Cooperative Hedgehog/GLI and JAK/STAT signaling drives immunosuppressive tryptophan/kynurenine metabolism via synergistic induction of IDO1 in skin cancer.

Authors: Elmer, Dominik P.¹ (AUTHOR), Stockmaier, Georg¹ (AUTHOR), Grund-Gröschke, Sandra¹ (AUTHOR), Strobl, Victoria¹ (AUTHOR), Dang, Hieu-Hoa¹ (AUTHOR), Wiederstein, Markus¹ (AUTHOR), Licha, David¹ (AUTHOR), Strobl, Anna¹ (AUTHOR), Eglseer, Anna¹ (AUTHOR), Sternberg, Christina^1,2,3,4 (AUTHOR), Tesanovic, Suzana¹ (AUTHOR), Gruber, Wolfgang¹ (AUTHOR), Wolff, Florian¹ (AUTHOR), Moriggl, Richard^1,5,6 (AUTHOR), Risch, Angela^1,5 (AUTHOR), Reischl, Roland¹ (AUTHOR), Huber, Christian G.^1,5 (AUTHOR), Krenn, Peter W.¹ (AUTHOR), Fortelny, Nikolaus^1,5 (AUTHOR), Horejs-Hoeck, Jutta^1,5 (AUTHOR)

Source: Cell Communication & Signaling. 2/17/2025, Vol. 23 Issue 1, p1-17. 17p.

Subject Terms: *STAT proteins, *BASAL cell carcinoma, *HEDGEHOG signaling proteins, *MEDICAL sciences, *SKIN proteins

Association of Selected STAT Inhibitors with Prolactin-Induced Protein (PIP) in Breast Cancer.

Authors: Jabłońska, Karolina¹ (AUTHOR) karolina.jablonska@umw.edu.pl, Kmiecik, Alicja^1,2 (AUTHOR), Nowińska, Katarzyna^1,3 (AUTHOR), Piotrowska, Aleksandra^1,4 (AUTHOR), Suchański, Jarosław^2,5 (AUTHOR), Ratajczak-Wielgomas, Katarzyna^1,6 (AUTHOR), Partyńska, Aleksandra¹ (AUTHOR), Romanowicz, Hanna^2,3 (AUTHOR), Smolarz, Beata³ (AUTHOR), Matkowski, Rafał^4,5 (AUTHOR), Dzięgiel, Piotr^1,5,6 (AUTHOR)

Source: International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 4, p1416. 32p.

Subject Terms: *STAT proteins, *SUPPRESSORS of cytokine signaling, *ESTROGEN receptors, *PROGESTERONE receptors, *ADJUVANT chemotherapy, *BREAST

Correction: Singh et al. Stat3 Inhibitors TTI-101 and SH5-07 Suppress Bladder Cancer Cell Survival in 3D Tumor Models. Cells 2024, 13 , 1463.

Authors: Singh, Surya P.^1,2 (AUTHOR) adam-asch@ouhsc.edu, Pathuri, Gopal^1,2 (AUTHOR) gopal-pathuri@ouhsc.edu, Asch, Adam S.² (AUTHOR), Rao, Chinthalapally V.^1,2 (AUTHOR) cv-rao@ouhsc.edu, Madka, Venkateshwar^1,2 (AUTHOR) vmadka@ouhsc.edu

Source: Cells (2073-4409). Feb2025, Vol. 14 Issue 4, p299. 4p.

Subject Terms: *STAT proteins, *CELL survival, *BLADDER cancer, *CELL lines, *CANCER cells

Correction: Circular RNA-encoded oncogenic PIAS1 variant blocks immunogenic ferroptosis by modulating the balance between SUMOylation and phosphorylation of STAT1.

Authors: Zang, Xin¹ (AUTHOR), He, Xiao‑Yu¹ (AUTHOR), Xiao, Cheng‑Mei¹ (AUTHOR), Lin, Qing¹ (AUTHOR), Wang, Meng‑Yue¹ (AUTHOR), Liu, Cheng‑Yan¹ (AUTHOR), Kong, Ling‑Yi¹ (AUTHOR) cpu_lykong@126.com, Chen, Zhong² (AUTHOR) chenzhong342501@sina.com, Xia, Yuan‑Zheng^1,3 (AUTHOR) xiayz@cpu.edu.cn

Source: Molecular Cancer. 12/23/2024, Vol. 23 Issue 1, p1-6. 6p.

Subject Terms: *STAT proteins, *GENETIC overexpression, *PHOSPHORYLATION, *AUTHORS

Functional Involvement of Signal Transducers and Activators of Transcription in the Pathogenesis of Influenza A Virus.

