Mechanisms of antigen-dependent resistance to chimeric antigen receptor (CAR)-T cell therapies.

Authors: Nasiri, Fatemeh^1,2 (AUTHOR) Fatima.Nasiri@umanitoba.ca, Safarzadeh Kozani, Pouya^2,3 (AUTHOR) puyasafarzadeh@gmail.com, Salem, Faeze³ (AUTHOR) faezesalem73@gmail.com, Mahboubi Kancha, Maral⁴ (AUTHOR) mm9041c@greenwich.ac.uk, Dashti Shokoohi, Setareh² (AUTHOR) setareh.d.shokoohi@gmail.com, Safarzadeh Kozani, Pooria^2,3 (AUTHOR) pooriasafarzadeh@modares.ac.ir

Source: Cancer Cell International. 2/24/2025, Vol. 25 Issue 1, p1-24. 24p.

Subject Terms: *CHIMERIC antigen receptors, *SYNTHETIC receptors, *MEDICAL sciences, *CANCER remission, *DISEASE relapse

Refining minimal engineered receptors for specific activation of on-target signaling molecules.

Authors: Miura, Masashi¹ (AUTHOR), Kawahara, Masahiro¹ (AUTHOR) m-kawahara@nibiohn.go.jp

Source: Scientific Reports. 12/30/2024, Vol. 14 Issue 1, p1-11. 11p.

Subject Terms: *SYNTHETIC receptors, *LIFE sciences, *STAT proteins, *LIGANDS (Biochemistry), *CYTOLOGY, *SYNTHETIC biology

New Psychoactive Substances in the Homeless Population: A Cross-Sectional Study in the United Kingdom.

Authors: Coombs, Thomas^1,2 (AUTHOR) tcoombs@bournemouth.ac.uk, Ginige, Tilak¹ (AUTHOR), Van Calster, Patrick³ (AUTHOR), Abdelkader, Amor¹ (AUTHOR), Corazza, Ornella⁴ (AUTHOR), Assi, Sulaf⁵ (AUTHOR)

Source: International Journal of Mental Health & Addiction. Aug2024, Vol. 22 Issue 4, p2322-2337. 16p.

Subject Terms: *CANNABINOID receptors, *SYNTHETIC receptors, *CONVENIENCE sampling (Statistics), *REGRESSION analysis, *DESCRIPTIVE statistics

Effects of Synthetic Toll-Like Receptor 9 Ligand Molecules on Pulpal Immunomodulatory Response and Repair after Injuries.

Authors: Quispe-Salcedo, Angela¹ (AUTHOR) aquispesa@dent.niigata-u.ac.jp, Yamazaki, Tomohiko² (AUTHOR) yamazaki.tomohiko@nims.go.jp, Ohshima, Hayato¹ (AUTHOR) histoman@dent.niigata-u.ac.jp

Source: Biomolecules (2218-273X). Aug2024, Vol. 14 Issue 8, p931. 16p.

Subject Terms: *DENTAL pulp, *SYNTHETIC receptors, *BIOMARKERS, *DENTAL pulp cavities, *TOLL-like receptors

Activity-based detection of synthetic cannabinoid receptor agonists in plant materials.

Authors: Timmerman, Axelle¹ (AUTHOR), Balcaen, Margot² (AUTHOR), Coopman, Vera³ (AUTHOR), Degreef, Maarten² (AUTHOR), Pottie, Eline¹ (AUTHOR), Stove, Christophe P.¹ (AUTHOR) christophe.stove@ugent.be

Source: Harm Reduction Journal. 7/1/2024, Vol. 21 Issue 1, p1-11. 11p.

Subject Terms: *CANNABINOID receptors, *SYNTHETIC receptors, *CANNABIS (Genus), *DANCE festivals, *BIOLOGICAL assay

Calix[5]arene Self‐Folding Cavitands: A New Family of Bio‐Inspired Receptors with Enhanced Induced Fit Behavior.

Authors: Álvarez‐Yebra, Rubén¹ (AUTHOR), López‐Coll, Ricard¹ (AUTHOR), Clos‐Garrido, Núria¹ (AUTHOR), Lozano, David¹ (AUTHOR) agusti.lledo@udg.edu, Lledó, Agustí¹ (AUTHOR) davidlozanomena@gmail.com

Source: Israel Journal of Chemistry. Jul2024, Vol. 64 Issue 6/7, p1-13. 13p.

Subject Terms: *SYNTHETIC receptors, *SUPRAMOLECULAR chemistry, *MOLECULAR recognition, *RESORCINOL, *CAVITANDS

DREADD Microglia? Targeted Microglial Gi Activation in the Acute Phase can Reduce Seizure Severity, but is Detrimental in the Long Term.

Authors: Bodea, Liviu-Gabriel¹ (AUTHOR), Borges, Karin² (AUTHOR)

Source: Epilepsy Currents. Nov/Dec2024, Vol. 24 Issue 6, p420-422. 3p.

