Preclinical Protein Signatures of Crohn’s Disease and Ulcerative Colitis: A Nested Case-Control Study Within Large Population-Based Cohorts

Authors: Almer, Sven ^{1, 3}, Blomberg, André ², Bresso, Francesca ³, Carstens, Adam ⁴, Hjortswang, Henrik ⁵, Hreinsson, Jóhann Páll ⁶, Ling Lundström, Maria ⁷, Marsal, Jan ⁸, Strid, Hans ³, Grännö, Olle ^{1, ∗}, Bergemalm, Daniel ², Salomon, Benita ³, Lindqvist, Carl Mårten ³, Hedin, Charlotte R.H. ^{4, 5}, Carlson, Marie ⁶, Dannenberg, Katharina ², Andersson, Erik ², Keita, Åsa V. ⁷, Magnusson, Maria K. ⁸, Eriksson, Carl ^{2, 9}, Lanka, Vivekananda ¹⁰, Magnusson, Patrik K.E. ¹⁰, D’Amato, Mauro ^{11, 12, 13}, Öhman, Lena ⁸, Söderholm, Johan D. ^{7, 14}, Hultdin, Johan ¹⁵, Kruse, Robert ¹⁶, Cao, Yang ^{17, 18}, Repsilber, Dirk ³, Grip, Olof ¹⁹, Karling, Pontus ²⁰, Halfvarson, Jonas ²

Source: In Gastroenterology April 2025 168(4):741-753

Acute psychological stress increases paracellular permeability and modulates immune activity in rectal mucosa of healthy volunteers

Authors: Gerdin, Linda, González‐Castro, Ana M., Ericson, Ann‐Charlott, Persborn, Mats, Santos, Javier, Walter, Susanna A., Keita, Åsa V., Vicario, Maria, Söderholm, Johan D.

Source: United European Gastroenterology journal. 11(1):31-41

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173079017.0x000001&indx=1&recIds=ETOCvdc_100173079017.0x000001

Systemic Inflammation in Preclinical Ulcerative Colitis

Authors: Arnott, Ian D., Bayes, Monica, Bonfiglio, Ferdinando, Boyapati, Ray K., Carstens, Adam, Casén, Christina, Ciemniejewska, Ewa, Dahl, Fredrik A., Detlie, Trond Espen, Drummond, Hazel E., Ekeland, Gunn S., Ekman, Daniel, Frengen, Anna B., Gullberg, Mats, Gut, Ivo G., Gut, Marta, Heath, Simon C., Hjelm, Fredrik, Hjortswang, Henrik, Ho, Gwo-Tzer, Jonkers, Daisy, Söderholm, Johan, Kennedy, Nicholas A., Lees, Charles W., Lindahl, Torbjørn, Lindqvist, Mårten, Merkel, Angelika, Modig, Eddie, Moen, Aina E.F., Nilsen, Hilde, Nimmo, Elaine R., Noble, Colin L., Nordberg, Niklas, O’Leary, Kate R., Ocklind, Anette, Olbjørn, Christine, Pettersson, Erik, Pierik, Marieke, Dominique, Bergemalm, Daniel, Andersson, Erik, Hultdin, Johan, Eriksson, Carl, Rush, Stephen T., Kalla, Rahul, Adams, Alex T., Keita, Åsa V., D’Amato, Mauro, Gomollon, Fernando, Jahnsen, Jørgen, Ricanek, Petr, Satsangi, Jack, Repsilber, Dirk, Karling, Pontus, Halfvarson, Jonas

Source: In Gastroenterology November 2021 161(5):1526-1539

Effects of analgesic and surgical modality on immune response in colorectal cancer surgery

Authors: Faisal, Mohammed, Schäfer, Christopher Niels, Myrelid, Pär, Winberg, Martin E., Söderholm, Johan D., Keita, Åsa V., Eintrei, Christina

Source: In Surgical Oncology September 2021 38

Preclinical Protein Signatures of Crohn's Disease and Ulcerative Colitis: A Nested Case-Control Study Within Large Population-Based Cohorts.

Authors: Grännö, Olle, Bergemalm, Daniel, Salomon, Benita, Lindqvist, Carl Mårten, Hedin, Charlotte R.H., Carlson, Marie, Dannenberg, Katharina, Andersson, Erik, Keita, Åsa V., Magnusson, Maria K., Eriksson, Carl, Lanka, Vivekananda, Magnusson, Patrik K.E., D'Amato, Mauro, Öhman, Lena, Söderholm, Johan D., Hultdin, Johan, Kruse, Robert, Cao, Yang, Repsilber, Dirk

Source: Gastroenterology (0016-5085); Apr2025, Vol. 168 Issue 4, p741-753, 13p

Crohn’s Disease Pathobiont Adherent-Invasive E coli Disrupts Epithelial Mitochondrial Networks With Implications for Gut Permeability

Authors: Mancini, Nicole L., Rajeev, Sruthi, Jayme, Timothy S., Wang, Arthur, Keita, Åsa V., Workentine, Matthew L., Hamed, Samira, Söderholm, Johan D., Lopes, Fernando, Shutt, Timothy E., Shearer, Jane, McKay, Derek M.

