TCF7L2 plays a complex role in human adipose progenitor biology, which might contribute to genetic susceptibility to type 2 diabetes

Authors: Verma, Manu, Loh, Nellie Y., Sabaratnam, Rugivan, Vasan, Senthil K., van Dam, Andrea D., Todorčević, Marijana, Neville, Matthew J., Toledo, Enrique, Karpe, Fredrik, Christodoulides, Constantinos

Source: In Metabolism August 2022 133

HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution

Authors: Kuo, Feng-Chih, Neville, Matt J., Sabaratnam, Rugivan, Wesolowska-Andersen, Agata, Phillips, Daniel, Wittemans, Laura B.L., van Dam, Andrea D., Loh, Nellie Y., Todorčević, Marijana, Denton, Nathan, Kentistou, Katherine A., Joshi, Peter K., Christodoulides, Constantinos, Langenberg, Claudia, Collas, Philippe, Karpe, Fredrik, Pinnick, Katherine E.

Source: In Cell Reports 26 July 2022 40(4)

Effect of long-term testosterone therapy on molecular regulators of skeletal muscle mass and fibre-type distribution in aging men with subnormal testosterone

Authors: Kruse, Rikke, Petersson, Stine J., Christensen, Louise L., Kristensen, Jonas M., Sabaratnam, Rugivan, Ørtenblad, Niels, Andersen, Marianne, Højlund, Kurt

Source: In Metabolism November 2020 112

Acute Exercise Increases GDF15 and Unfolded Protein Response/Integrated Stress Response in Muscle in Type 2 Diabetes.

Authors: Sabaratnam, Rugivan, Kristensen, Jonas M, Pedersen, Andreas J T, Kruse, Rikke, Handberg, Aase, Wojtaszewski, Jørgen F P, Højlund, Kurt

Source: Journal of Clinical Endocrinology & Metabolism; Jul2024, Vol. 109 Issue 7, p1754-1764, 11p

Subject Terms: UNFOLDED protein response, TYPE 2 diabetes, GROWTH differentiation factors, GENE expression, PREVENTION of obesity, PANCREATIC beta cells, CHILDHOOD obesity, MUSCLE growth

A Signature of Exaggerated Adipose Tissue Dysfunction in Type 2 Diabetes Is Linked to Low Plasma Adiponectin and Increased Transcriptional Activation of Proteasomal Degradation in Muscle.

Authors: Sabaratnam, Rugivan^1,2,3 (AUTHOR) christensen-thea@hotmail.com, Skov, Vibe⁴ (AUTHOR) vihs@regionsjaelland.dk, Paulsen, Søren K.⁵ (AUTHOR) soerpaul@rm.dk, Juhl, Stine^1,2 (AUTHOR) cecilie_halkier@hotmail.com, Kruse, Rikke^1,2 (AUTHOR) rkruse@health.sdu.dk, Hansen, Thea² (AUTHOR), Halkier, Cecilie² (AUTHOR), Kristensen, Jonas M.^1,6 (AUTHOR) jmkristensen@nexs.ku.dk, Vind, Birgitte F.¹ (AUTHOR) birgitte.falbe.vind@rsyd.dk, Richelsen, Bjørn⁷ (AUTHOR) bjoern.richelsen@aarhus.rm.dk, Knudsen, Steen⁸ (AUTHOR) investorrelations@allarity.com, Dahlgaard, Jesper^9,10 (AUTHOR) jesd@via.dk, Beck-Nielsen, Henning¹ (AUTHOR) beck-nielsen@dadlnet.dk, Kruse, Torben A.¹¹ (AUTHOR) torben.kruse@rsyd.dk, Højlund, Kurt^1,2 (AUTHOR) kurt.hoejlund@rsyd.dk

Source: Cells (2073-4409). Jul2022, Vol. 11 Issue 13, pN.PAG-N.PAG. 18p.

Subject Terms: *TYPE 2 diabetes, *ADIPOSE tissues, *ADIPONECTIN, *SKELETAL muscle, *UBIQUITIN ligases, *MYOSTATIN

Factors mediating exercise‐induced organ crosstalk

Authors: Sabaratnam, Rugivan, Wojtaszewski, Jørgen F. P., Højlund, Kurt

Source: Acta physiologica. 234(2)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139809166.0x000001&indx=1&recIds=ETOCvdc_100139809166.0x000001

The prevalent deep intronic c. 639 + 919 G > A GLA mutation causes pseudoexon activation and Fabry disease by abolishing the binding of hnRNPA1 and hnRNP A2/B1 to a splicing silencer

Authors: Palhais, Bruno, Dembic, Maja, Sabaratnam, Rugivan, Nielsen, Kira S., Doktor, Thomas Koed, Bruun, Gitte Hoffmann, Andresen, Brage Storstein

Source: In Molecular Genetics and Metabolism November 2016 119(3):258-269

White adipose tissue mitochondrial bioenergetics in metabolic diseases.

