Effect of dupilumab on exhaled nitric oxide, mucus plugs, and functional respiratory imaging in patients with type 2 asthma (VESTIGE): a randomised, double-blind, placebo-controlled, phase 4 trial

Authors: Castro, Mario ^{a, *}, Papi, Alberto ^b, Porsbjerg, Celeste ^c, Lugogo, Njira L ^d, Brightling, Christopher E ^e, González-Barcala, Francisco-Javier ^{f, g}, Bourdin, Arnaud ^h, Ostrovskyy, Mykola ⁱ, Staevska, Maria ^j, Chou, Pai-Chien ^k, Duca, Liliana ^l, Pereira, Ana Margarida ^{m, n}, Fogarty, Charles ^o, Nadama, Rufai ^p, Zhang, Mei ^q, Rodrigues, Amelie ^r, Soler, Xavier ^s, Sacks, Harry J ^s, Deniz, Yamo ^s, Rowe, Paul J ^q, de Prado Gómez, Lucía ^t, Jacob-Nara, Juby A ^q

Source: In The Lancet Respiratory Medicine March 2025 13(3):208-220

Mild and symptom-free months in patients with chronic rhinosinusitis with nasal polyps treated with dupilumab

Authors: Bachert, Claus ^*, Khan, Asif H., Hopkins, Claire, Han, Joseph K., Fokkens, Wytske J., Mannent, Leda P., Msihid, Jérôme, Borsos, Kinga, Kamat, Siddhesh, Nash, Scott, Sacks, Harry, Rowe, Paul J., Deniz, Yamo, Jacob-Nara, Juby A.

Source: In Annals of Allergy, Asthma & Immunology January 2025 134(1):61-69

Dupilumab response onset, maintenance, and durability in patients with severe CRSwNP

Authors: Bachert, Claus, Khan, Asif H., Fokkens, Wytske J., Hopkins, Claire, Gevaert, Philippe, Han, Joseph K., Hellings, Peter W., Lee, Stella E., Msihid, Jérôme, Nash, Scott, Sacks, Harry, Jacob-Nara, Juby A., Deniz, Yamo, Rowe, Paul J.

Source: In The Journal of Allergy and Clinical Immunology December 2024 154(6):1442-1449

Type 2 Inflammation and Asthma in Children: A Narrative Review

Authors: Papadopoulos, Nikolaos G., Bacharier, Leonard B., Jackson, Daniel J., Deschildre, Antoine, Phipatanakul, Wanda, Szefler, Stanley J., Gall, Rebecca, Ledanois, Olivier, Jacob-Nara, Juby A., Sacks, Harry

Source: In The Journal of Allergy and Clinical Immunology: In Practice September 2024 12(9):2310-2324

The Effect of EDS-FLU on Objective and Patient-Reported Subjective Outcomes for Patients with Chronic Rhinosinusitis with Nasal Polyps.

Authors: Ow, Randall A, McGinnis II, John P, Sacks, Harry J, Mehle, Mark E

Source: ENT: Ear, Nose & Throat Journal; Feb2025, Vol. 104 Issue 2, p93-101, 9p

Subject Terms: ADRENOCORTICAL hormones, INTRANASAL administration, RESEARCH funding, PLACEBOS, RESPIRATION, AEROSOLS, STATISTICAL sampling, BLIND experiment, QUESTIONNAIRES, SINUSITIS, DRUG delivery systems, ENDOSCOPIC surgery, TREATMENT effectiveness, RANDOMIZED controlled trials, DESCRIPTIVE statistics, NASAL polyps, CHRONIC diseases, FLUTICASONE, HEALTH outcome assessment, COMPARATIVE studies, ENDOSCOPY, DISEASE complications

Geographic Terms: UNITED States

Dupilumab improves sense of smell and clinical outcomes in patients with severe chronic rhinosinusitis with nasal polyps with anosmia.

Authors: Lane, Andrew P., Mullol, Joaquim, Hopkins, Claire, Fokkens, Wytske J., Lee, Stella E., Msihid, Jerome, Nash, Scott, Sacks, Harry, Borsos, Kinga, Kamat, Siddhesh, Rowe, Paul J., Deniz, Yamo, Jacob-Nara, Juby A.

Source: Current Medical Research & Opinion; Jan2025, Vol. 41 Issue 1, p53-59, 7p

Subject Terms: OLFACTOMETRY, NASAL polyps, SMELL, DUPILUMAB, DYSPNEA

Association Between Smell Loss, Disease Burden, and Dupilumab Efficacy in Chronic Rhinosinusitis with Nasal Polyps.

