Bemcentinib enhances sensitivity to estrogen receptor inhibitors in breast cancer cells

Authors: Kim, Gyeongmi ^{a, b, 1}, Ahn, Se Hee ^{a, c, 1}, Jang, Se-Kyeong ^a, Kim, Selim ^{a, b}, Kim, Hyunggee ^b, Park, Ki Soo ^c, Jin, Hyeon-Ok ^d, Park, Chan Sub ^e, Seong, Min-Ki ^e, Kim, Hyun-Ah ^{e, ⁎}, Park, In-Chul ^{a, ⁎, 2}

Source: In International Journal of Biochemistry and Cell Biology March 2025 180

Inhibition of p70 Ribosomal S6K1 Protects the Myocardium against Ischemia/Reperfusion-Induced Necrosis through Downregulation of RIP3

Authors: Hui Shang, Jinjin Shi, Jun Zhu, Yunfeng Guo, Xiaoyan Wang

Source: Frontiers in Bioscience-Landmark, Vol 30, Iss 1, p 26186 (2025)

Subject Terms: necrosis, ischemia-reperfusion injury, myocardial infarction, pf-470867, rip3, s6k1, Biochemistry, QD415-436, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL26186; https://doaj.org/toc/2768-6701

Access URL: https://doaj.org/article/42e11a5b46bc4d06a5551eb6bb2c419c

Chronic mild stress leads to anxiety-like behavior and decreased p70 S6K1 activity in the hippocampus of male mice

Authors: David, Jazmine ^a, Mousset, Marike ^a, Trombetti, Kirby ^a, Sayasouk, Beverly ^a, Neilsen, Calvin ^a, Suorsa, Parker ^a, Ruben, Melissa ^a, Ruben, Elias ^a, Thiessen, Jacob ^a, Pychewicz, Taylor ^b, Chu, Ping ^c, Huynh, Thu N. ^{a, c, ⁎}

Source: In Physiology & Behavior 1 January 2024 273

Hyperbaric oxygen treatment increases intestinal stem cell proliferation through the mTORC1/S6K1 signaling pathway in Mus musculus

Authors: Ignacio Casanova-Maldonado, David Arancibia, Pablo Lois, Isaac Peña-Villalobos, Verónica Palma

Source: Biological Research, Vol 56, Iss 1, Pp 1-15 (2023)

Subject Terms: Hyperbaric oxygen treatment, Intestinal stem cells, Progenitor cells, Caloric restriction, mTORC1, S6K1, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/0717-6287

Access URL: https://doaj.org/article/d12c81af98e84ec1beabbb4dd3582da9

Sexual dimorphism in the molecular mechanisms of insulin resistance during a critical developmental window in Wistar rats

Authors: Rosa Isela Ortiz-Huidobro, Carlos Larqué, Myrian Velasco, Juan Pablo Chávez-Maldonado, Jean Sabido, Yuriko Itzel Sanchez-Zamora, Marcia Hiriart

Source: Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-15 (2022)

Subject Terms: Insulin resistance, Sexual dimorphism, Insulin signaling pathway, Critical developmental window, Glucose homeostasis, S6K1 kinase, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/be6f5af8ed6c4bf6b9e7466123cdf9bd

S6K1 amplification confers innate resistance to CDK4/6 inhibitors through activating c-Myc pathway in patients with estrogen receptor-positive breast cancer

Authors: Hongnan Mo, Xuefeng Liu, Yu Xue, Hongyan Chen, Shichao Guo, Zhangfu Li, Shuang Wang, Caiming Li, Jiashu Han, Ming Fu, Yongmei Song, Dan Li, Fei Ma

Source: Molecular Cancer, Vol 21, Iss 1, Pp 1-19 (2022)

Subject Terms: Breast cancer, CDK4/6 inhibitors, Drug resistance, Circulating tumour DNA, S6K1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/e116ef9a09024d378290ec5982810b3b

Insights into Overlappings of Fibrosis and Cancer: Exploring the Tumor-related Cardinal Genes in Idiopathic Pulmonary Fibrosis

Authors: Marjan Taherian, Paria Bayati, Mohammad-Ali Assarehzadegan, Mansoureh Soleimani, Hadi Poormoghim, Nazanin Mojtabavi

Source: Iranian Journal of Allergy, Asthma and Immunology, Vol 22, Iss 2 (2023)