Source: In Cellular and Molecular Gastroenterology and Hepatology 2021 11(2):551-571

Colonic paracellular permeability and circulating zonulin-related proteins

Authors: Meira de-Faria, Felipe, Bednarska, Olga, Ström, Magnus, Söderholm, Johan D., Walter, Susanna A., Keita, Åsa V.

Source: Scandinavian journal of gastroenterology. 56(4):424-431

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116732742.0x000001&indx=1&recIds=ETOCvdc_100116732742.0x000001

Antagonism of Adherent Invasive E. coli LF82 With Human α-defensin 5 in the Follicle-associated Epithelium of Patients With Ileal Crohn's Disease

Authors: Alkaissi, Lina Y, Winberg, Martin E, Heil, Stéphanie D S, Haapaniemi, Staffan, Myrelid, Pär, Stange, Eduard F, Söderholm, Johan D, Keita, Åsa V

Source: Inflammatory bowel diseases. 27(7):1116-1127

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135744062.0x000001&indx=1&recIds=ETOCvdc_100135744062.0x000001

Su1757 A NOVEL DIAGNOSTIC SERUM PROTEIN SIGNATURE FOR PEDIATRIC INFLAMMATORY BOWEL DISEASE: A DISCOVERY AND VALIDATION STUDY IN TWO INDEPENDENT INCEPTION COHORTS

Authors: Mathisen, Charlotte B., Bazov, Igor, Nyström, Niklas, Andersen, Svend, Olbj⊘rn, Christine, Perminow, G⊘ri, Kristensen, Vendel, Opheim, Randi, Ricanek, Petr, D'Amato, Mauro, Carlson, Marie, Hedin, Charlotte R., Keita, Åsa V., Kruse, Robert, Lindqvist, Carl Mårten, Magnusson, Maria K., Salihovic, Samira, Söderholm, Johan D., Ohman, Lena, Repsilber, Dirk, H⊘ivik, Marte Lie, Halfvarson, Jonas

Source: Gastroenterology. 164(6):S-668-S-668

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194401007.0x000001&indx=1&recIds=ETOCvdc_100194401007.0x000001

Su1759 IDENTIFICATION AND VALIDATION OF A LIPIDOMIC SIGNATURE AS A NOVEL DIAGNOSTIC BIOMARKER OF PEDIATRIC INFLAMMATORY BOWEL DISEASE

Authors: Salihovic, Samira, Nyström, Niklas, Mathisen, Charlotte B., Andersen, Svend, Olbj⊘rn, Christine, Perminow, G⊘ri, Opheim, Randi, Detlie, Trond Espen, Huppertz-Hauss, Gert, Bazov, Igor, Kruse, Robert, Lindqvist, Carl Mårten, Hedin, Charlotte R., Carlson, Marie, Ohman, Lena, Magnusson, Maria K., Keita, Åsa V., Söderholm, Johan D., D'Amato, Mauro, Oresic, Matej, Repsilber, Dirk, Hyötyläinen, Tuulia, Hoivik, Marte L., Halfvarson, Jonas

Source: Gastroenterology. 164(6):S-669-S-669

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194401012.0x000001&indx=1&recIds=ETOCvdc_100194401012.0x000001

Image‐Based Cell Profiling Enables Quantitative Tissue Microscopy in Gastroenterology

Authors: Wills, John W., Robertson, Jack, Summers, Huw D., Miniter, Michelle, Barnes, Claire, Hewitt, Rachel E., Keita, Åsa V., Söderholm, Johan D., Rees, Paul, Powell, Jonathan J.

Source: Cytometry.Part A. 97(12):1222-1237

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112553473.0x000001&indx=1&recIds=ETOCvdc_100112553473.0x000001

Faecal biomarkers for diagnosis and prediction of disease course in treatment‐naïve patients with IBD.

Authors: Ling Lundström, Maria, Peterson, Christer, Hedin, Charlotte R. H., Bergemalm, Daniel, Lampinen, Maria, Magnusson, Maria K., Keita, Åsa V., Kruse, Robert, Lindqvist, Carl Mårten, Repsilber, Dirk, D'Amato, Mauro, Hjortswang, Henrik, Strid, Hans, Söderholm, Johan D., Öhman, Lena, Venge, Per, Halfvarson, Jonas, Carlson, Marie

Source: Alimentary Pharmacology & Therapeutics; Sep2024, Vol. 60 Issue 6, p765-777, 13p

Subject Terms: CROHN'S disease, RECEIVER operating characteristic curves, BASIC proteins, INFLAMMATORY bowel diseases, ULCERATIVE colitis, DISEASE progression

Interactions between gut permeability and brain structure and function in health and irritable bowel syndrome

Authors: Witt, Suzanne T., Bednarska, Olga, Keita, Åsa V., Icenhour, Adriane, Jones, Michael P., Elsenbruch, Sigrid, Söderholm, Johan D., Engström, Maria, Mayer, Emeran A., Walter, Susanna

