1, SFRP2, SDC2, and PRIMA1 in plasma samples

Authors: Barbara Kinga Barták, Alexandra Kalmár, Bálint Péterfia, Árpád V. Patai, Orsolya Galamb, Gábor Valcz, Sándor Spisák, Barnabás Wichmann, Zsófia Brigitta Nagy, Kinga Tóth, Zsolt Tulassay, Péter Igaz, Béla Molnár

Source: Epigenetics, Vol 12, Iss 9, Pp 751-763 (2017)

Subject Terms: adenoma, cell-free dna, colorectal cancer, dna methylation, liquid biopsy, plasma, biomarker, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1559-2294; https://doaj.org/toc/1559-2308

Access URL: https://doaj.org/article/08e2287f96fc4c1aa3f9998da55ad3fe

En bloc release of MVB-like small extracellular vesicle clusters by colorectal carcinoma cells

Authors: Gábor Valcz, Edit I. Buzás, Ágnes Kittel, Tibor Krenács, Tamás Visnovitz, Sándor Spisák, György Török, László Homolya, Sára Zsigrai, Gábor Kiszler, Géza Antalffy, Krisztina Pálóczi, Zoltán Szállási, Vanessza Szabó, Anna Sebestyén, Norbert Solymosi, Alexandra Kalmár, Kristóf Dede, Péter Lőrincz, Zsolt Tulassay, Péter Igaz, Béla Molnár

Source: Journal of Extracellular Vesicles, Vol 8, Iss 1 (2019)

Subject Terms: ev, migrating cancer cells, mvb, colorectal carcinoma, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2001-3078

Access URL: https://doaj.org/article/00068c82b34b4d0f9a0b2d8080de71f7

Potential Biomarkers of Colorectal Adenoma–Dysplasia–Carcinoma Progression: mRNA Expression Profiling and In Situ Protein Detection on TMAs Reveal 15 Sequentially Upregulated and 2 Downregulated Genes

Authors: Orsolya Galamb, Ferenc Sipos, Sándor Spisák, Barnabás Galamb, Tibor Krenács, Gábor Valcz, Zsolt Tulassay, Béla Molnár

Source: Cellular Oncology, Vol 31, Iss 1, Pp 19-29 (2009)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1570-5870; https://doaj.org/toc/1875-8606

Access URL: https://doaj.org/article/2eb1a7a00a1b4d33abe493a1416bd8a8

Cell Free DNA of Tumor Origin Induces a 'Metastatic' Expression Profile in HT-29 Cancer Cell Line.

Authors: István Fűri, Alexandra Kalmár, Barnabás Wichmann, Sándor Spisák, Andrea Schöller, Barbara Barták, Zsolt Tulassay, Béla Molnár

Source: PLoS ONE, Vol 10, Iss 7, p e0131699 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4489610?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/187432e6beb84154b3d15bb4911bc9be