Subject Terms: Idiopathic pulmonary fibrosis, Cancer, mTOR, Rptor, S6k1, 4E-bp1, Medicine

File Description: electronic resource

Relation: https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3663; https://doaj.org/toc/1735-1502; https://doaj.org/toc/1735-5249

Access URL: https://doaj.org/article/70b7d21923c24a7280410465770c5cd5

S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair

Authors: Adi Amar-Schwartz, Vered Ben Hur, Amina Jbara, Yuval Cohen, Georgina D Barnabas, Eliran Arbib, Zahava Siegfried, Bayan Mashahreh, Fouad Hassouna, Asaf Shilo, Mohammad Abu-Odeh, Michael Berger, Reuven Wiener, Rami Aqeilan, Tamar Geiger, Rotem Karni

Source: eLife, Vol 11 (2022)

Subject Terms: S6K1, MSH6, DNA repair, MSH2, mTORC1, CDK1, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/79128; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/415f0119bfe2430898b264371e2f1a67

Effect of 8 Weeks of Endurance Training on S6K1 and 4EBP1 Proteins Content in the Left Ventricle of the Heart of Diabetic Rats Induced by Streptozotocin and Nicotinamide

Authors: Maryam Shabani, Mohammad Sherafati Moghadam, Kamilia Moghaddami

Source: Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 29, Iss 4, Pp 3658-3668 (2021)

Subject Terms: endurance training, nicotinamide, protein 4ebp1, protein s6k1, streptozotocin., Medicine (General), R5-920

File Description: electronic resource

Relation: http://jssu.ssu.ac.ir/article-1-5262-en.html; https://doaj.org/toc/2228-5741; https://doaj.org/toc/2228-5733

Access URL: https://doaj.org/article/09ede5f6b6514ad4bf89060c9b43b555

FERONIA functions through Target of Rapamycin (TOR) to negatively regulate autophagy

Authors: Ping Wang, Natalie M. Clark, Trevor M. Nolan, Gaoyuan Song, Olivia G. Whitham, Ching-Yi Liao, Christian Montes-Serey, Diane C. Bassham, Justin W. Walley, Yanhai Yin, Hongqing Guo

Source: Frontiers in Plant Science, Vol 13 (2022)

Subject Terms: Autophagy, AZD8055, FERONIA, S6K1 phosphorylation, TOR, Plant culture, SB1-1110

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpls.2022.961096/full; https://doaj.org/toc/1664-462X

Access URL: https://doaj.org/article/fb004857ef154aef94e597176407fced

Glucose Transporter-1 Cooperating with AKT Signaling Promote Gastric Cancer Progression

Authors: Zhou D, Jiang L, Jin L, Yao Y, Wang P, Zhu X

Source: Cancer Management and Research, Vol Volume 12, Pp 4151-4160 (2020)

Subject Terms: akt, gastric cancer, glut1, s6k1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.dovepress.com/glucose-transporter-1-cooperating-with-akt-signaling-promote-gastric-c-peer-reviewed-article-CMAR; https://doaj.org/toc/1179-1322

Access URL: https://doaj.org/article/878a43817de64265904c1d6aa91f53be

Sidekick No More Neural Translation Control by p70 ribosomal S6 kinase 1

Authors: Bhattacharya, Aditi

Contributors: Sossin, Wayne S., book editor

Source: The Oxford Handbook of Neuronal Protein Synthesis.

Availability: https://doi.org/10.1093/oxfordhb/9780190686307.013.10

Repurposing Tranexamic Acid as an Anticancer Agent

Authors: Mary E. Law, Bradley J. Davis, Amanda F. Ghilardi, Elham Yaaghubi, Zaafir M. Dulloo, Mengxiong Wang, Olga A. Guryanova, Coy D. Heldermon, Stephan C. Jahn, Ronald K. Castellano, Brian K. Law

Source: Frontiers in Pharmacology, Vol 12 (2022)

Subject Terms: MYC, S6K1, CDCP1, STAT3, protein synthesis, acetylation, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.792600/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/5f7f9ec5aa3941a2b5245b8c17992f04

Identification of a novel S6K1 inhibitor, rosmarinic acid methyl ester, for treating cisplatin-resistant cervical cancer

