Measurable residual disease monitoring in AML with FLT3-ITD treated with intensive chemotherapy plus midostaurin

Authors: Rücker, Frank G. ¹, Bullinger, Lars ², Cocciardi, Sibylle ¹, Skambraks, Sabrina ¹, Luck, Tamara J. ^{1, 2}, Weber, Daniela ¹, Krzykalla, Julia ³, Pozek, Ema ³, Schneider, Isabelle ¹, Corbacioglu, Andrea ¹, Gaidzik, Verena I. ¹, Meid, Annika ¹, Aicher, Sophia ¹, Stegelmann, Frank ¹, Schrade, Anika ¹, Theis, Frauke ¹, Fiedler, Walter ⁴, Salih, Helmut R. ⁵, Wulf, Gerald ⁶, Salwender, Hans ⁷, Schroeder, Thomas ⁸, Götze, Katharina S. ⁹, Kühn, Michael W. M. ¹⁰, Lübbert, Michael ¹¹, Schlenk, Richard F. ^{12, 13}, Benner, Axel ³, Thol, Felicitas ¹⁴, Heuser, Michael ¹⁴, Ganser, Arnold ¹⁴, Döhner, Hartmut ¹, Döhner, Konstanze ^{1, ∗}

Source: In Blood Advances 10 December 2024 8(23):6067-6080

Long-term efficacy of the peptide-based COVID-19 T cell activator CoVac-1 in healthy adults

Authors: Tandler, Claudia, Heitmann, Jonas S., Michel, Tanja M., Marconato, Maddalena, Jaeger, Simon U., Tegeler, Christian M., Denk, Monika, Richter, Marion, Oezbek, Melek Tutku, Maringer, Yacine, Schroeder, Sarah M., Schneiderhan-Marra, Nicole, Wiesmüller, Karl-Heinz, Bitzer, Michael, Ruetalo, Natalia, Schindler, Michael, Meisner, Christoph, Fischer, Imma, Rammensee, Hans-Georg, Salih, Helmut R., Walz, Juliane S.

Source: In International Journal of Infectious Diseases February 2024 139:69-77

An optimized IgG-based B7-H3xCD3 bispecific antibody for treatment of gastrointestinal cancers

Authors: Zekri, Latifa, Lutz, Martina, Prakash, Nisha, Manz, Timo, Klimovich, Boris, Mueller, Stefanie, Hoerner, Sebastian, Hagelstein, Ilona, Engel, Monika, Chashchina, Anna, Pfluegler, Martin, Heitmann, Jonas S., Jung, Gundram, Salih, Helmut R.

Source: Molecular therapy. 31(4):1033-1045

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194465294.0x000001&indx=1&recIds=ETOCvdc_100194465294.0x000001

Performance of phase‐I dose finding designs with and without a run‐in intra‐patient dose escalation stage

Authors: Labrenz, Jannik, Edelmann, Dominic, Heitmann, Jonas S., Salih, Helmut R., Kopp‐Schneider, Annette, Schlenk, Richard F.

Source: Pharmaceutical statistics. 22(2):236-247

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177746094.0x000001&indx=1&recIds=ETOCvdc_100177746094.0x000001

10-day decitabine versus 3 + 7 chemotherapy followed by allografting in older patients with acute myeloid leukaemia: an open-label, randomised, controlled, phase 3 trial

