Poly (I:C)-induced inflammation requires the activation of toll-like receptor 3/Ca ²⁺ /CaMKII/pannexin 1-dependent signaling.

Authors: Salgado, Magdiel, Sepúlveda-Arriagada, Vania, Konar-Nié, Macarena, García-Robles, María A., Sáez, Juan C.

Source: Theranostics; 2025, Vol. 15 Issue 6, p2470-2486, 17p

Inhibition of Hypothalamic MCT4 and MCT1–MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions

Authors: Elizondo-Vega, Roberto, Oyarce, Karina, Salgado, Magdiel, Barahona, María José, Recabal, Antonia, Ordenes, Patricio, López, Sergio, Pincheira, Roxana, Luz-Crawford, Patricia, García-Robles, María Angeles

Source: Molecular neurobiology. 57(2):896-909

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164107765.0x000001&indx=1&recIds=ETOCvdc_100164107765.0x000001

Ca²⁺ permeation through C-terminal cleaved, but not full-length human Pannexin1 hemichannels, mediates cell death.

Authors: Salgado, Magdiel¹ magdiel.salgado@cinv.cl, Márquez-Miranda, Valeria², Ferrada, Luciano³, Rojas, Maximiliano², Poblete-Flores, Gonzalo⁴, González-Nilo, Fernando D.^1,2 fernando.gonzalez@unab.cl, Ardiles, Álvaro O.^1,4, Sáez, Juan C.¹ juancarlos.saez@uv.cl

Source: Proceedings of the National Academy of Sciences of the United States of America. 6/18/2024, Vol. 121 Issue 25, p1-10. 19p.

Subject Terms: *CELL death, *INTRACELLULAR space, *HELA cells, *EXTRACELLULAR space, *ALKALINE solutions

Mutagenic and kinetic support for an allosteric site in arginase from the extreme thermophile Bacillus caldovelox, which allows activation by arginine

Authors: García, David, Uribe, Elena, Salgado, Magdiel, Martínez, María Paz, Carvajal, Nelson

Source: In Biochimie January 2015 108:8-12

The connexin hemichannel inhibitor D4 produces rapid antidepressant-like effects in mice.

Authors: Li, Huanhuan, Guo, Anni, Salgado, Magdiel, Sáez, Juan C., Lau, Chunyue Geoffrey

Source: Journal of Neuroinflammation; 8/20/2023, Vol. 20 Issue 1, p1-18, 18p

Subject Terms: ENTORHINAL cortex, AFFECTIVE disorders, MENTAL depression, IMMOBILIZATION stress, MICE

Unnexin is a protein subunit of a large-pore channel expressed by unicellular organisms.

Authors: Juan Güiza, Solís, Francisco, Valenzuela, Bernardita, Arancibia, Duxan, Zamorano, Pedro, González, Jorge, Saavedra, Jonathan, Neely, Alan, Salgado, Magdiel, Martínez, Agustín D., Sáez, Juan C., Vega, José L.

Source: Proceedings of the National Academy of Sciences of the United States of America; 8/1/2023, Vol. 120 Issue 31, p1-8, 14p

Subject Terms: UNICELLULAR organisms, TRANSMEMBRANE domains, SMALL molecules, PROTEIN subunits, TRYPANOSOMA cruzi

Author Correction: Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior

Authors: Uranga, Romina María, Millán, Carola, Barahona, María José, Recabal, Antonia, Salgado, Magdiel, Martinez, Fernando, Ordenes, Patricio, Elizondo-Vega, Roberto, Sepúlveda, Fernando, Uribe, Elena, García-Robles, María de los Ángeles

Source: Scientific reports. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131446899.0x000001&indx=1&recIds=ETOCvdc_100131446899.0x000001

Skeletal Muscle Atrophy Induced by Diabetes Is Mediated by Non-Selective Channels and Prevented by Boldine.

Authors: Cea, Luis A., Vásquez, Walter, Hernández-Salinas, Romina, Vielma, Alejandra Z., Castillo-Ruiz, Mario, Velarde, Victoria, Salgado, Magdiel, Sáez, Juan C.

Source: Biomolecules (2218-273X); Apr2023, Vol. 13 Issue 4, p708, 14p

Subject Terms: MUSCULAR atrophy, SKELETAL muscle, DIABETES complications, STREPTOZOTOCIN, SARCOLEMMA

A Short-Term Sucrose Diet Impacts Cell Proliferation of Neural Precursors in the Adult Hypothalamus.

Authors: Recabal, Antonia, López, Sergio, Salgado, Magdiel, Palma, Alejandra, Obregón, Ana M., Elizondo-Vega, Roberto, Sáez, Juan C., García-Robles, María Á.

Source: Nutrients; Jul2022, Vol. 14 Issue 13, p2564-N.PAG, 18p

GKRP-dependent modulation of feeding behavior by tanycyte-released monocarboxylates.

Authors: Salgado, Magdiel, Elizondo-Vega, Roberto, Villar, Pablo S., Konar, Macarena, Gallegos, Scarlet, Tarifeño-Saldivia, Estefanía, Luz-Crawford, Patricia, Aguayo, Luis G., Araneda, Ricardo C., Uribe, Elena, Ángeles García-Robles, María

Source: Theranostics; 2022, Vol. 12 Issue 4, p1518-1536, 19p

Purinergic signaling in tanycytes and its contribution to nutritional sensing.

Authors: Salgado, Magdiel, García-Robles, María Á., Sáez, Juan C.

Source: Purinergic Signalling; Dec2021, Vol. 17 Issue 4, p607-618, 12p

Dynamic Localization of Glucokinase and Its Regulatory Protein in Hypothalamic Tanycytes.

Authors: Salgado, Magdiel¹, Tarifeño-Saldivia, Estefanía¹, Ordenes, Patricio¹, Millán, Carola², Yañez, María José¹, Llanos, Paula¹, Villagra, Marcos¹, Elizondo-Vega, Roberto¹ mgarcia@udec.cl, Martínez, Fernando¹, Nualart, Francisco¹, Uribe, Elena³, de los Angeles García-Robles, María¹

Source: PLoS ONE. Apr2014, Vol. 9 Issue 4, p1-15. 15p.

Subject Terms: *GLUCOKINASE, *NEURONS, *HYPOTHALAMUS, *MEASUREMENT of glucose in the body, *INTRACELLULAR membranes, *CYTOPLASM, *SACCHAROMYCES cerevisiae

The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential.

Authors: Contreras-Lopez, Rafael, Elizondo-Vega, Roberto, Luque-Campos, Noymar, Torres, María José, Pradenas, Carolina, Tejedor, Gautier, Paredes-Martínez, María José, Vega-Letter, Ana María, Campos-Mora, Mauricio, Rigual-Gonzalez, Yandi, Oyarce, Karina, Salgado, Magdiel, Jorgensen, Christian, Khoury, Maroun, Garcia-Robles, María de los Ángeles, Altamirano, Claudia, Djouad, Farida, Luz-Crawford, Patricia

Source: Theranostics; 2021, Vol. 11 Issue 1, p445-460, 16p

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When a Little Bit More Makes the Difference: Expression Levels of GKRP Determines the Subcellular Localization of GK in Tanycytes.

Authors: Salgado, Magdiel, Ordenes, Patricio, Villagra, Marcos, Uribe, Elena, García-Robles, María de los Angeles, Tarifeño-Saldivia, Estefanía

Source: Frontiers in Neuroscience; 3/29/2019, pN.PAG-N.PAG, 14p

Subject Terms: GLUCOSE in the body, HOMEOSTASIS, GLUCOKINASE, LIVER cells, PHOSPHORYLATION

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