Diabetic individuals with COVID-19 exhibit reduced efficacy of gliptins in inhibiting dipeptidyl peptidase 4 (DPP4). A suggested explanation for increased COVID-19 susceptibility in patients with type 2 diabetes mellitus (T2DM)

Authors: Mora-Rodríguez, José María, Sánchez, Belén G., Bort, Alicia, Díaz-Yuste, Alba, Ballester-González, Rubén, Arrieta, Francisco, Sebastián-Martín, Alba, Díaz-Laviada, Inés

Source: In Life Sciences 1 January 2024 336

Resistance to 2-Hydroxy-Flutamide in Prostate Cancer Cells Is Associated with the Downregulation of Phosphatidylcholine Biosynthesis and Epigenetic Modifications.

Authors: Mora-Rodríguez, José María^1,2 (AUTHOR) josem.mora@uah.es, Sánchez, Belén G.^1,2 (AUTHOR) belen.sanchezg@uah.es, Sebastián-Martín, Alba^1,2 (AUTHOR) alba.sebastian@uah.es, Díaz-Yuste, Alba^1,2 (AUTHOR) alba.diazy@edu.uah.es, Sánchez-Chapado, Manuel³ (AUTHOR) manuel.sanchezc@uah.es, Palacín, Ana María³ (AUTHOR) anapalacin@hotmail.com, Sánchez-Rodríguez, Carlos³ (AUTHOR) sanchezrodriguez.car@gmail.com, Bort, Alicia^1,2,4 (AUTHOR) alicia.bort@uah.es, Díaz-Laviada, Inés^1,2 (AUTHOR) alicia.bort@uah.es

Source: International Journal of Molecular Sciences. Nov2023, Vol. 24 Issue 21, p15626. 18p.

Subject Terms: *PROSTATE cancer, *CANCER cells, *CANCER stem cells, *BIOSYNTHESIS, *ANDROGEN receptors, *HISTONE deacetylase

The red pepper’s spicy ingredient capsaicin activates AMPK in HepG2 cells through CaMKKβ.

Authors: Bort, Alicia¹, Sánchez, Belén G.¹, Spínola, Elena², Mateos-Gómez, Pedro A.¹, Rodríguez-Henche, Nieves¹, Díaz-Laviada, Inés^1,3 ines.diazlaviada@uah.es

Source: PLoS ONE. 1/29/2019, Vol. 14 Issue 1, p1-15. 15p.

Subject Terms: *THERAPEUTIC use of capsaicin, *PEPPERS, *LIVER cancer, *CANCER cells, *REACTIVE oxygen species

Alteration of the HIF-1α/VEGF Signaling Pathway and Disruption of the Cell Cycle by Second Generation Carbosilan Dendrimers.

Authors: Barrios, Oscar¹ (AUTHOR), Sánchez, Belén G.² (AUTHOR), Rodríguez-Prieto, Tamara^1,3,4 (AUTHOR), Cano, Jesús^1,3,4 (AUTHOR), Bort, Alicia^2,5 (AUTHOR), Gómez, Rafael^1,3,4 (AUTHOR) rafael.gomez@uah.es, Díaz-Laviada, Inés² (AUTHOR) ines.diazlaviada@uah.es

Source: Biomacromolecules. 12/12/2022, Vol. 23 Issue 12, p5043-5055. 13p.

Role of Dipeptidyl Peptidase-4 (DPP4) on COVID-19 Physiopathology.

Authors: Sebastián-Martín, Alba, Sánchez, Belén G., Mora-Rodríguez, José M., Bort, Alicia, Díaz-Laviada, Inés

Source: Biomedicines; Aug2022, Vol. 10 Issue 8, pN.PAG-N.PAG, 21p

Subject Terms: CD26 antigen, THYROID crisis, COVID-19, PATHOLOGICAL physiology, MEMBRANE proteins, CARBOHYDRATE metabolism

Company/Entity: UNITED States. Food & Drug Administration

The Natural Chemotherapeutic Capsaicin Activates AMPK through LKB1 Kinase and TRPV1 Receptors in Prostate Cancer Cells.