Authors: Finke, Jürgen, Schaap, Nicolaas Petrus Michael, Zucenka, Andrius, Metzelder, Stephan, Jost, Edgar, Perić, Zinaida, Forghieri, Fabio, Allione, Bernadino, Martelli, Maurizio, Iori, Anna Paola, Wittnebel, Sebastian, Mengarelli, Andrea, Imovilli, Annalisa, Olivieri, Attilio, De Prijck, Bernard José Marie, van der Poel, Marjolein W.M., Junghanß, Christian, Salih, Helmut Rainer, Tafuri, Agostino, Guimarães, José Eduardo, Musso, Maurizio, De Fabritiis, Paolo, Chevallier, Patrice, Selleslag, Dominik Luc, Cascavilla, Nicola, Berneman, Zwi, Jaspers, Aurélie, Zuffa, Eliana, Vanstraelen, Gaëtan, Visani, Giuseppe, Cuijpers, Maria Louisa Henriëtte, De Becker, Ann, Mianulli, Anna Maria, Hackanson, Björn, Mihaylov, Georgi Georgiev, Martinelli, Giovanni, Paolini, Stefania, Zinzani, Pier Luigi, Henkes, Martin, Al-Ali, Haifa Kathrin, La Rosée, Paul, Chierichini, Anna, Cudillo, Laura, Specchia, Giorgina, Šimec, Njetočka Gredelj, Capalbo, Silvana Franca, Spinosa, Giuseppina, Molica, Stefano, de Jonge-Peeters, Susan Dorothé, Lübbert, Michael ^{*, *}, Wijermans, Pierre W ^*, Kicinski, Michal, Chantepie, Sylvain, Van der Velden, Walter J F M, Noppeney, Richard, Griškevičius, Laimonas, Neubauer, Andreas, Crysandt, Martina, Vrhovac, Radovan, Luppi, Mario, Fuhrmann, Stephan, Audisio, Ernesta, Candoni, Anna, Legrand, Olivier, Foà, Robin, Gaidano, Gianluca, van Lammeren-Venema, Danielle, Posthuma, Eduardus F M, Hoogendoorn, Mels, Giraut, Anne, Stevens-Kroef, Marian, Jansen, Joop H, de Graaf, Aniek O, Efficace, Fabio, Ammatuna, Emanuele, Vilque, Jean-Pierre, Wäsch, Ralph, Becker, Heiko, Blijlevens, Nicole, Dührsen, Ulrich, Baron, Frédéric, Suciu, Stefan, Amadori, Sergio, Venditti, Adriano, Huls, Gerwin ^**

Source: In The Lancet Haematology November 2023 10(11):e879-e889

Retained functional normal and preleukemic HSCs at diagnosis are associated with good prognosis in DNMT3AmutNPM1mut AMLs

Authors: Donato, Elisa ^∗, Correia, Nadia ^∗, Andresen, Carolin ^∗, Karpova, Darja, Würth, Roberto, Klein, Corinna, Sohn, Markus, Przybylla, Adriana, Zeisberger, Petra, Rothfelder, Kathrin, Salih, Helmut, Bonig, Halvard, Stasik, Sebastian, Röllig, Christoph, Dolnik, Anna, Bullinger, Lars, Buchholz, Frank, Thiede, Christian, Hübschmann, Daniel, Trumpp, Andreas

Source: In Blood Advances 28 March 2023 7(6):1011-1018

Prevalence of COVID-19-associated symptoms during acute infection in relation to SARS-CoV-2-directed humoral and cellular immune responses in a mild-diseased convalescent cohort

Authors: Tegeler, Christian M., Bilich, Tatjana, Maringer, Yacine, Salih, Helmut R., Walz, Juliane S., Nelde, Annika, Heitmann, Jonas S.

Source: International journal of infectious diseases. 120:187-195

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163678177.0x000001&indx=1&recIds=ETOCvdc_100163678177.0x000001

Midostaurin plus intensive chemotherapy for younger and older patients with AML and FLT3 internal tandem duplications

Authors: Döhner, Hartmut ^*, Weber, Daniela, Krzykalla, Julia, Fiedler, Walter, Wulf, Gerald, Salih, Helmut, Lübbert, Michael, Kühn, Michael W.M., Schroeder, Thomas, Salwender, Hans, Götze, Katharina, Westermann, Jörg, Fransecky, Lars, Mayer, Karin, Hertenstein, Bernd, Ringhoffer, Mark, Tischler, Hans-Joachim, Machherndl-Spandl, Sigrid, Schrade, Anika, Paschka, Peter, Gaidzik, Verena I., Theis, Frauke, Thol, Felicitas, Heuser, Michael, Schlenk, Richard F., Bullinger, Lars, Saadati, Maral, Benner, Axel, Larson, Richard, Stone, Richard, Döhner, Konstanze, Ganser, Arnold

