Resource competition-driven bistability and stochastic switching amplify gene expression noise.

Authors: Goetz, Hanah¹ (AUTHOR), Zhang, Rong¹ (AUTHOR), Wang, Xiao¹ (AUTHOR), Tian, Xiao-Jun¹ (AUTHOR) xiaojun.tian@asu.edu

Source: PLoS Computational Biology. 4/23/2025, Vol. 21 Issue 4, p1-18. 18p.

Subject Terms: *GENE regulatory networks, *SYNTHETIC genes, *GENE expression, *GENE therapy, *GREEN business

Genetic Bioaugmentation‐Mediated Bioremediation of Terephthalate in Soil Microcosms Using an Engineered Environmental Plasmid.

Authors: Marquiegui – Alvaro, Alejandro¹ (AUTHOR), Kottara, Anastasia² (AUTHOR), Chacón, Micaela¹ (AUTHOR), Cliffe, Lisa¹ (AUTHOR), Brockhurst, Michael² (AUTHOR) michael.brockhurst@manchester.ac.uk, Dixon, Neil¹ (AUTHOR) neil.dixon@manchester.ac.uk

Source: Microbial Biotechnology. Jan2025, Vol. 18 Issue 1, p1-12. 12p.

Subject Terms: *HORIZONTAL gene transfer, *SYNTHETIC genes, *SOIL microbiology, *SOIL pollution, *BIOREMEDIATION

Over expression of modified Isomaltulose Synthase Gene II (ImSyGII) under single and double promoters drive unprecedented sugar contents in sugarcane.

Authors: Awan, Mudassar Fareed¹ (AUTHOR) mudassar.fareed@skt.umt.edu.pk, Ali, Sajed¹ (AUTHOR), Sarwar, Muhammad Farhan¹ (AUTHOR), Shafiq, Muhammad¹ (AUTHOR), Arif, Usman¹ (AUTHOR), Ali, Qurban² (AUTHOR) saim1692@gmail.com, Farooq, Abdul Munim³ (AUTHOR), Han, Shiming⁴ (AUTHOR) hanshiliang888@163.com, Nasir, Idrees Ahmad³ (AUTHOR)

Source: PLoS ONE. 11/19/2024, Vol. 19 Issue 11, p1-20. 20p.

Subject Terms: *SYNTHETIC genes, *MOLECULAR cloning, *GENE expression, *PLANT breeding, *BIOTECHNOLOGY

Construction of multilayered gene circuits using de-novo-designed synthetic transcriptional regulators in cell-free systems.

Authors: Zhao, Mingming¹ (AUTHOR), Kim, Jeongwon² (AUTHOR), Jiao, Jiayan¹ (AUTHOR), Lim, Yelin² (AUTHOR), Shi, Xianai^1,3,4 (AUTHOR), Guo, Shaobin^1,3,4 (AUTHOR) sguo@fzu.edu.cn, Kim, Jongmin² (AUTHOR) jongmin.kim@postech.ac.kr

Source: Journal of Biological Engineering. 11/5/2024, Vol. 18 Issue 1, p1-11. 11p.

Subject Terms: *GENE regulatory networks, *SYNTHETIC genes, *LOGIC circuits, *GENETIC transcription, *CIRCUIT complexity

Metabolic engineering of Streptomyces roseosporus for increased production of clinically important antibiotic daptomycin.

Authors: Li, Xingwang¹ (AUTHOR), Sang, Ziwei¹ (AUTHOR), Zhao, Xuejin² (AUTHOR) zhaoxj@im.ac.cn, Wen, Ying¹ (AUTHOR) wen@cau.edu.cn

Source: Microbial Biotechnology. Nov2024, Vol. 17 Issue 11, p1-15. 15p.

Subject Terms: *LIPOPEPTIDE antibiotics, *SYNTHETIC genes, *GENE clusters, *CRISPRS, *TITERS

Synthetic biology-based bioreactor and its application in biochemical analysis.