Authors: Liu, Shasha^1,2 (AUTHOR) 000q820074@fafu.edu.cn, Qiu, Feng^1,2 (AUTHOR), Gu, Rongrong^1,2 (AUTHOR), Xu, Erying^1,2 (AUTHOR)

Source: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 24, p13589. 14p.

Subject Terms: *STAT proteins, *IMMUNITY, *INFLUENZA A virus, *CELLULAR signal transduction, *GROWTH factors, *HOST-virus relationships

The CCL5/CCR5/SHP2 axis sustains Stat1 phosphorylation and activates NF-κB signaling promoting M1 macrophage polarization and exacerbating chronic prostatic inflammation.

Authors: Jin, Chen^1,2,3,4 (AUTHOR), Zhang, Fei^1,2,3 (AUTHOR), Luo, Hailang^1,2,3 (AUTHOR), Li, Boyang^1,2,3 (AUTHOR), Jiang, Xue⁴ (AUTHOR), Pirozzi, Christopher J.⁴ (AUTHOR), Liang, Chaozhao^1,2,3 (AUTHOR) liang_chaozhao@ahmu.edu.cn, Zhang, Meng^1,2,3 (AUTHOR) zhangmeng@ahmu.edu.cn

Source: Cell Communication & Signaling. 12/5/2024, Vol. 22 Issue 1, p1-19. 19p.

Subject Terms: *CHEMOKINE receptors, *STAT proteins, *MACROPHAGE activation, *CELLULAR signal transduction, *TRANSCRIPTOMES

STAT3 inhibition ameliorates renal interstitial inflammation in MRL/lpr mice with diffuse proliferative lupus nephritis.

Authors: Zhu, Jianfen¹ (AUTHOR), Chen, Yijing² (AUTHOR), Chen, Yulan² (AUTHOR), Lv, Yinqiu³ (AUTHOR), Chen, Tianxin³ (AUTHOR) ctxzjf@163.COM

Source: Renal Failure. Dec2024, Vol. 46 Issue 2, p1-9. 9p.

Subject Terms: *STAT proteins, *LUPUS nephritis, *KIDNEY cortex, *ACUTE kidney failure, *PATHOLOGICAL physiology, *IMMUNOSTAINING

Inhibition of CEACAM1 expression in cytokine-activated neutrophils using JAK inhibitors.

Authors: Matsumoto, Haruki¹ (AUTHOR), Sudo, Ryota¹ (AUTHOR), Fujita, Yuya¹ (AUTHOR), Onizawa, Michio² (AUTHOR), Saito, Kenji¹ (AUTHOR), Sumichika, Yuya¹ (AUTHOR), Yoshida, Shuhei¹ (AUTHOR), Temmoku, Jumpei¹ (AUTHOR), Matsuoka, Naoki¹ (AUTHOR), Asano, Tomoyuki¹ (AUTHOR), Sato, Shuzo¹ (AUTHOR), Suzuki, Eiji¹ (AUTHOR), Machida, Takeshi³ (AUTHOR), Migita, Kiyoshi^1,4 (AUTHOR) migita@fmu.ac.jp

Source: BMC Immunology. 10/1/2024, Vol. 25 Issue 1, p1-10. 10p.

Subject Terms: *STAT proteins, *GRANULOCYTE-macrophage colony-stimulating factor, *TUMOR necrosis factors, *IMMUNE system, *NEUTROPHILS

Bergenin protects against osteoarthritis by inhibiting STAT3, NF-κB and Jun pathways and suppressing osteoclastogenesis.

Authors: Zhang, Zhiwei^1,2,3, Li, Bo^1,2,3, Wu, Shuqin⁴, Yang, Yuxin⁴, Wu, Binkang^1,2,3, Lai, Qi^1,2,3, Lai, Fuchong^1,2,3, Mo, Fengbo^1,2,3, Zhong, Yufei⁴, Wang, Song^1,2,3 ndyfy10323@ncu.edu.cn, Guo, Runsheng^1,2,3 ndyfy02752@ncu.edu.cn, Zhang, Bin^1,2,3 ndyfy01354@ncu.edu.cn

Source: Scientific Reports. 9/3/2024, Vol. 14 Issue 1, p1-15. 15p.

Subject Terms: *OSTEOCLASTOGENESIS, *STAT proteins, *OSTEOARTHRITIS, *PROTEIN-protein interactions, *CELLULAR signal transduction, *CARTILAGE regeneration

STAT3 Increases CVB3 Replication and Acute Pancreatitis and Myocarditis Pathology via Impeding Nuclear Translocation of STAT1 and Interferon-Stimulated Gene Expression.

