Prevention of post COVID-19 condition by early treatment with ensitrelvir in the phase 3 SCORPIO-SR trial

Authors: Yotsuyanagi, Hiroshi, Ohmagari, Norio, Doi, Yohei, Yamato, Masaya, Fukushi, Akimasa, Imamura, Takumi, Sakaguchi, Hiroki, Sonoyama, Takuhiro, Sanaki, Takao, Ichihashi, Genki, Tsuge, Yuko, Uehara, Takeki, Mukae, Hiroshi

Source: In Antiviral Research September 2024 229

Acsl1 is essential for skin barrier function through the activation of linoleic acid and biosynthesis of ω-O-acylceramide in mice

Authors: Kato, Ayumi, Ito, Mana, Sanaki, Takao, Okuda, Tomohiko, Tsuchiya, Noriko, Yoshimoto, Ryo, Yukioka, Hideo

Source: In BBA - Molecular and Cell Biology of Lipids February 2022 1867(2)

Efficacy of ensitrelvir against SARS-CoV-2 in a delayed-treatment mouse model

Authors: Nobori, Haruaki, Fukao, Keita, Kuroda, Takayuki, Anan, Naomi, Tashima, Ryoichi, Nakashima, Masaaki, Noda, Sayuri, Tajiri, Minako, Torii, Mikinori, Toba, Shinsuke, Uemura, Kentaro, Sanaki, Takao, Shishido, Takao, Tachibana, Yuki, Kato, Teruhisa

Source: Journal of antimicrobial chemotherapy. 77(11):2984-2991

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163726883.0x000001&indx=1&recIds=ETOCvdc_100163726883.0x000001

5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2

Authors: Uemura, Kentaro, Nobori, Haruaki, Sato, Akihiko, Sanaki, Takao, Toba, Shinsuke, Sasaki, Michihito, Murai, Akiho, Saito-Tarashima, Noriko, Minakawa, Noriaki, Orba, Yasuko, Kariwa, Hiroaki, Hall, William W., Sawa, Hirofumi, Matsuda, Akira, Maenaka, Katsumi

Source: In iScience 22 October 2021 24(10)

Air-liquid interphase culture confers SARS-CoV-2 susceptibility to A549 alveolar epithelial cells

Authors: Sasaki, Michihito, Kishimoto, Mai, Itakura, Yukari, Tabata, Koshiro, Intaruck, Kittiya, Uemura, Kentaro, Toba, Shinsuke, Sanaki, Takao, Sato, Akihiko, Hall, William W., Orba, Yasuko, Sawa, Hirofumi

Source: Biochemical and biophysical research communications. 577:146-151

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140746372.0x000001&indx=1&recIds=ETOCvdc_100140746372.0x000001

Identification of quinolone derivatives as effective anti-Dengue virus agents

Authors: Nobori, Haruaki, Uemura, Kentaro, Toba, Shinsuke, Sanaki, Takao, Shishido, Takao, Hall, William W., Orba, Yasuko, Sawa, Hirofumi, Sato, Akihiko

Source: In Antiviral Research December 2020 184

Inhibition of dengue virus infection by 1‐stearoyl‐2‐arachidonoyl‐phosphatidylinositol in vitro

Authors: Sanaki, Takao, Wakabayashi, Masato, Yoshioka, Takeshi, Yoshida, Ryu, Shishido, Takao, Hall, William W., Sawa, Hirofumi, Sato, Akihiko

Source: FASEB journal. 33(12):13866-13881

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182057665.0x000001&indx=1&recIds=ETOCvdc_100182057665.0x000001

Contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors

Authors: Sakurai, Yusuke, Fujita, Masahide, Kawasaki, Shiori, Sanaki, Takao, Yoshioka, Takeshi, Higashino, Kenichi, Tofukuji, Soichi, Yoneda, Sosuke, Takahashi, Tatsuya, Koda, Ken, Asaki, Toshiyuki, Hasegawa, Minoru, Morioka, Yasuhide

Source: Pain. 160(4):895-907

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180421445.0x000001&indx=1&recIds=ETOCvdc_100180421445.0x000001

Efficacy and Safety of Ensitrelvir for Asymptomatic or Mild COVID‐19: An Exploratory Analysis of a Multicenter, Randomized, Phase 2b/3 Clinical Trial.