Authors: Soler, Zachary M., Patel, Zara M., Mullol, Joaquim, Mattos, Jose, Nash, Scott, Xia, Changming, Wang, Zhixiao, Borsos, Kinga, Corbett, Mark, Jacob-Nara, Juby A., Sacks, Harry, Rowe, Paul, Deniz, Yamo, Lane, Andrew P.

Source: American Journal of Rhinology & Allergy; Jan2025, Vol. 39 Issue 1, p6-12, 7p

Subject Terms: QUALITY of life, NASAL polyps, VISUAL analog scale, DUPILUMAB, INTERLEUKIN-4

Reduced Sense of Smell in Patients with Severe Chronic Rhinosinusitis and its Implications for Diagnosis and Management: A Narrative Review.

Authors: Soler, Zachary M., Nash, Scott, Lane, Andrew P., Patel, Zara M., Lee, Stella E., Fokkens, Wytske J., Corbett, Mark, Jacob-Nara, Juby A., Sacks, Harry

Source: Advances in Therapy; Dec2024, Vol. 41 Issue 12, p4384-4395, 12p

Dupilumab 200 mg was efficacious in children (6–11 years) with moderate‐to‐severe asthma for up to 2 years: EXCURSION open‐label extension study.

Authors: Phipatanakul, Wanda, Vogelberg, Christian, Bacharier, Leonard B., Dell, Sharon, Altincatal, Arman, Gall, Rebecca, Ledanois, Oliver, Sacks, Harry, Jacob‐Nara, Juby A., Deniz, Yamo, Rowe, Paul J.

Source: Pediatric Pulmonology; Nov2024, Vol. 59 Issue 11, p2976-2983, 8p

Long-term dupilumab efficacy in type 2 asthma regardless of baseline characteristics.

Authors: Wechsler, Michael E., Rogers, Linda, Canonica, G. Walter, Bourdin, Arnaud, Altincatal, Arman, Hardin, Megan, Soler, Xavier, Rowe, Paul J., Deniz, Yamo, Sacks, Harry, Jacob-Nara, Juby A.

Source: ERJ Open Research; Nov2024, Vol. 10 Issue 6, p1-5, 5p

EDS‐FLU: An important step in appropriate medical therapy for chronic rhinosinusitis with nasal polyps

Authors: Leopold, Donald A., Elkayam, David, Han, Joseph K., Soteres, Daniel F., Messina, John C., Carothers, Jennifer L., Sacks, Harry J., Mahmoud, Ramy A., Djupesland, Per G., Sindwani, Raj

Source: International forum of allergy & rhinology. 12(6):893-895

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100149842137.0x000001&indx=1&recIds=ETOCvdc_100149842137.0x000001

DUPILUMAB IMPROVES ASTHMA CONTROL AND REDUCES FRACTIONAL EXHALED NITRIC OXIDE AND EXACERBATIONS WITH INHALED CORTICOSTEROID WITHDRAWAL: A PHASE 2 STUDY.

Authors: WECHSLER, MICHAEL E, JACKSON, DAVID, RABE, KLAUS F, PAVORD, IAN D, VIRCHOW, J C, KATIAL, ROHIT, ISRAEL, ELLIOT, XIA, CHANGMING, SOLIMAN, MENA, PANDIT-ABID, NAMI, JACOB-NARA, JUBY A, SACKS, HARRY, ROWE, PAUL J, DENIZ, YAMO

Source: CHEST; 2024 Supplement, Vol. 166 Issue 4, pA4779-A4796, 18p

DUPILUMAB SAFETY AND EFFICACY IN A REAL-WORLD CLINICAL SETTING: THE RAPID ASTHMA REGISTRY

Authors: PETERS, ANJU T, HILBERG, OLE, LUGOGO, NJIRA L, RAMSEY, ALLISON C, SHAO, LIYANG, DE PRADO GOMEZ, LUCIA, JACOB-NARA, JUBY A, SACKS, HARRY, ROWE, PAUL J, DENIZ, YAMO, GALL, REBECCA

Source: In Chest October 2024 166(4) Supplement:A6457-A6460

BASELINE CHARACTERISTICS OF PATIENTS ON MEDIUM- VS HIGH-DOSE INHALED CORTICOSTEROIDS IN PATIENTS INITIATING DUPILUMAB IN A REAL-WORLD CLINICAL SETTING: THE RAPID REGISTRY

Authors: LUGOGO, NJIRA L, CÔTÉ, ANDRÉANNE, BOURDIN, ARNAUD, PETERS, ANJU T, BACHARIER, LEONARD B, XIA, CHANGMING, PANDIT-ABID, NAMI, JACOB-NARA, JUBY A, SACKS, HARRY, ROWE, PAUL J, DENIZ, YAMO, SOLIMAN, MENA