Authors: Liang, Tianming¹ (AUTHOR), Zhang, Zhipeng¹ (AUTHOR), Bai, Zhenxin¹ (AUTHOR), Xu, Le¹ (AUTHOR), Xu, Wei¹ (AUTHOR) xuwei828@suda.edu.cn

Source: International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 16, p9007. 17p.

Subject Terms: *STAT proteins, *GENE expression, *CELLULAR signal transduction, *HEART fibrosis, *GENETIC transcription

Sorcin Inhibits Mitochondrial Apoptosis by Interacting with STAT3 via NF-κB Pathway.

Authors: Li, Yizi¹ (AUTHOR) 17304807750@163.com, Tian, Manlin¹ (AUTHOR) tianmanlin0214@163.com, Pires Sanches, Jaceline Gislaine¹ (AUTHOR) jacelinesanches26@gmail.com, Zhang, Qingqing¹ (AUTHOR) zqqzfg@163.com, Hou, Li¹ (AUTHOR) lihou1972@163.com, Zhang, Jun^1,2 (AUTHOR) zhangjun@dmu.edu.cn

Source: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 13, p7206. 18p.

Subject Terms: *STAT proteins, *MITOCHONDRIA, *CELLULAR signal transduction, *HEPATOCELLULAR carcinoma, *WESTERN immunoblotting

Correction: Effect and potential mechanism of oncometabolite succinate promotes distant metastasis of colorectal cancer by activating STAT3.

Authors: Yu, Jiangnan¹ (AUTHOR), Yang, Hong² (AUTHOR), Zhang, Lin² (AUTHOR), Ran, Suye² (AUTHOR), Shi, Qing² (AUTHOR), Peng, Pailan² (AUTHOR), Liu, Qi² (AUTHOR) gyqiliu6071@sina.com, Song, Lingyu² (AUTHOR) songlingyu1991@gmc.edu.cn

Source: BMC Gastroenterology. 11/5/2024, Vol. 24 Issue 1, p1-3. 3p.

Subject Terms: *COLORECTAL cancer, *STAT proteins, *METASTASIS

Crosstalk between CXCL12/CXCR4/ACKR3 and the STAT3 Pathway.

Authors: Ma, Zelong¹ (AUTHOR) mazeloong@163.com, Zhou, Faxiao¹ (AUTHOR), Jin, Hua¹ (AUTHOR), Wu, Xiaoming¹ (AUTHOR) xiao_tracy@kust.edu.cn

Source: Cells (2073-4409). Jun2024, Vol. 13 Issue 12, p1027. 22p.

Subject Terms: *STAT proteins, *CELLULAR signal transduction, *STROMAL cell-derived factor 1, *TUMOR treatment, *DRUG target

Asymmetric post-translational modifications regulate the nuclear translocation of STAT3 homodimers in response to leukemia inhibitory factor.

Authors: Diallo, Mickael^1,2 (AUTHOR), Pimenta, Constança¹ (AUTHOR), Murtinheira, Fernanda^1,2 (AUTHOR), Martins-Alves, Daniela¹ (AUTHOR), Pinto, Francisco R.¹ (AUTHOR), da Costa, André Abrantes¹ (AUTHOR), Letra-Vilela, Ricardo^1,2 (AUTHOR), Martin, Vanesa^3,4 (AUTHOR), Rodriguez, Carmen^3,4 (AUTHOR), Rodrigues, Mário S.¹ (AUTHOR), Herrera, Federico¹ (AUTHOR) fherrera@fc.ul.pt

Source: Cellular Oncology (2211-3428). Jun2024, Vol. 47 Issue 3, p1065-1070. 6p.

Subject Terms: *LEUKEMIA inhibitory factor, *STAT proteins, *TRANSCRIPTION factors, *HOMODIMERS, *POST-translational modification, *HELA cells

Alantolactone enhances the sensitivity of melanoma to MAPK pathway inhibitors by targeting inhibition of STAT3 activation and down-regulating stem cell markers.

Authors: Zhao, Kun¹ (AUTHOR), Zhao, Qi² (AUTHOR), Dai, Xinzhi³ (AUTHOR), Wen, Xue² (AUTHOR), Luo, Xing² (AUTHOR), Duan, Yi² (AUTHOR), Yang, Zhihui² (AUTHOR) yzhih73@swmu.edu.cn, Dai, Qiong⁴ (AUTHOR) 709230152@qq.com

Source: Cancer Cell International. 5/31/2024, Vol. 24 Issue 1, p1-14. 14p.

Subject Terms: *STAT proteins, *MITOGEN-activated protein kinases, *MELANOMA, *STEM cells, *PROTEIN kinase inhibitors, *DACARBAZINE

STATs signaling pathways in dendritic cells: As potential therapeutic targets?

