Spleen tyrosine kinase inhibitors disrupt human neutrophil swarming and antifungal functions

Authors: Alex Hopke, Adam L. Viens, Natalie J. Alexander, Seok Joon Mun, Michael K. Mansour, Daniel Irimia

Source: Microbiology Spectrum, Vol 13, Iss 1 (2025)

Subject Terms: swarming, neutrophil, SYK inhibitor, JNK signaling, PI3Ky signaling, GCSF, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/405c525355904105b5a31c22c595ad5e

HL-60 cells as a valuable model to study LPS-induced neutrophil extracellular traps release

Authors: Sonya J. Malavez-Cajigas, Fabiana I. Marini-Martinez, Mercedes Lacourt-Ventura, Karla J. Rosario-Pacheco, Natalia M. Ortiz-Perez, Bethzaly Velazquez-Perez, Wilfredo De Jesús-Rojas, Daniel S. Chertow, Jeffrey R. Strich, Marcos J. Ramos-Benítez

Source: Heliyon, Vol 10, Iss 16, Pp e36386- (2024)

Subject Terms: Neutrophils, Neutrophil Extracellular Traps, Lipopolysaccharide, SYK inhibitor, Human leukemia cell line, HL-60, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024124176; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/2953a90a615f482497fcdba9c53ed978

Phase I study of novel SYK inhibitor TAK‐659 (mivavotinib) in combination with R‐CHOP for front‐line treatment of high‐risk diffuse large B‐cell lymphoma

Authors: Reem Karmali, Frederique St‐Pierre, Shuo Ma, Kelly D. Foster, Jason Kaplan, Xinlei Mi, Barbara Pro, Jane N. Winter, Leo I. Gordon

Source: eJHaem, Vol 4, Iss 1, Pp 108-114 (2023)

Subject Terms: aggressive non‐Hodgkin's lymphoma, diffuse large B‐cell lymphoma, mivavotinib, SYK inhibitor, TAK‐659, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2688-6146

Access URL: https://doaj.org/article/4ddec0d795ad48768f1172140048cc49

3D-QSAR-Based Pharmacophore Modeling, Virtual Screening, and Molecular Dynamics Simulations for the Identification of Spleen Tyrosine Kinase Inhibitors

Authors: Vikas Kumar, Shraddha Parate, Danishuddin, Amir Zeb, Pooja Singh, Gihwan Lee, Tae Sung Jung, Keun Woo Lee, Min Woo Ha

Source: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Subject Terms: SYK inhibitor, 3D QSAR, pharmacophore, autoimmune diseases, molecular docking, MD simulation, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2022.909111/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/ea1eb675088e4e62bd07745f8e6cee97

Targeting Syk in autoimmune rheumatic diseases

Authors: GUO-MIN eDENG, Vasileios C Kyttaris, George C Tsokos

Source: Frontiers in Immunology, Vol 7 (2016)

Subject Terms: IgG, autoimmune disease, Fcgamma receptors, Syk, Syk inhibitor, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00078/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/63b44b45840e42ceb31e578b5c93cc52

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