Authors: Mao, Changqing¹ (AUTHOR), Mao, Yichun¹ (AUTHOR), Zhu, Xiaoli² (AUTHOR) xiaolizhu@tongji.edu.cn, Chen, Guifang^1,3 (AUTHOR) gfchen@shu.edu.cn, Feng, Chang¹ (AUTHOR) cfeng@shu.edu.cn

Source: Critical Reviews in Analytical Chemistry. 2024, Vol. 54 Issue 7, p2467-2484. 18p.

Subject Terms: *WATER pollution monitoring, *SYNTHETIC genes, *METHODS engineering, *METAL detectors, *BIOLOGISTS, *BIOSENSORS, *SYNTHETIC biology

Development of an RNA virus-based episomal vector with artificial aptazyme for gene silencing.

Authors: Komorizono, Ryo¹, Yoshizumi, Shima¹, Tomonaga, Keizo^1,2,3, tomonaga@infront.kyoto-u.ac.jp

Source: Applied Microbiology & Biotechnology; 10/18/2024, Vol. 108 Issue 1, p1-13, 13p

Probiotic and Postbiotic Potentials of Enterococcus faecalis EF-2001: A Safety Assessment.

Authors: Han, Kwon Il¹ (AUTHOR) kihan@bereum.com, Shin, Hyun-Dong¹ (AUTHOR) hshin@bereum.com, Lee, Yura¹ (AUTHOR) lyr@bereum.com, Baek, Sunhwa¹ (AUTHOR) an20112246@bereum.com, Moon, Eunjung¹ (AUTHOR) moonej@bereum.com, Park, Youn Bum¹ (AUTHOR) pyb12345@bereum.com, Cho, Junhui¹ (AUTHOR) jhcho@bereum.com, Lee, Jin-Ho² (AUTHOR) drlogos@naver.com, Kim, Tack-Joong² (AUTHOR) ktj@yonsei.ac.kr, Manoharan, Ranjith Kumar¹ (AUTHOR) ktj@yonsei.ac.kr

Source: Pharmaceuticals (14248247). Oct2024, Vol. 17 Issue 10, p1383. 18p.

Subject Terms: *SYNTHETIC genes, *ESSENTIAL amino acids, *GUT microbiome, *ERYTHROCYTES, *ENTEROCOCCUS faecalis, *BIOGENIC amines

Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling.

Authors: Chen, Wei^1,2,3,4 (AUTHOR), Yang, Kai-Bin^1,2 (AUTHOR), Zhang, Yuan-Zhe^1,2 (AUTHOR), Lin, Zai-Shan^1,2 (AUTHOR), Chen, Jin-Wei² (AUTHOR), Qi, Si-Fan² (AUTHOR), Wu, Chen-Fei^1,2,4 (AUTHOR), Feng, Gong-Kan² (AUTHOR), Yang, Da-Jun² (AUTHOR) yangdj@sysucc.org.cn, Chen, Ming^1,2 (AUTHOR) chenm326@mail.sysu.edu.cn, Zhu, Xiao-Feng² (AUTHOR) zhuxfeng@mail.sysu.edu.cn, Li, Xuan^1,2 (AUTHOR) lixuan56@mail.sysu.edu.cn

Source: Journal of Experimental & Clinical Cancer Research (17569966). 8/31/2024, Vol. 43 Issue 1, p1-20. 20p.

Subject Terms: *LETHAL mutations, *SYNTHETIC genes, *REACTIVE oxygen species, *GENETIC transcription, *PYROPTOSIS

Nanomaterials-assisted gene editing and synthetic biology for optimizing the treatment of pulmonary diseases.