Authors: Sohrabi, Sepideh^1,2 (AUTHOR), Masoumi, Javad¹ (AUTHOR), Naseri, Bahar¹ (AUTHOR), Ghorbaninezhad, Farid¹ (AUTHOR), Alipour, Shiva¹ (AUTHOR), Kazemi, Tohid¹ (AUTHOR), Ahmadian Heris, Javad¹ (AUTHOR), Aghebati Maleki, Leili¹ (AUTHOR), Basirjafar, Pedram³ (AUTHOR), Zandvakili, Raziyeh³ (AUTHOR), Doustvandi, Mohammad Amin¹ (AUTHOR), Baradaran, Behzad^1,2 (AUTHOR) baradaranb@tbzmed.ac.ir

Source: International Reviews of Immunology. May2024, Vol. 43 Issue 3, p138-159. 22p.

Subject Terms: *STAT proteins, *CELLULAR signal transduction, *DENDRITIC cells, *AUTOIMMUNE diseases, *T helper cells, *DRUG target

Expression of STAT3 and hypoxia markers in long-term surviving malignant glioma patients.

Authors: Dvorakova, Katerina¹ (AUTHOR), Skarkova, Veronika¹ (AUTHOR), Vitovcova, Barbora¹ (AUTHOR), Soukup, Jiri^2,3,4 (AUTHOR), Vosmikova, Hana² (AUTHOR), Pleskacova, Zuzana⁵ (AUTHOR), Skarka, Adam⁶ (AUTHOR), Bartos, Michael Christian⁷ (AUTHOR), Krupa, Petr⁷ (AUTHOR), Kasparova, Petra² (AUTHOR), Petera, Jiri⁵ (AUTHOR), Rudolf, Emil¹ (AUTHOR) rudolf@lfhk.cuni.cz

Source: BMC Cancer. 4/23/2024, Vol. 24 Issue 1, p1-12. 12p.

Subject Terms: *GLIOMAS, *STAT proteins, *HYPOXEMIA, *GLIOBLASTOMA multiforme, *BRAIN tumors, *CELL survival

Improvement of 5-fluorouracil chemosensitivity in colorectal cancer cells by siRNA-mediated silencing of STAT6 oncogene.

Authors: Farzam, Omid Rahbar^1,2,3, Baradaran, Behzad², Akbari, Bahman^1,3 ba1389@yahoo.com, Najafi, Souzan², Amini, Mohammad², Yari, AmirHossein^2,4, Dabbaghipour, Reza⁵, Kaleybar, Vahid Pourabdollah², Khosroshahi, Shiva Ahdi²

Source: Iranian Journal of Basic Medical Sciences. Apr2024, Vol. 27 Issue 4, p475-484. 10p.

Subject Terms: *STAT proteins, *COLORECTAL cancer, *CANCER cells, *SMALL interfering RNA, *FLUOROURACIL, *GENE ontology, *VASCULOGENIC mimicry

The Ethanolic Extract of Dictyopteris Divaricata Induces Apoptosis in Non-Small Cell Lung Cancer Cells by Inhibiting STAT3 Activity.

Authors: Park, Hyun-Ji¹, Park, Shin-Hyung¹ omdpark@deu.ac.kr

Source: Nutrition & Cancer. 2024, Vol. 76 Issue 3, p305-315. 11p.

Subject Terms: *LUNG cancer, *STAT proteins, *GENETIC mutation, *EPIDERMAL growth factor receptors, *APOPTOSIS, *ANTINEOPLASTIC agents, *CELL survival, *CELL proliferation, *DESCRIPTIVE statistics, *PLANT extracts, *CASPASES, *PHOSPHORYLATION, *ENZYME inhibitors, *PHARMACODYNAMICS

Geographic Terms: SOUTH Korea

Effect and potential mechanism of oncometabolite succinate promotes distant metastasis of colorectal cancer by activating STAT3.

Authors: Yu, Jiangnan¹ (AUTHOR), Yang, Hong² (AUTHOR), Zhang, Lin² (AUTHOR), Ran, Suye² (AUTHOR), Shi, Qing² (AUTHOR), Peng, Pailan² (AUTHOR), Liu, Qi² (AUTHOR) gyqiliu6071@sina.com, Song, Lingyu² (AUTHOR) songlingyu1991@gmc.edu.cn

Source: BMC Gastroenterology. 3/14/2024, Vol. 24 Issue 1, p1-11. 11p.

Subject Terms: *COLORECTAL cancer, *STAT proteins, *METASTASIS, *CANCER cell growth, *WESTERN immunoblotting