Authors: Ohmagari, Norio, Yotsuyanagi, Hiroshi, Doi, Yohei, Yamato, Masaya, Imamura, Takumi, Sakaguchi, Hiroki, Yamanaka, Hideki, Imaoka, Ryosuke, Fukushi, Akimasa, Ichihashi, Genki, Sanaki, Takao, Tsuge, Yuko, Uehara, Takeki, Mukae, Hiroshi

Source: Influenza & Other Respiratory Viruses; Jun2024, Vol. 18 Issue 6, p1-5, 5p

Subject Terms: COVID-19

Geographic Terms: SOUTH Korea, JAPAN

Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5, 6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis

Authors: Hinata, Mikie, Imai, Sunao, Sanaki, Takao, Tsuchida, Junji, Yoshioka, Takeshi, Higashino, Kenichi, Yamamoto, Miyuki, Imai, Masayuki, Soga, Masahiko, Horita, Narumi, Fukuda, Isao, Ikeda, Minoru, Yamane, Shoji, Morita, Atsushi, Kanemasa, Toshiyuki, Sakaguchi, Gaku, Hasegawa, Minoru, Minami, Masabumi, Morioka, Yasuhide

Source: Pain. 159(5):939-947

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174972241.0x000001&indx=1&recIds=ETOCvdc_100174972241.0x000001

Possible roles of long-chain sphingomyelines and sphingomyelin synthase 2 in mouse macrophage inflammatory response

Authors: Sakamoto, Hideaki, Yoshida, Tetsuya, Sanaki, Takao, Shigaki, Shuhei, Morita, Hirotoshi, Oyama, Miki, Mitsui, Masaru, Tanaka, Yoshikazu, Nakano, Toru, Mitsutake, Susumu, Igarashi, Yasuyuki, Takemoto, Hiroshi

Source: Biochemical and biophysical research communications. 482(2):202-207

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100050833582.0x000001&indx=1&recIds=ETOCvdc_100050833582.0x000001

Direct Involvement of Arachidonic Acid in the Development of Ear Edema via TRPV3

Authors: Sanaki, Takao, Kasai-Yamamoto, Erika, Yoshioka, Takeshi, Sakai, Shota, Yuyama, Kohei, Fujiwara, Takuji, Numata, Yoshito, Igarashi, Yasuyuki

Source: Journal of oleo science. 66(6):591-600

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN612000704&indx=1&recIds=ETOCRN612000704

A phase 2/3 study of S-217622 in participants with SARS-CoV-2 infection (Phase 3 part)

Authors: Yotsuyanagi, Hiroshi, Ohmagari, Norio, Doi, Yohei, Imamura, Takumi, Sonoyama, Takuhiro, Ichihashi, Genki, Sanaki, Takao, Tsuge, Yuko, Uehara, Takeki, Mukae, Hiroshi

Source: Medicine. 102(8):e33024-e33024

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191474600.0x000001&indx=1&recIds=ETOCvdc_100191474600.0x000001

Efficacy and Safety of Ensitrelvir in Patients With Mild-to-Moderate Coronavirus Disease 2019: The Phase 2b Part of a Randomized, Placebo-Controlled, Phase 2/3 Study.