Subject Terms: *SYNTHETIC receptors, *PHENOTYPIC plasticity, *STATUS epilepticus, *DESIGNER drugs, *KAINIC acid

Towards Biomimetic Recognition of Glycans by Synthetic Receptors.

Authors: Milanesi, Francesco¹ (AUTHOR), Roelens, Stefano¹ (AUTHOR), Francesconi, Oscar¹ (AUTHOR) oscar.francesconi@unifi.it

Source: ChemPlusChem. Apr2024, Vol. 89 Issue 4, p1-15. 15p.

Subject Terms: *SYNTHETIC receptors, *BIOMOLECULES, *GLYCAN structure, *CARBOHYDRATE-binding proteins, *GLYCANS, *MOLECULAR recognition

Synthetic receptor scaffolds significantly affect the efficiency of cell fate signals.

Authors: Umene, Kirato¹ (AUTHOR), Kawahara, Masahiro^1,2 (AUTHOR) m-kawahara@nibiohn.go.jp

Source: Scientific Reports. 3/8/2024, Vol. 14 Issue 1, p1-8. 8p.

Subject Terms: *SYNTHETIC receptors, *CELL communication, *BIOENGINEERING, *SYNTHETIC biology, *CELL growth, *TISSUE scaffolds

Eliminating collinearity observed in chemical mass balance analysis using multi linear regression and synthetic receptor source profile dataset.

Authors: Rejivas, V A¹ (AUTHOR) rejivas@gmail.com, Praveen, A¹ (AUTHOR), Ajitha, T¹ (AUTHOR)

Source: Sādhanā: Academy Proceedings in Engineering Sciences. Mar2024, Vol. 49 Issue 1, p1-10. 10p.

Subject Terms: *SYNTHETIC receptors, *PARTICULATE matter, *MULTICOLLINEARITY

Antigen loss following CAR‐T cell therapy: Mechanisms, implications, and potential solutions.

Authors: Mishra, Archana¹ (AUTHOR), Maiti, Rituparna¹ (AUTHOR), Mohan, Prafull² (AUTHOR), Gupta, Pooja³ (AUTHOR) drgupta.pooja@gmail.com

Source: European Journal of Haematology. Feb2024, Vol. 112 Issue 2, p211-222. 12p.

Subject Terms: *CELLULAR therapy, *SYNTHETIC receptors, *ANTIGENS, *CHIMERIC antigen receptors, *DISEASE relapse

AdipoRon ameliorates the progression of heart failure with preserved ejection fraction via mitigating lipid accumulation and fibrosis.

Authors: Tan, Wuping^{1,2,3,4,5,6,7} (AUTHOR), Wang, Yijun^{1,2,3,4,5,6,7} (AUTHOR), Cheng, Siyi^{1,2,3,4,5,6,7} (AUTHOR), Liu, Zhihao^{1,2,3,4,5,6,7} (AUTHOR), Xie, Mengjie^{1,2,3,4,5,6,7} (AUTHOR), Song, Lingpeng^{1,2,3,4,5,6,7} (AUTHOR), Qiu, Qinfang^{1,2,3,4,5,6,7} (AUTHOR), Wang, Xiaofei^{1,2,3,4,5,6,7} (AUTHOR), Li, Zeyan^{1,2,3,4,5,6,7} (AUTHOR), Liu, Tianyuan^{1,2,3,4,5,6,7} (AUTHOR), Guo, Fuding^{1,2,3,4,5,6,7} (AUTHOR) guofuding@whu.edu.cn, Wang, Jun^1,8 (AUTHOR) Junwang0607@whu.edu.cn, Zhou, Xiaoya^{1,2,3,4,5,6,7} (AUTHOR) whuzhouxiaoya@whu.edu.cn

Source: Journal of Advanced Research. Feb2025, Vol. 68, p299-315. 17p.

Subject Terms: *FATTY acid oxidation, *SYNTHETIC receptors, *MOLECULAR biology, *TRANSMISSION electron microscopy, *LIPID metabolism

Chiral synthetic hosts for efficient enantioselective molecular recognition. Design principles and synthetic aspects.

Authors: Marchi Luciano, Hugo¹ (AUTHOR), Lledó, Agustí² (AUTHOR) agusti.lledo@udg.edu

Source: Chemical Communications. 1/28/2025, Vol. 61 Issue 9, p1790-1799. 10p.

Subject Terms: *ENANTIOSELECTIVE catalysis, *SYNTHETIC receptors, *MOLECULES, *CHIRAL recognition

Microenvironment actuated CAR T cells improve solid tumor efficacy without toxicity.

Authors: Vogt, Kristen C.^1,2,3, Silberman, Pedro C.^1,2,4, Qianqian Lin^1,2,5, Han, James E.¹, Laflin, Amy⁶, Gellineau, Hendryck A.¹, Heller, Daniel A.^1,2,3,4, Scheinberg, David A.^1,2,3,4 scheinbd@mskcc.org

Source: Science Advances. 1/24/2025, Vol. 11 Issue 4, p1-16. 16p.