Source: In Blood Advances 27 September 2022 6(18):5345-5355

Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin

Authors: Schmalbrock, Laura K., Dolnik, Anna, Cocciardi, Sibylle, Sträng, Eric, Theis, Frauke, Jahn, Nikolaus, Panina, Ekaterina, Blätte, Tamara J., Herzig, Julia, Skambraks, Sabrina, Rücker, Frank G., Gaidzik, Verena I., Paschka, Peter, Fiedler, Walter, Salih, Helmut R., Wulf, Gerald, Schroeder, Thomas, Lübbert, Michael, Schlenk, Richard F., Thol, Felicitas, Heuser, Michael, Larson, Richard A., Ganser, Arnold, Stunnenberg, Hendrik G., Minucci, Saverio, Stone, Richard M., Bloomfield, Clara D., Döhner, Hartmut, Döhner, Konstanze ^{*, *}, Bullinger, Lars ^*

Source: In Blood 3 June 2021 137(22):3093-3104

Expression profiles of HMGB1 on B-CLL related leukocytes contribute to prediction of relapse

Authors: Schmohl, Joerg, Guenther, Thomas, Sutanto, Wishnu, Schuster, Friedhelm, Kroell, Tanja, Hartmann, Amely, Salih, Helmut, Stoetzer, Oliver, Schmetzer, H.

Source: In Immunobiology January 2021 226(1)

Expression levels of HLA-DR in acute myeloid leukemia: implications for antigenicity and clinical outcome

Authors: Roerden, Malte, Märklin, Melanie, Salih, Helmut R., Bethge, Wolfgang A., Klein, Reinhild, Rammensee, Hans-Georg, Nelde, Annika, Walz, Juliane S.

Source: Leukemia & lymphoma. 62(8):1907-1919

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100156246478.0x000001&indx=1&recIds=ETOCvdc_100156246478.0x000001

AML-VAC-XS15-01: protocol of a first-in-human clinical trial to evaluate the safety, tolerability and preliminary efficacy of a multi-peptide vaccine based on leukemia stem cell antigens in acute myeloid leukemia patients.

Authors: Jung, Susanne, Nelde, Annika, Maringer, Yacine, Denk, Monika, Zieschang, Lisa, Kammer, Christine, Özbek, Melek, Martus, Peter, Hackenbruch, Christopher, Englisch, Alexander, Heitmann, Jonas S., Salih, Helmut R., Walz, Juliane S.

Source: Frontiers in Oncology; 2024, p1-9, 9p

Subject Terms: TUMOR antigens, ACUTE myeloid leukemia, MEDICAL societies, BOOSTER vaccines, HLA histocompatibility antigens

Targeting CD276 for T cell-based immunotherapy of breast cancer.

Authors: Hagelstein, Ilona, Wessling, Laura, Rochwarger, Alexander, Zekri, Latifa, Klimovich, Boris, Tegeler, Christian M., Jung, Gundram, Schürch, Christian M., Salih, Helmut R., Lutz, Martina S.

Source: Journal of Translational Medicine; 10/4/2024, Vol. 22 Issue 1, p1-15, 15p

Subject Terms: IMMUNE checkpoint inhibitors, IMMUNOLOGIC memory, BISPECIFIC antibodies, LYSIS, T cells

Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis

Authors: Geue, Sascha ^*, Aurbach, Katja ^*, Manke, Mailin-Christin, Manukjan, Georgi, Münzer, Patrick, Stegner, David, Brähler, Caroline, Walker-Allgaier, Britta, Märklin, Melanie, Borst, Carla E., Quintanilla-Fend, Leticia, Rath, Dominik, Geisler, Tobias, Salih, Helmut R., Seizer, Peter, Lang, Florian, Nieswandt, Bernhard, Gawaz, Meinrad, Schulze, Harald, Pleines, Irina, Borst, Oliver