Authors: Lei, Lanjie¹ (AUTHOR), Pan, Wenjie² (AUTHOR), Shou, Xin¹ (AUTHOR), Shao, Yunyuan¹ (AUTHOR), Ye, Shuxuan¹ (AUTHOR), Zhang, Junfeng³ (AUTHOR), Kolliputi, Narasaiah⁴ (AUTHOR), Shi, Liyun¹ (AUTHOR) sly0202@zjsru.edu.cn

Source: Journal of Nanobiotechnology. 6/18/2024, Vol. 22 Issue 1, p1-29. 29p.

Subject Terms: *SYNTHETIC biology, *SYNTHETIC genes, *GENOME editing, *LUNG diseases, *COVID-19 pandemic, *THERAPEUTICS

Genome-Wide Identification and Characterization of Lignin Synthesis Genes in Maize.

Authors: Wang, Shuai¹ (AUTHOR), Wang, Xiaofang¹ (AUTHOR), Yue, Liangxu¹ (AUTHOR) b20190394@xs.ustb.edu.cn, Li, Huangai¹ (AUTHOR), Zhu, Lei¹ (AUTHOR), Dong, Zhenying¹ (AUTHOR) zydong@ustb.edu.cn, Long, Yan¹ (AUTHOR) zydong@ustb.edu.cn

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 12, p6710. 14p.

Subject Terms: *LIGNINS, *SYNTHETIC genes, *PLANT cell walls, *GENE expression, *GENE families, *CORN

Evolving robots.

Authors: Hart, Emma

Source: New Scientist. 2/26/2022, Vol. 253 Issue 3375, p48-51. 4p. 2 Color Photographs.

Subjects: ROBOTS, ALGORITHMS, RECOMBINANT DNA, GENETIC variation, SYNTHETIC genes

VqERF1B‐VqERF062‐VqNSTS2 transcriptional cascade enhances stilbene biosynthesis and resistance to powdery mildew in grapevine.

Authors: Yan, Chaohui^1,2,3 (AUTHOR), Liu, Wandi^1,2,3 (AUTHOR), Li, Ruimin^1,2,3 (AUTHOR), Liu, Guotian^1,2,3 (AUTHOR) gtliu@nwafu.edu.cn, Wang, Yuejin^1,2,3 (AUTHOR) wangyj@nwsuaf.edu.cn

Source: Plant Biotechnology Journal. Mar2025, p1. 18p. 8 Illustrations.

Subject Terms: *TRANSCRIPTION factors, *SYNTHETIC genes, *BIOSYNTHESIS, *STILBENE, *PHYTOALEXINS, *POWDERY mildew diseases

Heterologous biosynthesis of myxobacterial lanthipeptides melittapeptins.

Authors: Kaweewan, Issara^1,2, Mukai, Keiichiro^3,4, Rukthanapitak, Pratchaya⁵, Nakagawa, Hiroyuki⁶, Hosaka, Takeshi^3,4, Kodani, Shinya^1,5,7, kodani.shinya@shizuoka.ac.jp

Source: Applied Microbiology & Biotechnology; 1/15/2024, Vol. 108 Issue 1, p1-11, 11p

Differential gene regulation by a synthetic vitamin D receptor ligand and active vitamin D in human cells.

Authors: Iwaki, Miho¹ (AUTHOR), Kanemoto, Yoshiaki^2,3 (AUTHOR), Sawada, Takahiro^2,3 (AUTHOR), Nojiri, Koki^2,3 (AUTHOR), Kurokawa, Tomohiro^3,4 (AUTHOR), Tsutsumi, Rino¹ (AUTHOR), Nagasawa, Kazuo¹ (AUTHOR), Kato, Shigeaki^2,3,4 (AUTHOR) shigeaki.kato@isu.ac.jp

Source: PLoS ONE. 12/13/2023, Vol. 18 Issue 12, p1-25. 25p.

Subject Terms: *VITAMIN D receptors, *SYNTHETIC genes, *VITAMIN D, *GENETIC regulation, *ANDROGEN receptors, *GENE expression

StBIN2 Positively Regulates Potato Formation through Hormone and Sugar Signaling.

