χ-Conotoxins are an Evolutionary Innovation of Mollusk-Hunting Cone Snails as a Counter-Adaptation to Prey Defense.

Authors: Espino, Samuel, Watkins, Maren, Probst, Rodolfo, Koch, Thomas Lund, Chase, Kevin, Imperial, Julita, Robinson, Samuel D, Salcedo, Paula Flórez, Taylor, Dylan, Gajewiak, Joanna, Yandell, Mark, Safavi-Hemami, Helena, Olivera, Baldomero M

Source: Molecular Biology & Evolution; Nov2024, Vol. 41 Issue 11, p1-15, 15p

Subject Terms: CONUS, SNAILS, CONOTOXINS, VENOM, PROBLEM solving

Insights into a putative polychaete-gastropod symbiosis from a newly identified annelid worm that predates upon Conus ermineus eggs.

Authors: Giglio, Matías L.¹ matias.giglio@utah.edu, Salcedo, Paula Flórez² paula.florez@neuro.utah.edu, Watkins, Maren¹, Olivera, Baldomero¹

Source: Contributions to Zoology. 2023, Vol. 92 Issue 2, p97-111. 15p.

Subject Terms: *ANNELIDA, *EGG cases (Zoology), *POLYCHAETA, *CONUS, *EGGS, *SYMBIOSIS

Prey Shifts Drive Venom Evolution in Cone Snails.

Authors: Koch, Thomas Lund, Robinson, Samuel D, Salcedo, Paula Flórez, Chase, Kevin, Biggs, Jason, Fedosov, Alexander E, Yandell, Mark, Olivera, Baldomero M, Safavi-Hemami, Helena

Source: Molecular Biology & Evolution; Aug2024, Vol. 41 Issue 8, p1-15, 15p

Subject Terms: CONUS, DRUG discovery, ANTIVENINS, CONOTOXINS, SPECIES diversity, VENOM, VENOM glands

A toxin-based approach to neuropeptide and peptide hormone discovery.

Authors: Koch, Thomas Lund, Torres, Joshua P., Baskin, Robert P., Salcedo, Paula Flórez, Chase, Kevin, Olivera, Baldomero M., Safavi-Hemami, Helena

Source: Frontiers in Molecular Neuroscience; 2023, p1-14, 14p

Subject Terms: PEPTIDE hormones, SIGNAL peptides, CONUS, PEPTIDES, NEUROPEPTIDES, TOXINS, MOLLUSKS

Reconstructing the Origins of the Somatostatin and Allatostatin-C Signaling Systems Using the Accelerated Evolution of Biodiverse Cone Snail Toxins.

Authors: Koch, Thomas Lund, Ramiro, Iris Bea L., Salcedo, Paula Flórez, Engholm, Ebbe, Jensen, Knud Jørgen, Chase, Kevin, Olivera, Baldomero M., Bjørn-Yoshimoto, Walden Emil, Safavi-Hemami, Helena

Source: Molecular Biology & Evolution; Apr2022, Vol. 39 Issue 4, p1-20, 20p

Subject Terms: CONUS, SOMATOSTATIN, CONOTOXINS, TOXINS, PEPTIDES, CHROMOSOME duplication, MOLLUSKS

Design of Thermoresponsive Polyamine Cross-Linked Perfluoropolyether Hydrogels for Imaging and Delivery Applications.

Authors: Herneisey, Michele, Salcedo, Paula Flórez, Domenech, Trystan, Bagia, Christina, George, Simon S., Tunney, Robert, Velankar, Sachin, Hitchens, T. Kevin, Janjic, Jelena M.

Source: ACS Medicinal Chemistry Letters; 10/8/2020, Vol. 11 Issue 10, p2032-2040, 9p

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Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads.

Authors: Ramiro, Iris Bea L.^1,2, Bjørn-Yoshimoto, Walden E.¹, Imperial, Julita S.³, Gajewiak, Joanna³, Salcedo, Paula Flórez⁴, Watkins, Maren³, Taylor, Dylan³, Resager, William⁵, Ueberheide, Beatrix⁵, Bräuner-Osborne, Hans⁶, Whitby, Frank G.⁷, Hill, Christopher P.⁷, Martin, Laurent F.⁸, Patwardhan, Amol⁸, Concepcion, Gisela P.², Olivera, Baldomero M.³, Safavi-Hemami, Helena^1,3,7 safavihelena@sund.ku.dk

Source: Science Advances. 3/25/2022, Vol. 8 Issue 12, p1-16. 16p.

Subject Terms: *CONOTOXINS, *CONUS, *VENOM, *SOMATOSTATIN, *MEDICAL sciences, *LIFE sciences

Small-molecule mimicry hunting strategy in the imperial cone snail, Conus imperialis.

Authors: Torres, Joshua P.¹, Zhenjian Lin¹ z.j.lin@utah.edu, Watkins, Maren², Salcedo, Paula Flórez³, Baskin, Robert P.², Elhabian, Shireen⁴, Safavi-Hemami, Helena^2,5,6, Taylor, Dylan², Tun, Jortan², Concepcion, Gisela P.⁷, Saguil, Noel¹, Yanagihara, Angel A.⁸, Yixin Fang¹, McArthur, Jeffrey R.⁹, Han-Shen Tae⁹, Finol-Urdaneta, Rocio K.⁹, Özpolat, B. Duygu¹⁰, Olivera, Baldomero M.², Schmidt, Eric W.^1,2 ews1@utah.edu

Source: Science Advances. 3/10/2021, Vol. 7 Issue 11, p1-12. 12p.

Subject Terms: *CONOTOXINS, *CONUS, *SEXUAL cycle, *LIFE sciences, *BIOLOGICAL systems, *MEDICAL sciences