Authors: Ki Hong Nam, Sang Ah Yi, Gibeom Nam, Jae Sung Noh, Jong Woo Park, Min Gyu Lee, Jee Hun Park, Hwamok Oh, Jieun Lee, Kang Ro Lee, Hyun-Ju Park, Jaecheol Lee, Jeung-Whan Han

Source: BMC Cancer, Vol 19, Iss 1, Pp 1-13 (2019)

Subject Terms: Rosmarinic acid methyl ester, S6K1, Autophagy, Apoptosis, Cervical cancer, Cisplatin resistance, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-019-5997-2; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/bac10dabdb2243da8070712d388c21f5

Pulmonary Artery Smooth Muscle Cell Senescence Promotes the Proliferation of PASMCs by Paracrine IL-6 in Hypoxia-Induced Pulmonary Hypertension

Authors: Ai-Ping Wang, Fang Yang, Ying Tian, Jian-Hui Su, Qing Gu, Wei Chen, Shao-Xin Gong, Xiao-Feng Ma, Xu-Ping Qin, Zhi-Sheng Jiang

Source: Frontiers in Physiology, Vol 12 (2021)

Subject Terms: pulmonary artery smooth muscle cells senescence, interleukin-6 (IL-6), mTOR- S6K1 signaling, pulmonary hypertension, proliferation, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2021.656139/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/7294662aef78431c997cbbe07ad251de

Pharmacological inhibition of S6K1 facilitates platelet activation by enhancing Akt phosphorylation

Authors: Wen Gao, Kemin Wang, Lin Zhang, Jian Li, Junling Liu, Xue Chen, Xinping Luo

Source: Platelets, Vol 30, Iss 2, Pp 241-250 (2019)

Subject Terms: pdk1, platelet activation, s6k1, signaling pathway, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/0953-7104; https://doaj.org/toc/1369-1635

Access URL: https://doaj.org/article/b7cfa83b77e1452390558168f4d00c24

LXRɑ participates in the mTOR/S6K1/SREBP-1c signaling pathway during sodium palmitate-induced lipogenesis in HepG2 cells

Authors: Youping Zhou, Shengjie Yu, Can Cai, Li Zhong, Huihong Yu, Wei Shen

Source: Nutrition & Metabolism, Vol 15, Iss 1, Pp 1-9 (2018)

Subject Terms: LXRα, mTOR, S6K1, NAFLD, HepG2 cells, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12986-018-0268-9; https://doaj.org/toc/1743-7075

Access URL: https://doaj.org/article/1ca0ba99968e48dfb972fb50537c3b2a

Tuberous Sclerosis Complex Tumor Suppressor-Mediated S6 Kinase Inhibition by Phosphatidylinositide-3-OH Kinase Is mTOR Independent

Authors: Jaeschke, Anja, Hartkamp, Joerg, Saitoh, Masao, Roworth, Wendy, Nobukuni, Takahiro, Hodges, Angela, Sampson, Julian, Thomas, George, Lamb, Richard

Source: The Journal of Cell Biology, 2002 Oct . 159(2), 217-224.

Access URL: https://www.jstor.org/stable/1621288

Absence of the kinase S6k1 mimics the effect of chronic endurance exercise on glucose tolerance and muscle oxidative stress

Authors: C. Binsch, T. Jelenik, A. Pfitzer, M. Dille, S. Müller-Lühlhoff, S. Hartwig, S. Karpinski, S. Lehr, D.G. Kabra, A. Chadt, M. Roden, H. Al-Hasani, T.R. Castañeda

Source: Molecular Metabolism, Vol 6, Iss 11, Pp 1443-1453 (2017)

Subject Terms: S6K1, Exercise, Glycemic control, Metabolic phenotyping, Reactive oxidative species, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877817305422; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/d16280e1f30b47cd9e357efdd3bbf472

mTORC1 Signaling in Individual Human Muscle Fibers Following Resistance Exercise in Combination With Intake of Essential Amino Acids

Authors: Sebastian Edman, Karin Söderlund, Marcus Moberg, William Apró, Eva Blomstrand

Source: Frontiers in Nutrition, Vol 6 (2019)

Subject Terms: muscle fiber type, protein expression, S6K1, single muscle fiber, EAA, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnut.2019.00096/full; https://doaj.org/toc/2296-861X

Access URL: https://doaj.org/article/cf18e557886c43d49bfebd08a2529be5