Source: In Blood 21 November 2019 134(21):1847-1858

The Deubiquitinase Inhibitor b-AP15 and Its Effect on Phenotype and Function of Monocyte-Derived Dendritic Cells

Authors: Schmidt, Moritz, Altdörfer, Vanessa, Schnitte, Sarah, Fuchs, Alexander Rolf, Kropp, Korbinian Nepomuk, Maurer, Stefanie, Müller, Martin Rudolf, Salih, Helmut Rainer, Rittig, Susanne Malaika, Grünebach, Frank, Dörfel, Daniela

Source: In Neoplasia July 2019 21(7):653-664

CD105 (endoglin) as risk marker in AML patients undergoing stem cell transplantation

Authors: Märklin, Melanie, Hagelstein, Ilona, Hinterleitner, Clemens, Salih, Helmut R., Kauer, Joseph, Heitmann, Jonas S.

Source: International journal of hematology. 112(1):57-64

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174278235.0x000001&indx=1&recIds=ETOCvdc_100174278235.0x000001

Fc gamma receptor expression serves as prognostic and diagnostic factor in AML

Authors: Heitmann, Jonas S., Hagelstein, Ilona, Hinterleitner, Clemens, Osburg, Lukas, Salih, Helmut R., Kauer, Joseph, Märklin, Melanie

Source: Leukemia & lymphoma. 61(10):2466-2474

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110728119.0x000001&indx=1&recIds=ETOCvdc_100110728119.0x000001

Identification of CD318 (CDCP1) as novel prognostic marker in AML

Authors: Heitmann, Jonas S., Hagelstein, Ilona, Hinterleitner, Clemens, Roerden, Malte, Jung, Gundram, Salih, Helmut R., Märklin, Melanie, Kauer, Joseph

Source: Annals of hematology. 99(3):477-486

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164296161.0x000001&indx=1&recIds=ETOCvdc_100164296161.0x000001

iVAC-XS15-CLL01: personalized multi-peptide vaccination in combination with the TLR1/2 ligand XS15 in CLL patients undergoing BTK-inhibitor-based regimens.

Authors: Englisch, Alexander, Hayn, Clara, Jung, Susanne, Heitmann, Jonas S., Hackenbruch, Christopher, Maringer, Yacine, Nelde, Annika, Wacker, Marcel, Denk, Monika, Zieschang, Lisa, Kammer, Christine, Martus, Peter, Salih, Helmut R., Walz, Juliane S.

Source: Frontiers in Oncology; 2024, p1-10, 10p

Subject Terms: BRUTON tyrosine kinase, CHRONIC lymphocytic leukemia, PEPTIDE vaccines, VACCINE immunogenicity, PROTEIN-tyrosine kinase inhibitors

Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with FLT3-ITD

Authors: Schlenk, Richard F. ^*, Weber, Daniela, Fiedler, Walter, Salih, Helmut R., Wulf, Gerald, Salwender, Hans, Schroeder, Thomas, Kindler, Thomas, Lübbert, Michael, Wolf, Dominik, Westermann, Jörg, Kraemer, Doris, Götze, Katharina S., Horst, Heinz-August, Krauter, Jürgen, Girschikofsky, Michael, Ringhoffer, Mark, Südhoff, Thomas, Held, Gerhard, Derigs, Hans-Günter, Schroers, Roland, Greil, Richard, Grießhammer, Martin, Lange, Elisabeth, Burchardt, Alexander, Martens, Uwe, Hertenstein, Bernd, Marretta, Lore, Heuser, Michael, Thol, Felicitas, Gaidzik, Verena I., Herr, Wolfgang, Krzykalla, Julia, Benner, Axel, Döhner, Konstanze, Ganser, Arnold, Paschka, Peter, Döhner, Hartmut

Source: In Blood 21 February 2019 133(8):840-851