Synthesis, in silico modelling, and in vitro biological evaluation of substituted pyrazole derivatives as potential anti-skin cancer, anti-tyrosinase, and antioxidant agents

Authors: Samuel T. Boateng, Tithi Roy, Kara Torrey, Uchechi Owunna, Sergette Banang-Mbeumi, David Basnet, Eleonora Niedda, Alexis D. Alexander, Denzel El Hage, Siriki Atchimnaidu, Bolni Marius Nagalo, Dinesh Aryal, Ann Findley, Navindra P. Seeram, Tatiana Efimova, Mario Sechi, Ronald A. Hill, Hang Ma, Jean Christopher Chamcheu, Siva Murru

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

Subject Terms: Antitumor agents, apoptosis, tyrosinase inhibition, antioxidant, molecular docking and ADMET, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/6723a7780c15410686963a027f101484

α-Glucosidase inhibition by green, white and oolong teas: in vitro activity and computational studies

Authors: Fabio Esposito, Nicolino Pala, Mauro Carcelli, Samuel T. Boateng, Paolo S. D’Aquila, Alberto Mariani, Sandro Satta, Jean Christopher Chamcheu, Mario Sechi, Vanna Sanna

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

Subject Terms: α-glucosidase inhibition, tea, polyphenols, catechins, molecular docking, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/a8426010c28e45e2be3e2b777b431689

Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation

Authors: Tithi Roy, Sergette Banang-Mbeumi, Samuel T. Boateng, Emmanuelle M. Ruiz, Roxane-Cherille N. Chamcheu, Lin Kang, Judy A. King, Anthony L. Walker, Bolni Marius Nagalo, Konstantin G. Kousoulas, Stephane Esnault, Shile Huang, Jean Christopher Chamcheu

Source: Frontiers in Immunology, Vol 13 (2023)

Subject Terms: autophagy, fisetin, psoriasis, Akt/mTOR and IL-17A, rapamycin, topical administration, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1075804/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/aac2a82940c348b5a3ec4d64743b35a6

The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

Authors: Tithi Roy, Samuel T. Boateng, Mohammad B. Uddin, Sergette Banang-Mbeumi, Rajesh K. Yadav, Chelsea R. Bock, Joy T. Folahan, Xavier Siwe-Noundou, Anthony L. Walker, Judy A. King, Claudia Buerger, Shile Huang, Jean Christopher Chamcheu

Source: Cells, Vol 12, Iss 12, p 1671 (2023)

Subject Terms: acne, PI3K-Akt-mTOR signaling pathway, skin inflammation, phytochemicals, psoriasis, atopic dermatitis, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/12/1671; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/7b00fedceb10450bb4ff237acb393a0b

Standardized Pomegranate (Pomella®) and Red Maple (Maplifa®) Extracts and Their Phenolics Protect Type I Collagen by the Inhibition of Matrix Metalloproteinases, Collagenase, and Collagen Cross-Linking

Authors: Huifang Li, Tithi Roy, Samuel T. Boateng, Hao He, Chang Liu, Weixi Liu, Dongli Li, Panpan Wu, Navindra P. Seeram, Jean Christopher Chamcheu, Hang Ma

Source: Molecules, Vol 27, Iss 22, p 7919 (2022)

Subject Terms: pomegranate (Punica granatum), red maple (Acer rubrum), punicalagin, ginnalin A, collagenase, cross-linking, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/22/7919; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/e9cff1bded1c4cc1ac3989d3f4e99a74

Identification of new fisetin analogs as kinase inhibitors: Data on synthesis and anti-skin cancer activities evaluation

Authors: Tithi Roy, Samuel T. Boateng, Sergette Banang-Mbeumi, Pankaj K. Singh, Pratik Basnet, Roxane-Cherille N. Chamcheu, Federico Ladu, Isabel Chauvin, Vladimir S. Spiegelman, Ronald A. Hill, Konstantin G. Kousoulas, Bolni Marius Nagalo, Anthony L. Walker, Jean Fotie, Siva Murru, Mario Sechi, Jean Christopher Chamcheu

Source: Data in Brief, Vol 35, Iss , Pp 106858- (2021)

Subject Terms: Anticancer evaluation, skin cancers, fisetin analogs, target prediction, computational docking, kinase activities, Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352340921001426; https://doaj.org/toc/2352-3409

Access URL: https://doaj.org/article/8f9eb6ff82c7476a93275e6a6773652e