Authors: Liu, Jie^1,2 (AUTHOR) liujie-116@foxmail.com, Cai, Chengcheng^1,2 (AUTHOR) cccqyj@hotmail.com, Liu, Shifeng^1,2 (AUTHOR) 2020101001@stu.sicau.edu.cn, Li, Liqin^1,2 (AUTHOR) liliqin88@163.com, Wang, Qiang^1,2 (AUTHOR) qwang@sicau.edu.cn, Wang, Xiyao^1,2 (AUTHOR) qwang@sicau.edu.cn

Source: International Journal of Molecular Sciences. Nov2023, Vol. 24 Issue 22, p16087. 15p.

Subject Terms: *SYNTHETIC genes, *POTATOES, *GENE expression, *PLANT growth, *FOOD crops, *TRANSGENIC plants

Characterization of an efficient CRISPR-iCas9 system in Yarrowia lipolytica for the biosynthesis of carotenoids.

Authors: Chen, Qi Hang¹ (AUTHOR), Qian, Ya Dan¹ (AUTHOR), Niu, Yong Jie² (AUTHOR), Hu, Ching Yuan^1,3 (AUTHOR), Meng, Yong Hong¹ (AUTHOR) mengyonghong@snnu.edu.cn

Source: Applied Microbiology & Biotechnology. Oct2023, Vol. 107 Issue 20, p6299-6313. 15p.

Subject Terms: *BIOSYNTHESIS, *SYNTHETIC genes, *CAROTENOIDS, *ZEAXANTHIN, *CAROTENES, *GENE knockout, *CHROMOSOMES, *CRISPRS

Expression of Synthetic cyp102A1-LG23 Gene and Functional Analysis of Recombinant Cytochrome P450 BM3-LG23 in the Actinobacterium Mycolicibacterium smegmatis.

Authors: Poshekhontseva, Veronika Y.¹ (AUTHOR) rikahameleon@mail.ru, Strizhov, Nikolai I.¹ (AUTHOR), Karpov, Mikhail V.¹ (AUTHOR), Nikolaeva, Vera M.¹ (AUTHOR), Kazantsev, Alexey V.² (AUTHOR), Sazonova, Olesya I.¹ (AUTHOR), Shutov, Andrey A.¹ (AUTHOR), Donova, Marina V.¹ (AUTHOR)

Source: Biochemistry (00062979). Sep2023, Vol. 88 Issue 9, p1347-1355. 9p.

Subject Terms: *SYNTHETIC genes, *GENE expression, *CYTOCHROME P-450, *FUNCTIONAL analysis, *OPERONS, *BACILLUS megaterium

Engineering drive-selection balance for localized population suppression with neutral dynamics.

Authors: Willis, Katie¹ katie.willis@imperial.ac.uk, Burt, Austin¹

Source: Proceedings of the National Academy of Sciences of the United States of America. 2/11/2025, Vol. 122 Issue 6, p1-9. 37p.

Subject Terms: *SYNTHETIC genes, *GENETIC engineering, *GENOME editing, *CRISPRS, *COMPUTER simulation

All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants.

Authors: Ikram, Aziz Ul¹ (AUTHOR), Khan, Muhammad Saad Shoaib¹ (AUTHOR), Islam, Faisal¹ (AUTHOR), Ahmed, Sulaiman¹ (AUTHOR), Ling, Tengfang² (AUTHOR), Feng, Feng³ (AUTHOR), Sun, Zongtao⁴ (AUTHOR) sunzongtao@nbu.edu.cn, Chen, Huan⁵ (AUTHOR) huan.chen@sjtu.edu.cn, Chen, Jian¹ (AUTHOR) jianchen@ujs.edu.cn

Source: Advanced Science. 2/3/2025, Vol. 12 Issue 5, p1-25. 25p.

Subject Terms: *DISEASE resistance of plants, *SYNTHETIC genes, *PLANT breeding, *GENETIC engineering, *PLANT diseases