Subject Terms: *SYNTHETIC receptors, *TUMOR antigens, *CHIMERIC antigen receptors, *TUMOR-infiltrating immune cells, *CANCER cells, *T cells

Assembly-enhanced recognition: A biomimetic pathway to achieve ultrahigh affinities.

Authors: Fang-Yuan Chen¹, Wen-Chao Geng¹, Meng-Meng Chen¹, Rong Fu², Han Han³, Zhan-Zhan Zhang⁴, Wen-Bo Li¹, Yuan-Qiu Cheng¹, Juan-Juan Li¹, Stoddart, J. Fraser^3,5,6,7,8,9, Kang Cai², Dong-Sheng Guo¹

Source: Proceedings of the National Academy of Sciences of the United States of America. 1/21/2025, Vol. 122 Issue 3, p1-8. 35p.

Subject Terms: *SYNTHETIC receptors, *BIOMIMETICS, *MOLECULAR recognition, *PHOTODYNAMIC therapy, *AQUEOUS solutions

Polyanionic Receptors for Carboxylates in Water.

Authors: Ren, Xudong¹ (AUTHOR), Flint, Alister J.¹ (AUTHOR), Austin, Daniel¹ (AUTHOR), Davis, Anthony P.¹ (AUTHOR) Anthony.Davis@bristol.ac.uk

Source: Angewandte Chemie International Edition. Jan2025, Vol. 64 Issue 1, p1-7. 7p.

Subject Terms: *SYNTHETIC receptors, *SUPRAMOLECULAR chemistry, *BINDING sites, *MOLECULAR recognition, *CARBOXYLATES

Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB2 receptor.

Authors: Patel, Monica¹ (AUTHOR), Grimsey, Natasha L.² (AUTHOR), Banister, Samuel D.^3,4 (AUTHOR), Finlay, David B.¹ (AUTHOR), Glass, Michelle¹ (AUTHOR) michelle.glass@otago.ac.nz

Source: Pharmacology Research & Perspectives. Dec2023, Vol. 11 Issue 6, p1-15. 15p.

Subject Terms: *CANNABINOID receptors, *SYNTHETIC receptors, *MOLECULAR pharmacology, *OPERATIONS research, *G proteins, *LIGAND analysis

Syntheses, Structures and Reactivity of Metal Complexes of Trindane, Trindene, Truxene, Decacyclene and Related Ring Systems: Manifestations of Three-Fold Symmetry.

Authors: Lock, Philippa E.¹ (AUTHOR) julia.bruno@ucd.ie, Reginato, Nada¹ (AUTHOR), Bruno-Colmenárez, Julia¹ (AUTHOR), McGlinchey, Michael J.¹ (AUTHOR) michael.mcglinchey@ucd.ie

Source: Molecules. Dec2023, Vol. 28 Issue 23, p7796. 25p.

Subject Terms: *METAL complexes, *SYNTHETIC receptors, *X-ray crystallography, *ORGANIC chemistry, *SYMMETRY, *DEBROMINATION

Interaction of Synthetic Cannabinoid Receptor Agonists with Cannabinoid Receptor I: Insights into Activation Molecular Mechanism.

Authors: Gavryushov, Sergei^1,2 (AUTHOR) anton_bashilov@mail.ru, Bashilov, Anton^2,3 (AUTHOR) alknaphel199502@gmail.com, Cherashev-Tumanov, Konstantin V.² (AUTHOR) burykina58@mail.ru, Kuzmich, Nikolay N.⁴ (AUTHOR) nnkuzmich@gmail.com, Burykina, Tatyana I.² (AUTHOR) bn38@mail.ru, Izotov, Boris N.² (AUTHOR)

Source: International Journal of Molecular Sciences. Oct2023, Vol. 24 Issue 19, p14874. 33p.

Subject Terms: *CANNABINOID receptors, *SYNTHETIC receptors, *TRANSMEMBRANE domains, *MOLECULAR dynamics, *PROTEIN-ligand interactions, *POTENTIAL barrier

Supramolecular Motifs in the Crystal Structures of Triethylbenzene Derivatives Bearing Pyridinium Subunits in Combination with Pyrimidinyl or Pyridinyl Groups.

Authors: Weiße, Andrea¹ (AUTHOR) andrea.weisse@extern.tu-freiberg.de, Seichter, Wilhelm¹ (AUTHOR), Mazik, Monika¹ (AUTHOR) monika.mazik@chemie.tu-freiberg.de

Source: Molecules. Sep2023, Vol. 28 Issue 18, p6485. 19p.

Subject Terms: *CRYSTAL structure, *SYNTHETIC receptors, *INTERMOLECULAR interactions, *MOLECULES, *ANIONS, *PYRIMIDINES, *MOLECULAR recognition