Using synthetic biology to understand the gut-brain axis

Authors: Cesaro, Angela ^{1, 2, 3, 4, 8}, Broset, Esther ^{1, 2, 3, 4, 8}, Salimando, Gregory J. ⁵, Öztekin, Sebahat ^{1, 2, 3, 4, 7}, Mai, David ², Bennett, Mariko L. ^{5, 6}, de la Fuente-Nunez, Cesar ^{1, 2, 3, 4, ∗}

Source: In Cell Reports Physical Science 19 March 2025 6(3)

BNST GluN2D‐containing NMDARs contribute to ethanol intake but not negative affective behaviors in female mice.

Authors: Doyle, Marie A.^1,2,3, Salimando, Gregory J.^2,3, Altemus, Megan E.³, Badt, Justin K.³, Bedenbaugh, Michelle N.^2,3, Vardy, Alexander S.³, Adank, Danielle N.³, Park, Anika S.³, Winder, Danny G.^1,2,3 danny.winder@umassmed.edu

Source: Alcohol, Clinical & Experimental Research. Oct2024, Vol. 48 Issue 10, p1876-1891. 16p.

Subject Terms: *DRINKING (Physiology), *TELENCEPHALON, *RESEARCH funding, *T-test (Statistics), *DATA analysis, *ETHANOL, *BRAIN, *SEX distribution, *POLYMERASE chain reaction, *TEMPERANCE, *AFFECTIVE disorders, *DESCRIPTIVE statistics, *MICE, *GENE expression, *RNA, *ANIMAL behavior, *ANIMAL experimentation, *ANALYSIS of variance, *STATISTICS, *AFFECT (Psychology), *EXCITATORY amino acid antagonists, *ALCOHOL drinking, *COMPARATIVE studies, *CELL receptors, *ELECTROPHYSIOLOGY

BNST GluN2D-Containing NMDA Receptors Influence Anxiety- and Depressive-like Behaviors and Modulate Cell-Specific Excitatory/Inhibitory Synaptic Balance

Authors: Salimando, Gregory J., Hyun, Minsuk, Boyt, Kristen M., Winder, Danny G.

Source: Journal of neuroscience. 40(20):3949-3968

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN623954314&indx=1&recIds=ETOCRN623954314

Chronic Intermittent Ethanol and Acute Stress Similarly Modulate BNST CRF Neuron Activity via Noradrenergic Signaling

Authors: Snyder, Angela E., Salimando, Gregory J., Winder, Danny G., Silberman, Yuval

Source: Alcoholism. 43(8):1695-1701

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100087157255.0x000001&indx=1&recIds=ETOCvdc_100087157255.0x000001

Viral Strategies for Targeting and Manipulating Opioidergic Neuronal Populations for Cell Specific Study and Therapeutic Intervention

Authors: Salimando, Gregory J., Tremblay, Sebastien, Borner, Tito, Hayes, Matthew, De Jonghe, Bart, Platt, Michael, Renthal, William, Ramakrishnan, Charu, Deisseroth, Karl, Corder, Gregory

Source: Journal of pain. 23(S):18-19

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161606132.0x000001&indx=1&recIds=ETOCvdc_100161606132.0x000001

Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types.

Authors: Salimando, Gregory J., Tremblay, Sébastien, Kimmey, Blake A., Li, Jia, Rogers, Sophie A., Wojick, Jessica A., McCall, Nora M., Wooldridge, Lisa M., Rodrigues, Amrith, Borner, Tito, Gardiner, Kristin L., Jayakar, Selwyn S., Singeç, Ilyas, Woolf, Clifford J., Hayes, Matthew R., De Jonghe, Bart C., Bennett, F. Christian, Bennett, Mariko L., Blendy, Julie A., Platt, Michael L.

Source: Nature Communications; 9/13/2023, Vol. 14 Issue 1, p1-24, 24p

Subject Terms: INDUCED pluripotent stem cells, OPIOID abuse, OPIOID receptors, TRANSGENE expression, GENE expression, GENETIC vectors, CELL populations, NOCICEPTORS

Cocaine Augments Dopamine-Mediated Inhibition of Neuronal Activity in the Dorsal Bed Nucleus of the Stria Terminalis.

Authors: Melchior, James R., Perez, Rafael E., Salimando, Gregory J., Luchsinger, Joseph R., Basu, Aakash, Winder, Danny G.

Source: Journal of Neuroscience; 7/7/2021, Vol. 41 Issue 27, p5876-5893, 18p

Subject Terms: COCAINE, LABORATORY mice, CYCLIC voltammetry, DOPAMINE, NORADRENALINE, PHOTOMETRY

Delineation of an insula-BNST circuit engaged by struggling behavior that regulates avoidance in mice.

Authors: Luchsinger, Joseph R., Fetterly, Tracy L., Williford, Kellie M., Salimando, Gregory J., Doyle, Marie A., Maldonado, Jose, Simerly, Richard B., Winder, Danny G., Centanni, Samuel W.

Source: Nature Communications; 6/11/2021, Vol. 12 Issue 1, p1-18, 18p

Subject Terms: INSULAR cortex, SOMATOSENSORY cortex, AFFERENT pathways, PREMOTOR cortex, MOTOR cortex, IMMOBILIZATION stress, STRUGGLE

BNST GluN2D-Containing NMD A Receptors Influence Anxiety- and Depressive-like Behaviors and Modulate Cell-Specific Excitatory/Inhibitory Synaptic Balance.

Authors: Salimando, Gregory J.^1,2,3,4, Minsuk Hyun⁵, Boyt, Kristen M.⁶, Winder, Danny G.^1,2,3,4,7,8

Source: Journal of Neuroscience. 5/13/2020, Vol. 40 Issue 20, p3949-3968. 20p.

Subject Terms: *EMOTIONAL state, *LONG-term synaptic depression, *CELL anatomy, *CELL populations, *AFFECTIVE disorders, *BEHAVIOR, *ELECTROPHYSIOLOGY

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Role and Regulation of BNST GluN2D-containing NMDARs in a Continuous Access Ethanol Task

Authors: Doyle, Marie A., Altemus, Megan E., Salimando, Gregory J., Badt, Justin K., Bedenbaugh, Michelle N., Park, Anika S., Adank, Danielle N., Simerly, Richard B., Winder, Danny G.

Source: The Journal of Pharmacology and Experimental Therapeutics; June 2023, Vol. 385 Issue: 1, Number 1 Supplement 3 p143-143, 1p