Discovery of Ligand-Efficient Scaffolds for the Design of Novel Trichomonas vaginalis Uridine Nucleoside Ribohydrolase Inhibitors Using Fragment Screening

Authors: Shannon Auletta, Wagma Caravan, Julia K. Persaud, Samantha F. Thuilot, Dean G. Brown, David W. Parkin, Brian J. Stockman

Source: ACS Omega, Vol 4, Iss 14, Pp 16226-16232 (2019)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2470-1343

Access URL: https://doaj.org/article/8917d2ad193a48c396a856be3a3a17da

NMR-Based Activity Assays for Determining Compound Inhibition, IC50 Values, Artifactual Activity, and Whole-Cell Activity of Nucleoside Ribohydrolases

Authors: Brian J. Stockman, author¹, Abinash Kaur, author¹, Julia K. Persaud, author¹, Maham Mahmood, author¹, Samantha F. Thuilot, author¹, Melissa B. Emilcar, author¹, Madison Canestrari, author¹, Juliana A. Gonzalez, author¹, Shannon Auletta, author¹, Vital Sapojnikov, author¹, Wagma Caravan, author^{1, 2}, Samantha N. Muellers, author^{1, 3}

Source: Journal of Visualized Experiments. (148)

Availability: http://www.jove.com/video/59928