Source: In NeuroImage: Clinical 2019 21

Mucosal permeability and mast cells as targets for functional gastrointestinal disorders

Authors: Keita, Åsa V, Söderholm, Johan D

Source: In Current Opinion in Pharmacology December 2018 43:66-71

ER-stress mobilization of death-associated protein kinase-1–dependent xenophagy counteracts mitochondria stress–induced epithelial barrier dysfunction

Authors: Lopes, Fernando, Keita, Åsa V., Saxena, Alpana, Reyes, Jose Luis, Mancini, Nicole L., Al Rajabi, Ala, Wang, Arthur, Baggio, Cristiane H., Dicay, Michael, van Dalen, Rob, Ahn, Younghee, Carneiro, Matheus B.H. ^**, Peters, Nathan C. ^**, Rho, Jong M., MacNaughton, Wallace K., Girardin, Stephen E., Jijon, Humberto, Philpott, Dana J., Söderholm, Johan D., McKay, Derek M.

Source: In Journal of Biological Chemistry 2 March 2018 293(9):3073-3087

Su1758 A NOVEL SERUM PROTEIN SIGNATURE AS BIOMARKER FOR INFLAMMATORY BOWEL DISEASE: A DIAGNOSTIC PERFORMANCE AND PREDICTION MODELLING STUDY USING DATA FROM TWO INDEPENDENT INCEPTION COHORTS

Authors: Bazov, Igor, Kruse, Robert, Daniel, Bergemalm, Eriksson, Carl, Hedin, Charlotte R., Carlson, Marie, van Nieuwenhoven, Michiel, Keita, Åsa V., Magnusson, Maria K., Almer, Sven, Strid, Hans, Mathisen, Charlotte B., Bengtson, May-Bente, Aaabrekke, Tone Bergene, Medhus, Asle W., Detlie, Trond Espen, Frigstad, Svein Oskar, Huppertz-Hauss, Gert, Opheim, Randi, Ricanek, Petr, Kristensen, Vendel, Salihovic, Samira, D'Amato, Mauro, Ohman, Lena, Söderholm, Johan D., Lindqvist, Carl Mårten, Repsilber, Dirk, H⊘ivik, Marte Lie, Halfvarson, Jonas

Source: Gastroenterology. 164(6):S-668-S-669

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194401023.0x000001&indx=1&recIds=ETOCvdc_100194401023.0x000001

Enhanced E. coli LF82 Translocation through the Follicle-associated Epithelium in Crohn's Disease is Dependent on Long Polar Fimbriae and CEACAM6 expression, and Increases Paracellular Permeability

Authors: Keita, Åsa V, Alkaissi, Lina Yakymenko, Holm, Elin B, Heil, Stéphanie D S, Chassaing, Benoit, Darfeuille-Michaud, Arlette, McKay, Derek M, Söderholm, Johan D

Source: Journal of Crohn's and colitis. 14(2):216-229

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100100258121.0x000001&indx=1&recIds=ETOCvdc_100100258121.0x000001

Anorectal Function After Ileo-Rectal Anastomosis Is Better than Pelvic Pouch in Selected Ulcerative Colitis Patients

Authors: Abdalla, Maie, Norblad, Rickard, Olsson, Malin, Landerholm, Kalle, Andersson, Peter, Söderholm, Johan D., Andersson, Roland, Myrelid, Pär

Source: Digestive diseases and sciences. 65(1):250-259

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127326526.0x000001&indx=1&recIds=ETOCvdc_100127326526.0x000001

Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease.

Authors: Salihovic, Samira, Nyström, Niklas, Mathisen, Charlotte Bache-Wiig, Kruse, Robert, Olbjørn, Christine, Andersen, Svend, Noble, Alexandra J., Dorn-Rasmussen, Maria, Bazov, Igor, Perminow, Gøri, Opheim, Randi, Detlie, Trond Espen, Huppertz-Hauss, Gert, Hedin, Charlotte R. H., Carlson, Marie, Öhman, Lena, Magnusson, Maria K., Keita, Åsa V., Söderholm, Johan D., D'Amato, Mauro

Source: Nature Communications; 6/3/2024, Vol. 15 Issue 1, p1-15, 15p

Subject Terms: INFLAMMATORY bowel diseases, CLINICAL decision support systems, BLOOD testing, C-reactive protein, CHILD patients

Infliximab restores colonic barrier to adherent-invasive E. coli in Crohn's disease via effects on epithelial lipid rafts

Authors: Yakymenko, Olena, Schoultz, Ida, Gullberg, Elisabeth, Ström, Magnus, Almer, Sven, Wallon, Conny, Wang, Arthur, Keita, Åsa V., Campbell, Barry J., McKay, Derek M., Söderholm, Johan D.

Source: Scandinavian journal of gastroenterology. 53(6):677-684

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100104127057.0x000001&indx=1&recIds=ETOCvdc_100104127057.0x000001