Authors: Sánchez, Belén G.¹ (AUTHOR) belen.sanchezg@edu.uah.es, Bort, Alicia¹ (AUTHOR) alicia.bort@uah.es, Mora-Rodríguez, José M.¹ (AUTHOR) josem.mora@uah.es, Díaz-Laviada, Inés^1,2 (AUTHOR) ines.diazlaviada@uah.es

Source: Pharmaceutics. Feb2022, Vol. 14 Issue 2, p329. 1p.

Subject Terms: *TRP channels, *TRPV cation channels, *PROSTATE cancer, *CANCER cells, *CAPSAICIN, *CANCER chemotherapy

Dysregulated lipid metabolism in hepatocellular carcinoma cancer stem cells.

Authors: Bort, Alicia, Sánchez, Belén G., de Miguel, Irene, Mateos-Gómez, Pedro A., Diaz-Laviada, Inés

Source: Molecular Biology Reports; Apr2020, Vol. 47 Issue 4, p2635-2647, 13p

Targeting AMP‐activated kinase impacts hepatocellular cancer stem cells induced by long‐term treatment with sorafenib.

Authors: Bort, Alicia, Sánchez, Belén G., Mateos‐Gómez, Pedro A., Vara‐Ciruelos, Diana, Rodríguez‐Henche, Nieves, Díaz‐Laviada, Inés

Source: Molecular Oncology; May2019, Vol. 13 Issue 5, p1311-1331, 21p

Androgen Deprivation Induces Reprogramming of Prostate Cancer Cells to Stem-Like Cells.

Authors: Sánchez, Belén G.¹ (AUTHOR) belen.sanchezg@edu.uah.es, Bort, Alicia¹ (AUTHOR) alicia.bort@edu.uah.es, Vara-Ciruelos, Diana¹ (AUTHOR) dianavara83@hotmail.com, Díaz-Laviada, Inés^1,2 (AUTHOR) ines.diazlaviada@uah.es

Source: Cells (2073-4409). Jun2020, Vol. 9 Issue 6, p1441-1441. 1p.

Subject Terms: *ANDROGEN drugs, *CANCER cells, *PROSTATE cancer, *ANDROGEN receptors, *VASCULAR endothelial growth factors, *HYPOXIA-inducible factors, *ANTIANDROGENS, *HYPOXIA-inducible factor 1

Capsaicin Targets Lipogenesis in HepG2 Cells Through AMPK Activation, AKT Inhibition and PPARs Regulation.

Authors: Bort, Alicia¹, Sánchez, Belén G.¹, Mateos-Gómez, Pedro A.¹, Rodríguez-Henche, Nieves¹, Díaz-Laviada, Inés^1,2

Source: International Journal of Molecular Sciences. Apr2019, Vol. 20 Issue 7, p1660-1660. 1p. 1 Diagram, 5 Graphs.

Subject Terms: *CAPSAICIN, *LIPID metabolism, *GLUCOSE metabolism, *OBESITY, *FATTY liver

Combination of the natural product capsaicin and docetaxel synergistically kills human prostate cancer cells through the metabolic regulator AMP-activated kinase.

Authors: Sánchez, Belén G.¹ Belensg.88@gmail.com, Bort, Alicia¹ aliciabort@gmail.com, Mateos-Gómez, Pedro A.¹ pedroantonio.mateos@uah.es, Rodríguez-Henche, Nieves¹ nieves.rhenche@uah.es, Díaz-Laviada, Inés^1,2 ines.diazlaviada@uah.es

Source: Cancer Cell International. 3/8/2019, Vol. 19 Issue 1, pN.PAG-N.PAG. 1p.

Subject Terms: *CASTRATION-resistant prostate cancer, *ABIRATERONE acetate, *NATURAL products, *PROSTATE cancer, *CANCER cells