Authors: Sabaratnam, Rugivan, Hansen, Didde Riisager, Svenningsen, Per

Source: Reviews in Endocrine & Metabolic Disorders; Dec2023, Vol. 24 Issue 6, p1121-1133, 13p

Urinary extracellular vesicles: Origin, role as intercellular messengers and biomarkers; efficient sorting and potential treatment options

Authors: Svenningsen, Per, Sabaratnam, Rugivan, Jensen, Boye L.

Source: Acta physiologica. 228(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100095810501.0x000001&indx=1&recIds=ETOCvdc_100095810501.0x000001

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Adipocyte-Endothelium Crosstalk in Obesity.

Authors: Sabaratnam, Rugivan, Svenningsen, Per

Source: Frontiers in Endocrinology; 8/12/2021, Vol. 12, p1-10, 10p

Subject Terms: HOMEOSTASIS, ADIPOSE tissues, INSULIN sensitivity, VASCULAR endothelium, EXTRACELLULAR vesicles

NIn human nephrectomy specimens, the kidney level of tubular transport proteins does not correlate with their abundance in urinary extracellular vesicles.

Authors: Sabaratnam, Rugivan^1,2, Geertsen, Louise³, Skjødt, Karsten², Højlund, Kurt^1,2, Dimke, Henrik^2,4, Lund, Lars^3,5, Svenningsen, Per² psvenningsen@health.sdu.dk

Source: American Journal of Physiology: Renal Physiology. Sep2019, Vol. 317 Issue 3, pF560-F571. 12p.

Subject Terms: *RENAL tubular transport, *CARRIER proteins, *UROMODULIN, *MEMBRANE proteins, *WESTERN immunoblotting

Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes.

Authors: Sabaratnam, Rugivan^1,2, Pedersen, Andreas J. T.², Kristensen, Jonas M.³, Handberg, Aase^4,5, Wojtaszewski, Jørgen F. P.³, Højlund, Kurt^1,2 kurt.hoejlund@rsyd.dk

Source: Physiological Reports. Jun2018, Vol. 6 Issue 12, p1-1. 12p.

Subject Terms: *TYPE 2 diabetes, *SKELETAL muscle, *PLASMA cells, *METABOLIC disorders, *INSULIN resistance

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Acute Exercise Increases Plasma Levels of Muscle-Derived Microvesicles Carrying Fatty Acid Transport Proteins.

Authors: Nielsen, Morten Hjuler, Sabaratnam, Rugivan, Pedersen, Andreas James Thestrup, Højlund, Kurt, Handberg, Aase

Source: The Journal of Clinical Endocrinology & Metabolism; October 2019, Vol. 104 Issue: 10 p4804-4814, 11p

Exercise Induction of Key Transcriptional Regulators of Metabolic Adaptation in Muscle Is Preserved in Type 2 Diabetes.

Authors: Sabaratnam, Rugivan, Pedersen, Andreas J, Eskildsen, Tilde V, Kristensen, Jonas M, Wojtaszewski, Jørgen F P, Højlund, Kurt

Source: The Journal of Clinical Endocrinology & Metabolism; October 2019, Vol. 104 Issue: 10 p4909-4920, 12p

In human nephrectomy specimens, the kidney level of tubular transport proteins does not correlate with their abundance in urinary extracellular vesicles

Authors: Sabaratnam, Rugivan, Geertsen, Louise, Skjødt, Karsten, Højlund, Kurt, Dimke, Henrik, Lund, Lars, Svenningsen, Per

Source: American Journal of Physiology - Renal Physiology; September 2019, Vol. 317 Issue: 3 pF560-F571, 12p

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Splice-shifting oligonucleotide (SSO) mediated blocking of an exonic splicing enhancer (ESE) created by the prevalent c.903+469T>C MTRR mutation corrects splicing and restores enzyme activity in patient cells.

Authors: Palhais, Bruno, Præstegaard, Veronica S., Sabaratnam, Rugivan, Doktor, Thomas Koed, Lutz, Seraina, Burda, Patricie, Suormala, Terttu, Baumgartner, Matthias, Fowler, Brian, Bruun, Gitte Hoffmann, Andersen, Henriette Skovgaard, Kožich, Viktor, Andresen, Brage Storstein

Source: Nucleic Acids Research; May2015, Vol. 43 Issue 9, p4627-4639, 13p, 3 Diagrams, 3 Graphs