Authors: Mukae, Hiroshi, Yotsuyanagi, Hiroshi, Ohmagari, Norio, Doi, Yohei, Sakaguchi, Hiroki, Sonoyama, Takuhiro, Ichihashi, Genki, Sanaki, Takao, Baba, Keiko, Tsuge, Yuko, Uehara, Takeki

Source: Clinical Infectious Diseases; 4/15/2023, Vol. 76 Issue 8, p1403-1411, 9p

Subject Terms: DRUG efficacy, COVID-19, TIME, ANTIVIRAL agents, SEVERITY of illness index, RANDOMIZED controlled trials, TREATMENT effectiveness, PLACEBOS, PATIENT safety, COVID-19 pandemic, PHARMACODYNAMICS

Geographic Terms: JAPAN

SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells.

Authors: Sasaki, Michihito¹, m-sasaki@czc.hokudai.ac.jp, Uemura, Kentaro^1,2,3, Sato, Akihiko^1,2, Toba, Shinsuke^1,2, Sanaki, Takao^1,2, Maenaka, Katsumi^3,4, Hall, William W.^5,6,7, Orba, Yasuko^1,5, Sawa, Hirofumi^1,5,7

Source: PLoS Pathogens; 1/21/2021, Vol. 17 Issue 1, p1-17, 17p

S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters.

Authors: Sasaki, Michihito, Tabata, Koshiro, Kishimoto, Mai, Itakura, Yukari, Kobayashi, Hiroko, Ariizumi, Takuma, Uemura, Kentaro, Toba, Shinsuke, Kusakabe, Shinji, Maruyama, Yuki, Iida, Shun, Nakajima, Noriko, Suzuki, Tadaki, Yoshida, Shinpei, Nobori, Haruaki, Sanaki, Takao, Kato, Teruhisa, Shishido, Takao, Hall, William W., Orba, Yasuko

Source: Science Translational Medicine; 1/18/2023, Vol. 15 Issue 679, p1-12, 12p

Subject Terms: SARS-CoV-2, PROTEASE inhibitors, COVID-19, SARS-CoV-2 Delta variant, CORONAVIRUS disease treatment, SARS-CoV-2 Omicron variant

Discovery of S‑217622, a Noncovalent Oral SARS-CoV‑2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19.

Authors: Unoh, Yuto, Uehara, Shota, Nakahara, Kenji, Nobori, Haruaki, Yamatsu, Yukiko, Yamamoto, Shiho, Maruyama, Yuki, Taoda, Yoshiyuki, Kasamatsu, Koji, Suto, Takahiro, Kouki, Kensuke, Nakahashi, Atsufumi, Kawashima, Sho, Sanaki, Takao, Toba, Shinsuke, Uemura, Kentaro, Mizutare, Tohru, Ando, Shigeru, Sasaki, Michihito, Orba, Yasuko

Source: Journal of Medicinal Chemistry; 5/12/2022, Vol. 65 Issue 9, p6499-6512, 14p

MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2.

Authors: Uemura, Kentaro, Sasaki, Michihito, Sanaki, Takao, Toba, Shinsuke, Takahashi, Yoshimasa, Orba, Yasuko, Hall, William W., Maenaka, Katsumi, Sawa, Hirofumi, Sato, Akihiko

Source: Scientific Reports; 3/8/2021, Vol. 11 Issue 1, p1-9, 9p

Subject Terms: ANTIVIRAL agents, COVID-19 pandemic, VIRAL replication, DISEASE susceptibility, CELL lines

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Efficacy and Safety of 5-Day Oral Ensitrelvir for Patients With Mild to Moderate COVID-19: The SCORPIO-SR Randomized Clinical Trial.

Authors: Yotsuyanagi, Hiroshi, Ohmagari, Norio, Doi, Yohei, Yamato, Masaya, Bac, Nguyen Hoang, Cha, Bong Ki, Imamura, Takumi, Sonoyama, Takuhiro, Ichihashi, Genki, Sanaki, Takao, Tsuge, Yuko, Uehara, Takeki, Mukae, Hiroshi

Source: JAMA Network Open; 2/9/2024, Vol. 7 Issue 2, pe2354991-e2354991, 1p