Source: In Chest October 2024 166(4) Supplement:A4721-A4724

BASELINE CHARACTERISTICS AND COEXISTING TYPE 2 INFLAMMATORY DISEASES OF PATIENTS WITH ASTHMA INITIATING DUPILUMAB IN A REAL-WORLD SETTING: THE RAPID REGISTRY

Authors: LUGOGO, NJIRA L, PETERS, ANJU T, CÔTÉ, ANDRÉANNE, HILBERG, OLE, HEFFLER, ENRICO, MUNOZ, XAVIER, VINGE, INES, MANSUR, ADEL, NAGASE, HIROYUKI, SHAO, LIYANG, GALL, REBECCA, DE PRADO GOMEZ, LUCIA, JACOB-NARA, JUBY A, SACKS, HARRY, ROWE, PAUL J, DENIZ, YAMO, BOURDIN, ARNAUD

Source: In Chest October 2024 166(4) Supplement:A4725-A4728

DUPILUMAB PLUS MEDIUM-DOSE INHALED CORTICOSTEROID IMPROVES OUTCOMES COMPARED WITH PLACEBO PLUS HIGH-DOSE INHALED CORTICOSTEROID IN PEDIATRIC PATIENTS WITH UNCONTROLLED ASTHMA

Authors: BACHARIER, LEONARD B, MASPERO, JORGE F, PAPADOPOULOS, NIKOLAOS, GUILBERT, THERESA, XIA, CHANGMING, SOLIMAN, MENA, LEDANOIS, OLIVIER, ROWE, PAUL J, DENIZ, YAMO, JACOB-NARA, JUBY A, SACKS, HARRY

Source: In Chest October 2024 166(4) Supplement:A4806-A4808

ASSESSING THE IMPACT OF ASTHMA CONTROL QUESTIONNAIRE SCORE CUTOFFS WITHIN THE MULTICOMPONENT CLINICAL REMISSION ENDPOINT ON CLINICAL OUTCOMES: TRAVERSE OPEN-LABEL STUDY

Authors: PAVORD, IAN D, PETERS, ANJU T, PORSBJERG, CELESTE, CASTRO, MARIO, VIRCHOW, J C, COUILLARD, SIMON, XIA, CHANGMING, GALL, REBECCA, PANDIT-ABID, NAMI, ROWE, PAUL J, DENIZ, YAMO, JACOB-NARA, JUBY A, SACKS, HARRY

Source: In Chest October 2024 166(4) Supplement:A4797-A4800

CLINICAL EFFICACY OF DUPILUMAB TREATMENT DURING WITHDRAWAL OF INHALED CORTICOSTEROIDS/LONG-ACTING BETA AGONISTS

Authors: WECHSLER, MICHAEL E, JACKSON, DAVID, RABE, KLAUS F, PAVORD, IAN D, VIRCHOW, J C, KATIAL, ROHIT, ISRAEL, ELLIOT, XIA, CHANGMING, PANDIT-ABID, NAMI, SOLIMAN, MENA, ROWE, PAUL J, DENIZ, YAMO, SACKS, HARRY, JACOB-NARA, JUBY A

Source: In Chest October 2024 166(4) Supplement:A4761-A4778

Dupilumab improves outcomes in patients with chronic rhinosinusitis with nasal polyps irrespective of gender: results from the SINUS‐52 trial.

Authors: Fokkens, Wytske J, Bachert, Claus, Hopkins, Claire, Marglani, Osama, Praestgaard, Amy, Nash, Scott, Deniz, Yamo, Rowe, Paul J, Sacks, Harry, Jacob‐Nara, Juby A

Source: Clinical & Translational Immunology; 2024, Vol. 13 Issue 6, p1-8, 8p

Subject Terms: NASAL polyps, DUPILUMAB, PATIENTS, SINUSITIS, OLFACTOMETRY

Company/Entity: UNIVERSITY of Pennsylvania

Baseline Systemic Oral Corticosteroid Use in Patients with Asthma Initiating Dupilumab Treatment in the Real World: From the RAPID Global Registry.

Authors: Lugogo, Nijra L, Heffler, Enrico, Plaza, Vicente, Hilberg, Ole, Xia, Changming, Nash, Scott, Pandit, Nami, Jacob-Nara, Juby A, Sacks, Harry J, Rowe, Paul J, Deniz, Yamo, Hardin, Megan, Soler, Xavier

Source: Journal of Asthma & Allergy; Jun2024, Vol. 17, p551-556, 6p

Subject Terms: FORCED expiratory volume, ASTHMATICS, EXPIRATORY flow, EMPLOYEE ownership, ADRENERGIC beta agonists